Mr Patrick Flagmeier

Patrick Flagmeier

University position

PhD student
Supervised by Prof Christopher M. Dobson

Mr Patrick Flagmeier is pleased to consider applications from prospective PhD students.


Department of Chemistry

Home page

Research Theme

Cellular and Molecular Neuroscience


My main research interests focus on contributing to our understanding of how proteins aggregate and lead to disease. This involves in particular characterising the mechanism by which monomeric proteins form amlyoid.

Research Focus


Neurodegenerative disorders



Clinical conditions

Alzheimer's disease

Parkinson's disease


Atomic Force Microscopy

Circular Dichroism

Fluorescence microscopy




Protein purification

Recombinant protein expression


No collaborators listed

Associated News Items


in press

Flagmeier P*, De S*, Wirthensohn DC, Lee SF, Vincke C, Muyldermans S, Knowles TPJ, Gandhi S, Dobson CM, Klenerman D (in press), “Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates” Angew Chem Int Ed Engl


Michele Perni, Céline Galvagnion, Alexander Maltsev, Georg Meisl, Martin B. D. Müller, Pavan K. Challa, Julius B. Kirkegaard, Patrick Flagmeier, Samuel I. A. Cohen, Roberta Cascella, Serene W. Chen, Ryan Limbocker, Pietro Sormanni, Gabriella T. Heller, Francesco A. Aprile, Nunilo Cremades, Cristina Cecchi, Fabrizio Chiti, Ellen A. A. Nollen, Tuomas P. J. Knowles, Michele Vendruscolo, Adriaan Bax, Michael Zasloff, and Christopher M. Dobson (2017), “A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity” Proc Natl Acad Sci U S A


Brown JW, Buell AK, Michaels TC, Meisl G, Carozza J, Flagmeier P, Vendruscolo M, Knowles TP, Dobson CM, Galvagnion C. (2016), “β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces.” Scientific Reports

Flagmeier P, Meisl G, Vendruscolo M, Knowles TP, Dobson CM, Buell AK, Galvagnion C (2016), “Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation.” Proc Natl Acad Sci U S A. 113(37):10328-33.

Galvagnion C, Brown JW, Ouberai MM, Flagmeier P, Vendruscolo M, Buell AK, Sparr E, Dobson CM (2016), “Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein.” Proc Natl Acad Sci U S A. 113(26):7065-70.


Shimanovich U, Efimov I, Mason TO, Flagmeier P, Buell AK, Gedanken A, Linse S, Åkerfeldt KS, Dobson CM, Weitz DA, Knowles TP (2015), “Protein microgels from amyloid fibril networks.” ACS Nano 27;9(1):43-51.