Mr Patrick Flagmeier
My main research interests focus on contributing to our understanding of how proteins aggregate and lead to disease. This involves characterising the mechanism by which monomeric proteins form amlyoid fibrils and how this process can be inhibited to prevent disease onset. In addition my research focusses on the study of the detrimental species with a focus on the characterisation of membrane permeabilising forms of the aggregating protein as membrane permeation was suggested to be the most ubiquitious neurotoxic effect of protein aggregates.
No equipment indicated
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Associated News Items
Chia S*, Flagmeier P*, Habchi J*, Lattanzi V, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M. (2017), “Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates.” Proc Natl Acad Sci U S A
Flagmeier P*, De S*, Wirthensohn DC, Lee SF, Vincke C, Muyldermans S, Knowles TPJ, Gandhi S, Dobson CM, Klenerman D (2017), “Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates” Angew Chem Int Ed Engl 56(27): 7750-7754
Michele Perni, Céline Galvagnion, Alexander Maltsev, Georg Meisl, Martin B. D. Müller, Pavan K. Challa, Julius B. Kirkegaard, Patrick Flagmeier, Samuel I. A. Cohen, Roberta Cascella, Serene W. Chen, Ryan Limbocker, Pietro Sormanni, Gabriella T. Heller, Francesco A. Aprile, Nunilo Cremades, Cristina Cecchi, Fabrizio Chiti, Ellen A. A. Nollen, Tuomas P. J. Knowles, Michele Vendruscolo, Adriaan Bax, Michael Zasloff, and Christopher M. Dobson (2017), “A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity” Proc Natl Acad Sci U S A 114(6):E1009-E1017
Brown JW, Buell AK, Michaels TC, Meisl G, Carozza J, Flagmeier P, Vendruscolo M, Knowles TP, Dobson CM, Galvagnion C. (2016), “β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces.” Scientific Reports 6:36010
Flagmeier P, Meisl G, Vendruscolo M, Knowles TP, Dobson CM, Buell AK, Galvagnion C (2016), “Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation.” Proc Natl Acad Sci U S A. 113(37):10328-33.
Galvagnion C, Brown JW, Ouberai MM, Flagmeier P, Vendruscolo M, Buell AK, Sparr E, Dobson CM (2016), “Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein.” Proc Natl Acad Sci U S A. 113(26):7065-70.
Shimanovich U, Efimov I, Mason TO, Flagmeier P, Buell AK, Gedanken A, Linse S, Åkerfeldt KS, Dobson CM, Weitz DA, Knowles TP (2015), “Protein microgels from amyloid fibril networks.” ACS Nano 27;9(1):43-51.