Dr Phil Corlett
Dr Phil Corlett is pleased to consider applications from prospective PhD students.
http://www-bmu.psychiatry.cam.ac.uk/people/... (personal home page)
Delusions are odd beliefs. They accompany many psychiatric illnesses, notably schizophrenia. A major challenge is to understand delusions in terms of changes in brain function. I attempted to meet this challenge by investigating the neural basis of human associative learning and belief formation, relating these processes to the formation of delusional beliefs. My findings have shaped the development of a novel mechanistic model of delusion formation.
I am currently a visiting fellow at Yale Medical School, Department of Psychiatry in the laboratories of Professor Jane Taylor and Professor John Krystal
Magnetic resonance imaging (MRI)
Positron Emission Tomography (PET)
Randomised control trials
Transcranial Magnetic Stimulation (TMS)
Karl Friston Web: http://www.fil.ion.ucl.ac.uk/Friston/
David Shanks Web: http://www.psychol.ucl.ac.uk/david.s...
Klaas Stephan Web: http://www.fil.ion.ucl.ac.uk/~kstephan/
John Krystal Web: http://www.med.yale.edu/psych/f...
Jane Taylor Web: http://www.med.yale.edu/psych/f...
Corlett PR, Murray GK, Honey GD, Aitken MR, Shanks DR, Robbins TW, Bullmore ET, Dickinson A, Fletcher PC (2007), “Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions” Brain 130 (9):2387-2400 Details
Corlett PR, Honey GD, Aitken MR, Dickinson A, Shanks DR, Absalom AR, Lee M, Pomarol-Clotet E, Murray GK, McKenna PJ, Robbins TW, Bullmore ET, Fletcher PC (2006), “Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine: linking cognition, brain activity, and psychosis” Arch Gen Psychiatry 63(6):611-21 Details
Corlett PR, Aitken MR, Dickinson A, Shanks DR, Honey GD, Honey RA, Robbins TW, Bullmore ET, Fletcher PC (2004), “Prediction error during retrospective revaluation of causal associations in humans: fMRI evidence in favor of an associative model of learning” Neuron 44(5):877-88 Details
Corlett PR, Frith CD, Fletcher PC (2009), “From drugs to deprivation: a Bayesian framework for understanding models of psychosis.” Psychopharmacology (Berl) Details
Honey GD, Corlett PR, Absalom AR, Lee M, Pomarol-Clotet E, Murray GK, McKenna PJ, Bullmore ET, Menon DK, Fletcher PC (2008), “Individual differences in psychotic effects of ketamine are predicted by brain function measured under placebo.” J Neurosci 28(25):6295-303 Details
Murray GK, Clark L, Corlett PR, Blackwell AD, Cools R, Jones PB, Robbins TW, Poustka L (2008), “Incentive motivation in first-episode psychosis: a behavioural study.” BMC Psychiatry 8:34 Details
Murray GK, Corlett PR, Clark L, Pessiglione M, Blackwell AD, Honey G, Jones PB, Bullmore ET, Robbins TW, Fletcher PC (2008), “Substantia nigra/ventral tegmental reward prediction error disruption in psychosis.” Mol Psychiatry 13(3):239, 267-76 Details
Corlett PR, Honey GD, Fletcher PC (2007), “From prediction error to psychosis: ketamine as a pharmacological model of delusions.” J Psychopharmacol 21(3):238-52 Details
Honey GD, O'loughlin C, Turner DC, Pomarol-Clotet E, Corlett PR, Fletcher PC (2006), “The effects of a subpsychotic dose of ketamine on recognition and source memory for agency: implications for pharmacological modelling of core symptoms of schizophrenia.” Neuropsychopharmacology 31(2):413-23 Details
Pomarol-Clotet E, Honey GD, Murray GK, Corlett PR, Absalom AR, Lee M, McKenna PJ, Bullmore ET, Fletcher PC (2006), “Psychological effects of ketamine in healthy volunteers. Phenomenological study.” Br J Psychiatry 189:173-9 Details
Dalley JW, Lääne K, Theobald DE, Armstrong HC, Corlett PR, Chudasama Y, Robbins TW (2005), “Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens.” Proc Natl Acad Sci U S A 102(17):6189-94 Details
Honey GD, Pomarol-Clotet E, Corlett PR, Honey RA, McKenna PJ, Bullmore ET, Fletcher PC (2005), “Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function.” Brain 128(Pt 11):2597-611 Details