Dr Peter Arthur-Farraj
Wellcome Clinical Research Career Development Fellow
I am a neurology registrar with an interest in neuromuscular disorders and nerve repair. I have recently been awarded a Wellcome Trust Clinical Career Development Fellowship, to work with Professor Michael Coleman’s group at the John Van Geest Centre for Brain Repair. My research is focused on how the nerve supporting cells, Schwann cells, transform after injury into a specialized cell type called Repair Schwann cells, to help promote both nerve cell (neuron) survival and regrowth.
I am using a variety of techniques, including live imaging of Schwann cells-neuronal interactions in zebrafish, mammalian Schwann cells/neuron co-cultures, genetic mouse models, viral vectors and CRISPR-Cas9 gene editing. My long-term career aim will be to translate my research to human disease models and thus help generate new therapies for neuromuscular disease and traumatic nerve injury.
CRISPR/Cas gene editing
Associated News Items
Arthur-Farraj P, Morgan CC, Adamowicz M, Gomez-Sanchez JA, Fazal SV, Beucher A, Razzaghi B, Mirsky R, Jessen K.R, Aitman TJ (2017), “Changes in the Coding and Non-coding Transcriptome and DNA Methylome that Define the Schwann cell Repair Phenotype after Nerve Injury” Cell Reports 20:1-16
Jessen KR, Mirsky R, Arthur-Farraj P (2015), “The Role of Cell Plasticity in Tissue Repair: Adaptive Cellular Reprogramming” Developmental Cell 34:613-620
Arthur-Farraj P, Latouche-Hartman, M, Wilton DK, Quintes S, Chabrol E, Banerjee A, Woodhoo A, Jenkins B, Rahman M, Turmaine M, Wicher GK, Mitter R, Greensmith L, Behrens A, Raivich G, Mirsky R, Jessen KR. (2012), “c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration” Neuron 75:633-647
Arthur-Farraj PJ, Murphy SM, Laura M, Lunn MP, Manji H, Blake J, Ramdharry G, Fox Z, Reilly MM (2012), “Hand weakness in Charcot-Marie-Tooth disease 1X” Neuromuscular Disorders 22:622-626
Peroos S, Forsythe E, Pugh JH, Arthur-Farraj P, Hodes D (2012), “Longevity and Patau syndrome: what determines survival?” BMJ Case Reports 6;2012. pii: bcr0620114381.
Arthur-Farraj P, Wanek K, Hantke J, Davis CM, Jayakar A, Parkinson DB, Mirsky R, Jessen KR (2011), “Mouse schwann cells need both NRG1 and cyclic AMP to myelinate” Glia 59:720-733
Mirsky R, Woodhoo A, Parkinson DB, Arthur-Farraj P, Bhaskaran A, Jessen KR (2008), “Novel signals controlling embryonic Schwann cell development, myelination and dedifferentiation” Journal of Peripheral Nervous System 13:122-135
Parkinson DB, Bhaskaran A, Arthur-Farraj P, Noon LA, Woodhoo A, Lloyd AC, Feltri ML, Wrabetz L, Behrens A, Mirsky R, Jessen KR (2008), “c-Jun is a negative regulator of myelination” Journal of Cell Biology 181:625-637
Arthur-Farraj P, Mirsky R, Parkinson DB, Jessen KR (2006), “A double point mutation in the DNA-binding region of Egr2 switches its function from inhibition to induction of proliferation: A potential contribution to the development of congenital hypomyelinating neuropathy” Neurobiology of Disease 24:159-169