Dr Abteen Mostofi

University position

Research Associate

Departments

Department of Physiology, Development and Neuroscience

Institutes

School of Clinical Medicine

Email

am503@cam.ac.uk

Home page

http://www.pdn.cam.ac.uk/groups/...

Research Themes

Systems and Computational Neuroscience

Cognitive and Behavioural Neuroscience

Interests

The cerebellum contains one of most anatomically regular and seemingly simple arrangements of neurons in the vertebrate brain. My research focuses on the neural mechanisms of its contribution to motor control and utilises electrophysiological techniques to record the activity of cerebellar neurons in vivo. Specifically, I am investigating the neuronal basis of the classically-conditioned eyeblink response, a simple model of cerebellar motor learning.

Cerebellar Golgi cell labelled juxtacellularly in vivo
Cerebellar Golgi cell labelled juxtacellularly in vivo, viewed with dark field microscopy.
View image full-size (1045x740 pixels)

Research Focus

Keywords

cerebellum

motor system

classical conditioning

learning

electrophysiology

Clinical conditions

Cerebellar ataxias

Equipment

Behavioural analysis

Electrophysiological recording techniques

Field potential recording

Immunohistochemistry

Microscopy

Collaborators

No collaborators listed

Associated News Items


    Key publications

    Holtzman T, Rajapaksa T, Mostofi A, Edgley SA (2006), “Different responses of rat cerebellar Purkinje cells and Golgi cells evoked by widespread convergent sensory inputs.” J Physiol 574(Pt 2):491-507 Details

    Publications

    2013

    Van Dijck G, Van Hulle MM, Heiney SA, Blazquez PM, Meng H, Angelaki DE, Arenz A, Margrie TW, Mostofi A, Edgley S, Bengtsson F, Ekerot CF, J├Ârntell H, Dalley JW, Holtzman T (2013), “Probabilistic identification of cerebellar cortical neurones across species.” PLoS One 8(3):e57669 Details

    2010

    Mostofi A, Holtzman T, Grout AS, Yeo CH, Edgley SA (2010), “Electrophysiological localization of eyeblink-related microzones in rabbit cerebellar cortex.” J Neurosci 30(26):8920-34 Details

    2006

    Holtzman T, Mostofi A, Phuah CL, Edgley SA (2006), “Cerebellar Golgi cells in the rat receive multimodal convergent peripheral inputs via the lateral funiculus of the spinal cord.” J Physiol 577(Pt 1):69-80 Details