Dr Marta Costa

Interests

Our project, started in October 2016, aims to build the adult olfactory connectome of Drosophila. That is, to describe every neuron that is involved in olfactory behaviour, and its connections. We are part of a consortium of groups in Cambridge (Jefferis, Landgraf), Oxford (Waddell) and Janelia Research Campus (Rubin, Bock labs) that are doing this, using a whole brain EM volume generated at Janelia by Davi Bock's group.

The project focuses on the pathways and neuropils involved in innate and learned olfactory behaviour, from the primary olfactory centre - the antennal lobe - to the integration centres - lateral horn (LH) for innate and mushroom body (MB) for learned behaviours. Within the MB, we wish to describe the modulation of dopaminergic neurons (convey valence), onto the Kenyon cells-MB output neurons synapses, the site of likely synaptic plasticity. For the LH, we wish to understand if there is integration of odours of similar valence, and how this integration is achieved.

Research Focus

Keywords

drosophila

connectomics

neuroanatomy

neuron

brain

Clinical conditions

No direct clinical relevance

Equipment

Computational techniques: electron microscopy reconstruction, image registration, image analysis

Collaborators

Cambridge

Cahir O'Kane

United Kingdom

Douglas Armstrong Web: http://homepages.inf.ed.ac.uk/jda/ind...

David Osumi-Sutherland Web: http://www.ebi.ac.uk/about/p...

Helen Parkinson Web: https://www.ebi.ac.uk/about/p...

International

Davi Bock Web: https://www.janelia.org/lab/boc...

Gerry Rubin Web: https://www.janelia.org/lab/rub...

Associated News Items


    Key publications

    Costa, Marta and Manton, James D and Ostrovsky, Aaron D and Prohaska, Steffen and Jefferis, Gregory S X E (2016), “NBLAST: Rapid, Sensitive Comparison of Neuronal Structure and Construction of Neuron Family Databases” Neuron 91(2):293-311

    Costa, Marta and Ostrovsky, Aaron D and Manton, James D and Prohaska, Steffen and Jefferis, Gregory SXE (2014), “NBLAST: Rapid, sensitive comparison of neuronal structure and construction of neuron family databases” bioRxiv

    Manton, James D and Ostrovsky, Aaron D and Goetz, Lea and Costa, Marta and Rohlfing, Torsten and Jefferis, Gregory SXE (2014), “Combining genome-scale Drosophila 3D neuroanatomical data by bridging template brains” bioRxiv

    Publications

    2016

    Marygold, Steven J and Antonazzo, Giulia and Attrill, Helen and Costa, Marta and Crosby, Madeline A and dos Santos, Gilberto and Goodman, Joshua L and Gramates, L Sian and Matthews, Beverley B and Rey, Alix J and others (2016), “Exploring FlyBase Data Using QuickSearch” Current Protocols in Bioinformatics 1--31

    2014

    Araya C, Tawk M, Girdler GC, Costa M, Carmona-Fontaine C, Clarke JD (2014), “Mesoderm is required for coordinated cell movements within zebrafish neural plate in vivo.” Neural Dev 9(1):9 Details

    2013

    Costa M, Reeve S, Grumbling G, Osumi-Sutherland D (2013), “The Drosophila anatomy ontology.” J Biomed Semantics 4(1):32 Details

    Costa, M, Calleja, M, Alonso, CR and Simpson, P (2013), “The bristle patterning genes hairy and extramacrochaetae regulate the development of structures required for flight in Diptera” Dev. Biol 388:205–215

    Marygold SJ, Leyland PC, Seal RL, Goodman JL, Thurmond J, Strelets VB, Wilson RJ, FlyBase consortium (2013), “FlyBase: improvements to the bibliography.” Nucleic Acids Res 41(Database issue):D751-7 Details

    2012

    McQuilton P, FlyBase Consortium (2012), “Opportunities for text mining in the FlyBase genetic literature curation workflow.” Database (Oxford) 2012:bas039 Details

    2007

    Correia AC, Costa M, Moraes F, Bom J, Nóvoa A, Mallo M (2007), “Bmp2 is required for migration but not for induction of neural crest cells in the mouse.” Dev Dyn 236(9):2493-501 Details