Dr Michelle Ware
Our team focuses on understanding the mechanisms underlying neurodegeneration and developing strategies to delay or prevent the death of neurones in the injured or degenerating brain, particularly in Huntington's disease.
My project will investigate the molecular mechanisms involved in the disruption to sleep and body clock patterns in Huntington patients. Using R6/2 mouse, a Huntington's disease transgenic mouse model, I will analyse the changes in expression of a number of clock genes and neuropeptides in the suprachiasmatic nucleus within the anterior hypothalamus.
In situ hybridisation
No collaborators listed
Associated News Items
Ware M, Hamdi-Rozé H, Le Friec J, David V, Dupé V (2016), “Regulation of downstream neuronal genes by proneural transcription factors during initial neurogenesis in the vertebrate brain” Neural Development 11(1) 22
Ware M, Dupé V, Schubert FR (2015), “Evolutionary conservation of the early axon scaffold in the vertebrate brain.” Dev Dyn Details
Lavado A, Ware M, Paré J, Cao X (2014), “The tumor suppressor Nf2 regulates corpus callosum development by inhibiting the transcriptional coactivator Yap.” Development 141(21):4182-93 Details
Ratié L, Ware M, Jagline H, David V, Dupé V (2014), “Dynamic expression of Notch-dependent neurogenic markers in the chick embryonic nervous system.” Front Neuroanat 8:158 Details
Ware M, Hamdi-Rozé H, Dupé V (2014), “Notch signaling and proneural genes work together to control the neural building blocks for the initial scaffold in the hypothalamus.” Front Neuroanat 8:140 Details
Ware M, Waring CP, Schubert FR (2014), “Development of the Early Axon Scaffold in the Rostral Brain of the Small Spotted Cat Shark (Scyliorhinus canicula) Embryo” International Scholarly Research Notices
Ratié L, Ware M, Barloy-Hubler F, Romé H, Gicquel I, Dubourg C, David V, Dupé V (2013), “Novel genes upregulated when NOTCH signalling is disrupted during hypothalamic development.” Neural Dev 8:25 Details
Ware M, Schubert FR (2011), “Development of the early axon scaffold in the rostral brain of the chick embryo.” J Anat 219(2):203-16 Details