Dr Nicholas Walsh


I am lecturer in Developmental Psychology at UEA and a Visiting Scientist in the Department of Psychiatry, University of Cambridge.

In my research I am investigating the effects of genetic and early-life environmental factors upon brain structure and function. To do this I am scanning participants from the ROOTS cohort [http://www.roots.group.cam.ac.uk/]. This work is carried out in collaboration with colleagues at the Department of Psychiatry, University of Cambridge and the MRC Cognition and Brain Sciences Unit.

More broadly I am interested in the following areas:

Translational epidemiology / Population Neuroscience

Cognitive control and self-regulation across the life-course.

Effects of the psychosocial environment on brain structure and function over the life-course.

Psychiatric genetics

Neural mechanisms of antidepressant treatments: psychological and pharmacological.

For my personal blog see familyneuroscience.com

Research Focus



Cognitive control

Psychiatric genetics



Clinical conditions

Anxiety disorders

Bipolar disorder

Childhood disorders

Depressive disorders

Genetic disorders



Behavioural analysis

Cross-sectional and cohort studies

Magnetic resonance imaging (MRI)

Neuropsychological testing



Tim Dalgleish

Ian Goodyer

Associated News Items

    Key publications

    Walsh ND, Dalgleish T, Lombardo MV, Dunn VJ, Van Harmelen AL, Ban M, Goodyer IM (2014), “General and specific effects of early-life psychosocial adversities on adolescent grey matter volume.” Neuroimage Clin 4:308-18 PDF Details

    Walsh ND, Dalgleish T, Dunn VJ, Abbott R, St Clair MC, Owens M, Fairchild G, Kerslake WS, Hiscox LV, Passamonti L, Ewbank M, Ban M, Calder AJ, Goodyer IM (2012), “5-HTTLPR-environment interplay and its effects on neural reactivity in adolescents.” Neuroimage 63(3):1670-80 PDF Details

    Walsh ND, Phillips ML (2010), “Interacting outcome retrieval, anticipation, and feedback processes in the human brain.” Cereb Cortex 20(2):271-81 PDF Details

    Walsh ND, Seal ML, Williams SC, Mehta MA (2009), “A investigation of cognitive 'branching' processes in major depression.” BMC Psychiatry 9(1):69 PDF Details

    Walsh ND, Williams SC, Brammer MJ, Bullmore ET, Kim J, Suckling J, Mitterschiffthaler MT, Cleare AJ, Pich EM, Mehta MA, Fu CH (2007), “A longitudinal functional magnetic resonance imaging study of verbal working memory in depression after antidepressant therapy” Biological Psychiatry 62 11:1236-1243 Details



    Fairchild G, Hagan CC, Passamonti L, Walsh ND, Goodyer IM, Calder AJ (2014), “Atypical neural responses during face processing in female adolescents with conduct disorder.” J Am Acad Child Adolesc Psychiatry 53(6):677-687.e5 Details


    Fairchild G, Hagan CC, Walsh ND, Passamonti L, Calder AJ, Goodyer IM (2013), “Brain structure abnormalities in adolescent girls with conduct disorder.” J Child Psychol Psychiatry 54(1):86-95 Details


    Owens M, Goodyer IM, Wilkinson P, Bhardwaj A, Abbott R, Croudace T, Dunn V, Jones PB, Walsh ND, Ban M, Sahakian BJ (2012), “5-HTTLPR and early childhood adversities moderate cognitive and emotional processing in adolescence.” PLoS One 7(11):e48482 Details


    Walsh N.D. (2011), “Book review of 'Next generation antidepressants: Moving beyond monoamines to discover novel treatment strategies for mood disorders'. Edited by Beyer C.E. and Stahl. S.M.” Psychological Medicine 41, 1109-1111


    Cole J, Toga AW, Hojatkashani C, Thompson P, Costafreda SG, Cleare AJ, Williams SC, Bullmore ET, Scott JL, Mitterschiffthaler MT, Walsh ND, Donaldson C, Mirza M, Marquand A, Nosarti C, McGuffin P, Fu CH (2010), “Subregional hippocampal deformations in major depressive disorder.” J Affect Disord Details


    Chen CH, Suckling J, Ooi C, Fu CH, Williams SC, Walsh ND, Mitterschiffthaler MT, Pich EM, Bullmore E (2008), “Functional coupling of the amygdala in depressed patients treated with antidepressant medication.” Neuropsychopharmacology 33(8):1909-18 Details

    Fu CH, Williams SC, Cleare AJ, Scott J, Mitterschiffthaler MT, Walsh ND, Donaldson C, Suckling J, Andrew C, Steiner H, Murray RM (2008), “Neural responses to sad facial expressions in major depression following cognitive behavioral therapy.” Biol Psychiatry 64(6):505-12 Details

    Mitterschiffthaler MT, Williams SC, Walsh ND, Cleare AJ, Donaldson C, Scott J, Fu CH (2008), “Neural basis of the emotional Stroop interference effect in major depression.” Psychol Med 38(2):247-56 Details

    Versace A, Almeida JR, Hassel S, Walsh ND, Novelli M, Klein CR, Kupfer DJ, Phillips ML (2008), “Elevated left and reduced right orbitomedial prefrontal fractional anisotropy in adults with bipolar disorder revealed by tract-based spatial statistics.” Arch Gen Psychiatry 65(9):1041-52 Details


    Fu CH, Williams SC, Brammer MJ, Suckling J, Kim J, Cleare AJ, Walsh ND, Mitterschiffthaler MT, Andrew CM, Pich EM, Bullmore ET (2007), “Neural responses to happy facial expressions in major depression following antidepressant treatment.” Am J Psychiatry 164(4):599-607 Details


    Fu CH, Williams SC, Cleare AJ, Brammer MJ, Walsh ND, Kim J, Andrew CM, Pich EM, Williams PM, Reed LJ, Mitterschiffthaler MT, Suckling J, Bullmore ET (2004), “Attenuation of the neural response to sad faces in major depression by antidepressant treatment: a prospective, event-related functional magnetic resonance imaging study.” Arch Gen Psychiatry 61(9):877-89 Details


    Whiskey E, Wykes T, Duncan-McConnell D, Haworth E, Walsh N, Hastilow S (2003), “Continuation of clozapine treatment: Practice makes perfect.” Psychiatric Bulletin 23:211-213