Dr Peter Arthur-Farraj

University position

Wellcome Clinical Research Career Development Fellow

Departments

Department of Clinical Neurosciences

Institutes

Cambridge Centre for Brain Repair

Email

pja47@cam.ac.uk

Research Theme

Cellular and Molecular Neuroscience

Interests

I am a neurology registrar with an interest in neuromuscular disorders and nerve repair. I have recently been awarded a Wellcome Trust Clinical Career Development Fellowship, to work with Professor Michael Coleman’s group at the John Van Geest Centre for Brain Repair. My research is focused on how the nerve supporting cells, Schwann cells, transform after injury into a specialized cell type called Repair Schwann cells, to help promote both nerve cell (neuron) survival and regrowth.

I am using a variety of techniques, including live imaging of Schwann cells-neuronal interactions in zebrafish, mammalian Schwann cells/neuron co-cultures, genetic mouse models, viral vectors and CRISPR-Cas9 gene editing. My long-term career aim will be to translate my research to human disease models and thus help generate new therapies for neuromuscular disease and traumatic nerve injury.

Research Focus

Keywords

Repair Schwann cell

Nerve repair

axon degeneration

epigenetics

non-coding RNA

Clinical conditions

Motor neuron disease

Peripheral neuropathy

Equipment

Cell culture

Confocal microscopy

CRISPR/Cas gene editing

Fluorescence microscopy

Immunohistochemistry

Live imaging

Microscopy

Mouse models

Transcriptomics

Viral vectors

Zebrafish

Collaborators

Cambridge

Michael Coleman

Ben Steventon

United Kingdom

Kristjan Jessen Web: http://www.ucl.ac.uk/jessenm...

International

Hugo Cabedo Web: http://in.umh-csic.es/persona...

Jose Gomez-Sanchez Web: http://in.umh-csic.es/persona...

Kelly Monk Web: https://www.ohsu.edu/xd/rese...

Associated News Items


    Key publications

    Arthur-Farraj P, Morgan CC, Adamowicz M, Gomez-Sanchez JA, Fazal SV, Beucher A, Razzaghi B, Mirsky R, Jessen K.R, Aitman TJ (2017), “Changes in the Coding and Non-coding Transcriptome and DNA Methylome that Define the Schwann cell Repair Phenotype after Nerve Injury” Cell Reports 20:1-16

    Jessen KR, Mirsky R, Arthur-Farraj P (2015), “The Role of Cell Plasticity in Tissue Repair: Adaptive Cellular Reprogramming” Developmental Cell 34:613-620

    Arthur-Farraj P, Latouche-Hartman, M, Wilton DK, Quintes S, Chabrol E, Banerjee A, Woodhoo A, Jenkins B, Rahman M, Turmaine M, Wicher GK, Mitter R, Greensmith L, Behrens A, Raivich G, Mirsky R, Jessen KR. (2012), “c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration” Neuron 75:633-647

    Publications

    2012

    Arthur-Farraj PJ, Murphy SM, Laura M, Lunn MP, Manji H, Blake J, Ramdharry G, Fox Z, Reilly MM (2012), “Hand weakness in Charcot-Marie-Tooth disease 1X” Neuromuscular Disorders 22:622-626

    Peroos S, Forsythe E, Pugh JH, Arthur-Farraj P, Hodes D (2012), “Longevity and Patau syndrome: what determines survival?” BMJ Case Reports 6;2012. pii: bcr0620114381.

    2011

    Arthur-Farraj P, Wanek K, Hantke J, Davis CM, Jayakar A, Parkinson DB, Mirsky R, Jessen KR (2011), “Mouse schwann cells need both NRG1 and cyclic AMP to myelinate” Glia 59:720-733

    2008

    Mirsky R, Woodhoo A, Parkinson DB, Arthur-Farraj P, Bhaskaran A, Jessen KR (2008), “Novel signals controlling embryonic Schwann cell development, myelination and dedifferentiation” Journal of Peripheral Nervous System 13:122-135

    Parkinson DB, Bhaskaran A, Arthur-Farraj P, Noon LA, Woodhoo A, Lloyd AC, Feltri ML, Wrabetz L, Behrens A, Mirsky R, Jessen KR (2008), “c-Jun is a negative regulator of myelination” Journal of Cell Biology 181:625-637

    2006

    Arthur-Farraj P, Mirsky R, Parkinson DB, Jessen KR (2006), “A double point mutation in the DNA-binding region of Egr2 switches its function from inhibition to induction of proliferation: A potential contribution to the development of congenital hypomyelinating neuropathy” Neurobiology of Disease 24:159-169