Professor Robin Irvine

Robin Irvine

University position

Professor

Professor Robin Irvine is pleased to consider applications from prospective PhD students.

Departments

Department of Pharmacology

Home page

http://www.phar.cam.ac.uk/ri/irvi...

Research Theme

Cellular and Molecular Neuroscience

Interests

All my research centres around inositides, which fall into two groups, inositol lipids and inositol phosphates. Most of our work focuses on some of the kinases that phosphorylate inositides, and the functions of their substrates and products, including exploration of possible effectors. As with any family of proteins associated with cell signalling, the kinases and effectors are more highly expressed in the brain than any other organ. Moroever, some enzymes that we work with, for example, IP3 3-kinase A and PI4P 5-kinase I gamma 93, are only expressed in neurons in the brain. Thus our reserach is partly generic, using brain as a 'super-signalling' organ to study univeral functions; and part specific, exploring inositide functions that are unique to neuroscience.

Research Focus

Keywords

inositol

insoitide

lipid

phosphate

neural circuit

Clinical conditions

No direct clinical relevance

Equipment

No equipment indicated

Collaborators

No collaborators listed

Associated News Items


    Key publications

    Clarke JH, Irvine RF (2013), “Enzyme activity of the PIP4K2A gene product polymorphism that is implicated in schizophrenia.” Psychopharmacology (Berl) 230(2):329-31 Details

    Hammond GR, Fischer MJ, Anderson KE, Holdich J, Koteci A, Balla T, Irvine RF (2012), “PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identity.” Science 337(6095):727-30 Details

    Clarke JH, Emson PC, Irvine RF (2009), “Distribution and neuronal expression of phosphatidylinositol phosphate kinase IIgamma in the mouse brain.” J Comp Neurol 517(3):296-312 Details

    Hammond GR, Sim Y, Lagnado L, Irvine RF (2009), “Reversible binding and rapid diffusion of proteins in complex with inositol lipids serves to coordinate free movement with spatial information.” J Cell Biol 184(2):297-308 Details

    Schell MJ, Irvine RF (2006), “Calcium-triggered exit of F-actin and IP3 3-kinase A from dendritic spines is rapid and reversible” Eur J Neurosci 24:2491-2503 Details

    Giudici ML, Emson PC, Irvine RF (2004), “A novel neuronal-specific splice variant of Type I Phosphatidylinositol 4-phosphate 5-kinase isoform gamma” Biochem J 379:489-496 Details

    Publications

    2013

    Clarke JH, Irvine RF (2013), “Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization.” Biochem J 454(1):49-57 Details

    Irvine RF (2013), “Absence of detectable inositol hexakisphosphate (phytate) in plasma.” J Chromatogr B Analyt Technol Biomed Life Sci Details

    2012

    Clarke JH, Irvine RF (2012), “The activity, evolution and association of phosphatidylinositol 5-phosphate 4-kinases.” Adv Biol Regul 52(1):40-5 Details

    2011

    Irvine RF, Denton RM (2011), “Cell biology. Pyro-technic control of metabolism.” Science 334(6057):770-1 Details

    Xia Y, Irvine RF, Giudici ML (2011), “Phosphatidylinositol 4-phosphate 5-kinase Iγ_v6, a new splice variant found in rodents and humans.” Biochem Biophys Res Commun 411(2):416-20 Details

    2010

    Clarke JH, Wang M, Irvine RF (2010), “Localization, regulation and function of type II phosphatidylinositol 5-phosphate 4-kinases.” Adv Enzyme Regul 50(1):12-8 Details

    Letcher AJ, Schell MJ, Irvine RF (2010), “A femtomole-sensitivity mass assay for inositol hexakisphosphate.” Methods Mol Biol 645:61-71 Details

    Wang M, Bond NJ, Letcher AJ, Richardson JP, Lilley KS, Irvine RF, Clarke JH (2010), “Genomic tagging reveals a random association of endogenous PtdIns5P 4-kinases IIalpha and IIbeta and a partial nuclear localization of the IIalpha isoform.” Biochem J 430(2):215-21 Details

    2009

    Hammond GR, Schiavo G, Irvine RF (2009), “Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P(2).” Biochem J 422(1):23-35 Details

    2008

    Clarke JH, Emson PC, Irvine RF (2008), “Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron.” Am J Physiol Renal Physiol 295(5):F1422-30 Details

    Letcher AJ, Schell MJ, Irvine RF (2008), “Do mammals make all their own inositol hexakisphosphate?” Biochem J 416(2):263-70 Details

    2007

    Clarke JH, Richardson JP, Hinchliffe KA, Irvine RF (2007), “Type II PtdInsP kinases: location, regulation and function.” Biochem Soc Symp (74):149-59 Details

    Lloyd-Burton SM, Yu JC, Irvine RF, Schell MJ (2007), “Regulation of inositol 1,4,5-trisphosphate 3-kinases by calcium and localization in cells.” J Biol Chem 282(13):9526-35 Details

    Richardson JP, Wang M, Clarke JH, Patel KJ, Irvine RF (2007), “Genomic tagging of endogenous type IIbeta phosphatidylinositol 5-phosphate 4-kinase in DT40 cells reveals a nuclear localisation.” Cell Signal 19(6):1309-14 Details

    2006

    Giudici ML, Lee K, Lim R, Irvine RF (2006), “The intracellular localisation and mobility of Type Igamma phosphatidylinositol 4P 5-kinase splice variants.” FEBS Lett 580(30):6933-7 Details

    Hinchliffe KA, Irvine RF (2006), “Regulation of type II PIP kinase by PKD phosphorylation.” Cell Signal 18(11):1906-13 Details

    Irvine RF (2006), “Nuclear inositide signalling -- expansion, structures and clarification.” Biochim Biophys Acta 1761(5-6):505-8 Details

    Irvine RF, Lloyd-Burton SM, Yu JC, Letcher AJ, Schell MJ (2006), “The regulation and function of inositol 1,4,5-trisphosphate 3-kinases.” Adv Enzyme Regul 46:314-23 Details

    Veiga N, Torres J, Domínguez S, Mederos A, Irvine RF, Díaz A, Kremer C (2006), “The behaviour of myo-inositol hexakisphosphate in the presence of magnesium(II) and calcium(II): protein-free soluble InsP6 is limited to 49 microM under cytosolic/nuclear conditions.” J Inorg Biochem 100(11):1800-10 Details

    2005

    Brough D, Bhatti F, Irvine RF (2005), “Mobility of proteins associated with the plasma membrane by interaction with inositol lipids.” J Cell Sci 118(Pt 14):3019-25 Details

    Brough D, Schell MJ, Irvine RF (2005), “Agonist-induced regulation of mitochondrial and endoplasmic reticulum motility.” Biochem J 392(Pt 2):291-7 Details

    Brough D, Sim Y, Thorn P, Irvine RF (2005), “The structural integrity of the endoplasmic reticulum, and its possible regulation by inositol 1,3,4,5-tetrakisphosphate.” Cell Calcium 38(2):153-9 Details

    Irvine RF (2005), “Inositide evolution - towards turtle domination?” J Physiol 566(Pt 2):295-300 Details

    Powner DJ, Payne RM, Pettitt TR, Giudici ML, Irvine RF, Wakelam MJ (2005), “Phospholipase D2 stimulates integrin-mediated adhesion via phosphatidylinositol 4-phosphate 5-kinase Igamma b.” J Cell Sci 118(Pt 13):2975-86 Details

    Roberts HF, Clarke JH, Letcher AJ, Irvine RF, Hinchliffe KA (2005), “Effects of lipid kinase expression and cellular stimuli on phosphatidylinositol 5-phosphate levels in mammalian cell lines.” FEBS Lett 579(13):2868-72 Details

    Torres J, Domínguez S, Cerdá MF, Obal G, Mederos A, Irvine RF, Díaz A, Kremer C (2005), “Solution behaviour of myo-inositol hexakisphosphate in the presence of multivalent cations. Prediction of a neutral pentamagnesium species under cytosolic/nuclear conditions.” J Inorg Biochem 99(3):828-40 Details

    Yu JC, Lloyd-Burton SM, Irvine RF, Schell MJ (2005), “Regulation of the localization and activity of inositol 1,4,5-trisphosphate 3-kinase B in intact cells by proteolysis.” Biochem J 392(Pt 3):435-41 Details

    Yu JCH, Lloyd-Burton SM, Irvine RF, Schell MJ (2005), “Regulation of the localization and activity of inositol 1,4,5-trisphosphate 3-kinase B in intact cells by proteolysis” Biochem J 392:435-441

    2004

    Giudici ML, Hinchliffe KA, Irvine RF (2004), “Phosphatidylinositol phosphate kinases.” J Endocrinol Invest 27(6 Suppl):137-42 Details

    González B, Schell MJ, Letcher AJ, Veprintsev DB, Irvine RF, Williams RL (2004), “Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase.” Mol Cell 15(5):689-701 Details

    2003

    Dawson AP, Lea EJ, Irvine RF (2003), “Kinetic model of the inositol trisphosphate receptor that shows both steady-state and quantal patterns of Ca2+ release from intracellular stores.” Biochem J 370(Pt 2):621-9 Details

    Irvine RF (2003), “20 years of Ins(1,4,5)P3, and 40 years before.” Nat Rev Mol Cell Biol 4(7):586-90 Details

    Irvine RF (2003), “Nuclear lipid signalling.” Nat Rev Mol Cell Biol 4(5):349-60 Details

    2002

    Hinchliffe KA, Giudici ML, Letcher AJ, Irvine RF (2002), “Type IIalpha phosphatidylinositol phosphate kinase associates with the plasma membrane via interaction with type I isoforms.” Biochem J 363(Pt 3):563-70 Details

    Irvine RF (2002), “Nuclear lipid signaling.” Sci STKE 2002(150):re13 Details

    2001

    Clarke JH, Letcher AJ, D'santos CS, Halstead JR, Irvine RF, Divecha N (2001), “Inositol lipids are regulated during cell cycle progression in the nuclei of murine erythroleukaemia cells.” Biochem J 357(Pt 3):905-10 Details

    Irvine RF, Schell MJ (2001), “Back in the water: the return of the inositol phosphates.” Nat Rev Mol Cell Biol 2(5):327-38 Details

    McNulty TJ, Letcher AJ, Dawson AP, Irvine RF (2001), “Tissue distribution of GAP1(IP4BP) and GAP1(m): two inositol 1,3,4,5-tetrakisphosphate-binding proteins.” Cell Signal 13(12):877-86 Details

    Schell MJ, Erneux C, Irvine RF (2001), “Inositol 1,4,5-trisphosphate 3-kinase A associates with F-actin and dendritic spines via its N terminus.” J Biol Chem 276(40):37537-46 Details

    2000

    Ciruela A, Hinchliffe KA, Divecha N, Irvine RF (2000), “Nuclear targeting of the beta isoform of type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its alpha-helix 7.” Biochem J 346 Pt 3:587-91 Details

    Jones DH, Morris JB, Morgan CP, Kondo H, Irvine RF, Cockcroft S (2000), “Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the golgi compartment.” J Biol Chem 275(18):13962-6 Details

    Morris JB, Hinchliffe KA, Ciruela A, Letcher AJ, Irvine RF (2000), “Thrombin stimulation of platelets causes an increase in phosphatidylinositol 5-phosphate revealed by mass assay.” FEBS Lett 475(1):57-60 Details

    Smith PM, Harmer AR, Letcher AJ, Irvine RF (2000), “The effect of inositol 1,3,4,5-tetrakisphosphate on inositol trisphosphate-induced Ca2+ mobilization in freshly isolated and cultured mouse lacrimal acinar cells.” Biochem J 347 Pt 1:77-82 Details

    1999

    D'Santos CS, Clarke JH, Irvine RF, Divecha N (1999), “Nuclei contain two differentially regulated pools of diacylglycerol.” Curr Biol 9(8):437-40 Details

    Hinchliffe KA, Ciruela A, Letcher AJ, Divecha N, Irvine RF (1999), “Regulation of type IIalpha phosphatidylinositol phosphate kinase localisation by the protein kinase CK2.” Curr Biol 9(17):983-6 Details

    Hinchliffe KA, Ciruela A, Morris JA, Divecha N, Irvine RF (1999), “The type II PIPkins (PtdIns5P 4-kinases): enzymes in search of a function?” Biochem Soc Trans 27(4):657-61 Details

    Irvine RF, McNulty TJ, Schell MJ (1999), “Inositol 1,3,4,5-tetrakisphosphate as a second messenger--a special role in neurones?” Chem Phys Lipids 98(1-2):49-57 Details

    Lockyer PJ, Vanlingen S, Reynolds JS, McNulty TJ, Irvine RF, Parys JB, Cullen PJ (1999), “Tissue-specific expression and endogenous subcellular distribution of the inositol 1,3,4,5-tetrakisphosphate-binding proteins GAP1(IP4BP) and GAP1(m).” Biochem Biophys Res Commun 255(2):421-6 Details

    Schell MJ, Letcher AJ, Brearley CA, Biber J, Murer H, Irvine RF (1999), “PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase.” FEBS Lett 461(3):169-72 Details

    1998

    Cooper DM, Schell MJ, Thorn P, Irvine RF (1998), “Regulation of adenylyl cyclase by membrane potential.” J Biol Chem 273(42):27703-7 Details

    Hinchliffe KA, Ciruela A, Irvine RF (1998), “PIPkins1, their substrates and their products: new functions for old enzymes.” Biochim Biophys Acta 1436(1-2):87-104 Details

    Hinchliffe KA, Irvine RF, Divecha N (1998), “Regulation of PtdIns4P 5-kinase C by thrombin-stimulated changes in its phosphorylation state in human platelets.” Biochem J 329 ( Pt 1):115-9 Details

    Irvine RF (1998), “Manganese-stimulated phosphatidylinositol headgroup exchange in rat liver microsomes.” Biochim Biophys Acta 1393(2-3):292-8 Details

    Loomis-Husselbee JW, Walker CD, Bottomley JR, Cullen PJ, Irvine RF, Dawson AP (1998), “Modulation of Ins(2,4,5)P3-stimulated Ca2+ mobilization by ins(1,3,4, 5)P4: enhancement by activated G-proteins, and evidence for the involvement of a GAP1 protein, a putative Ins(1,3,4,5)P4 receptor.” Biochem J 331 ( Pt 3):947-52 Details

    Molendijk AJ, Irvine RF (1998), “Inositide signalling in Chlamydomonas: characterization of a phosphatidylinositol 3-kinase gene.” Plant Mol Biol 37(1):53-66 Details

    Munnik T, Irvine RF, Musgrave A (1998), “Phospholipid signalling in plants.” Biochim Biophys Acta 1389(3):222-72 Details

    1997

    Cullen PJ, Loomis-Husselbee J, Dawson AP, Irvine RF (1997), “Inositol 1,3,4,5-tetrakisphosphate and Ca2+ homoeostasis: the role of GAP1IP4BP.” Biochem Soc Trans 25(3):991-6 Details

    Divecha N, Banfic H, Treagus JE, Vann L, Irvine RF, D'Santos C (1997), “Nuclear diacylglycerol, the cell cycle, the enzymes and a red herring (or how we came to love phosphatidylcholine).” Biochem Soc Trans 25(2):571-5 Details

    Marchant JS, Chang YT, Chung SK, Irvine RF, Taylor CW (1997), “Rapid kinetic measurements of 45Ca2+ mobilization reveal that Ins(2,4,5)P3 is a partial agonist at hepatic InsP3 receptors.” Biochem J 321 ( Pt 3):573-6 Details

    Vann LR, Wooding FB, Irvine RF, Divecha N (1997), “Metabolism and possible compartmentalization of inositol lipids in isolated rat-liver nuclei.” Biochem J 327 ( Pt 2):569-76 Details

    1996

    Hinchliffe KA, Irvine RF, Divecha N (1996), “Aggregation-dependent, integrin-mediated increases in cytoskeletally associated PtdInsP2 (4,5) levels in human platelets are controlled by translocation of PtdIns 4-P 5-kinase C to the cytoskeleton.” EMBO J 15(23):6516-24 Details

    Loomis-Husselbee JW, Cullen PJ, Dreikausen UE, Irvine RF, Dawson AP (1996), “Synergistic effects of inositol 1,3,4,5-tetrakisphosphate on inositol 2,4,5-triphosphate-stimulated Ca2+ release do not involve direct interaction of inositol 1,3,4,5-tetrakisphosphate with inositol triphosphate-binding sites.” Biochem J 314 ( Pt 3):811-6 Details

    Munnik T, de Vrije T, Irvine RF, Musgrave A (1996), “Identification of diacylglycerol pyrophosphate as a novel metabolic product of phosphatidic acid during G-protein activation in plants.” J Biol Chem 271(26):15708-15 Details

    1995

    Cullen PJ, Chung SK, Chang YT, Dawson AP, Irvine RF (1995), “Specificity of the purified inositol (1,3,4,5) tetrakisphosphate-binding protein from porcine platelets.” FEBS Lett 358(3):240-2 Details

    Cullen PJ, Dawson AP, Irvine RF (1995), “Purification and characterization of an Ins(1,3,4,5)P4 binding protein from pig platelets: possible identification of a novel non-neuronal Ins(1,3,4,5)P4 receptor.” Biochem J 305 ( Pt 1):139-43 Details

    Cullen PJ, Hsuan JJ, Truong O, Letcher AJ, Jackson TR, Dawson AP, Irvine RF (1995), “Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family.” Nature 376(6540):527-30 Details

    Divecha N, Irvine RF (1995), “Phospholipid signaling.” Cell 80(2):269-78 Details

    Divecha N, Letcher AJ, Banfic HH, Rhee SG, Irvine RF (1995), “Changes in the components of a nuclear inositide cycle during differentiation in murine erythroleukaemia cells.” Biochem J 312 ( Pt 1):63-7 Details

    Divecha N, Truong O, Hsuan JJ, Hinchliffe KA, Irvine RF (1995), “The cloning and sequence of the C isoform of PtdIns4P 5-kinase.” Biochem J 309 ( Pt 3):715-9 Details

    Irvine RF (1995), “Inositide evolution: what can it tell us about functions?” Biochem Soc Trans 23(1):27-35 Details

    1994

    Cullen PJ, Patel Y, Kakkar VV, Irvine RF, Authi KS (1994), “Specific binding sites for inositol 1,3,4,5-tetrakisphosphate are located predominantly in the plasma membranes of human platelets.” Biochem J 298 Pt 3:739-42 Details

    Divecha N, Banfić H, Irvine RF (1994), “The nuclear phosphoinositide cycle--does it play a role in nuclear Ca2+ homoeostasis?” Cell Calcium 16(4):297-300 Details

    Munnik T, Irvine RF, Musgrave A (1994), “Rapid turnover of phosphatidylinositol 3-phosphate in the green alga Chlamydomonas eugametos: signs of a phosphatidylinositide 3-kinase signalling pathway in lower plants?” Biochem J 298 ( Pt 2):269-73 Details

    1993

    Banfić H, Zizak M, Divecha N, Irvine RF (1993), “Nuclear diacylglycerol is increased during cell proliferation in vivo.” Biochem J 290 ( Pt 3):633-6 Details

    Brooksbank CE, Hutchings A, Butcher GW, Irvine RF, Divecha N (1993), “Monoclonal antibodies to phosphatidylinositol 4-phosphate 5-kinase: distribution and intracellular localization of the C isoform.” Biochem J 291 ( Pt 1):77-82 Details

    Divecha N, Banfic H, Irvine RF (1993), “Unclear or nuclear: another role for the phosphatidylinositol cycle?” Biochem Soc Trans 21(4):877-8 Details

    Divecha N, Banfić H, Irvine RF (1993), “Inositides and the nucleus and inositides in the nucleus.” Cell 74(3):405-7 Details

    Divecha N, Rhee SG, Letcher AJ, Irvine RF (1993), “Phosphoinositide signalling enzymes in rat liver nuclei: phosphoinositidase C isoform beta 1 is specifically, but not predominantly, located in the nucleus.” Biochem J 289 ( Pt 3):617-20 Details

    Hawkins PT, Poyner DR, Jackson TR, Letcher AJ, Lander DA, Irvine RF (1993), “Inhibition of iron-catalysed hydroxyl radical formation by inositol polyphosphates: a possible physiological function for myo-inositol hexakisphosphate.” Biochem J 294 ( Pt 3):929-34 Details

    Irvine RF, Cullen PJ (1993), “Will the real IP4 receptor please stand up?” Curr Biol 3(8):540-3 Details

    Wreggett KA, Irvine RF (1993), “Evidence for receptor-specific regulation of the metabolism of the second messenger, inositol trisphosphate, in human endothelial cells.” Biochem Biophys Res Commun 193(3):855-63 Details

    1992

    Chattaway JA, Drøbak BK, Watkins PA, Dawson AP, Letcher AJ, Stephens LR, Irvine RF (1992), “An inositol 1,4,5-trisphosphate-6-kinase activity in pea roots.” Planta 187(4):542-5 Details

    Cullen PJ, Irvine RF (1992), “Inositol 1,3,4,5-tetrakisphosphate binding sites in neuronal and non-neuronal tissues. Properties, comparisons and potential physiological significance.” Biochem J 288 ( Pt 1):149-54 Details

    Divecha N, Brooksbank CE, Irvine RF (1992), “Purification and characterization of phosphatidylinositol 4-phosphate 5-kinases.” Biochem J 288 ( Pt 2):637-42 Details

    Irvine RF (1992), “Inositol phosphates and Ca2+ entry: toward a proliferation or a simplification?” FASEB J 6(12):3085-91 Details

    Irvine RF (1992), “Inositol lipids in cell signalling.” Curr Opin Cell Biol 4(2):212-9 Details

    Irvine RF (1992), “Is inositol tetrakisphosphate the second messenger that controls Ca2+ entry into cells?” Adv Second Messenger Phosphoprotein Res 26:161-85 Details

    Irvine RF, Divecha N (1992), “Phospholipids in the nucleus--metabolism and possible functions.” Semin Cell Biol 3(4):225-35 Details

    Irvine RF, Letcher AJ, Stephens LR, Musgrave A (1992), “Inositol polyphosphate metabolism and inositol lipids in a green alga, Chlamydomonas eugametos.” Biochem J 281 ( Pt 1):261-6 Details

    1991

    Brederoo J, de Wildt P, Popp-Snijders C, Irvine RF, Musgrave A, van den Ende H (1991), “Polyphosphoinositol lipids in Chlamydomonas eugametos gametes.” Planta 184(2):175-81 Details

    Divecha N, Banfić H, Irvine RF (1991), “The polyphosphoinositide cycle exists in the nuclei of Swiss 3T3 cells under the control of a receptor (for IGF-I) in the plasma membrane, and stimulation of the cycle increases nuclear diacylglycerol and apparently induces translocation of protein kinase C to the nucleus.” EMBO J 10(11):3207-14 Details

    Divecha N, Lander DJ, Scott TW, Irvine RF (1991), “Molecular species analysis of 1,2-diacylglycerols and phosphatidic acid formed during bombesin stimulation of Swiss 3T3 cells.” Biochim Biophys Acta 1093(2-3):184-8 Details

    Irvine RF (1991), “Inositol tetrakisphosphate as a second messenger: confusions, contradictions, and a potential resolution.” Bioessays 13(8):419-27 Details

    Irvine RF (1991), “Calcium control and InsP4.” Nature 352(6331):115 Details

    Ivorra I, Gigg R, Irvine RF, Parker I (1991), “Inositol 1,3,4,6-tetrakisphosphate mobilizes calcium in Xenopus oocytes with high potency.” Biochem J 273(Pt 2):317-21 Details

    Loomis-Husselbee JW, Cullen PJ, Irvine RF, Dawson AP (1991), “Electroporation can cause artefacts due to solubilization of cations from the electrode plates. Aluminum ions enhance conversion of inositol 1,3,4,5-tetrakisphosphate into inositol 1,4,5-trisphosphate in electroporated L1210 cells.” Biochem J 277 ( Pt 3):883-5 Details

    Mattingly RR, Stephens LR, Irvine RF, Garrison JC (1991), “Effects of transformation with the v-src oncogene on inositol phosphate metabolism in rat-1 fibroblasts. D-myo-inositol 1,4,5,6-tetrakisphosphate is increased in v-src-transformed rat-1 fibroblasts and can be synthesized from D-myo-inositol 1,3,4-trisphosphate in cytosolic extracts.” J Biol Chem 266(23):15144-53 Details

    Neylon CB, Irvine RF (1991), “Thrombin attenuates the stimulatory effect of histamine on Ca2+ entry in confluent human umbilical vein endothelial cell cultures.” J Biol Chem 266(7):4251-6 Details

    Neylon CB, Mason WT, Irvine RF (1991), “Histamine-induced calcium oscillations in human vascular smooth muscle: temporal sequence and spatial organization in single cells.” Clin Exp Pharmacol Physiol 18(5):299-302 Details

    Stephens LR, Hawkins PT, Stanley AF, Moore T, Poyner DR, Morris PJ, Hanley MR, Kay RR, Irvine RF (1991), “myo-inositol pentakisphosphates. Structure, biological occurrence and phosphorylation to myo-inositol hexakisphosphate.” Biochem J 275 ( Pt 2):485-99 Details

    Stephens LR, Hughes KT, Irvine RF (1991), “Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils.” Nature 351(6321):33-9 Details

    Tregear RT, Dawson AP, Irvine RF (1991), “Quantal release of Ca2+ from intracellular stores by InsP3: tests of the concept of control of Ca2+ release by intraluminal Ca2+.” Proc Biol Sci 243(1308):263-8 Details

    1990

    Cocco L, Capitani S, Martelli AM, Irvine RF, Gilmour RS, Maraldi NM, Barnabei O, Manzoli FA (1990), “Nuclear inositol lipids. Relationship between growth factor induced metabolic changes and protein kinase C activity.” Adv Enzyme Regul 30:155-72 Details

    Cullen PJ, Irvine RF, Dawson AP (1990), “Synergistic control of Ca2+ mobilization in permeabilized mouse L1210 lymphoma cells by inositol 2,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate.” Biochem J 271(2):549-53 Details

    Harrison RA, Roldan ER, Lander DJ, Irvine RF (1990), “Ram spermatozoa produce inositol 1,4,5-trisphosphate but not inositol 1,3,4,5-tetrakisphosphate during the Ca2+/ionophore-induced acrosome reaction.” Cell Signal 2(3):277-84 Details

    Irvine RF (1990), “'Quantal' Ca2+ release and the control of Ca2+ entry by inositol phosphates--a possible mechanism.” FEBS Lett 263(1):5-9 Details

    Irvine RF (1990), “Care and cleaning of the non-contemporary photographic image.” J Audiov Media Med 13(2):61-3 Details

    Neylon CB, Hoyland J, Mason WT, Irvine RF (1990), “Spatial dynamics of intracellular calcium in agonist-stimulated vascular smooth muscle cells.” Am J Physiol 259(4 Pt 1):C675-86 Details

    Neylon CB, Irvine RF (1990), “Synchronized repetitive spikes in cytoplasmic calcium in confluent monolayers of human umbilical vein endothelial cells.” FEBS Lett 275(1-2):173-6 Details

    Stephens LR, Berrie CP, Irvine RF (1990), “Agonist-stimulated inositol phosphate metabolism in avian erythrocytes.” Biochem J 269(1):65-72 Details

    Stephens LR, Irvine RF (1990), “Stepwise phosphorylation of myo-inositol leading to myo-inositol hexakisphosphate in Dictyostelium.” Nature 346(6284):580-3 Details

    Stephens LR, Kay RR, Irvine RF (1990), “A myo-inositol D-3 hydroxykinase activity in Dictyostelium.” Biochem J 272(1):201-10 Details

    Wreggett KA, Lander DJ, Irvine RF (1990), “Two-stage analysis of radiolabeled inositol phosphate isomers.” Methods Enzymol 191:707-18 Details

    1989

    Berridge MJ, Irvine RF (1989), “Inositol phosphates and cell signalling.” Nature 341(6239):197-205 Details

    Changya L, Gallacher DV, Irvine RF, Petersen OH (1989), “Inositol 1,3,4,5-tetrakisphosphate and inositol 1,4,5-trisphosphate act by different mechanisms when controlling Ca2+ in mouse lacrimal acinar cells.” FEBS Lett 251(1-2):43-8 Details

    Changya L, Gallacher DV, Irvine RF, Potter BV, Petersen OH (1989), “Inositol 1,3,4,5-tetrakisphosphate is essential for sustained activation of the Ca2+-dependent K+ current in single internally perfused mouse lacrimal acinar cells.” J Membr Biol 109(1):85-93 Details

    Cocco L, Martelli AM, Gilmour RS, Ognibene A, Manzoli FA, Irvine RF (1989), “Changes in nuclear inositol phospholipids induced in intact cells by insulin-like growth factor I.” Biochem Biophys Res Commun 159(2):720-5 Details

    Cullen PJ, Irvine RF, Drøbak BK, Dawson AP (1989), “Inositol 1,3,4,5-tetrakisphosphate causes release of Ca2+ from permeabilized mouse lymphoma L1210 cells by its conversion into inositol 1,4,5-trisphosphate.” Biochem J 259(3):931-3 Details

    Irvine RF (1989), “Ensuring permanence of contemporary photographs.” J Audiov Media Med 12(4):135-7 Details

    Irvine RF (1989), “How do inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate regulate intracellular Ca2+?” Biochem Soc Trans 17(1):6-9 Details

    Irvine RF, Letcher AJ, Lander DJ, Drøbak BK, Dawson AP, Musgrave A (1989), “Phosphatidylinositol(4,5)bisphosphate and Phosphatidylinositol(4)phosphate in Plant Tissues.” Plant Physiol 89(3):888-92 Details

    Willcocks AL, Strupish J, Irvine RF, Nahorski SR (1989), “Inositol 1:2-cyclic,4,5-trisphosphate is only a weak agonist at inositol 1,4,5-trisphosphate receptors.” Biochem J 257(1):297-300 Details

    Wreggett KA, Irvine RF (1989), “Automated isocratic high-performance liquid chromatography of inositol phosphate isomers.” Biochem J 262(3):997-1000 Details

    1988

    Brown JE, Rudnick M, Letcher AJ, Irvine RF (1988), “Formation of methylphosphoryl inositol phosphates by extractions that employ methanol.” Biochem J 253(3):703-10 Details

    Cocco L, Martelli AM, Gilmour RS, Ognibene A, Manzoli FA, Irvine RF (1988), “Rapid changes in phospholipid metabolism in the nuclei of Swiss 3T3 cells induced by treatment of the cells with insulin-like growth factor I.” Biochem Biophys Res Commun 154(3):1266-72 Details

    Cran DG, Moor RM, Irvine RF (1988), “Initiation of the cortical reaction in hamster and sheep oocytes in response to inositol trisphosphate.” J Cell Sci 91 ( Pt 1):139-44 Details

    Drøbak BK, Ferguson IB, Dawson AP, Irvine RF (1988), “Inositol-containing lipids in suspension-cultured plant cells: an isotopic study.” Plant Physiol 87(1):217-22 Details

    Irvine RF, Moor RM, Pollock WK, Smith PM, Wreggett KA (1988), “Inositol phosphates: proliferation, metabolism and function.” Philos Trans R Soc Lond B Biol Sci 320(1199):281-98 Details

    McMurray WC, Irvine RF (1988), “Phosphatidylinositol 4,5-bisphosphate phosphodiesterase in higher plants.” Biochem J 249(3):877-81 Details

    Pollock WK, Wreggett KA, Irvine RF (1988), “Inositol phosphate production and Ca2+ mobilization in human umbilical-vein endothelial cells stimulated by thrombin and histamine.” Biochem J 256(2):371-6 Details

    1987

    Bradford PG, Irvine RF (1987), “Specific binding sites for [3H]inositol(1,3,4,5)tetrakisphosphate on membranes of HL-60 cells.” Biochem Biophys Res Commun 149(2):680-5 Details

    Cocco L, Gilmour RS, Ognibene A, Letcher AJ, Manzoli FA, Irvine RF (1987), “Synthesis of polyphosphoinositides in nuclei of Friend cells. Evidence for polyphosphoinositide metabolism inside the nucleus which changes with cell differentiation.” Biochem J 248(3):765-70 Details

    Connolly TM, Bansal VS, Bross TE, Irvine RF, Majerus PW (1987), “The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes.” J Biol Chem 262(5):2146-9 Details

    Irvine RF (1987), “Inositol phosphates and calcium entry.” Nature 328(6129):386 Details

    Irvine RF (1987), “The metabolism and function of inositol phosphates.” Biochem Soc Trans 15(1):122-3 Details

    Irvine RF, Letcher AJ, Lander DJ, Heslop JP, Berridge MJ (1987), “Inositol(3,4)bisphosphate and inositol(1,3)bisphosphate in GH4 cells--evidence for complex breakdown of inositol(1,3,4)trisphosphate.” Biochem Biophys Res Commun 143(1):353-9 Details

    Irvine RF, Moor RM (1987), “Inositol(1,3,4,5)tetrakisphosphate-induced activation of sea urchin eggs requires the presence of inositol trisphosphate.” Biochem Biophys Res Commun 146(1):284-90 Details

    Lindon JC, Baker DJ, Williams JM, Irvine RF (1987), “Confirmation of the identities of inositol 1,3,4-trisphosphate and inositol 1,3,4,5-tetrakisphosphate by the use of one-dimensional and two-dimensional n.m.r. spectroscopy.” Biochem J 244(3):591-5 Details

    Morris AP, Gallacher DV, Irvine RF, Petersen OH (1987), “Synergism of inositol trisphosphate and tetrakisphosphate in activating Ca2+-dependent K+ channels.” Nature 330(6149):653-5 Details

    Shears SB, Parry JB, Tang EK, Irvine RF, Michell RH, Kirk CJ (1987), “Metabolism of D-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate.” Biochem J 246(1):139-47 Details

    Tertoolen LG, Tilly BC, Irvine RF, Moolenaar WH (1987), “Electrophysiological responses to bradykinin and microinjected inositol polyphosphates in neuroblastoma cells. Possible role of inositol 1,3,4-trisphosphate in altering membrane potential.” FEBS Lett 214(2):365-9 Details

    Wreggett KA, Howe LR, Moore JP, Irvine RF (1987), “Extraction and recovery of inositol phosphates from tissues.” Biochem J 245(3):933-4 Details

    Wreggett KA, Irvine RF (1987), “A rapid separation method for inositol phosphates and their isomers.” Biochem J 245(3):655-60 Details

    1986

    Downes CP, Hawkins PT, Irvine RF (1986), “Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland.” Biochem J 238(2):501-6 Details

    Heslop JP, Blakeley DM, Brown KD, Irvine RF, Berridge MJ (1986), “Effects of bombesin and insulin on inositol (1,4,5)trisphosphate and inositol (1,3,4)trisphosphate formation in Swiss 3T3 cells.” Cell 47(5):703-9 Details

    Irvine RF (1986), “Calcium transients: mobilization of intracellular Ca2+.” Br Med Bull 42(4):369-74 Details

    Irvine RF, Letcher AJ, Heslop JP, Berridge MJ (1986), “The inositol tris/tetrakisphosphate pathway--demonstration of Ins(1,4,5)P3 3-kinase activity in animal tissues.” Nature 320(6063):631-4 Details

    Irvine RF, Letcher AJ, Lander DJ, Berridge MJ (1986), “Specificity of inositol phosphate-stimulated Ca2+ mobilization from Swiss-mouse 3T3 cells.” Biochem J 240(1):301-4 Details

    Irvine RF, Moor RM (1986), “Micro-injection of inositol 1,3,4,5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca2+.” Biochem J 240(3):917-20 Details

    Pollock WK, Irvine RF, Rink TJ (1986), “Free Ca2+ requirements of agonist-induced thromboxane A2 synthesis in human platelets.” Eur J Pharmacol 132(2-3):309-12 Details

    Pollock WK, Rink TJ, Irvine RF (1986), “Liberation of [3H]arachidonic acid and changes in cytosolic free calcium in fura-2-loaded human platelets stimulated by ionomycin and collagen.” Biochem J 235(3):869-77 Details

    1985

    Banfić H, Pokrajac N, Irvine RF (1985), “Incorporation of 32P into phospholipids in vivo during compensatory renal growth.” Biochim Biophys Acta 833(2):223-8 Details

    Batty IR, Nahorski SR, Irvine RF (1985), “Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices.” Biochem J 232(1):211-5 Details

    Berridge MJ, Brown KD, Irvine RF, Heslop JP (1985), “Phosphoinositides and cell proliferation.” J Cell Sci Suppl 3:187-98 Details

    Berridge MJ, Heslop JP, Irvine RF, Brown KD (1985), “Inositol lipids and cell proliferation.” Biochem Soc Trans 13(1):67-71 Details

    Burgess GM, McKinney JS, Irvine RF, Putney JW Jr (1985), “Inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate formation in Ca2+-mobilizing-hormone-activated cells.” Biochem J 232(1):237-43 Details

    Dawson RM, Hemington N, Irvine RF (1985), “The inhibition of diacylglycerol-stimulated intracellular phospholipases by phospholipids with a phosphocholine-containing polar group. A possible physiological role for sphingomyelin.” Biochem J 230(1):61-8 Details

    Heslop JP, Irvine RF, Tashjian AH Jr, Berridge MJ (1985), “Inositol tetrakis- and pentakisphosphates in GH4 cells.” J Exp Biol 119:395-401 Details

    Irvine RF, Anggård EE, Letcher AJ, Downes CP (1985), “Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands.” Biochem J 229(2):505-11 Details

    Streb H, Heslop JP, Irvine RF, Schulz I, Berridge MJ (1985), “Relationship between secretagogue-induced Ca2+ release and inositol polyphosphate production in permeabilized pancreatic acinar cells.” J Biol Chem 260(12):7309-15 Details

    1984

    Berridge MJ, Heslop JP, Irvine RF, Brown KD (1984), “Inositol trisphosphate formation and calcium mobilization in Swiss 3T3 cells in response to platelet-derived growth factor.” Biochem J 222(1):195-201 Details

    Berridge MJ, Irvine RF (1984), “Inositol trisphosphate, a novel second messenger in cellular signal transduction.” Nature 312(5992):315-21 Details

    Biden TJ, Prentki M, Irvine RF, Berridge MJ, Wollheim CB (1984), “Inositol 1,4,5-trisphosphate mobilizes intracellular Ca2+ from permeabilized insulin-secreting cells.” Biochem J 223(2):467-73 Details

    Brown JE, Rubin LJ, Ghalayini AJ, Tarver AP, Irvine RF, Berridge MJ, Anderson RE (1984), “myo-Inositol polyphosphate may be a messenger for visual excitation in Limulus photoreceptors.” Nature 311(5982):160-3 Details

    Brown KD, Blay J, Irvine RF, Heslop JP, Berridge MJ (1984), “Reduction of epidermal growth factor receptor affinity by heterologous ligands: evidence for a mechanism involving the breakdown of phosphoinositides and the activation of protein kinase C.” Biochem Biophys Res Commun 123(1):377-84 Details

    Burgess GM, Godfrey PP, McKinney JS, Berridge MJ, Irvine RF, Putney JW Jr (1984), “The second messenger linking receptor activation to internal Ca release in liver.” Nature 309(5963):63-6 Details

    Burgess GM, Irvine RF, Berridge MJ, McKinney JS, Putney JW Jr (1984), “Actions of inositol phosphates on Ca2+ pools in guinea-pig hepatocytes.” Biochem J 224(3):741-6 Details

    Burgess GM, McKinney JS, Irvine RF, Berridge MJ, Hoyle PC, Putney JW Jr (1984), “Inositol 1,4,5-trisphosphate may be a signal for f-Met-Leu-Phe-induced intracellular Ca mobilisation in human leucocytes (HL-60 cells).” FEBS Lett 176(1):193-6 Details

    Dawson AP, Irvine RF (1984), “Inositol (1,4,5)trisphosphate-promoted Ca2+ release from microsomal fractions of rat liver.” Biochem Biophys Res Commun 120(3):858-64 Details

    Dawson RM, Irvine RF, Bray J, Quinn PJ (1984), “Long-chain unsaturated diacylglycerols cause a perturbation in the structure of phospholipid bilayers rendering them susceptible to phospholipase attack.” Biochem Biophys Res Commun 125(2):836-42 Details

    Fein A, Payne R, Corson DW, Berridge MJ, Irvine RF (1984), “Photoreceptor excitation and adaptation by inositol 1,4,5-trisphosphate.” Nature 311(5982):157-60 Details

    Irvine RF, Brown KD, Berridge MJ (1984), “Specificity of inositol trisphosphate-induced calcium release from permeabilized Swiss-mouse 3T3 cells.” Biochem J 222(1):269-72 Details

    Irvine RF, Letcher AJ, Dawson RM (1984), “Phosphatidylinositol-4,5-bisphosphate phosphodiesterase and phosphomonoesterase activities of rat brain. Some properties and possible control mechanisms.” Biochem J 218(1):177-85 Details

    Irvine RF, Letcher AJ, Lander DJ, Downes CP (1984), “Inositol trisphosphates in carbachol-stimulated rat parotid glands.” Biochem J 223(1):237-43 Details

    Irvine RF, Letcher AJ, Meade CJ, Dawson RM (1984), “One-dimensional thin-layer chromatographic separation of the lipids involved in arachidonic acid metabolism.” J Pharmacol Methods 12(3):171-82 Details

    Joseph SK, Thomas AP, Williams RJ, Irvine RF, Williamson JR (1984), “myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.” J Biol Chem 259(5):3077-81 Details

    Prentki M, Biden TJ, Janjic D, Irvine RF, Berridge MJ, Wollheim CB (1984), “Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate.” Nature 309(5968):562-4 Details

    Streb H, Bayerdörffer E, Haase W, Irvine RF, Schulz I (1984), “Effect of inositol-1,4,5-trisphosphate on isolated subcellular fractions of rat pancreas.” J Membr Biol 81(3):241-53 Details

    1983

    Berridge MJ, Dawson RM, Downes CP, Heslop JP, Irvine RF (1983), “Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides.” Biochem J 212(2):473-82 Details

    Dawson RM, Hemington NL, Irvine RF (1983), “Diacylglycerol potentiates phospholipase attack upon phospholipid bilayers: possible connection with cell stimulation.” Biochem Biophys Res Commun 117(1):196-201 Details

    Dawson RM, Irvine RF, Hemington NL, Hirasawa K (1983), “The alkaline phospholipase A1 of rat liver cytosol.” Biochem J 209(3):865-72 Details

    Irvine RF, Dawson RM (1983), “Phosphatidylinositol phosphodiesterase of rat brain: Ca2+-dependency, pH optima and heterogeneity.” Biochem J 215(2):431-2 Details

    Streb H, Irvine RF, Berridge MJ, Schulz I (1983), “Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate.” Nature 306(5938):67-9 Details

    Varsanyi M, Tölle HG, Heilmeyer MG Jr, Dawson RM, Irvine RF (1983), “Activation of sarcoplasmic reticular Ca2+ transport ATPase by phosphorylation of an associated phosphatidylinositol.” EMBO J 2(9):1543-8 Details

    1982

    Dawson RM, Irvine RF, Hemington N, Hirasawa K (1982), “The stimulation of the brain alkaline phospholipase A1 attacking phosphatidylethanolamine by various salts and metal chelators.” Neurochem Res 7(9):1149-61 Details

    Dawson RM, Irvine RF, Hirasawa K, Hemington NL (1982), “Hydrolysis of phosphatidylinositol by pancreas and pancreatic secretion.” Biochim Biophys Acta 710(2):212-20 Details

    Hirasawa K, Irvine RF, Dawson RM (1982), “Proteolytic activation can produce a phosphatidylinositol phosphodiesterase highly sensitive to Ca2+.” Biochem J 206(3):675-8 Details

    Hirasawa K, Irvine RF, Dawson RM (1982), “Heterogeneity of the calcium-dependent phosphatidylinositol phosphodiesterase in rat brain.” Biochem J 205(2):437-42 Details

    Hirasawa K, Irvine RF, Dawson RM (1982), “Heterogeneity of the calcium-dependent phosphatidylinositol-phosphodiesterase of rat liver kidney, as revealed by column chromatofocusing.” Biochem Biophys Res Commun 107(2):533-7 Details

    Irvine RF (1982), “The enzymology of stimulated inositol lipid turnover.” Cell Calcium 3(4-5):295-309 Details

    Irvine RF (1982), “How is the level of free arachidonic acid controlled in mammalian cells?” Biochem J 204(1):3-16 Details

    Irvine RF, Berridge MJ, Letcher AJ, Dawson RM (1982), “Phosphatidylinositol-hydrolysing enzymes in blowfly salivary glands.” Biochem J 204(1):361-4 Details

    1981

    Clarke NG, Irvine RF, Dawson RM (1981), “Formation of bis(phosphatidyl)inositol and phosphatidic acid by phospholipase D action on phosphatidylinositol.” Biochem J 195(2):521-3 Details

    Hirasawa K, Irvine RF, Dawson RM (1981), “The catabolism of phosphatidylinisitol by an EDTA-insensitive phospholipase A1 and calcium-dependent phosphatidylinositol phosphodiesterase in rat brain.” Eur J Biochem 120(1):53-8 Details

    Hirasawa K, Irvine RF, Dawson RM (1981), “The hydrolysis of phosphatidylinositol monolayers at an air/water interface by the calcium-ion-dependent phosphatidylinositol phosphodiesterase of pig brain.” Biochem J 193(2):607-14 Details

    1980

    Dawson RM, Hemington N, Irvine RF (1980), “The inhibition and activation of Ca2+-dependent phosphatidylinositol phosphodiesterase by phospholipids and blood plasma.” Eur J Biochem 112(1):33-8 Details

    Irvine RF, Dawson RM (1980), “The mechanism and function of phosphatidylinositol turnover [proceedings].” Biochem Soc Trans 8(3):376-7 Details

    Irvine RF, Dawson RM (1980), “The control of phosphatidylinositol turnover in cell membranes.” Biochem Soc Trans 8(1):27-30 Details

    Irvine RF, Letcher AJ, Dawson RM (1980), “Phosphatidylinositol phosphodiesterase in higher plants.” Biochem J 192(1):279-83 Details

    Irvine RF, Letcher AJ, Dawson RM (1980), “Thyrotropin-stimulated phosphatidylinositol-specific phospholipase A2 in pig thyroid, a re-examination.” FEBS Lett 119(2):287-9 Details

    1979

    Dawson RM, Hemington N, Richards DE, Irvine RF (1979), “sn-Glycero(3)phosphoinositol glycerophosphohydrolase. A new phosphodiesterase in rat tissues.” Biochem J 182(1):39-45 Details

    Irvine RF, Dawson RM (1979), “Transfer of arachidonic acid between phospholipids in rat liver microsomes.” Biochem Biophys Res Commun 91(4):1399-405 Details

    Irvine RF, Dawson RM (1979), “Neural phospholipases hydrolysing phosphatidylinositol and their possible role in stimulated turnover of this phospholipid.” Biochem Soc Trans 7(2):353-7 Details

    Irvine RF, Hemington N, Dawson RM (1979), “The calcium-dependent phosphatidylinositol-phosphodiesterase of rat brain. Mechanisms of suppression and stimulation.” Eur J Biochem 99(3):525-30 Details

    Irvine RF, Letcher AJ, Dawson RM (1979), “Fatty acid stimulation of membrane phosphatidylinositol hydrolysis by brain phosphatidylinositol phosphodiesterase.” Biochem J 178(2):497-500 Details

    Richards DE, Irvine RF, Dawson RM (1979), “Hydrolysis of membrane phospholipids by phospholipases of rat liver lysosomes.” Biochem J 182(2):599-606 Details

    1978

    Dawson RM, Irvine RF (1978), “Possible role of lysosomal phospholidpases in inducing tissue prostaglandin synthesis.” Adv Prostaglandin Thromboxane Res 3:47-54 Details

    Irvine RF, Dawson RM (1978), “The distribution of calcium-dependent phosphatidylinositol-specific phosphodiesterase in rat brain.” J Neurochem 31(6):1427-34 Details

    Irvine RF, Dawson RM (1978), “Is there a membrane-bound, calcium-dependent phosphatidylinositol phosphodiesterase in rat brain?” Biochem Soc Trans 6(5):1020-2 Details

    Irvine RF, Hemington N, Dawson RM (1978), “The hydrolysis of phosphatidylinositol by lysosomal enzymes of rat liver and brain.” Biochem J 176(2):475-84 Details

    1977

    Irvine RF, Hemington N, Dawson RM (1977), “Phosphatidylinositol-degrading enzymes in liver lysosomes.” Biochem J 164(1):277-80 Details

    Irvine RF, Hemington N, Dawson RM (1977), “The role of lysosomes in phosphatidylinositol degradation [proceedings].” Biochem Soc Trans 5(5):1297-9 Details