Our ability to move voluntarily is fundamentally important, yet is often taken for granted until it is impaired by disease. My interest lies in understanding the mechanisms underlying voluntary motor control in healthy population and in patients with movement disorders, such as Parkinson’s disease and related conditions.
To study this, I am using experimental paradigms that home in on mechanisms of awareness and control of action in humans. My experiments measure what I call 'the behavioural signatures’ of voluntary control, that is, the perceptual changes that often accompany voluntary actions. I then associate these behavioural measures with their underlying structural and functional brain correlates in health and disease.
Alien Hand Syndrome
Magnetic resonance imaging (MRI)
Patrick Haggard Web: http://www.icn.ucl.ac.uk/Staff-L...
Hartwig Siebner Web: http://www.drcmr.dk/siebner
Wolpe N, Rowe JB (2014), “Beyond the "urge to move": objective measures for the study of agency in the post-Libet era.” Front Hum Neurosci 8:450 Details
Wolpe N, Wolpert DM, Rowe JB (2014), “Seeing what you want to see: priors for one's own actions represent exaggerated expectations of success.” Front Behav Neurosci 8:232 Details
Wolpe N, Haggard P, Siebner HR, Rowe JB (2013), “Cue integration and the perception of action in intentional binding.” Exp Brain Res Details
Wolpe N, Moore JW, Rae CL, Rittman T, Altena E, Haggard P, Rowe JB (2013), “The medial frontal-prefrontal network for altered awareness and control of action in corticobasal syndrome.” Brain Details
Galli G, Wolpe N, Otten LJ (2011), “Sex differences in the use of anticipatory brain activity to encode emotional events.” J Neurosci 31(34):12364-70 Details