Paul Brooks

Paul Brooks

University position

PhD student
Supervised by Paul Conduit

Departments

Department of Zoology

Research Themes

Developmental Neuroscience

Cellular and Molecular Neuroscience

Interests

My area of research focuses on how the cellular skeleton is formed and maintained in peripheral neurons.

Fundamentally, microtubules are comprised of just 3 proteins, however, their functions are diverse. During cell division MTs lock onto and pull apart chromosomes, as well as providing pushing and pulling forces, morphing cells into different shapes. I am interested in microtubules in neurons, whereby they a- form tracks for motor machinery to transport organelles, and b- provide pushing forces for dendritic and axonal elongation during neuronal growth.

I am investigating how the neuron can regulate its dendritic complexity by initiating site specific growth of microtubules. Drosophila neurons do not use centrosomes as microtubule organising centers (MTOCS), but likely use fragments of Golgi (Golgi outposts). I am investigating the relationship between Golgi Outposts and MT proteins with MT events in Drosophila, hopefully to shed light on nervous system regulation and complexity.

Research Focus

Keywords

Neuronal Network

Drosophila

Synaptogenesis

Locomotion

Clinical conditions

ALS

Genetic disorders

Huntington's disease

Movement disorders

Parkinson's disease

Equipment

Behavioural analysis

Calcium imaging

Cell culture

Confocal microscopy

CRISPR-Cas9

Electrophysiological recording techniques

Fluorescence microscopy

Immunohistochemistry

Intracellular recording

Microscopy

Protein purification

Whole cell patch clamp

Collaborators

No collaborators listed

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