Dr Omar Mahroo MA, MB, BChir, PhD, FRCOphth

Interests

In conjunction with Trevor Lamb FRS (now at the Australian National University), I am investigating aspects of retinal function by recording the electroretinogram (ERG) from human subjects, particularly during recovery following exposure to intense light (dark adaptation). I am also making recordings from patients with inherited retinal disease, age-related macular degeneration, diabetic retinopathy and Birdshot Uveitis, as well as a number of neurological conditions, to improve our understanding of mechanisms of disease and how best to monitor disease activity.

Support: Fight for Sight Grant 1409/10

Fight for Sight/Birdshot Uveitis Society 24BU141

Fight for Sight/Thomas Pocklington Trust 24TPT16

Recording of electroretinogram from human subject
Recording of electroretinogram from human subject
Click image to view full-size

Research Focus

Keywords

photoreceptor

retina

electroretinogram

vision

Clinical conditions

Age-related macular degeneration

Autism

Retinal diseases

Equipment

Electrophysiological recording techniques

Collaborators

United Kingdom

Chris Hammond Web: http://rg.kcl.ac.uk/staffpr...

Graham Holder Web: http://www.moorfieldsresearch.org.uk/orntemp...

International

Trevor Lamb Web: http://jcsmr.anu.edu.au/org/dns...

Anthony Moore Web: http://profiles.ucsf.edu/anthony...

John Robson Web: https://www.opt.uh.edu/research/

Associated News Items


    Key publications

    Cameron AM, Mahroo OAR & Lamb TD (2006), “Light adaptation and dark adaptation of human rod bipolar cells measured from the b-wave of the scotopic electroretinogram” Journal of Physiology 575:507-26

    Kenkre JS, Moran NA, Lamb TD & Mahroo OAR (2005), “Extremely rapid recovery of human cone circulating current at the extinction of bleaching exposures” Journal of Physiology 567:95-112

    Mahroo OAR & Lamb TD (2004), “Recovery of the human photopic electroretinogram after bleaching exposures: estimation of pigment regeneration kinetics” Journal of Physiology 554:417-437

    Publications

    2017

    Bhatti T, Tariq A, Shen T, Williams KM, Hammond CJ, Mahroo OA (2017), “Relative Genetic and Environmental Contributions to Variations in Human Retinal Electrical Responses Quantified in a Twin Study” Ophthalmology 2017 Apr 20

    Mahroo OA (2017), “Pupil area and photopigment spectral sensitivity are relevant to study of migraine photophobia” Brain 140(Pt 1):e2

    Mahroo OA, Williams KM, Hossain IT, Yonova-Doing E, Kozareva D, Yusuf A, Sheriff I, Oomerjee M, Soorma T, Hammond CJ (2017), “Do twins share the same dress code? Quantifying relative genetic and environmental contributions to subjective perceptions of “the dress” in a classical twin study ” J Vis 17(1): 29

    Williams KM, Yonova-Doing E, Hysi PG, Mahroo OA, Snieder H, Hammond CJ (2017), “Phenotypic and genotypic correlation between myopia and intelligence” Sci Rep. 2017 Apr 6;7:45977

    2016

    Alim-Marvasti A, Bi W, Mahroo OA, Barbur JL, Plant GT (2016), “Transient Smartphone “Blindness”” N Engl J Med 374:2502-2504

    Cromb D, Mahroo OA (2016), “Pediatric Ocular Tuberculosis – Choroidal Tubercles” J Pediatr. 169: 323

    Fahim AT, Simunovic MP, Mammo Z, Mitry D, Pakzad-Vaezi K, Bradley P, Mahroo OA (2016), “Comparison of ophthalmic training in 6 English-speaking countries” Can J Ophthalmol. 51(3): 212-218

    He X, Yonova EH, Kozareva D, Katta M, Hammond CJ, Mahroo OA (2016), “The heritability of implicit times of photopic flicker electroretinogram responses recorded using a handheld recording system with skin electrodes.” ARVO Meeting Abstracts 3589

    Heemraz BS, Lee CN, Hysi PG, Jones CA, Hammond CJ, Mahroo OA (2016), “Changes in quality of life shortly after routine cataract surgery” Can J Ophthalmol.

    Hobby AE, Kozareva D, Yonova EH, Hossain IT, Katta M, Huntjens B, Binns A, Hammond CJ, Mahroo OA (2016), “Effect of varying skin surface electrode position on electroretinogram responses recorded using a handheld stimulating and recording system.” ARVO Meeting Abstracts 3588

    Hossain IT, Yonova-Doing E, Kozareva D, Hammond CJ, Mahroo OA (2016), “ Investigating relative genetic and environmental contributions to subjective perceptions of the colour of "the dress" in a classic twin study” Proc Physiol Soc 37, PCB251

    Khan KN, Mahroo OA, Islam F, Webster AR, Moore AT, Michaelides M (2016), “FUNCTIONAL AND ANATOMICAL OUTCOMES OF CHOROIDAL NEOVASCULARIZATION COMPLICATING BEST1-RELATED RETINOPATHY.” Retina

    Khan KN, Mahroo OA, Khan R, Mohamed MD, McKibbin M, Bird A, Michaelides M, Tufail A, Moore AT (2016), “Differentiating drusen: Drusen and drusen-like appearances associated with ageing, age-related macular degeneration, inherited eye disease and other pathological processes” Prog Retin Eye Res

    Mahroo OA, Hobby AE, Yonova EH, Kozereva D, Hossain IT, Katta M, Hammond CJ, Stanford MR (2016), “Towards rapid assessment of retinal function in clinic: comparison of implicit times of photopic flicker electroretinogram responses recorded using a conventional and a portable system in patients with Birdshot chorioretinopathy.” ARVO Meeting Abstracts 3594

    Saidkasimova S, Shalchi Z, Mahroo OA, Shunmugam M, Laidlaw DA, Williamson TH, Howard J, Mohamed MD (2016), “Risk factors for visual impairment in patients with sickle cell disease in London” Eur J Ophthalmol.

    Tucker WR, Hobby AE, Hossain IT, Hammond CJ, Stanford MR, Mahroo OA (2016), “Exploring associations between anatomical and functional parameters in Birdshot chorioretinopathy using optical coherence tomography and electroretinography.” ARVO Meeting Abstracts 3319

    2015

    Kwong TQ, Mahroo O, Scoppettuolo E, Ansari E. (2015), “Outcomes of Trabeculectomy With Transconjunctival Application Versus Subconjunctival Application of Mitomycin C.” J Glaucoma

    Larkin G, Kailani O, Shalchi Z, Mahroo OA, Hammond CJ (2015), “Exploring the association between axial length and age in patients undergoing cataract surgery.” ARVO Meeting Abstracts 2962

    Mahroo OA (2015), “Electroretinography can provide objective assessment of inner retinal function prior to atrophic change on OCT.” Eye (Lond) Details

    Mahroo OA, Mitry D, Williamson TH, Shepherd A, Charteris DG, Hamilton RD (2015), “Exploring Sex and Laterality Imbalances in Patients Undergoing Laser Retinopexy.” JAMA Ophthalmol Details

    Mahroo OA, Mohamed MD, Graham EM, Mann SS, Plant GT, Afridi SK, Hammond CJ (2015), “Cilioretinal Artery Territory Infarction Associated With Papilledema in a Patient With Neurofibromatosis Type 2.” J Neuroophthalmol Details

    Mahroo OA, Robson JG, Webster AR, Moore AT, Hammond CJ (2015), “Insights into KCNV2 retinopathy from modelling ERG a-waves taking into account outer nuclear layer currents.” ARVO Meeting Abstracts 459

    Mahroo OA, Williams C, Hysi PG, Williams KM, Kailani O, Thompson J, Cumberland PM, Guggenheim JA, Rahi JS, Harrad RA, Hammond CJ (2015), “Interocular asymmetries in axial length and refractive error in 4 cohorts.” Ophthalmology 122(3):648-9 Details

    Shalchi Z, Mahroo OA, Shunmugam M, Mohamed M, Sullivan PM, Williamson TH (2015), “Spectral domain optical coherence tomography findings in long-term silicone oil-related visual loss.” Retina 35(3):555-63 Details

    Shen T, Tariq A, Bhatti T. Williams KM, Hammond CJ, Mahroo OA (2015), “Non-invasive assessment of retinal ganglion cell function using the electroretinogram: Data from healthy twin pairs” Proc Physiol Soc PC121

    Williams KM, Verhoeven VJ, Cumberland P, Bertelsen G, Wolfram C, Buitendijk GH, Hofman A, van Duijn CM, Vingerling JR, Kuijpers RW, Höhn R, Mirshahi A, Khawaja AP, Luben RN, Erke MG, von Hanno T, Mahroo O, Hogg R, Gieger C, Cougnard-Grégoire A, Anastasopoulos E, Bron A, Dartigues JF, Korobelnik JF, Creuzot-Garcher C, Topouzis F, Delcourt C, Rahi J, Meitinger T, Fletcher A, Foster PJ, Pfeiffer N, Klaver CC, Hammond CJ (2015), “Prevalence of refractive error in Europe: the European Eye Epidemiology (E3) Consortium.” Eur J Epidemiol Details

    2014

    Al-Sayegh AM, Tariq A, Kirmani A, Mann S, Hammond CJ, Mahroo OA (2014), “Assessing pan-retinal cone function following ranibizumab treatment for diabetic macular edema by recording the photopic electroretinogram” ARVO Meeting abstracts 55: 1763

    Bhatti T, Tariq A, Williams KM, Hammond CJ, O. Mahroo OA. (2014), “Genetic and environmental contributions to variation in human retinal responses: A twin study” Proc Physiol Soc 31, PCB075

    Bizrah M, Mahroo OA, Kailani O, Dar T, Nag A, Thompson J, Hammond CJ (2014), “Confirmation of association of axial length and young age with post-operative intraocular pressure rise in a large cataract cohort” ARVO Meeting abstracts 55: 6027

    Hysi PG, Mahroo OA, Cumberland P, Wojciechowski R, Williams KM, Young TL, Mackey DA, Rahi JS, Hammond CJ (2014), “Common mechanisms underlying refractive error identified in functional analysis of gene lists from genome-wide association study results in 2 European british cohorts.” JAMA Ophthalmol 132(1):50-6 Details

    Mahroo OA, Graham EM (2014), “Roth Spots in Infective Endocarditis.” N Engl J Med 370(25):e38 Details

    Mahroo OA, Hysi PG, Dey S, Gavin EA, Hammond CJ, Jones CA (2014), “Outcomes of ptosis surgery assessed using a patient-reported outcome measure: an exploration of time effects.” Br J Ophthalmol 98(3):387-90 Details

    Mahroo OA, Oomerjee M, Williams KM, O'Brart D, Hammond CJ (2014), “High heritability of posterior corneal tomography, as measured by Scheimpflug imaging, in a twin study.” Invest Ophthalmol Vis Sci Details

    Mahroo OA, Shalchi Z, Hammond CJ (2014), “'Dilatation' and 'dilation': trends in use on both sides of the Atlantic.” Br J Ophthalmol Details

    Mahroo OA, Shalchi Z, Kisimbi J, Sanyiwa AJ, Mohamed MD, Plant GT (2014), “Re: Abegg et al.: Microcystic Macular Edema: Retrograde Maculopathy Caused by Optic Neuropathy (Ophthalmology 2014;121:142-9).” Ophthalmology Details

    Mohamed M, Magan T, Robertson M, Mahroo OA (2014), “Spectral domain optical coherence tomography measurements of macular thickness in sickle cell disease: comparison between HbSS and HbSC genotypes” ARVO Meeting abstract 55: 3873

    Oomerjee M, Williams KM, O'Brart DP, Hammond CJ, Mahroo OA (2014), “Genetic and environmental influences on the anterior and posterior curvature of the human cornea as measured by Scheimpflug imaging: a twin study” Proc Physiol Soc 31, PCB124

    Piper RJ, Qureshi MH, Siddiqui S, Lam JJ, Hammond CJ, Mahroo OA (2014), “The effect of pre-adaptation scotopic/mesopic backgrounds on the growth in amplitude of the cone-driven flash electroretinogram after onset of a photopic background: evidence for rod system involvement” Proc Physiol Soc 31, PCB076

    Shalchi Z, Shunmugam M, Mahroo OA, McDonald RJ, Dogramaci M, Laidlaw DA, Stanford M, Mohamed M (2014), “Spectral Domain Optical Coherence Tomography Findings in a Case Series of Patients with Bilateral Diffuse Uveal Melanocytic Proliferation.” Ocul Immunol Inflamm :1-4 Details

    Tariq A, Mahroo OA, Williams KM, Liew SM, Beatty S, E Gilbert C, Van Kuijk FJ, Hammond CJ (2014), “The heritability of the ring-like distribution of macular pigment assessed in a twin study.” Invest Ophthalmol Vis Sci Details

    Tariq A, Sheriff I, Bhatti T, Sankoh A, Gao H, Hammond CJ, Mahroo OA (2014), “Effect of varying conductive fibre electrode position between fornix and lid margin on electroretinogram amplitudes and implicit times” ARVO Meeting abstracts 55: 5121

    2013

    Gavin EA, Mahroo OA, Lim R, de Benito-Llopis L (2013), “Using Cyanoacrylate Glue for Corneal Perforations: Caution With Use of a Needle and Syringe.” Cornea Details

    Kisimbi J, Shalchi Z, Mahroo OA, Mhina C, Sanyiwa AJ, Mabey D, Mohamed M, Plant GT (2013), “Macular spectral domain optical coherence tomography findings in Tanzanian endemic optic neuropathy.” Brain Details

    Mahroo OA, Gavin EA, Williams KM, De Smit E, Hammond CJ, Morrison DA (2013), “Potential effect of 'cut-off intensity' on correlation between light meter measurements and time outdoors.” Eye (Lond) Details

    Mahroo OA, Sakalauskaite R, Hammond CJ & Lamb TD (2013), “Recovery of human rod photoreceptors following prolonged illumination, assessed using the electroretinogram ” ARVO Meeting abstracts 54:6122

    Mahroo OA, Tariq A, van Kuijk FJ, Liew SHM, Beatty S, Gilbert CE, Hammond CJ (2013), “Heritability of the ring-like distribution of macular pigment assessed in a twin study” Eur J Ophthalmol 23(4): 611

    Mahroo OA, Zuberbuhler B (2013), “Potential effects of laterality and learning on misalignment in marking horizontal meridian.” J Cataract Refract Surg 39(6):966 Details

    2012

    Gavin EA, Mahroo OA, Lim KS (2012), “Limbus vs. Fornix-Based Trabeculectomy Results.” Ophthalmology 119(10):2196 Details

    Mahroo OA, Ban VS, Bussmann BM, Copley HC, Hammond CJ, Lamb TD (2012), “Modelling the initial phase of the human rod photoreceptor response to the onset of steady illumination.” Doc Ophthalmol 124(2):125-31 Details

    Mahroo OA, Dybowski R, Wong R, Williamson TH (2012), “Characteristics of rhegmatogenous retinal detachment in pseudophakic and phakic eyes.” Eye (Lond) 26(8):1114-21 Details

    Mahroo OA, Gavin EA, Mann S, Mohamed MD (2012), “Central visual disturbance associated with transient disruption of photoreceptor inner-outer segment junction.” Can J Ophthalmol 47(5):e19-20 Details

    Mahroo OA, Hammond CJ, Williamson TH (2012), “Choice of analytic approach for eye-specific outcomes: one eye or two?” Am J Ophthalmol 153(4):781-2 Details

    Mahroo OA, Lamb TD (2012), “Slowed recovery of human photopic ERG a-wave amplitude following intense bleaches: a slowing of cone pigment regeneration?” Doc Ophthalmol 125(2):137-47 Details

    Mahroo OA, Sirangam V, Zakri R, Ali N, Hammond CJ, Lamb TD (2012), “Full-field Photopic Electroretinogram Responses to Flashes are not Consistent with Correction for Stiles-Crawford effect” ARVO abstract 53:2465

    Smith HB, Jyothi SB, Mahroo OA, Shams PN, Sira M, Dey S, Adewoyin T, Cheung VT, Jones CA (2012), “Patient-reported benefit from oculoplastic surgery.” Eye (Lond) Details

    2011

    Mahroo OA, Scoppettuolo L, Ansari E (2011), “Outcomes of trabeculectomy with transconjunctival application of Mitomycin C” Acta Ophthalmol 89 (s246)

    Mahroo OA, Seshadri N, Whitefield LA (2011), “Case report: retinopathy in a patient with cold hemagglutinin disease.” Retin Cases Brief Rep 5(3):254-5 Details

    Mahroo OAR, Ban VS, Bussmann BM, Copley HC & Lamb TD (2011), “A model for the electrical responses of human rod photoreceptors to the onset of steady backgrounds. ” Proc Physiol Soc 22: C08

    2010

    Chan E, Mahroo OA, Spalton DJ (2010), “Complications of cataract surgery.” Clin Exp Optom Details

    Mahroo OA (2010), “Selecting tomorrow's doctors. Money, motivation, and medicine.” BMJ 341:c6830 Details

    Mahroo OA, Stanbury R, Lim KS (2010), “Were the groups in the trabeculectomy versus Ahmed valve study really comparable?” Br J Ophthalmol 94(11):1551-2 Details

    2009

    Mahroo OA, Hammond CJ (2009), “Anterior ischemic optic neuropathy after strabismus surgery.” J Neuroophthalmol 29(2):157-8 Details

    2008

    Mahroo OAR & Lamb TD (2008), “Human cone photopigment regeneration asessed using the electroretinogram: slower recovery following intense bleaches” Proc Physiol Soc 11, PC106

    Mahroo OAR, Hammond CJ (2008), “Optometric management of posterior segment eye disease - Optic nerve anomalies” Optometry Today Feb 2008, 30-40

    Mahroo OAR, Khan KN, Ganesan C, Shen S, Mustafa Y & Lamb TD (2008), “Suppression of human cone circulating current by steady backgrounds assessed at early times using the electroretinogram.” IOVS Abstract 5820

    2006

    Cameron AM, Mahroo OA, Lamb TD (2006), “Dark adaptation of human rod bipolar cells measured from the b-wave of the scotopic electroretinogram.” J Physiol 575(Pt 2):507-26 Details

    2005

    Cameron AM, Mahroo OAR & Lamb TD (2005), “Dark Adaptation of Human Rod Bipolar Cells Measured in vivo Using the Scotopic B–Wave of the ERG” IOVS Abstract 5687

    Kenkre JS, Moran NA, Lamb TD, Mahroo OA (2005), “Extremely rapid recovery of human cone circulating current at the extinction of bleaching exposures.” J Physiol 567(Pt 1):95-112 Details

    Mahroo OAR, Moran NA, Kenkre JS & Lamb TD (2005), “Rapid Recovery of Current in Human Cones Following Bleaching Exposures” IOVS Abstract 4633

    2004

    Mahroo OA, Lamb TD (2004), “Recovery of the human photopic electroretinogram after bleaching exposures: estimation of pigment regeneration kinetics.” J Physiol 554(Pt 2):417-37 Details

    2003

    Mahroo OAR, Husain N, Mehta H, Patel A & Lamb TD (2003), “Recovery of the human cone electroretinogram a-wave following bleaching exposures: A measure of pigment regeneration in vivo.” IOVS Abstract #4161

    Moran NA, Kenkre JS, Lamb TD & Mahroo OAR (2003), “Human cone photoreceptor circulating current assessed in vivo using the electroretinogram a-wave during and after intense illumination” J Physiol 551P, C17

    2002

    Lamb TD, Mahroo OAR & Pugh EN Jr (2002), “Absence of a change in amplification constant of transduction in human rod photoreceptors following bright illumination” J Physiol 543P, 110PA

    2001

    Mahroo OAR & Lamb TD (2001), “Recovery of the human cone electroretinogram a-wave following bleaching exposures.” J Physiol 536P, 40P

    2000

    Paupoo AA, Mahroo OA, Friedburg C, Lamb TD (2000), “Human cone photoreceptor responses measured by the electroretinogram [correction of electoretinogram] a-wave during and after exposure to intense illumination.” J Physiol 529 Pt 2:469-82 Details

    1999

    Mahroo OAR, Paupoo AAV, Friedburg C & Lamb TD (1999), “Recovery of human cone photoreceptors following bleaching exposures.” J Physiol 520P, 44P.