Matilde is taking advantage of well defined, standardized cross-species paradigms and innovative imaging techniques to precisely characterize patterns of abnormalities within fronto-striatal circuits in OCD patients. Aim of Matilde’s work is to test whether altered connectivity can be found in specific fronto-striatal loops in OCD patients and, crucially, to relate such disconnectivity to objective measures related to the compulsivity construct, such as cognitive flexibility and goal-directed behaviour.
Magnetic resonance imaging (MRI)
Associated News Items
Tettamanti M, Vaghi MM, Bara BG, Cappa SF, Enrici I, Adenzato M (2017), “Effective connectivity gateways to the Theory of Mind network in processing communicative intention.” Neuroimage 155, 169–176.
Vaghi MM, Hampshire A, Fineberg NA, Kaser M, Brühl AB, Sahakian BJ, Chamberlain SR, Robbins TW (in press), “Hypoactivation and dysconnectivity of a frontostriatal circuit during goal-directed planning as an endophenotype for Obsessive-Compulsive Disorder.” Biological psychiatry: cognitive neuroscience and neuroimaging
Vaghi MM, Vértes PE, Kitzbichler MG, Apergis-Schoute AM, van der Flier FE, Fineberg NA, Sule A, Zaman R, Voon V, Kundu P, Bullmore ET, Robbins TW (2017), “Specific frontostriatal circuits for impaired cognitive flexibility and goal-directed planning in Obsessive-Compulsive Disorder: Evidence from resting-state functional connectivity.” Biological Psychiatry 81(8), 708–717.
Ghio M, Vaghi MM, Perani D, Tettamanti M (2016), “Decoding the neural representation of fine-grained conceptual categories. ” Neuroimage 132:93-103
Vaghi MM, Robbins TW (in press), “Functional Imaging Studies of Obsessive Compulsive Disorder: A Hypothesis-Driven Review. ” In Obsessive-Compulsive Disorder: Phenomenology, Pathophysiology, and Treatment. Ed. C. Pittenger. Oxford University Press
Ghio M, Vaghi MM, Tettamanti M (2013), “Fine-grained semantic categorization across the abstract and concrete domains.” PLoS One 8(6):e67090 Details