Dr Rene Frank
Senior Investigator Scientist
I am interested in the molecular mechanisms that underly the acquisition of memory. The NMDA receptor and many other proteins with which it associates have been identified as essential players in the cognitive functions of learning and memory. My goal is to uncover the structure and mechanism of signal transduction in these complexes using biochemical methods, mouse genetics, cryo-electron microscopy and X-ray crystallography.
These studies are a part of the Genes to Cognition research consortium that integrates many experimental approaches in order to understand genetic contribution to behaviour and disease.
Recombinant protein expression
Associated News Items
Frank RA (2011), “Endogenous ion channel complexes: the NMDA receptor.” Biochem Soc Trans 39(3):707-18 Details
Frank RA, McRae AF, Pocklington AJ, van de Lagemaat LN, Navarro P, Croning MD, Komiyama NH, Bradley SJ, Challiss RA, Armstrong JD, Finn RD, Malloy MP, MacLean AW, Harris SE, Starr JM, Bhaskar SS, Howard EK, Hunt SE, Coffey AJ, Ranganath V, Deloukas P, Rogers J, Muir WJ, Deary IJ, Blackwood DH, Visscher PM, Grant SG (2011), “Clustered coding variants in the glutamate receptor complexes of individuals with schizophrenia and bipolar disorder.” PLoS One 6(4):e19011 Details
Frank RA, Kay CW, Hirst J, Luisi BF (2008), “Off-pathway, oxygen-dependent thiamine radical in the Krebs cycle.” J Am Chem Soc 130(5):1662-8 Details
Frank RA, Leeper FJ, Luisi BF (2007), “Structure, mechanism and catalytic duality of thiamine-dependent enzymes.” Cell Mol Life Sci 64(7-8):892-905 Details
Frank RA, Price AJ, Northrop FD, Perham RN, Luisi BF (2007), “Crystal structure of the E1 component of the Escherichia coli 2-oxoglutarate dehydrogenase multienzyme complex.” J Mol Biol 368(3):639-51 Details
Frank RA, Pratap JV, Pei XY, Perham RN, Luisi BF (2005), “The molecular origins of specificity in the assembly of a multienzyme complex.” Structure 13(8):1119-30 Details
Frank RA, Titman CM, Pratap JV, Luisi BF, Perham RN (2004), “A molecular switch and proton wire synchronize the active sites in thiamine enzymes.” Science 306(5697):872-6 Details