Dr Ragnhildur Thora Karadottir
Wellcome Trust RCD Fellow
Dr Ragnhildur Thora Karadottir is pleased to consider applications from prospective PhD students.
My lab’s interests are neurotransmitter signalling to oligodendrocytes and their progenitor cells, in both health and disease.
Oligodendrocytes produce myelin (in the CNS), which speeds the propagation of the action potential. When the myelin sheath is lost, in diseases like cerebral palsy, spinal cord injury and multiple sclerosis, it causes mental and physical disability. We study how oligodendrocytes respond to neurotransmitters released from axons, both in the normal brain and in pathological conditions.
Oligodendrocyte precursor cells (OPCs) comprise 5% of the cells in the adult brain, where they are the main proliferative cells present. They can generate both neurons and glial cells, making them an important stem cell population in the adult brain. I have shown that these cells fall into two classes, with distinct physiological properties. We study the role of the two classes of OPC, in both the normal brain and pathological conditions.
Spinal cord injury
Electrophysiological recording techniques
Whole cell patch clamp
David Attwell Web: http://www.ucl.ac.uk/npp/da....
Charles ffrench-Constant Web: http://www.crm.ed.ac.uk/researc...
Káradóttir R, Hamilton NB, Bakiri Y, Attwell D (2008), “Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter.” Nat Neurosci 11(4):450-6 Details
Káradóttir R & Attwell D (2006), “Combining patch-clamping of cells in brain slices with immunocytochemical labelling to define cell type and developmental stage” Nature Protocols 1(4):1977-1985 Details
Káradóttir R, Cavalier P, Bergersen LH & Attwell D (2005), “NMDA receptors are expressed in oligodendrocytes and activated in ischaemia” Nature 438:1162-1166