Professor Maria Grazia Spillantini

Collaborators

Key publications

Tofaris GK, O’Connell M, Ghetti B, Humby T, Lambourne L, Gossage H, Emson PC, Wilkinson LS, Goedert M, Spillantini MG (2006), “Pathological changes in dopaminergic neurones in mice transgenic for human a-synuclein (1-120): implications for Lewy body disorders” J Neuroscience 26:3942-3950

Bellucci A, Westwood AJ, Ingram E, Casamenti F, Goedert M, Spillantini MG (2004), “Neuroinflammation in mice transgenic for human P301S tau protein” American Journal of Pathology 165(5):1643-52 Details

Tofaris G, Razzaq A, Ghetti B, Lilley K, Spillantini MG (2003), “Ubiquitination of α-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function” Journal of Biological Chemistry 278:44405-44411

Publications

2010

Anderson JM, Patani R, Reynolds R, Nicholas R, Compston A, Spillantini MG, Chandran S (2010), “Abnormal tau phosphorylation in primary progressive multiple sclerosis.” Acta Neuropathol 119(5):591-600 Details

Bruni AC, Bernardi L, Colao R, Rubino E, Smirne N, Frangipane F, Terni B, Curcio SA, Mirabelli M, Clodomiro A, Di Lorenzo R, Maletta R, Anfossi M, Gallo M, Geracitano S, Tomaino C, Muraca MG, Leotta A, Lio SG, Pinessi L, Rainero I, Sorbi S, Nee L, Milan G, Pappatà S, Postiglione A, Abbamondi N, Forloni G, St George Hyslop P, Rogaeva E, Bugiani O, Giaccone G, Foncin JF, Spillantini MG, Puccio G (2010), “Worldwide distribution of PSEN1 Met146Leu mutation: a large variability for a founder mutation.” Neurology 74(10):798-806 Details

Garcia-Reitböck P, Anichtchik O, Bellucci A, Iovino M, Ballini C, Fineberg E, Ghetti B, Della Corte L, Spano P, Tofaris GK, Goedert M, Spillantini MG (2010), “SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease.” Brain 133(Pt 7):2032-44 Details

Hampton DW, Webber DJ, Bilican B, Goedert M, Spillantini MG, Chandran S (2010), “Cell-mediated neuroprotection in a mouse model of human tauopathy.” J Neurosci 30(30):9973-83 Details

Hodges JR, Mitchell J, Dawson K, Spillantini MG, Xuereb JH, McMonagle P, Nestor PJ, Patterson K (2010), “Semantic dementia: demography, familial factors and survival in a consecutive series of 100 cases.” Brain 133(Pt 1):300-6 Details

Pan-Montojo F, Anichtchik O, Dening Y, Knels L, Pursche S, Jung R, Jackson S, Gille G, Spillantini MG, Reichmann H, Funk RH (2010), “Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice.” PLoS One 5(1):e8762 Details

Rosi MC, Luccarini I, Grossi C, Fiorentini A, Spillantini MG, Prisco A, Scali C, Gianfriddo M, Caricasole A, Terstappen GC, Casamenti F (2010), “Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease.” J Neurochem 112(6):1539-51 Details

Scattoni ML, Gasparini L, Alleva E, Goedert M, Calamandrei G, Spillantini MG (2010), “Early behavioural markers of disease in P301S tau transgenic mice.” Behav Brain Res 208(1):250-7 Details

Van Deerlin VM, Sleiman PM, Martinez-Lage M, Chen-Plotkin A, Wang LS, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DM, Pickering-Brown SM, Seelaar H, Heutink P, van Swieten JC, Murrell JR, Ghetti B, Spina S, Grafman J, Hodges J, Spillantini MG, Gilman S, Lieberman AP, Kaye JA, Woltjer RL, Bigio EH, Mesulam M, Al-Sarraj S, Troakes C, Rosenberg RN, White CL 3rd, Ferrer I, Lladó A, Neumann M, Kretzschmar HA, Hulette CM, Welsh-Bohmer KA, Miller BL, Alzualde A, de Munain AL, McKee AC, Gearing M, Levey AI, Lah JJ, Hardy J, Rohrer JD, Lashley T, Mackenzie IR, Feldman HH, Hamilton RL, Dekosky ST, van der Zee J, Kumar-Singh S, Van Broeckhoven C, Mayeux R, Vonsattel JP, Troncoso JC, Kril JJ, Kwok JB, Halliday GM, Bird TD, Ince PG, Shaw PJ, Cairns NJ, Morris JC, McLean CA, DeCarli C, Ellis WG, Freeman SH, Frosch MP, Growdon JH, Perl DP, Sano M, Bennett DA, Schneider JA, Beach TG, Reiman EM, Woodruff BK, Cummings J, Vinters HV, Miller CA, Chui HC, Alafuzoff I, Hartikainen P, Seilhean (2010), “Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.” Nat Genet 42(3):234-9 Details

Xiong L, Xuereb JH, Spillantini MG, Patterson K, Hodges JR, Nestor PJ (2010), “Clinical comparison of progressive aphasia associated with Alzheimer versus FTD-spectrum pathology.” J Neurol Neurosurg Psychiatry Details

2009

Anderson JM, Patani R, Reynolds R, Nicholas R, Compston A, Spillantini MG, Chandran S (2009), “Evidence for abnormal tau phosphorylation in early aggressive multiple sclerosis.” Acta Neuropathol 117(5):583-9 Details

Borroni B, Gardoni F, Parnetti L, Magno L, Malinverno M, Saggese E, Calabresi P, Spillantini MG, Padovani A, Di Luca M (2009), “Pattern of Tau forms in CSF is altered in progressive supranuclear palsy.” Neurobiol Aging 30(1):34-40 Details

Bridge KE, Berg N, Adalbert R, Babetto E, Dias T, Spillantini MG, Ribchester RR, Coleman MP (2009), “Late onset distal axonal swelling in YFP-H transgenic mice.” Neurobiol Aging 30(2):309-21 Details

Gasparini L, Anthony Crowther R, Martin KR, Berg N, Coleman M, Goedert M, Spillantini MG (2009), “Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: Effects on axonal viability.” Neurobiol Aging Details

Pereira JM, Williams GB, Acosta-Cabronero J, Pengas G, Spillantini MG, Xuereb JH, Hodges JR, Nestor PJ (2009), “Atrophy patterns in histologic vs clinical groupings of frontotemporal lobar degeneration.” Neurology 72(19):1653-60 Details

2008

Anderson JM, Hampton DW, Patani R, Pryce G, Crowther RA, Reynolds R, Franklin RJ, Giovannoni G, Compston DA, Baker D, Spillantini MG, Chandran S (2008), “Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis.” Brain 131(Pt 7):1736-48 Details

Costa C, Belcastro V, Tozzi A, Di Filippo M, Tantucci M, Siliquini S, Autuori A, Picconi B, Spillantini MG, Fedele E, Pittaluga A, Raiteri M, Calabresi P (2008), “Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition.” J Neurosci 28(32):8040-52 Details

Delobel P, Lavenir I, Fraser G, Ingram E, Holzer M, Ghetti B, Spillantini MG, Crowther RA, Goedert M (2008), “Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy.” Am J Pathol 172(1):123-31 Details

Spina S, Farlow MR, Unverzagt FW, Kareken DA, Murrell JR, Fraser G, Epperson F, Crowther RA, Spillantini MG, Goedert M, Ghetti B (2008), “The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family.” Brain 131(Pt 1):72-89 Details

Ye L, Velasco A, Fraser G, Beach TG, Sue L, Osredkar T, Libri V, Spillantini MG, Goedert M, Lockhart A (2008), “In vitro high affinity alpha-synuclein binding sites for the amyloid imaging agent PIB are not matched by binding to Lewy bodies in postmortem human brain.” J Neurochem 105(4):1428-37 Details

2007

Goris A, Williams-Gray CH, Clark GR, Foltynie T, Lewis SJ, Brown J, Ban M, Spillantini MG, Compston A, Burn DJ, Chinnery PF, Barker RA, Sawcer SJ (2007), “Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease.” Ann Neurol 62(2):145-53 Details

Lambourne SL, Humby T, Isles AR, Emson PC, Spillantini MG, Wilkinson LS (2007), “Impairments in impulse control in mice transgenic for the human FTDP-17 tauV337M mutation are exacerbated by age.” Hum Mol Genet 16(14):1708-19 Details

Magnani E, Fan J, Gasparini L, Golding M, Williams M, Schiavo G, Goedert M, Amos LA, Spillantini MG (2007), “Interaction of tau protein with the dynactin complex.” EMBO J 26(21):4546-54 Details

Michell AW, Tofaris GK, Gossage H, Tyers P, Spillantini MG, Barker RA (2007), “The effect of truncated human alpha-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease.” Cell Transplant 16(5):461-74 Details

2006

Goedert M, Spillantini MG (2006), “A century of Alzheimer's disease.” Science 314(5800):777-81 Details

Goedert M, Spillantini MG (2006), “Frontotemporal lobar degeneration through loss of progranulin function.” Brain 129(Pt 11):2808-10 Details