Professor Roger Pedersen
Professor Roger Pedersen is pleased to consider applications from prospective PhD students.
Laboratory for Regenerative Medicine and Cambridge Stem Cell Initiative
Our principal objective is to define the molecular and genetic basis for the maintenance of the pluripotent status of human embryonic stem cells, and similarly, the basis for their differentiation into the primary body lineages: mesoderm, endoderm and neuroectoderm. Previous studies had revealed that pluripotency of human embryonic stem cells was not maintained by similar mechanisms as for mouse embryonic stem cells, whose self-renewal depends on Leukemia Inhibitor Factor and Bone Morphogenetic Protein. We have examined the effects of other growth factors known to be important in cell fate decisions of mammalian and other vertebrate embryos. We found that signaling through the Activin/Nodal pathway is critical for maintenance of pluripotency and that basic Fibroblast Growth Factor augments this pathway. We hypothesise that their effects in human embryonic stem cells involve alternative intermediate transcription factor(s) and target genes, which is the subject of our current studies.
Traumatic brain injury
Recombinant protein expression
Peter Andrews Web: http://www.shef.ac.uk/bms/res...
Bryan Turner Web: http://www.ii.bham.ac.uk/staff/a...
George Daley Web: http://www.childrenshospital.org/cfapps/...
Rudolf Jaenisch Web: http://www.wi.mit.edu/researc...
Bing Lim Web: http://www.dfhcc.harvard.edu/members...
Brons, IGM, Smithers LE, Trotter M, Rugg-Gunn P, Sun B, Chuva de Sousa Lopes SM, Howlett SK, Clarkson A, Ahrlund-Richter L, Pedersen RA and Vallier L (2007), “Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature” [Doi:10.1038/nature05950 Epub ahead of print 28 June 2007].
Vallier L, Alexander M, Pedersen R (2007), “Conditional gene expression in human embryonic stem cells” Stem Cells 25:1490-1497 Details
Bowles KM, Vallier L, Smith JR, Alexander MRJ, Pedersen RA (2006), “HOXB4 overexpression promotes hematopoietic development by human embryonic stem cells” Stem Cells 24:1359-1369