Dr Romina Vuono

Interests

My research interests include:

1)Molecular mechanisms involved in the pathogenesis of Huntington's disease

2)Embryonic stem cells as a source for cell therapy in Parkinson's disease

3)Sleep and Circadian rhytm dysruption in Parkinson’s disease

Research Focus

Keywords

Neurodegeneration

Disorder

MAPT

Function/Dysfunction

Cell Therapy

Clinical conditions

Huntington's disease

Parkinson's Disease

Equipment

Cell culture

Computational modelling

Confocal microscopy

Enzyme assays

Fluorescent microscopy

FPLC/HPLC

Immunohistochemistry

Microscopy

Protein purification

Recombinant protein expression

Collaborators

International

Ernest Arenas

Elena Cattaneo

Associated News Items


Publications

2013

Carri AD, Onorati M, Lelos MJ, Castiglioni V, Faedo A, Menon R, Camnasio S, Vuono R, Spaiardi P, Talpo F, Toselli M, Martino G, Barker RA, Dunnett SB, Biella G, Cattaneo E (2013), “Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32+ medium-sized spiny neurons.” Development 140(2):301-12 Details

2012

Ribeiro D, Laguna Goya R, Ravindran G, Vuono R, Parish CL, Foldi C, Piroth T, Yang S, Parmar M, Nikkhah G, Hjerling-Leffler J, Lindvall O, Barker RA, Arenas E (2012), “Efficient expansion and dopaminergic differentiation of human fetal ventral midbrain neural stem cells by midbrain morphogens.” Neurobiol Dis 49C:118-127 Details

2011

Anfossi M, Vuono R, Maletta R, Virdee K, Mirabelli M, Colao R, Puccio G, Bernardi L, Frangipane F, Gallo M, Geracitano S, Tomaino C, Curcio SA, Zannino G, Lamenza F, Duyckaerts C, Spillantini MG, Losso MA, Bruni AC (2011), “Compound heterozygosity of 2 novel MAPT mutations in frontotemporal dementia.” Neurobiol Aging 32(4):757.e1-757.e11 Details

Spillantini MG, Iovino M, Vuono R (2011), “Release of growth factors by neuronal precursor cells as a treatment for diseases with tau pathology.” Arch Ital Biol 149(2):215-23 Details