Professor Roger Pedersen

Roger Pedersen

University position

Professor

Professor Roger Pedersen is pleased to consider applications from prospective PhD students.

Departments

Department of Surgery

Institutes

Laboratory for Regenerative Medicine and Cambridge Stem Cell Initiative

Email

Roger@stemcells.cam.ac.uk

Home page

http://www.stemcells.cam.ac.uk

Research Themes

Developmental Neuroscience

Cellular and Molecular Neuroscience

Interests

Our principal objective is to define the molecular and genetic basis for the maintenance of the pluripotent status of human embryonic stem cells, and similarly, the basis for their differentiation into the primary body lineages: mesoderm, endoderm and neuroectoderm. Previous studies had revealed that pluripotency of human embryonic stem cells was not maintained by similar mechanisms as for mouse embryonic stem cells, whose self-renewal depends on Leukemia Inhibitor Factor and Bone Morphogenetic Protein. We have examined the effects of other growth factors known to be important in cell fate decisions of mammalian and other vertebrate embryos. We found that signaling through the Activin/Nodal pathway is critical for maintenance of pluripotency and that basic Fibroblast Growth Factor augments this pathway. We hypothesise that their effects in human embryonic stem cells involve alternative intermediate transcription factor(s) and target genes, which is the subject of our current studies.

Migratory behaviour in Human embryonic stemcells
Migratory behaviour in human embryonic stemcells
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Research Focus

Keywords

stem cells

development

differentiation

pluripotency

neurosciences

Clinical conditions

Alzheimer's disease

Autoimmune diseases

Cancers

Cerebrovascular disorders

Deafness

Dementia

Diabetes

Genetic disorders

Huntington's disease

Multiple sclerosis

Parkinson's disease

Traumatic brain injury

Equipment

Cell culture

Confocal microscopy

Fluorescence microscopy

Microscopy

Protein purification

Recombinant protein expression

Collaborators

Cambridge

Anne Ferguson-Smith

William Harris

Jim Smith

United Kingdom

Peter Andrews Web: http://www.shef.ac.uk/bms/res...

Bryan Turner Web: http://www.ii.bham.ac.uk/staff/a...

International

George Daley Web: http://www.childrenshospital.org/cfapps/...

Rudolf Jaenisch Web: http://www.wi.mit.edu/researc...

Bing Lim Web: http://www.dfhcc.harvard.edu/members...

Key publications

Brons, IGM, Smithers LE, Trotter M, Rugg-Gunn P, Sun B, Chuva de Sousa Lopes SM, Howlett SK, Clarkson A, Ahrlund-Richter L, Pedersen RA and Vallier L (2007), “Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature” [Doi:10.1038/nature05950 Epub ahead of print 28 June 2007].

Vallier L, Alexander M, Pedersen R (2007), “Conditional gene expression in human embryonic stem cells” Stem Cells 25:1490-1497 Details

Bowles KM, Vallier L, Smith JR, Alexander MRJ, Pedersen RA (2006), “HOXB4 overexpression promotes hematopoietic development by human embryonic stem cells” Stem Cells 24:1359-1369