Interests

Our ability to move voluntarily is fundamentally important, yet is often taken for granted until it is impaired by disease. My interest lies in understanding the mechanisms underlying voluntary motor control in healthy population and in patients with movement disorders, such as Parkinson’s disease and related conditions.

To study this, I am using experimental paradigms that home in on mechanisms of awareness and control of action in humans. My experiments measure what I call 'the behavioural signatures’ of voluntary control, that is, the perceptual changes that often accompany voluntary actions. I then associate these behavioural measures with their underlying structural and functional brain correlates in health and disease.

Research Focus

Keywords

Sensorimotor control

Movement disorders

Voluntary action

MRI

Bayesian models

Clinical conditions

Alien Hand Syndrome

Corticobasal degeneration

Movement disorders

Parkinson's disease

Equipment

Behavioural analysis

Computational modelling

Electroencephalography (EEG)

Magnetic resonance imaging (MRI)

Neuropsychological testing

Collaborators

Cambridge

Daniel Wolpert

United Kingdom

Patrick Haggard Web: http://www.icn.ucl.ac.uk/Staff-L...

James Moore Web: http://www.gold.ac.uk/psychol...

International

Hartwig Siebner Web: http://www.drcmr.dk/siebner

Publications

2013

Wolpe N, Haggard P, Siebner HR, Rowe JB (2013), “Cue integration and the perception of action in intentional binding.” Exp Brain Res Details

Wolpe N, Moore JW, Rae CL, Rittman T, Altena E, Haggard P, Rowe JB (2013), “The medial frontal-prefrontal network for altered awareness and control of action in corticobasal syndrome.” Brain Details

2011

Galli G, Wolpe N, Otten LJ (2011), “Sex differences in the use of anticipatory brain activity to encode emotional events.” J Neurosci 31(34):12364-70 Details