Dr RATNASEKHAR CH

Interests

Life is a cyclical chemical process from birth to death, which consists of developmental changes from single cell to adult and aging changes from adult to death. There are internal circannual cycles, circadian rhythms with in this birth to death cycle. Disruption of circadian rhythms might increase the risk of cancer, obesity. Mechanisms based on transcriptional and translational feedback loop (TTFL) is a current model for molecular circadian clocks in eukaryotic cells. Recent discovery of Red-Ox cycles of peroxiredoxin proteins in cells has prompted a reappraisal of TTFL model.

Our research work is focused on the temporal compartmentalization of metabolism that takes place during such circadian cycles. Studying cyclic changes in cell’s metabolic state, which may be a fundamental driving force for such biological oscillations. By using un-targeted & targeted metabolomics, we are trying to understand metabolic state of cells and different model organisms.

Biological clock controls our daily life
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Research Focus

Keywords

Circadian rhythms

Red-Ox metabolism

Metabolomics

Eukaryotic cells

metabolic cycles

Clinical conditions

Cancers

Sleep disorders

Stress

Equipment

Behavioural analysis

Cell culture

FPLC/HPLC

GC-MS,

LC-MS,

NMR

Collaborators

No collaborators listed

Associated News Items


    Publications

    2015

    Ratnasekhar Ch & Arvind Kumar Shukla & Prakash Pragya & Hitesh Singh Chaouhan & Devendra Kumar Patel & Debapratim Kar Chowdhuri & Mohana Krishna Reddy Mudiam (2015), “Metabolomic Analysis Provides Insights on Paraquat-Induced Parkinson-Like Symptoms in Drosophila melanogaster” Molecular Neurobiology