Dr Michelle Ware

Interests

Our team focuses on understanding the mechanisms underlying neurodegeneration and developing strategies to delay or prevent the death of neurones in the injured or degenerating brain, particularly in Huntington's disease.

My project will investigate the molecular mechanisms involved in the disruption to sleep and body clock patterns in Huntington patients. Using R6/2 mouse, a Huntington's disease transgenic mouse model, I will analyse the changes in expression of a number of clock genes and neuropeptides in the suprachiasmatic nucleus within the anterior hypothalamus.

Research Focus

Keywords

Huntington's

Neurodegeneration

Circadian clocks

Hypothalamus

Clinical conditions

Huntington's disease

Equipment

Cloning

Immunohistochemistry

In situ hybridisation

Microscopy

Tissue sectioning

Collaborators

No collaborators listed

Associated News Items


    Publications

    2016

    Ware M, Hamdi-Rozé H, Le Friec J, David V, Dupé V (2016), “Regulation of downstream neuronal genes by proneural transcription factors during initial neurogenesis in the vertebrate brain” Neural Development 11(1) 22

    2015

    Ware M, Dupé V, Schubert FR (2015), “Evolutionary conservation of the early axon scaffold in the vertebrate brain.” Dev Dyn Details

    2014

    Lavado A, Ware M, Paré J, Cao X (2014), “The tumor suppressor Nf2 regulates corpus callosum development by inhibiting the transcriptional coactivator Yap.” Development 141(21):4182-93 Details

    Ratié L, Ware M, Jagline H, David V, Dupé V (2014), “Dynamic expression of Notch-dependent neurogenic markers in the chick embryonic nervous system.” Front Neuroanat 8:158 Details

    Ware M, Hamdi-Rozé H, Dupé V (2014), “Notch signaling and proneural genes work together to control the neural building blocks for the initial scaffold in the hypothalamus.” Front Neuroanat 8:140 Details

    Ware M, Waring CP, Schubert FR (2014), “Development of the Early Axon Scaffold in the Rostral Brain of the Small Spotted Cat Shark (Scyliorhinus canicula) Embryo” International Scholarly Research Notices

    2013

    Ratié L, Ware M, Barloy-Hubler F, Romé H, Gicquel I, Dubourg C, David V, Dupé V (2013), “Novel genes upregulated when NOTCH signalling is disrupted during hypothalamic development.” Neural Dev 8:25 Details

    2011

    Ware M, Schubert FR (2011), “Development of the early axon scaffold in the rostral brain of the chick embryo.” J Anat 219(2):203-16 Details