Interests

My main research interest is the intermediate biology and cognitions of adolescent depression, in particular how such intermediate variables mediate associations between genotype, environment and disorder. The main intermediate variable I study is the hypothalamic-pituitary-adrenal axis.

I also investigate non-suicidal self-injury; and the treatment and prognosis of adolescent depression, including how genes and hormones moderate response to treatment.

Research Focus

Keywords

Depression

Neuropsychology

Cortisol

Serotonin

Epigenetics

Clinical conditions

Depressive disorders

Equipment

Cross-sectional and cohort studies

Neuropsychological testing

Randomised control trials

Collaborators

Cambridge

Ian Goodyer

United Kingdom

Thalia Eley

David Nutt

Robert Plomin

International

Robert Kumsta

Key publications

Wilkinson P, Kelvin R, Roberts C, Dubicka B, Goodyer I (2011), “Clinical and psychosocial predictors of suicide attempts and nonsuicidal self-injury in the Adolescent Depression Antidepressants and Psychotherapy Trial (ADAPT).” Am J Psychiatry 168(5):495-501 Details

Wilkinson P, Dubicka B, Kelvin R, Roberts C, Goodyer I (2009), “Treated depression in adolescents: predictors of outcome at 28 weeks.” Br J Psychiatry 194(4):334-41 Details

Goodyer I, Dubicka B, Wilkinson P, Kelvin R, Roberts C, Byford S, et al (2007), “Adolescent Depression Antidepressant and Psychotherapy Trial (ADAPT). A Randomised Controlled Trial of SSRIs with and without cognitive behaviour therapy in adolescents with major depression” BMJ 335:142

Publications

2011

Dunn VJ, Abbott RA, Croudace TJ, Wilkinson P, Jones PB, Herbert J, Goodyer IM (2011), “Profiles of family-focused adverse experiences through childhood and early adolescence: the ROOTS project a community investigation of adolescent mental health.” BMC Psychiatry 11:109 Details

Gardner J Wilkinson P (2011), “Is family therapy the most effective treatment for anorexia nervosa? ” Psychiatria Danubina 23(SUPPL. 1):S175-S177

Goodyer IM, Tsancheva S, Byford S, Dubicka B, Hill J, Kelvin R, Reynolds S, Roberts C, Senior R, Suckling J, Wilkinson P, Target M, Fonagy P (2011), “Improving mood with psychoanalytic and cognitive therapies (IMPACT): a pragmatic effectiveness superiority trial to investigate whether specialised psychological treatment reduces the risk for relapse in adolescents with moderate to severe unipolar depression: study protocol for a randomised controlled trial.” Trials 12:175 Details

Wilkinson P, Goodyer I (2011), “Non-suicidal self-injury.” Eur Child Adolesc Psychiatry 20(2):103-8 Details

Wilkinson PO, Goodyer IM (2011), “Childhood adversity and allostatic overload of the hypothalamic-pituitary-adrenal axis: a vulnerability model for depressive disorders.” Dev Psychopathol 23(4):1017-37 Details

Wilkinson, P (2011), “Non-Suicidal Self-Injury: a Clear Marker for Suicide Risk” JAACAP 50: 71-72

2010

Bhardwaj A, Wilkinson P, Srivastava C, Sharma M (2010), “Cognitive deficits in euthymic patients with recurrent depression.” J Nerv Ment Dis 198(7):513-5 Details

Dubicka B Wilkinson P Kelvin R Goodyer I (2010), “Pharmacological treatment of depression and bipolar disorder in children and adolescents” Advances in Psychiatric Treatment 16:402-412

Dubicka B, Elvins R, Roberts C, Chick G, Wilkinson P, Goodyer IM (2010), “Combined treatment with cognitive-behavioural therapy in adolescent depression: meta-analysis.” Br J Psychiatry 197:433-40 Details

Goodyer IM, Wilkinson P, Dubicka B, Kelvin R (2010), “Forum: the use of selective serotonin reuptake inhibitors in depressed children and adolescents: commentary on the meta-analysis by Hetrick et al.” Curr Opin Psychiatry 23(1):58-61 Details

Laura M Wilkinson P (2010), “Perinatally Acquired HIV and Emotional Disorders in Children” Acta Paediatrica 99 (Suppl 462): 89

Wilkinson, P (2010), “Diagnosing and treating depression in adolescents” European Paediatrics 4:77-80

Wilkinson, P (2010), “Predictors of Outcome of Treated Depression in Adolescents” Mind & Brain, The Journal of Psychiatry 1(1): 49-53

2009

Tomlinson D Wilkinson H Wilkinson P (2009), “Diet and Mental Health in Children and Adolescents” Child and Adolescent Mental Health 14(3): 148-155

Wilkinson P (2009), “In adolescents with SSRI resistant depression, CBT/combined treatment is most effective in those with comorbid disorders.” Evid Based Ment Health 12(4):108 Details

Wilkinson P (2009), “Conceptualization about internalizing problems in children and adolescents.” Cien Saude Colet 14(2):373-81 Details

Wilkinson, P (2009), “Which Risk Factors at Baseline and During Treatment Predict Short-Term Persistence of Major Depression in Adolescents? ” European Psychiatric Review 2(2): 21-24

Wilkinson, P (2009), “Depression in Childhood and Adolescence” London Journal of Primary Care 2(1): 15-20

2008

Goodyer IM, Dubicka B, Wilkinson P, Kelvin R, Roberts C, Byford S, Breen S, Ford C, Barrett B, Leech A, Rothwell J, White L, Harrington R (2008), “A randomised controlled trial of cognitive behaviour therapy in adolescents with major depression treated by selective serotonin reuptake inhibitors. The ADAPT trial.” Health Technol Assess 12(14):iii-iv, ix-60 Details

Wilkinson PO, Goodyer IM (2008), “The effects of cognitive-behavioural therapy on mood-related ruminative response style in depressed adolescents.” Child Adolesc Psychiatry Ment Health 2(1):3 Details

Wilkinson, P Goodyer, I (2008), “Attention in Adolescents Recovered from Major Depression” European Neuropsychopharmacology 18S1:S43-S44

2007

Byford S Barrett B Roberts C Wilkinson P Dubicka B Kelvin R White L Ford C Breen S Goodyer I (2007), “Cost-effectiveness of selective serotonin reuptake inhibitors and routine specialist care with and without cognitive behavioural therapy in adolescents with major depression” B J Psych 191:521-527

Byford S, Barrett B, Roberts C, Wilkinson P, Dubicka B, Kelvin RG, White L, Ford C, Breen S, Goodyer I (2007), “Cost-effectiveness of selective serotonin reuptake inhibitors and routine specialist care with and without cognitive behavioural therapy in adolescents with major depression.” Br J Psychiatry 191:521-7 Details

Dubicka B, Wilkinson P (2007), “Evidence-based treatment of adolescent major depression.” Evid Based Ment Health 10(4):100-2 Details

Goodyer I, Dubicka B, Wilkinson P, Kelvin R, Roberts C, Byford S, Breen S, Ford C, Barrett B, Leech A, Rothwell J, White L, Harrington R (2007), “Selective serotonin reuptake inhibitors (SSRIs) and routine specialist care with and without cognitive behaviour therapy in adolescents with major depression: randomised controlled trial.” BMJ 335(7611):142 Details

2006

Wilkinson PO, Goodyer IM (2006), “Attention difficulties and mood-related ruminative response style in adolescents with unipolar depression.” J Child Psychol Psychiatry 47(12):1284-91 Details

2005

Wilkinson P (2005), “Continuing fluoxetine treatment may delay relapse in children and adolescents with major depressive disorder.” Evid Based Ment Health 8(2):37 Details

2004

Wilkinson P (2004), “A controversy too far?” BMJ 329(7479):1397 Details