Professor Robin Franklin

Collaborators

Key publications

Fancy SP, Baranzini SE, Zhao C, Yuk DI, Irvine KA, Kaing S, Sanai N, Franklin RJ, Rowitch DH (2009), “Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS.” Genes Dev 23(13):1571-85 Details

Franklin RJM, ffrench-Constant C (2008), “Remyelination in the CNS: from biology to therapy” Nature Rev Neurosci 9(11): 839-55

Shen S, Sandoval J, Swiss V, Li J, Dupree J, Franklin RJM, Casaccia-Bonnefil P (2008), “Age-dependent epigenetic control of differentiation inhibitors: a critical determinant of remyelination efficiency” Nature Neurosci 11: 1024-1034.

Arnett HA, Fancy SPJ, Alberta JA, Zhao C, Plant SR, Som S, Raine CS, Rowitch D, Franklin RJM, Stiles CD (2004), “The bHLH transcription factor Olig1 is required for repair of demyelinated lesions in the CNS” Science 306:2111-2115

Publications

2009

Baer AS, Syed YA, Kang SU, Mitteregger D, Vig R, Ffrench-Constant C, Franklin RJ, Altmann F, Lubec G, Kotter MR (2009), “Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling.” Brain 132(Pt 2):465-81 Details

Bruce CC, Zhao C, Franklin RJ (2009), “Remyelination - An effective means of neuroprotection.” Horm Behav Details

Mi S, Miller RH, Tang W, Lee X, Hu B, Wu W, Zhang Y, Shields CB, Zhang Y, Miklasz S, Shea D, Mason J, Franklin RJ, Ji B, Shao Z, Chédotal A, Bernard F, Roulois A, Xu J, Jung V, Pepinsky B (2009), “Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells.” Ann Neurol 65(3):304-15 Details

2008

Anderson JM, Hampton DW, Patani R, Pryce G, Crowther RA, Reynolds R, Franklin RJ, Giovannoni G, Compston DA, Baker D, Spillantini MG, Chandran S (2008), “Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis.” Brain 131(Pt 7):1736-48 Details

Barraud P, He X, Caldwell MA, Franklin RJ (2008), “Secreted factors from olfactory mucosa cells expanded as free-floating spheres increase neurogenesis in olfactory bulb neurosphere cultures.” BMC Neurosci 9:24 Details

Brinkmann, B. G., Agarwal, A., Serada, M. W., Garratt, A. N., Mueller, T., Wende, H., Stassart, R. M., Nawaz, S., Humml, C., Velanac, V., Radyuschkin, K., Goebbels, S., Fischer, T. M., Franklin, R. J. M., Lai, C., Ehrenreich, H., Birchmeier, C., Schwab, M. H., Nave, K. A. (2008), “Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system” Neuron 59 581-594

Buckley CE, Goldsmith P, Franklin RJ (2008), “Zebrafish myelination: a transparent model for remyelination?” Dis Model Mech 1(4-5):221-8 Details

Chandran S, Hunt D, Joannides A, Zhao C, Compston A, Franklin RJ (2008), “Myelin repair: the role of stem and precursor cells in multiple sclerosis.” Philos Trans R Soc Lond B Biol Sci 363(1489):171-83 Details

Franklin RJ, Kotter MR (2008), “The biology of CNS remyelination: the key to therapeutic advances.” J Neurol 255 Suppl 1:19-25 Details

Hampton DW, Anderson J, Pryce G, Irvine KA, Giovannoni G, Fawcett JW, Compston A, Franklin RJ, Baker D, Chandran S (2008), “An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss.” J Neuroimmunol 201-202:200-11 Details

Ito D, Fujita N, Ibanez C, Sasaki N, Franklin RJ, Jeffery ND (2008), “Serum-free medium provides a clinically relevant method to increase olfactory ensheathing cell numbers in olfactory mucosa cell culture.” Cell Transplant 16(10):1021-7 Details

Neumann H, Kotter MR, Franklin RJ (2008), “Debris clearance by microglia: an essential link between degeneration and regeneration.” Brain Details

Rist JM, Franklin RJ (2008), “Taking ageing into account in remyelination-based therapies for multiple sclerosis.” J Neurol Sci 274(1-2):64-7 Details

Zhao C, Fancy SP, ffrench-Constant C, Franklin RJ (2008), “Osteopontin is extensively expressed by macrophages following CNS demyelination but has a redundant role in remyelination.” Neurobiol Dis 31(2):209-17 Details

Zhao C, Zawadzka M, Roulois AJ, Bruce CC, Franklin RJ (2008), “Promoting remyelination in multiple sclerosis by endogenous adult neural stem/precursor cells: defining cellular targets.” J Neurol Sci 265(1-2):12-6 Details

2007

Barraud P, He X, Zhao C, Ibanez C, Raha-Chowdhury R, Caldwell MA, Franklin RJ (2007), “Contrasting effects of basic fibroblast growth factor and epidermal growth factor on mouse neonatal olfactory mucosa cells.” Eur J Neurosci 26(12):3345-57 Details

Benninger Y, Thurnherr T, Pereira JA, Krause S, Wu X, Chrostek-Grashoff A, Herzog D, Nave KA, Franklin RJ, Meijer D, Brakebusch C, Suter U, Relvas JB (2007), “Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development.” J Cell Biol 177(6):1051-61 Details

Bowen S, Ateh DD, Deinhardt K, Bird MM, Price KM, Baker CS, Robson JC, Swash M, Shamsuddin W, Kawar S, El-Tawil T, Roos J, Hoyle A, Nickols CD, Knowles CH, Pullen AH, Luthert PJ, Weller RO, Hafezparast M, Franklin RJ, Revesz T, King RH, Berninghausen O, Fisher EM, Schiavo G, Martin JE (2007), “The phagocytic capacity of neurones.” Eur J Neurosci 25(10):2947-55 Details

Hamilton L, Franklin RJ, Jeffery ND (2007), “Development of a universal measure of quadrupedal forelimb-hindlimb coordination using digital motion capture and computerised analysis.” BMC Neurosci 8:77 Details

Ibanez C, Ito D, Zawadzka M, Jeffery ND, Franklin RJ (2007), “Calponin is expressed by fibroblasts and meningeal cells but not olfactory ensheathing cells in the adult peripheral olfactory system.” Glia 55(2):144-51 Details

Skelly BJ, Franklin RJ (2007), “Mutations in genes causing human familial isolated hyperparathyroidism do not account for hyperparathyroidism in Keeshond dogs.” Vet J 174(3):652-4 Details

Woodhoo A, Sahni V, Gilson J, Setzu A, Franklin RJ, Blakemore WF, Mirsky R, Jessen KR (2007), “Schwann cell precursors: a favourable cell for myelin repair in the Central Nervous System.” Brain 130(Pt 8):2175-85 Details

Zawadzka M, Franklin RJ (2007), “Myelin regeneration in demyelinating disorders: new developments in biology and clinical pathology.” Curr Opin Neurol 20(3):294-8 Details

2006

Benninger Y, Colognato H, Thurnherr T, Franklin RJ, Leone DP, Atanasoski S, Nave KA, Ffrench-Constant C, Suter U, Relvas JB (2006), “Beta1-integrin signaling mediates premyelinating oligodendrocyte survival but is not required for CNS myelination and remyelination.” J Neurosci 26(29):7665-73 Details

Dunning MD, Kettunen MI, Ffrench Constant C, Franklin RJ, Brindle KM (2006), “Magnetic resonance imaging of functional Schwann cell transplants labelled with magnetic microspheres.” Neuroimage 31(1):172-80 Details

Franklin RJ, Zhao C (2006), “Tyrosine kinases: maiming myelin in leprosy.” Nat Med 12(8):889-90 Details

Kotter MR, Li W-W, Chao Z, Franklin RJM (2006), “Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation” Journal of Neuroscience 26:328-332

Li WW, Penderis J, Zhao C, Schumacher M, Franklin RJ (2006), “Females remyelinate more efficiently than males following demyelination in the aged but not young adult CNS.” Exp Neurol 202(1):250-4 Details

Ligon KL, Fancy SP, Franklin RJ, Rowitch DH (2006), “Olig gene function in CNS development and disease.” Glia 54(1):1-10 Details

Setzu A, Lathia JD, Zhao C, Wells K, Rao MS, Ffrench-Constant C, Franklin RJ (2006), “Inflammation stimulates myelination by transplanted oligodendrocyte precursor cells.” Glia 54(4):297-303 Details

Thurnherr T, Benninger Y, Wu X, Chrostek A, Krause SM, Nave KA, Franklin RJ, Brakebusch C, Suter U, Relvas JB (2006), “Cdc42 and Rac1 signaling are both required for and act synergistically in the correct formation of myelin sheaths in the CNS.” J Neurosci 26(40):10110-9 Details

2004

Dunning MD, Lakatos A, Loizou L, Kettunen M, ffrench-Constant C, Brindle KM, Franklin RJM (2004), “Superparamagnetic iron oxide (SPIO)-labelled Schwann cells and olfactory ensheathing cells can be traced in vivo by magnetic resonance imaging and retain functional properties following transplantation into the CNS” Journal of Neuroscience 24:9799-9810