Professor Melissa Hines

Melissa Hines

University position

Professor

Professor Melissa Hines is pleased to consider applications from prospective PhD students.

Departments

Department of Psychology

Email

mh504@cam.ac.uk

Home page

http://www.psychol.cam.ac.uk/people/...

Research Themes

Cognitive and Behavioural Neuroscience

Developmental Neuroscience

Interests

I study gender development, and am particularly interested in how prenatal influences (e.g., gonadal hormones) interact with postnatal experience to shape brain development and behaviour. My current research programme includes studies of individuals with disorders of sex development (formerly called intersex conditions), as well as healthy individuals for whom we have measures of prenatal hormones. Behavioural outcomes of interest include gender identity, sexual orientation, aggression, empathy, mood, sex-typical interests in childhood (e.g., toy preferences) and adulthood, and clinical syndromes that show sex differences. I also study infants, so that we can identify sex differences as they emerge early in life and examine their relationship to prenatal hormones and postnatal socialiazation. In addition, I am interested in the neural and cognitive mechanisms related to behavioural changes in these areas, as well as in animal models of human behavior.

Non-human primates contacting sex-typed toys
Non-human primates contacting sex-typed toys. Left: female with doll; Right: male with car.
Click image to view full-size

Research Focus

Keywords

gender

sexual differentiation

androgen

intersex

infants

Clinical conditions

Gender identity disorder

Genetic disorders

Equipment

Behavioural analysis

Magnetic resonance imaging (MRI)

Neuropsychological testing

Psychometric testing

Steroid hormone measurement

Collaborators

Cambridge

Susan Golombok

Gerard Hackett

Ieuan Hughes

Vickie Pasterski

John Rust

United Kingdom

Vivette Glover Web: http://www1.imperial.ac.uk/medicin...

Peter Hindmarsh Web: http://www.ich.ucl.ac.uk/gosh/cl...

International

Mitchell Geffner Web: http://www.childrenshospitalla.org/1651.cfm

Kenneth Zucker Web: http://abigail.psych.utoronto.ca/psych/p...

Key publications

Pasterski VL, Geffner M, Brain C, Hindmarsh P, Brook C, Hines M (2005), “Prenatal hormones versus postnatal socialization by parents as determinants of male-typical toy play in girls with congenital adrenal hyperplasia” Child Development 76:264-278 Details

Hines M, Brook C, Conway GS (2004), “Androgen and psychosexual development: Core gender identity, sexual orientation and recalled childhood gender role behavior in men and women with congenital adrenal hyperplasia (CAH)” Journal of Sex Research 41:75-81 Details

Hines M, Golombok S, Rust J, Johnston KJ, Golding J, the ALSPAC study team (2002), “Testosterone during pregnancy and gender role behavior of children: A longitudinal population study” Child Development 73:1678-1687

Publications

2013

Wong WI, Pasterski V, Hindmarsh PC, Geffner ME, Hines M (2013), “Are there parental socialization effects on the sex-typed behavior of individuals with congenital adrenal hyperplasia?” Arch Sex Behav 42(3):381-91 Details

2012

Golombok S, Rust J, Zervoulis K, Golding J, Hines M (2012), “Continuity in sex-typed behavior from preschool to adolescence: a longitudinal population study of boys and girls aged 3-13 years.” Arch Sex Behav 41(3):591-7 Details

2011

Hines M (2011), “Gender development and the human brain.” Annu Rev Neurosci 34:69-88 Details

Hines M (2011), “Prenatal endocrine influences on sexual orientation and on sexually differentiated childhood behavior.” Front Neuroendocrinol 32(2):170-82 Details

Pasterski V, Geffner ME, Brain C, Hindmarsh P, Brook C, Hines M (2011), “Prenatal hormones and childhood sex segregation: playmate and play style preferences in girls with congenital adrenal hyperplasia.” Horm Behav 59(4):549-55 Details

2010

Barry JA, Kay AR, Navaratnarajah R, Iqbal S, Bamfo JE, David AL, Hines M, Hardiman PJ (2010), “Umbilical vein testosterone in female infants born to mothers with polycystic ovary syndrome is elevated to male levels.” J Obstet Gynaecol 30(5):444-6 Details

Hines M (2010), “Sex-related variation in human behavior and the brain.” Trends Cogn Sci 14(10):448-56 Details

Jadva V, Hines M, Golombok S (2010), “Infants' preferences for toys, colors, and shapes: sex differences and similarities.” Arch Sex Behav 39(6):1261-73 Details

Mattocks C, Hines M, Ness A, Leary S, Griffiths A, Tilling K, Blair SN, Riddoch C (2010), “Associations between sex-typed behaviour at age 31/2 and levels and patterns of physical activity at age 12: the Avon Longitudinal Study of Parents and Children.” Arch Dis Child 95(7):509-12 Details

Swan SH, Liu F, Hines M, Kruse RL, Wang C, Redmon JB, Sparks A, Weiss B (2010), “Prenatal phthalate exposure and reduced masculine play in boys.” Int J Androl 33(2):259-69 Details

2009

Auyeung B, Baron-Cohen S, Ashwin E, Knickmeyer R, Taylor K, Hackett G, Hines M (2009), “Fetal testosterone predicts sexually differentiated childhood behavior in girls and in boys.” Psychol Sci 20(2):144-8 Details

Collaer ML, Brook CG, Conway GS, Hindmarsh PC, Hines M (2009), “Motor development in individuals with congenital adrenal hyperplasia: strength, targeting, and fine motor skill.” Psychoneuroendocrinology 34(2):249-58 Details

Hines M (2009), “Sex hormones and human destiny.” J Neuroendocrinol 21(4):437-8 Details

Mathews GA, Fane BA, Conway GS, Brook CG, Hines M (2009), “Personality and congenital adrenal hyperplasia: possible effects of prenatal androgen exposure.” Horm Behav 55(2):285-91 Details

2008

Golombok S, Rust J, Zervoulis K, Croudace T, Golding J, Hines M (2008), “Developmental trajectories of sex-typed behavior in boys and girls: a longitudinal general population study of children aged 2.5-8 years.” Child Dev 79(5):1583-93 Details

Hines M (2008), “Early androgen influences on human neural and behavioural development.” Early Hum Dev 84(12):805-7 Details

Hines M, Alexander GM (2008), “Monkeys, girls, boys and toys: a confirmation Letter regarding "Sex differences in toy preferences: striking parallels between monkeys and humans".” Horm Behav 54(3):478-9; author reply 480-1 Details

2007

Pasterski V, Hindmarsh P, Geffner M, Brook C, Brain C, Hines M (2007), “Increased aggression and activity level in 3- to 11-year-old girls with congenital adrenal hyperplasia (CAH).” Horm Behav 52(3):368-74 Details

Shaheen SO, Hines M, Newson RB, Wheeler M, Herrick DR, Strachan DP, Jones RW, Burney PG, Henderson AJ (2007), “Maternal testosterone in pregnancy and atopic outcomes in childhood.” Allergy 62(1):25-32 Details

2006

Halari R, Sharma T, Hines M, Andrew C, Simmons A, Kumari V (2006), “Comparable fMRI activity with differential behavioural performance on mental rotation and overt verbal fluency tasks in healthy men and women.” Exp Brain Res 169(1):1-14 Details

Hines M (2006), “Prenatal testosterone and gender-related behaviour.” Eur J Endocrinol 155 Suppl 1:S115-21 Details

Knickmeyer R, Baron-Cohen S, Fane BA, Wheelwright S, Mathews GA, Conway GS, Brook CG, Hines M (2006), “Androgens and autistic traits: A study of individuals with congenital adrenal hyperplasia.” Horm Behav 50(1):148-53 Details

Miles C, Green R, Hines M (2006), “Estrogen treatment effects on cognition, memory and mood in male-to-female transsexuals.” Horm Behav 50(5):708-17 Details

Postma P, Gray JA, Sharma T, Geyer M, Mehrotra R, Das M, Zachariah E, Hines M, Williams SC, Kumari V (2006), “A behavioural and functional neuroimaging investigation into the effects of nicotine on sensorimotor gating in healthy subjects and persons with schizophrenia.” Psychopharmacology (Berl) 184(3-4):589-99 Details

2005

Halari R, Hines M, Kumari V, Mehrotra R, Wheeler M, Ng V, Sharma T (2005), “Sex differences and individual differences in cognitive performance and their relationship to endogenous gonadal hormones and gonadotropins.” Behav Neurosci 119(1):104-17 Details

Iervolino AC, Hines M, Golombok SE, Rust J, Plomin R (2005), “Genetic and environmental influences on sex-typed behavior during the preschool years.” Child Dev 76(4):826-40 Details

2004

Halari R, Kumari V, Mehrotra R, Wheeler M, Hines M, Sharma T (2004), “The relationship of sex hormones and cortisol with cognitive functioning in Schizophrenia.” J Psychopharmacol 18(3):366-74 Details

Hines M (2004), “Psychosexual development in individuals who have female pseudohermaphroditism.” Child Adolesc Psychiatr Clin N Am 13(3):641-56, ix Details

Mathews GA, Fane BA, Pasterski VL, Conway GS, Brook C, Hines M (2004), “Androgenic influences on neural asymmetry: Handedness and language lateralization in individuals with congenital adrenal hyperplasia.” Psychoneuroendocrinology 29(6):810-22 Details

2003

Hines M (2003), “Sex steroids and human behavior: prenatal androgen exposure and sex-typical play behavior in children.” Ann N Y Acad Sci 1007:272-82 Details

Hines M, Ahmed SF, Hughes IA (2003), “Psychological outcomes and gender-related development in complete androgen insensitivity syndrome.” Arch Sex Behav 32(2):93-101 Details

Hines M, Fane BA, Pasterski VL, Mathews GA, Conway GS, Brook C (2003), “Spatial abilities following prenatal androgen abnormality: targeting and mental rotations performance in individuals with congenital adrenal hyperplasia.” Psychoneuroendocrinology 28(8):1010-26 Details

2002

Brown WM, Hines M, Fane BA, Breedlove SM (2002), “Masculinized finger length patterns in human males and females with congenital adrenal hyperplasia.” Horm Behav 42(4):380-6 Details

Collaer ML, Geffner ME, Kaufman FR, Buckingham B, Hines M (2002), “Cognitive and behavioral characteristics of turner syndrome: exploring a role for ovarian hormones in female sexual differentiation.” Horm Behav 41(2):139-55 Details

Hines M, Golombok S, Rust J, Johnston KJ, Golding J, Avon Longitudinal Study of Parents and Children Study Team (2002), “Testosterone during pregnancy and gender role behavior of preschool children: a longitudinal, population study.” Child Dev 73(6):1678-87 Details

Hines M, Johnston KJ, Golombok S, Rust J, Stevens M, Golding J, ALSPAC Study Team. Avon Longitudinal Study of Parents and Children (2002), “Prenatal stress and gender role behavior in girls and boys: a longitudinal, population study.” Horm Behav 42(2):126-34 Details

Schober JM, Carmichael PA, Hines M, Ransley PG (2002), “The ultimate challenge of cloacal exstrophy.” J Urol 167(1):300-4 Details

2001

Postma P, Kumari V, Hines M, Gray JA (2001), “The relationship between prepulse detection and prepulse inhibition of the acoustic startle reflex.” Psychophysiology 38(3):377-82 Details

Postma P, Kumari V, Sharma T, Hines M, Gray JA (2001), “Startle response during smoking and 24 h after withdrawal predicts successful smoking cessation.” Psychopharmacology (Berl) 156(2-3):360-7 Details

2000

Rust J, Golombok S, Hines M, Johnston K, Golding J, ALSPAC Study Team (2000), “The role of brothers and sisters in the gender development of preschool children.” J Exp Child Psychol 77(4):292-303 Details

Smith LL, Hines M (2000), “Language lateralization and handedness in women prenatally exposed to diethylstilbestrol (DES).” Psychoneuroendocrinology 25(5):497-512 Details

1998

Alexander GM, Swerdloff RS, Wang C, Davidson T, McDonald V, Steiner B, Hines M (1998), “Androgen-behavior correlations in hypogonadal men and eugonadal men. II. Cognitive abilities.” Horm Behav 33(2):85-94 Details

Hines M (1998), “Abnormal sexual development and psychosexual issues.” Baillieres Clin Endocrinol Metab 12(1):173-89 Details

Miles C, Green R, Sanders G, Hines M (1998), “Estrogen and memory in a transsexual population.” Horm Behav 34(2):199-208 Details

1997

Alexander GM, Swerdloff RS, Wang C, Davidson T, McDonald V, Steiner B, Hines M (1997), “Androgen-behavior correlations in hypogonadal men and eugonadal men. I. Mood and response to auditory sexual stimuli.” Horm Behav 31(2):110-9 Details

1996

Hines M, Sandberg EC (1996), “Sexual differentiation of cognitive abilities in women exposed to diethylstilbestrol (DES) prenatally.” Horm Behav 30(4):354-63 Details

1995

Collaer ML, Hines M (1995), “Human behavioral sex differences: a role for gonadal hormones during early development?” Psychol Bull 118(1):55-107 Details

1994

Alexander GM, Hines M (1994), “Gender labels and play styles: their relative contribution to children's selection of playmates.” Child Dev 65(3):869-79 Details

Alexander GM, Packard MG, Hines M (1994), “Testosterone has rewarding affective properties in male rats: implications for the biological basis of sexual motivation.” Behav Neurosci 108(2):424-8 Details

Hines M, Kaufman FR (1994), “Androgen and the development of human sex-typical behavior: rough-and-tumble play and sex of preferred playmates in children with congenital adrenal hyperplasia (CAH).” Child Dev 65(4):1042-53 Details

1992

Hines M, Allen LS, Gorski RA (1992), “Sex differences in subregions of the medial nucleus of the amygdala and the bed nucleus of the stria terminalis of the rat.” Brain Res 579(2):321-6 Details

Hines M, Chiu L, McAdams LA, Bentler PM, Lipcamon J (1992), “Cognition and the corpus callosum: verbal fluency, visuospatial ability, and language lateralization related to midsagittal surface areas of callosal subregions.” Behav Neurosci 106(1):3-14 Details

Swerdloff RS, Wang C, Hines M, Gorski R (1992), “Effect of androgens on the brain and other organs during development and aging.” Psychoneuroendocrinology 17(4):375-83 Details

1989

Allen LS, Hines M, Shryne JE, Gorski RA (1989), “Two sexually dimorphic cell groups in the human brain.” J Neurosci 9(2):497-506 Details

1987

Hines M, Alsum P, Roy M, Gorski RA, Goy RW (1987), “Estrogenic contributions to sexual differentiation in the female guinea pig: influences of diethylstilbestrol and tamoxifen on neural, behavioral, and ovarian development.” Horm Behav 21(3):402-17 Details

1986

Döhler KD, Coquelin A, Davis F, Hines M, Shryne JE, Gorski RA (1986), “Aromatization of testicular androgens in physiological concentrations does not defeminize sexual brain functions.” Monogr Neural Sci 12:28-35 Details

Döhler KD, Coquelin A, Davis F, Hines M, Shryne JE, Sickmöller PM, Jarzab B, Gorski RA (1986), “Pre- and postnatal influence of an estrogen antagonist and an androgen antagonist on differentiation of the sexually dimorphic nucleus of the preoptic area in male and female rats.” Neuroendocrinology 42(5):443-8 Details

Handa RJ, Hines M, Schoonmaker JN, Shryne JE, Gorski RA (1986), “Evidence that serotonin is involved in the sexually dimorphic development of the preoptic area in the rat brain.” Brain Res 395(2):278-82 Details

1985

Hines M, Davis FC, Coquelin A, Goy RW, Gorski RA (1985), “Sexually dimorphic regions in the medial preoptic area and the bed nucleus of the stria terminalis of the guinea pig brain: a description and an investigation of their relationship to gonadal steroids in adulthood.” J Neurosci 5(1):40-7 Details

Hines M, Goy RW (1985), “Estrogens before birth and development of sex-related reproductive traits in the female guinea pig.” Horm Behav 19(3):331-47 Details

1984

Döhler KD, Coquelin A, Davis F, Hines M, Shryne JE, Gorski RA (1984), “Pre- and postnatal influence of testosterone propionate and diethylstilbestrol on differentiation of the sexually dimorphic nucleus of the preoptic area in male and female rats.” Brain Res 302(2):291-5 Details

1983

Döhler KD, Coquelin A, Davis F, Hines M, Shryne JE, Gorski RA (1983), “[Sex differences in the macrostructure of the rat brain and their defining by sex hormones].” Tierarztl Prax 11(4):543-50 Details

1982

Döhler KD, Coquelin A, Davis F, Hines M, Shryne JE, Gorski RA (1982), “Differentiation of the sexually dimorphic nucleus in the preoptic area of the rat brain is determined by the perinatal hormone environment.” Neurosci Lett 33(3):295-8 Details

Hines M (1982), “Prenatal gonadal hormones and sex differences in human behavior.” Psychol Bull 92(1):56-80 Details