Monica Killen

University position

PhD student
Supervised by Prof. P. Hutchinson, Dr. K. Carpenter

Departments

Department of Clinical Neurosciences

Institutes

Neurosurgery Unit

Email

mjk74@cam.ac.uk

Research Themes

Cellular and Molecular Neuroscience

Clinical and Veterinary Neuroscience

Interests

My PhD is focused on understanding the relationship between metabolic dysfunction and inflammation in traumatic brain injury (TBI). Many TBI patients experience a change in normal brain chemistry, which causes further neurodegeneration and cell death for many months to years after recovering from the initial injury. This is thought to be due to chronic inflammation, a process which is accompanied by a change in the cell’s means of energy production. I will be investigating the effects of supplementing the energy production process, and whether this is able to alter the release of inflammatory signalling proteins in stressed cells. Through supplementing this metabolism, we hope to hinder the continued cycle of inflammation and neurodegeneration.

Research Focus

Keywords

Neurochemistry

Cell Metabolism

Neuroinflammation

Microdialysis

Neurotrauma

Clinical conditions

Traumatic brain injury

Equipment

Cell culture

Microdialysis

Collaborators

No collaborators listed

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