Dr Philip Buttery

Philip Buttery

University position

Neurologist

Dr Philip Buttery is pleased to consider applications from prospective PhD students.

Departments

Department of Clinical Neurosciences

Institutes

Cambridge Centre for Brain Repair

Research Themes

Cellular and Molecular Neuroscience

Clinical and Veterinary Neuroscience

Interests

We work on the role of rho family GTPases and their regulators in the plasticity of CNS synapses, as related to brain disease and recovery from brain injury. We are currently focussing on a regulator of the GTPase Rac1 which is upregulated with neuronal activity and plays a role in pruning of dendritic spines, the sites of excitatory synaptic input. We use in vitro cell culture models to understand what role this molecule plays in the homeostatic regulation of synapse number in developing and adult brain.

A hippocampal neurone filled with green fluorescent protein (GFP) and labelled for pre-synaptic (blue) and post-synaptic (red) structures
A hippocampal neurone filled with green fluorescent protein (GFP) and labelled for pre-synaptic (blue) and post-synaptic (red) structures
View image full-size (2048x2048 pixels)

Research Focus

Keywords

Rho GTPase

Rac1

plasticity

spine

synapse

Clinical conditions

Alzheimer's disease

Autism

Dementia

Epilepsy

Learning disabilities

Stroke

Traumatic brain injury

Equipment

Cell culture

Confocal microscopy

Fluorescence microscopy

Immunohistochemistry

Microscopy

Recombinant protein expression

Collaborators

Cambridge

Olivier Raineteau

Associated News Items


    Key publications

    Buttery P, Beg AA, Chih B, Broder A, Mason CA, Scheiffele P (2006), “The diacylglycerol-binding protein alpha1-chimaerin regulates dendritic morphology” Proc Natl Acad Sci USA 103(6):1924-9 Details

    Publications

    2014

    Buttery PC, Barker RA (2014), “Treating Parkinson's disease in the 21st century: Can stem cell transplantation compete?” J Comp Neurol 522(12):2802-16 Details

    Palfi S, Gurruchaga JM, Ralph GS, Lepetit H, Lavisse S, Buttery PC, Watts C, Miskin J, Kelleher M, Deeley S, Iwamuro H, Lefaucheur JP, Thiriez C, Fenelon G, Lucas C, Brugières P, Gabriel I, Abhay K, Drouot X, Tani N, Kas A, Ghaleh B, Le Corvoisier P, Dolphin P, Breen DP, Mason S, Guzman NV, Mazarakis ND, Radcliffe PA, Harrop R, Kingsman SM, Rascol O, Naylor S, Barker RA, Hantraye P, Remy P, Cesaro P, Mitrophanous KA (2014), “Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial.” Lancet 383(9923):1138-46 Details

    2012

    Annamalai AK, Powlson AS, Kandasamy N, Lodge K, Graggaber J, Halsall DJ, Antoun NM, Cheow HK, Buttery PC, George E, Griffiths M, Price SJ, Pickard JD, Sivasothy P, Gurnell M (2012), “Hypopituitarism, pulmonary infiltration and a spontaneously resolving occipital mass.” QJM Details

    Antoniades CA, Buttery P, FitzGerald JJ, Barker RA, Carpenter RH, Watts C (2012), “Deep brain stimulation: eye movements reveal anomalous effects of electrode placement and stimulation.” PLoS One 7(3):e32830 Details

    2011

    Marland JR, Pan D, Buttery PC (2011), “Rac GTPase-activating protein (Rac GAP) α1-Chimaerin undergoes proteasomal degradation and is stabilized by diacylglycerol signaling in neurons.” J Biol Chem 286(1):199-207 Details

    2003

    Buttery P, Mason C (2003), “Maintaining stability in the face of change.” Nat Neurosci 6(11):1117-9 Details

    2001

    Buttery PC, ffrench-Constant C (2001), “Process extension and myelin sheet formation in maturing oligodendrocytes.” Prog Brain Res 132:115-30 Details

    Relvas JB, Setzu A, Baron W, Buttery PC, LaFlamme SE, Franklin RJ, ffrench-Constant C (2001), “Expression of dominant-negative and chimeric subunits reveals an essential role for beta1 integrin during myelination.” Curr Biol 11(13):1039-43 Details

    1999

    Buttery PC, ffrench-Constant C (1999), “Laminin-2/integrin interactions enhance myelin membrane formation by oligodendrocytes.” Mol Cell Neurosci 14(3):199-212 Details

    Buttery PC, Mallawaarachchi CM, Milner R, Doherty P, ffrench-Constant C (1999), “Mapping regions of the beta1 integrin cytoplasmic domain involved in migration and survival in primary oligodendrocyte precursors using cell-permeable homeopeptides.” Biochem Biophys Res Commun 259(1):121-7 Details

    Frost EE, Buttery PC, Milner R, ffrench-Constant C (1999), “Integrins mediate a neuronal survival signal for oligodendrocytes.” Curr Biol 9(21):1251-4 Details