Mr Patrick Flagmeier
My main research interests focus on contributing to our understanding of protein misfolding and aggregation associated with neurodegenerative disorders such as Alzheimer's and Parkinson's diseases.
One aspect of my work is the development of small molecules and antibodies that inhibit protein aggregation to enable disease treatment.
A second aspect of the research is the identification of the species of the protein that is neurotoxic and therefore directly linked to disease onset. The goal of the research is to develop methodologies that will enable not only the identification of damaging species but also to screen potential therapeutical agents.
No equipment indicated
No collaborators listed
Associated News Items
Iljina M, Dear AJ, Garcia GA, De S, Tosatto L, Flagmeier P, Whiten DR, Michaels TCT, Frenkel D, Dobson CM, Knowles TPJ, Klenerman D. (2018), “Quantifying Co-Oligomer Formation by α-Synuclein.” ACS Nano
Kundel F, De S, Flagmeier P, Horrocks MH, Kjaergaard M, Shammas SL, Jackson SE, Dobson CM, Klenerman D (2018), “Hsp70 inhibits the nucleation and elongation of tau and sequesters tau aggregates with high affinity” ACS Chemical Biology 13(3):636-646.
Lee JE, Sang JC, Rodrigues M, Carr AR, Horrocks MH, De S, Bongiovanni MN, Flagmeier P, Dobson CM, Wales DJ, Lee SF, Klenerman D. (2018), “Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale” Nano Letters
Perni M*, Flagmeier P*, Limbocker R*, Cascella R, Aprile FA, Galvagnion C, Meisl G, Chen SW, Kumita JR, Challa PK, Kirkegaard JB, Cohen SIA, Barbut D, Nollen EAA, Cecchi C, Cremades N, Knowles TPJ, Chiti F, Zasloff M, Vendruscolo M, Dobson CM (2018), “Multistep Inhibition of α - synuclein aggregation and toxicity in vitro and in vivo by an aminosterol” ACS Chemical Biology
Varela JA, Rodrigues M, De S, Flagmeier P, Gandhi S, Dobson CM, Klenerman D, Lee SF (2018), “Optical Structural Analysis of Individual α-Synuclein Oligomers.” Angew Chem Int Ed Engl. 57, 4886-4890.
Whiten DR*, Zuo Y*, Calo L, Choi CL, De S, Flagmeier P, Wirthensohn DC, Kundel F, Ranasinghe RT, Sanchez SE, Athauda D,Lee SF, Dobson CM, Gandhi S, Spillantini MG, Klenerman D, Horrocks MH (2018), “Nanoscopic characterization of individual endogenous protein aggregates in human neuronal cells” ChemBioChem
Whiten DR, Cox D, Horrocks MH, Taylor CG, De S, Flagmeier P, Tosatto L, Kumita JR, Heath Ecroyd H, Dobson CM, Klenerman D, Wilson MR (2018), “Single molecule characterisation of the interactions between extracellular chaperones and toxic α-synuclein oligomers” Cell Reports 23(12): 3492-3500
Chia S*, Flagmeier P*, Habchi J*, Lattanzi V, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M. (2017), “Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates.” Proc Natl Acad Sci U S A 114(30):8005-8010.
Drews A*, De S*, Flagmeier P*, Wirthensohn DC*, Chen WH, Whiten DR, Rodrigues M, Vincke C, Muyldermans S, Paterson RW, Slattery CF, Fox NC, Schott JM, Zetterberg H, Dobson CM, Gandhi S, Klenerman D (2017), “Inhibiting the Ca2+ Influx Induced by Human CSF” Cell Reports 21(11):3310-3316.
Flagmeier P*, De S*, Wirthensohn DC, Lee SF, Vincke C, Muyldermans S, Knowles TPJ, Gandhi S, Dobson CM, Klenerman D (2017), “Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates” Angew Chem Int Ed Engl 56(27): 7750-7754.
Perni M, Galvagnion C, Maltsev A, Meisl G, Müller MBD, Challa PK, Kirkegaard JB, Flagmeier P, Cohen SIA, Cascella R, Chen SW, Limbocker R, Sormanni P, Heller GT, Aprile FA, Cremades N, Cecchi C, Chiti F, Nollen EAA, Knowles TPJ, Vendruscolo M, Bax A, Zasloff M, and Dobson CM (2017), “A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity” Proc Natl Acad Sci U S A 114(6):E1009-E1017.
Brown JW, Buell AK, Michaels TC, Meisl G, Carozza J, Flagmeier P, Vendruscolo M, Knowles TP, Dobson CM, Galvagnion C. (2016), “β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces.” Scientific Reports 6:36010.
Flagmeier P, Meisl G, Vendruscolo M, Knowles TP, Dobson CM, Buell AK, Galvagnion C (2016), “Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation.” Proc Natl Acad Sci U S A. 113(37):10328-33.
Galvagnion C, Brown JW, Ouberai MM, Flagmeier P, Vendruscolo M, Buell AK, Sparr E, Dobson CM (2016), “Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein.” Proc Natl Acad Sci U S A. 113(26):7065-70.
Shimanovich U, Efimov I, Mason TO, Flagmeier P, Buell AK, Gedanken A, Linse S, Åkerfeldt KS, Dobson CM, Weitz DA, Knowles TP (2015), “Protein microgels from amyloid fibril networks.” ACS Nano 27;9(1):43-51.