Mr Patrick Flagmeier
Mr Patrick Flagmeier is pleased to consider applications from prospective PhD students.
My main research interests focus on contributing to our understanding of how proteins aggregate and lead to disease. This involves in particular characterising the mechanism by which monomeric proteins form amlyoid.
Atomic Force Microscopy
Recombinant protein expression
No collaborators listed
Associated News Items
Flagmeier P*, De S*, Wirthensohn DC, Lee SF, Vincke C, Muyldermans S, Knowles TPJ, Gandhi S, Dobson CM, Klenerman D (in press), “Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates” Angew Chem Int Ed Engl
Michele Perni, Céline Galvagnion, Alexander Maltsev, Georg Meisl, Martin B. D. Müller, Pavan K. Challa, Julius B. Kirkegaard, Patrick Flagmeier, Samuel I. A. Cohen, Roberta Cascella, Serene W. Chen, Ryan Limbocker, Pietro Sormanni, Gabriella T. Heller, Francesco A. Aprile, Nunilo Cremades, Cristina Cecchi, Fabrizio Chiti, Ellen A. A. Nollen, Tuomas P. J. Knowles, Michele Vendruscolo, Adriaan Bax, Michael Zasloff, and Christopher M. Dobson (2017), “A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity” Proc Natl Acad Sci U S A
Brown JW, Buell AK, Michaels TC, Meisl G, Carozza J, Flagmeier P, Vendruscolo M, Knowles TP, Dobson CM, Galvagnion C. (2016), “β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces.” Scientific Reports
Flagmeier P, Meisl G, Vendruscolo M, Knowles TP, Dobson CM, Buell AK, Galvagnion C (2016), “Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation.” Proc Natl Acad Sci U S A. 113(37):10328-33.
Galvagnion C, Brown JW, Ouberai MM, Flagmeier P, Vendruscolo M, Buell AK, Sparr E, Dobson CM (2016), “Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein.” Proc Natl Acad Sci U S A. 113(26):7065-70.
Shimanovich U, Efimov I, Mason TO, Flagmeier P, Buell AK, Gedanken A, Linse S, Åkerfeldt KS, Dobson CM, Weitz DA, Knowles TP (2015), “Protein microgels from amyloid fibril networks.” ACS Nano 27;9(1):43-51.