Mr Michael Hart

Interests

Resolving the dichotomy between effective resection of focal lesions and preservation of brain function is a fundamental goal in neurosurgery. To achieve this, I have started a PhD on brain mapping under the supervision of Professor John Suckling.

Resting state functional MRI allows identification of complex brain networks. Graph theoretical analysis allows characterisation of core features in these networks including how they respond to attack and disruption. Developing models of fully connected and weighted networks is key to understanding how the brain responds to focal lesions. Studying normal brain network development during adolescence will allow identification of principles that determine network formation and that ultimately may guide their reconstruction.

Functional connectome in a patient with a brain tumour
Functional connectome in a patient with a brain tumour
Click image to view full-size

Research Focus

Keywords

functional MRI

complex networks

graph theory

diffusion tensor imaging

semi-metricity

Clinical conditions

Brain tumours including low grade glioma

Epilepsy

Traumatic brain injury

Equipment

Computational modelling

diffusion tensor imaging

Electrophysiological recording techniques

Field potential recording

graph theoretical analysis of complex networks

Magnetic resonance imaging (MRI)

Neuropsychological testing

resting state functional MRI

Collaborators

Cambridge

Yaara Erez

Thomas Santarius

John Suckling

United Kingdom

Robin Grant Web: http://www.neuro-oncology.org.uk

International

Tiago Simas

Associated News Items


Key publications

Hart MG, Ypma R-J, Romero-Garcia R, Price SJ, Suckling J (2015), “Graph theory analysis of complex brain networks: new concepts in brain mapping applied to neurosurgery” Journal of Neurosurgery PDF

Publications

2014

Barone DG, Lawrie TA, Hart MG (2014), “Image guided surgery for the resection of brain tumours.” Cochrane Database Syst Rev 1:CD009685 Details

Hart MG, Czosnyka M, Czosnyka ZH, Fernandes HM (2014), “Combined Intracranial Pressure Monitoring and Cerebrospinal Fluid Infusion Study to Guide Management of Slit Ventricle Syndrome.” Pediatr Neurosurg Details

2013

Hart MG, Garside R, Rogers G, Stein K, Grant R (2013), “Temozolomide for high grade glioma.” Cochrane Database Syst Rev 4:CD007415 Details

Hart MG, Santarius T, Kirollos RW (2013), “How I do it--pineal surgery: supracerebellar infratentorial versus occipital transtentorial.” Acta Neurochir (Wien) 155(3):463-7 Details

Hart MG, Santarius T, Trivedi RA (2013), “Muscle and nerve biopsy for the neurosurgical trainee.” Br J Neurosurg 27(6):727-34 Details

Hart MG, Sarkies NJ, Santarius T, Kirollos RW (2013), “Ophthalmological outcome after resection of tumors based on the pineal gland.” J Neurosurg 119(2):420-6 Details

2012

Hart MG, Grant R (2012), “Brain Tumours” Evidence Based Neurology

Hart MG, Nowell M, Coakham HB (2012), “Radiofrequency thermocoagulation for trigeminal neuralgia without intra-operative patient waking.” Br J Neurosurg 26(3):392-6 Details

Hart MG, Trivedi RA, Hutchinson PJ (2012), “Boxing sparring complicated by an acute subdural haematoma and brainstem haemorrhage.” Br J Neurosurg 26(5):776-8 Details

Hart MG, Whittle IR, Grant R (2012), “Steroids and brain tumors.” Handb Clin Neurol 104:371-9 Details

2011

Erridge SC, Hart MG, Kerr GR, Smith C, McNamara S, Grant R, Gregor A, Whittle IR (2011), “Trends in classification, referral and treatment and the effect on outcome of patients with glioma: a 20¬†year cohort.” J Neurooncol 104(3):789-800 Details

Hart MG (2011), “External ventricular drain insertion” Core Surgery Journal 2(1):50-55

Hart MG (2011), “Hydrocephalus” Core Surgery Journal 1(6):54-61

Hart MG, Grant R, Garside R, Rogers G, Somerville M, Stein K (2011), “Chemotherapy wafers for high grade glioma.” Cochrane Database Syst Rev (3):CD007294 Details

Hart MG, Trivedi RA (2011), “Spinal cord trauma” Core Surgery Journal 1(3):42-49

2007

Connor S, Hart MG, Redhead DN, Ireland H, Madhavan KK, Parks RW, Garden OJ (2007), “Follow-up and outcomes for resection of colorectal liver metastases in Edinburgh.” Eur J Surg Oncol 33(1):55-60 Details

2005

Hart MG, Grant R, Walker M, Dickinson H (2005), “Surgical resection and whole brain radiation therapy versus whole brain radiation therapy alone for single brain metastases.” Cochrane Database Syst Rev (1):CD003292 Details

Hart MG, Hooper G (2005), “Clinical associations of Dupuytren's disease.” Postgrad Med J 81(957):425-8 Details

2000

Hart MG, Grant R, Metcalfe SE. (2000), “Biopsy or resection for High Grade Glioma. ” Cochrane Database of Systematic Reviews.