Dr Richard Adams
Dr Richard Adams is pleased to consider applications from prospective PhD students.
My group is interested in the mechanisms of morphogenesis that shape the early central nervous system. Using zebrafish as a developmental model, we image the movements of many hundreds of cells using time-lapse micoscopy. Applying methods of image analysis was are able to trace the movements that take place during gastrulation and neurulation to tranform the CNS into its 3D form.
Neural tube defects
No direct clinical relevance
No collaborators listed
Blanchard GB, Kabla AJ, Schultz NL, Butler LC, Sanson B, Gorfinkiel N, Mahadevan L, Adams RJ (2009), “Tissue tectonics: morphogenetic strain rates, cell shape change and intercalation.” Nat Methods 6(6):458-64 Details
England SJ, Blanchard GB, Mahadevan L, Adams RJ (2006), “A dynamic fate map of the forebrain shows how vertebrate eyes form and explains two causes of cyclopia.” Development 133(23):4613-7 Details
Rembold M, Loosli F, Adams RJ, Wittbrodt J (2006), “Individual cell migration serves as the driving force for optic vesicle evagination” Science 313:1130-4 Details
Glickman NS, Kimmel CB, Jones MA, Adams R (2003), “Shaping the zebrafish notochord” Development 130:873–87
Blanchard GB, Murugesu S, Adams RJ, Martinez-Arias A, Gorfinkiel N (2010), “Cytoskeletal dynamics and supracellular organisation of cell shape fluctuations during dorsal closure.” Development 137(16):2743-52 Details
Butler LC, Blanchard GB, Kabla AJ, Lawrence NJ, Welchman DP, Mahadevan L, Adams RJ, Sanson B (2009), “Cell shape changes indicate a role for extrinsic tensile forces in Drosophila germ-band extension.” Nat Cell Biol 11(7):859-64 Details
Gorfinkiel N, Blanchard GB, Adams RJ, Martinez Arias A (2009), “Mechanical control of global cell behaviour during dorsal closure in Drosophila.” Development 136(11):1889-98 Details
Meilhac SM, Adams RJ, Morris SA, Danckaert A, Le Garrec JF, Zernicka-Goetz M (2009), “Active cell movements coupled to positional induction are involved in lineage segregation in the mouse blastocyst.” Dev Biol 331(2):210-21 Details
England SJ, Adams RJ (2007), “Building a dynamic fate map.” Biotechniques 43(1 Suppl):20-4 Details
Strauss B, Adams RJ, Papalopulu N (2006), “A default mechanism of spindle orientation based on cell shape is sufficient to generate cell fate diversity in polarised Xenopus blastomeres.” Development 133(19):3883-93 Details