Dr Nikolina Skandali MD MSc

Nikolina Skandali

University position

PhD student
Supervised by Professor Barbara J Sahakian

Departments

Department of Psychiatry

Institutes

Behavioural and Clinical Neuroscience Institute

Home page

http://nikolinaskandali.com/ (personal home page)

Research Themes

Systems and Computational Neuroscience

Cognitive and Behavioural Neuroscience

Interests

I am interested in studying decision making process and the underlying neural mechanisms. It is suggested that choice behaviour arises from the interaction of two distinct neural mechanisms: goal-directed and habitual which are termed computationally as model-based and model-free.

My PhD research focuses on the balance and competition of these two systems and the effect of neuromodulatory systems, such as the serotonergic one. My research combines pharmacological manipulations, neuroimaging techniques and behavioural testing.

Research Focus

Keywords

decision-making

computational neuroscience

neuromodulation

serotonin

reward

Clinical conditions

No direct clinical relevance

Equipment

No equipment indicated

Collaborators

Cambridge

Trevor Robbins

Barbara Sahakian

Associated News Items


    Key publications

    Rutledge RB, Skandali N, Dayan P, Dolan RJ (2015), “Dopaminergic Modulation of Decision Making and Subjective Well-Being” J Neurosci 35(27): 9811-9822

    Rutledge RB, Skandali N, Dayan P, Dolan RJ (2014), “A computational and neural model of momentary subjective well-being.” Proc Natl Acad Sci U S A 111(33):12252-7 Details

    Publications

    2014

    Koromilas C, Liapi C, Zarros A, Stolakis V, Tsagianni A, Skandali N, Al-Humadi H, Tsakiris S (2014), “Effects of experimentally-induced maternal hypothyroidism on crucial offspring rat brain enzyme activities.” Int J Dev Neurosci 35:1-6 Details

    2013

    Bimpis A, Papalois A, Tsakiris S, Kalafatakis K, Zarros A, Gkanti V, Skandali N, Al-Humadi H, Kouzelis C, Liapi C (2013), “Modulation of crucial adenosinetriphosphatase activities due to U-74389G administration in a porcine model of intracerebral hemorrhage.” Metab Brain Dis 28(3):439-46 Details

    Botis J, Chatzigeorgiou A, Chatzilymperis G, Kalafatakis K, Katsouni E, Mylonas N, Skandali N, Skandalis A, Vagena E, Zarros A (2013), “Inform, conform, reform and do not deform: A four axons' framework for the Hellenic academic institutions facing the Greek crisis challenge.” J Nat Sci Biol Med 4(1):268-9 Details

    Katsouni E, Zarros A, Skandali N, Tsakiris S, Lappas D (2013), “The role of cholecystokinin in the induction of aggressive behavior: a focus on the available experimental data (review).” Acta Physiol Hung 100(4):361-77 Details

    Stolakis V, Tsakiris S, Kalafatakis K, Zarros A, Skandali N, Gkanti V, Kyriakaki A, Liapi C (2013), “Developmental neurotoxicity of cadmium on enzyme activities of crucial offspring rat brain regions.” Biometals 26(6):1013-21 Details

    Zarros A, Liapi C, Al-Humadi H, Almpani M, Stolakis V, Skandali N, Voumvourakis K, Katsouni E, Tsakiris S (2013), “Experimentally-induced Wernicke's encephalopathy modifies crucial rat brain parameters: the importance of Na+, K+ -ATPase and a potentially neuroprotective role for antioxidant supplementation.” Metab Brain Dis 28(3):387-96 Details

    2012

    Zarros A, Skandali N, Tsakiris S (2012), “Comments to the Editor concerning the cholinergic response to manganese-induced neurotoxicity, based on the paper entitled "The inhibitory effect of manganese on acetylcholinesterase activity enhances oxidative stress and neuroinflammation in the brain" by Santos et al.” Toxicology 298(1-3):59-60; author reply 61-2 Details

    2011

    Liapi C, Zarros A, Theocharis S, Voumvourakis K, Anifantaki F, Gkrouzman E, Mellios Z, Skandali N, Al-Humadi H, Tsakiris S (2011), “Short-term exposure to nickel alters the adult rat brain antioxidant status and the activities of crucial membrane-bound enzymes: neuroprotection by L-cysteine.” Biol Trace Elem Res 143(3):1673-81 Details

    2009

    Katsouni E, Sakkas P, Zarros A, Skandali N, Liapi C (2009), “The involvement of substance P in the induction of aggressive behavior.” Peptides 30(8):1586-91 Details

    Liapi C, Al-Humadi H, Zarros A, Galanopoulou P, Stolakis V, Gkrouzman E, Mellios Z, Skandali N, Anifantaki F, Tsakiris S (2009), “Combined thirty-day exposure to thioacetamide and choline-deprivation alters serum antioxidant status and crucial brain enzyme activities in adult rats.” Metab Brain Dis 24(3):441-51 Details

    Liapi C, Kyriakaki A, Zarros A, Al-Humadi H, Stolakis V, Gkrouzman E, Anifantaki F, Skandali N, Margaritis M, Tsakiris S (2009), “Effects of adult-onset choline deprivation on the activities of acetylcholinesterase, (Na+,K+)- and Mg2+-ATPase in crucial rat brain regions.” Food Chem Toxicol 47(1):82-5 Details

    Liapi C, Zarros A, Theocharis S, Al-Humadi H, Anifantaki F, Gkrouzman E, Mellios Z, Skandali N, Tsakiris S (2009), “The neuroprotective role of L-cysteine towards the effects of short-term exposure to lanthanum on the adult rat brain antioxidant status and the activities of acetylcholinesterase, (Na+,K+)- and Mg2+-ATPase.” Biometals 22(2):329-35 Details

    Zarros A, Liapi C, Galanopoulou P, Marinou K, Mellios Z, Skandali N, Al-Humadi H, Anifantaki F, Gkrouzman E, Tsakiris S (2009), “Effects of adult-onset streptozotocin-induced diabetes on the rat brain antioxidant status and the activities of acetylcholinesterase, (Na(+),K (+))- and Mg(2+)-ATPase: modulation by L-cysteine.” Metab Brain Dis 24(2):337-48 Details

    2008

    Liapi C, Zarros A, Galanopoulou P, Theocharis S, Skandali N, Al-Humadi H, Anifantaki F, Gkrouzman E, Mellios Z, Tsakiris S (2008), “Effects of short-term exposure to manganese on the adult rat brain antioxidant status and the activities of acetylcholinesterase, (Na,K)-ATPase and Mg-ATPase: modulation by L-cysteine.” Basic Clin Pharmacol Toxicol 103(2):171-5 Details

    Zarros A, Theocharis S, Skandali N, Tsakiris S (2008), “Effects of fulminant hepatic encephalopathy on the adult rat brain antioxidant status and the activities of acetylcholinesterase, (Na(+),K (+))- and Mg (2+)-ATPase: comparison of the enzymes' response to in vitro treatment with ammonia.” Metab Brain Dis 23(3):255-64 Details