Dr Phil Corlett

University position

Research Associate

Dr Phil Corlett is pleased to consider applications from prospective PhD students.

Departments

Department of Psychiatry

Institutes

Behavioural and Clinical Neuroscience Institute and Brain Mapping Unit

Email

prc28@cam.ac.uk

Home page

http://www-bmu.psychiatry.cam.ac.uk/people/... (personal home page)

Research Themes

Cognitive and Behavioural Neuroscience

Systems and Computational Neuroscience

The Cambridge Neuroscience Community

Interests

Delusions are odd beliefs. They accompany many psychiatric illnesses, notably schizophrenia. A major challenge is to understand delusions in terms of changes in brain function. I attempted to meet this challenge by investigating the neural basis of human associative learning and belief formation, relating these processes to the formation of delusional beliefs. My findings have shaped the development of a novel mechanistic model of delusion formation.

I am currently a visiting fellow at Yale Medical School, Department of Psychiatry in the laboratories of Professor Jane Taylor and Professor John Krystal

The effects of ketamine and endogenous psychosis on the brain response to prediction error
Click image to view full-size

Research Focus

Keywords

Schizophrenia

Delusions

Prediction error

Associative learning

fMRI

Clinical conditions

Addiction

Bipolar disorder

Schizophrenia

Equipment

Behavioural analysis

Computational modelling

Eye-Tracking

Magnetic resonance imaging (MRI)

Neuropsychological testing

Positron Emission Tomography (PET)

Randomised control trials

Transcranial Magnetic Stimulation (TMS)

Collaborators

Key publications

Corlett PR, Murray GK, Honey GD, Aitken MR, Shanks DR, Robbins TW, Bullmore ET, Dickinson A, Fletcher PC (2007), “Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions” Brain 130 (9):2387-2400 Details

Corlett PR, Honey GD, Aitken MR, Dickinson A, Shanks DR, Absalom AR, Lee M, Pomarol-Clotet E, Murray GK, McKenna PJ, Robbins TW, Bullmore ET, Fletcher PC (2006), “Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine: linking cognition, brain activity, and psychosis” Arch Gen Psychiatry 63(6):611-21 Details

Corlett PR, Aitken MR, Dickinson A, Shanks DR, Honey GD, Honey RA, Robbins TW, Bullmore ET, Fletcher PC (2004), “Prediction error during retrospective revaluation of causal associations in humans: fMRI evidence in favor of an associative model of learning” Neuron 44(5):877-88 Details

Publications

2009

Corlett PR, Frith CD, Fletcher PC (2009), “From drugs to deprivation: a Bayesian framework for understanding models of psychosis.” Psychopharmacology (Berl) Details

2008

Honey GD, Corlett PR, Absalom AR, Lee M, Pomarol-Clotet E, Murray GK, McKenna PJ, Bullmore ET, Menon DK, Fletcher PC (2008), “Individual differences in psychotic effects of ketamine are predicted by brain function measured under placebo.” J Neurosci 28(25):6295-303 Details

Murray GK, Clark L, Corlett PR, Blackwell AD, Cools R, Jones PB, Robbins TW, Poustka L (2008), “Incentive motivation in first-episode psychosis: a behavioural study.” BMC Psychiatry 8:34 Details

Murray GK, Corlett PR, Clark L, Pessiglione M, Blackwell AD, Honey G, Jones PB, Bullmore ET, Robbins TW, Fletcher PC (2008), “Substantia nigra/ventral tegmental reward prediction error disruption in psychosis.” Mol Psychiatry 13(3):239, 267-76 Details

2007

Corlett PR, Honey GD, Fletcher PC (2007), “From prediction error to psychosis: ketamine as a pharmacological model of delusions.” J Psychopharmacol 21(3):238-52 Details

2006

Honey GD, O'loughlin C, Turner DC, Pomarol-Clotet E, Corlett PR, Fletcher PC (2006), “The effects of a subpsychotic dose of ketamine on recognition and source memory for agency: implications for pharmacological modelling of core symptoms of schizophrenia.” Neuropsychopharmacology 31(2):413-23 Details

Pomarol-Clotet E, Honey GD, Murray GK, Corlett PR, Absalom AR, Lee M, McKenna PJ, Bullmore ET, Fletcher PC (2006), “Psychological effects of ketamine in healthy volunteers. Phenomenological study.” Br J Psychiatry 189:173-9 Details

2005

Dalley JW, Lääne K, Theobald DE, Armstrong HC, Corlett PR, Chudasama Y, Robbins TW (2005), “Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens.” Proc Natl Acad Sci U S A 102(17):6189-94 Details

Honey GD, Pomarol-Clotet E, Corlett PR, Honey RA, McKenna PJ, Bullmore ET, Fletcher PC (2005), “Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function.” Brain 128(Pt 11):2597-611 Details

Home