Dr Rickie Patani

University position

Wellcome Trust Intermediate Fellow, Anne Rowling Fellow

Departments

Department of Clinical Neurosciences

Institutes

The Anne McLaren Laboratory for Regenerative Medicine

Email

rp379@cam.ac.uk

Home page

http://www.brc.cam.ac.uk

Research Themes

Cellular and Molecular Neuroscience

Developmental Neuroscience

Interests

The focus of my research is neural lineage restriction from human pluripotent stem cells and the subsequent regional fate specification of derived neural precursors. One key area of study is to investigate temporal responsiveness of human neural precursors to morphogenetic cues and, by using insights gained from this work, to generate both neurons and glia in chemically defined conditions. The generation of clinically relevant human neural cell types provides an unprecedented experimental opportunity to both study human neurodevelopmental processes and to model neurodegenerative disease in-vitro.

Research Focus

Keywords

stem cells

neurodegenerative brain disorders

Clinical conditions

Motor neurone disease

Multiple sclerosis

Equipment

Cell culture

Immunohistochemistry

Collaborators

No collaborators listed

Associated News Items


    Key publications

    Patani R, Lewis PA, Trabzuni D, Puddifoot CA, Wyllie DJ, Walker R, Smith C, Hardingham GE, Weale M, Hardy J, Chandran S, Ryten M (2012), “Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole genome gene expression and splicing analysis.” J Neurochem Details

    Patani R, Sibley CR, Chandran S, Ule J (2012), “Using human pluripotent stem cells to study post-transcriptional mechanisms of neurodegenerative diseases.” Brain Res Details

    Patani R, Hollins AJ, Wishart TM, Puddifoot CA, Alvarez S, de Lera AR, Wyllie DJ, Compston DA, Pedersen RA, Gillingwater TH, Hardingham GE, Allen ND, Chandran S (2011), “Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state.” Nat Commun 2:214 Details

    Tollervey JR, Curk T, Rogelj B, Briese M, Cereda M, Kayikci M, König J, Hortobágyi T, Nishimura AL, Zupunski V, Patani R, Chandran S, Rot G, Zupan B, Shaw CE, Ule J (2011), “Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.” Nat Neurosci Details

    Hardingham GE, Patani R, Baxter P, Wyllie DJ, Chandran S (2010), “Human Embryonic Stem Cell-Derived Neurons as a Tool for Studying Neuroprotection and Neurodegeneration.” Mol Neurobiol Details

    Patani R, Compston A, Puddifoot CA, Wyllie DJ, Hardingham GE, Allen ND, Chandran S (2009), “Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity.” PLoS One 4(10):e7327 Details

    Patani R, Balaratnam M, Vora A, Reynolds R (2007), “Remyelination can be extensive in multiple sclerosis despite a long disease course.” Neuropathol Appl Neurobiol 33(3):277-87 Details

    Publications

    2013

    Athappily C, Patani R, Chawda S, Rosser E, de Silva R (2013), “TS or not TS?” Pract Neurol Details

    Patani R, Muhammed N, Chaudhuri A (2013), “Flexor hallucis brevis spasm.” Muscle Nerve 47(6):939 Details

    Reimer MM, Norris A, Ohnmacht J, Patani R, Zhong Z, Dias TB, Kuscha V, Scott AL, Chen YC, Rozov S, Frazer SL, Wyatt C, Higashijima SI, Patton EE, Panula P, Chandran S, Becker T, Becker CG (2013), “Dopamine from the Brain Promotes Spinal Motor Neuron Generation during Development and Adult Regeneration.” Dev Cell Details

    Shribman S, Patani R, Deeb J, Chaudhuri A (2013), “Voltage-gated potassium channelopathy: an expanding spectrum of clinical phenotypes.” BMJ Case Rep 2013 Details

    2012

    Connick P, Kolappan M, Crawley C, Webber DJ, Patani R, Michell AW, Du MQ, Luan SL, Altmann DR, Thompson AJ, Compston A, Scott MA, Miller DH, Chandran S (2012), “Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study.” Lancet Neurol Details

    Patani R, Chandran S (2012), “Experimental and therapeutic opportunities for stem cells in multiple sclerosis.” Int J Mol Sci 13(11):14470-91 Details

    Thomson SR, Wishart TM, Patani R, Chandran S, Gillingwater TH (2012), “Using induced pluripotent stem cells (iPSC) to model human neuromuscular connectivity: promise or reality?” J Anat 220(2):122-130 Details

    2011

    Bell KF, Al-Mubarak B, Fowler JH, Baxter PS, Gupta K, Tsujita T, Chowdhry S, Patani R, Chandran S, Horsburgh K, Hayes JD, Hardingham GE (2011), “Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning.” Proc Natl Acad Sci U S A 108(1):E1-2; author reply E3-4 Details

    Connick P, Kolappan M, Patani R, Scott MA, Crawley C, He XL, Richardson K, Barber K, Webber DJ, Wheeler-Kingshott CA, Tozer DJ, Samson RS, Thomas DL, Du MQ, Luan SL, Michell AW, Altmann DR, Thompson AJ, Miller DH, Compston A, Chandran S (2011), “The Mesenchymal Stem Cells in Multiple Sclerosis (MSCIMS) Trial protocol and baseline cohort characteristics: an open-label pre-test : post-test study with blinded outcome assessments.” Trials 12(1):62 Details

    Connick P, Patani R, Chandran S (2011), “Stem cells as a resource for regenerative neurology.” Pract Neurol 11(1):29-36 Details

    Gupta K, Patani R, Baxter P, Serio A, Story D, Tsujita T, Hayes JD, Pedersen RA, Hardingham GE, Chandran S (2011), “Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms.” Cell Death Differ Details

    Tan CL, Kwok JC, Patani R, Ffrench-Constant C, Chandran S, Fawcett JW (2011), “Integrin activation promotes axon growth on inhibitory chondroitin sulfate proteoglycans by enhancing integrin signaling.” J Neurosci 31(17):6289-95 Details

    2010

    Anderson JM, Patani R, Reynolds R, Nicholas R, Compston A, Spillantini MG, Chandran S (2010), “Abnormal tau phosphorylation in primary progressive multiple sclerosis.” Acta Neuropathol 119(5):591-600 Details

    Iovino M, Patani R, Watts C, Chandran S, Spillantini MG (2010), “Human stem cell-derived neurons: a system to study human tau function and dysfunction.” PLoS One 5(11):e13947 Details

    2009

    Anderson JM, Patani R, Reynolds R, Nicholas R, Compston A, Spillantini MG, Chandran S (2009), “Evidence for abnormal tau phosphorylation in early aggressive multiple sclerosis.” Acta Neuropathol 117(5):583-9 Details

    2008

    Anderson JM, Hampton DW, Patani R, Pryce G, Crowther RA, Reynolds R, Franklin RJ, Giovannoni G, Compston DA, Baker D, Spillantini MG, Chandran S (2008), “Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis.” Brain 131(Pt 7):1736-48 Details