Dr Mark Kotter

University position

Clinical Lecturer

Dr Mark Kotter is pleased to consider applications from prospective PhD students.

Departments

Department of Clinical Neurosciences

Institutes

Wellcome Trust Centre for Stem Cell Research

Home page

http://www.lrm.medschl.cam.ac.uk/researc... (personal home page)

Research Themes

Cellular and Molecular Neuroscience

Clinical and Veterinary Neuroscience

Interests

My group is interested in the biology of adult CNS stem and precursor cells in the context of disease. A particular focus lies on mechanisms of CNS remyelination, a stem/precursor cell-mediated process in which new myelin sheaths are restored to demyelinated nerve fibres (axons). To understand how the differentiation of multipotent oligodendrocyte precursor cells (OPCs) is regulated we use a combination of in vitro and in vivo models. Furthermore, we integrate findings of post mortem studies and aim at translating our findings into clinical studies.

Research Focus

Keywords

neural stem cells

remyelination

clinical disease

Clinical conditions

Cancers

Multiple sclerosis

Traumatic brain injury

Equipment

Cell culture

Confocal microscopy

Enzyme assays

Fluorescence microscopy

FPLC/HPLC

Immunohistochemistry

Microscopy

Protein purification

Recombinant protein expression

Collaborators

Cambridge

Robin Franklin

International

Klaus-Amin Nave

Christine Stadelmann-Nessler

Associated News Items


    Key publications

    Baer AS, Syed YA, Kang SU, Mitteregger D, Vig R, Ffrench-Constant C, Franklin RJ, Altmann F, Lubec G, Kotter MR (2009), “Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling.” Brain 132(Pt 2):465-81 Details

    Neumann H, Kotter MR, Franklin RJ (2009), “Debris clearance by microglia: an essential link between degeneration and regeneration.” Brain 132(Pt 2):288-95 Details

    Kotter MR, Li WW, Zhao C, Franklin RJ (2006), “Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation.” J Neurosci 26(1):328-32 Details

    Kotter MR, Setzu A, Sim FJ, Van Rooijen N, Franklin RJ (2001), “Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination.” Glia 35(3):204-12 Details