Professor Michael Coleman

Michael Coleman

University position

Professor

Professor Michael Coleman is pleased to consider applications from prospective PhD students.

Departments

Department of Clinical Neurosciences

Institutes

Babraham Institute

Email

mc469@cam.ac.uk

Home page

http://www.babraham.ac.uk/our-res... (personal home page)

Research Theme

Cellular and Molecular Neuroscience

Interests

We study axon degeneration and its roles in neurodegenerative disease. One focus is proteins regulating the degeneration of injured axons (‘Wallerian degeneration'), which we have linked into a molecular pathway. Disease models involving similar mechanisms include several of peripheral neuropathies, Parkinson’s disease, glaucoma, motor neuron disease and multiple sclerosis. We aim to completely characterize the Wallerian pathway, identify human diseases associated with it and develop drugs to modify it.

A second major interest is axonal pathology in Alzheimer’s disease. Using a new organotypic hippocampal slice culture model, we are studying the earliest pathogenic events in amyloid pathology and their dependence on Abeta and tau.

We are collaborating on ALS, traumatic brain injury, neuropathic pain and white matter damage in Alzheimer’s disease. Finally, we have a developing interest in roles that rare axonal disease genes could play in axon survival in more common disorders.

14 day lesioned sciatic nerves from wild-type and WldS mice and rats, showing neuroprotective effect of the WldS gene
14 day lesioned sciatic nerves from wild-type and WldS mice and rats, showing neuroprotective effect of the WldS gene
View image full-size (2999x2249 pixels)

Research Focus

Keywords

Axon degeneration

Axonal transport

Ageing

Wallerian degeneration

Alzheimer's disease

Clinical conditions

Alzheimer's disease

Amyotrophic lateral sclerosis

Dementia

Diabetes

Huntington's disease

Multiple sclerosis

Parkinson's disease

Peripheral neuropathy

Prion diseases

Stroke

Traumatic brain injury

Equipment

Calcium imaging

Cell culture

Confocal microscopy

Fluorescence microscopy

Immunohistochemistry

Live imaging

Microscopy

Mouse genetics

Protein purification

Recombinant protein expression

Collaborators

Cambridge

Ragnhildur Thora Karadottir

David Menon

Jemeen Sreedharan

United Kingdom

Diane Hanger Web: https://www.kcl.ac.uk/ioppn/d...

Richard Ribchester Web: http://www.ed.ac.uk/integra...

International

Marc Freeman Web: http://profiles.umassmed.edu/profile...

Giuseppe Orsomando Web: http://www.univpm.it/giusepp...

Associated News Items


Key publications

Harwell CS, Coleman MP (2016), “Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice” Mol Neurodegener 11(1):44

Gilley J, Orsomando G, Nascimento-Ferreira I, Hsueh Y-P, Coleman MP (2015), “Absence of SARM1 rescues development and survival of NMNAT2-deficient axons” Cell Reports 10: 1974-81

Conforti L, Gilley J, Coleman MP (2014), “Wallerian degeneration: an emerging axon death pathway linking injury and disease.” Nat Rev Neurosci 15(6):394-409 Details

Osterloh JM, Yang J, Rooney TM, Fox AN, Adalbert R, Powell EH, Sheehan AE, Avery MA, Hackett R, Logan MA, MacDonald JM, Ziegenfuss JS, Milde S, Hou YJ, Nathan C, Ding A, Brown RH Jr, Conforti L, Coleman M, Tessier-Lavigne M, Züchner S, Freeman MR (2012), “dSarm/Sarm1 is required for activation of an injury-induced axon death pathway.” Science 337(6093):481-4 Details

Coleman MP, Freeman MR (2010), “Wallerian degeneration, wld(s), and nmnat.” Annu Rev Neurosci 33:245-67 Details

Gilley J, Coleman MP (2010), “Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons.” PLoS Biol 8(1):e1000300 Details

Adalbert R, Nogradi A, Babetto E, Janeckova L, Walker SA, Kerschensteiner M, Misgeld T, Coleman MP (2009), “Severely dystrophic axons at amyloid plaques remain continuous and connected to viable cell bodies.” Brain 132(Pt 2):402-16 Details

Beirowski B, Babetto E, Gilley J, Mazzola F, Conforti L, Janeckova L, Magni G, Ribchester RR, Coleman MP (2009), “Non-nuclear Wld(S) determines its neuroprotective efficacy for axons and synapses in vivo.” J Neurosci 29(3):653-68 Details

Conforti L, Fang G, Beirowski B, Wang MS, Sorci L, Asress S, Adalbert R, Silva A, Bridge K, Huang XP, Magni G, Glass JD, Coleman MP (2007), “NAD(+) and axon degeneration revisited: Nmnat1 cannot substitute for Wld(S) to delay Wallerian degeneration.” Cell Death Differ 14(1):116-27 Details

Publications

2016

Clark DE, Waszkowycz B, Wong M, Lockey PM, Adalbert R, Gilley J, Clark J, Coleman MP (2016), “Application of virtual screening to the discovery of novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with potential for the treatment of cancer and axonopathies” Bioorg Med Chem Lett 26(12):2920-6

Gilley J, Ando K, Seereeram A, Rodriguez-Martin T, Pooler AM, Sturdee L, Anderton BH, Brion JP, Hanger DP, Coleman MP (2016), “Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice” Neurobiol Aging 39:1-18

Hill CS, Coleman MP, Menon, DK (2016), “Traumatic Axonal Injury: Mechanisms and Translational Opportunities” Trends Neurosci 39(5):311-24

Hung CO, Coleman MP (2016), “KIF1A mediates axonal transport of BACE1 and identification of independently moving cargoes in living SCG neurons” Traffic

Rodriguez-Martin T, Pooler AM, Morotz G, de Vos K, Gilley J, Coleman MP, Hanger DP (2016), “Axonal mitochondrial number is reduced in neurons of mice expressing the P301L tau mutation associated with frontotemporal dementia” Neurobiol Dis 85:1-10

2015

Di Stefano M, Nascimento-Ferreira I, Orsomando G, Mori V, Gilley J, Brown R, Janeckova L, Vargas ME, Worrell LA, Loreto A, Tickle J, Patrick J, Webster JR, Marangoni M, Carpi FM, Pucciarelli S, Rossi F, Meng W, Sagasti A, Ribchester RR, Magni G, Coleman MP, Conforti L (2015), “A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration” Cell Death Diff 22:731-42

Munidinger TO, Cooper E, Coleman MP, Taborsky GJ (2015), “Short-term diabetic hyperglycemia suppresses celiac ganglia neurotransmission thereby impairing sympathetically-mediated glucagon responses” Am J Physiol 309:E246-55

2014

Godzik K, Coleman MP (2014), “The axon protective WldS protein partially rescues mitochondrial respiration and glycolysis after axonal injury” J Mol Neurosci 55: 865-71

Marangoni M, Adalbert R, Janeckova L, Patrick J, Kohli J, Coleman MP, Conforti L (2014), “Age-related axonal swellings precede other neuropathological hallmarks in a knock-in mouse model of Huntington's disease.” Neurobiol Aging 35(10):2382-93 Details

Milde S, Adalbert R, Elaman H, Coleman MP (2014), “Axonal transport declines in two phases during growth and in old age but remains stable throughout adult life” Neurobiol Aging 36:971-81

Milde S, Coleman MP (2014), “Identification of palmitoyltransferase and thioesterase enzymes that control the subcellular localisation of axon survival factor Nmnat2” J Biol Chem 289:32858-70

2013

Coleman MP (2013), “The challenges of axon survival: introduction to the special issue on axonal degeneration.” Exp Neurol 246:1-5 Details

Evans C, Cook SJ, Coleman MP, Gilley J (2013), “MEK inhibitor U0126 reverses protection of axons from Wallerian degeneration independently of MEK-ERK signaling.” PLoS One 8(10):e76505 Details

Gilley J, Adalbert R, Yu G, Coleman MP (2013), “Rescue of peripheral and CNS axon defects in mice lacking NMNAT2.” J Neurosci 33(33):13410-24 Details

Milde S, Fox AN, Freeman MR, Coleman MP (2013), “Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivo.” Sci Rep 3:2567 Details

Milde S, Gilley J, Coleman MP (2013), “Axonal trafficking of NMNAT2 and its roles in axon growth and survival in vivo.” Bioarchitecture 3(5):133-140 Details

Milde S, Gilley J, Coleman MP (2013), “Subcellular localization determines the stability and axon protective capacity of axon survival factor Nmnat2.” PLoS Biol 11(4):e1001539 Details

Yang Y, Coleman M, Zhang L, Zheng X, Yue Z (2013), “Autophagy in axonal and dendritic degeneration.” Trends Neurosci 36(7):418-28 Details

2012

Adalbert R, Coleman MP (2012), “Axon pathology in age-related neurodegenerative disorders.” Neuropathol Appl Neurobiol Details

Adalbert R, Morreale G, Paizs M, Conforti L, Walker SA, Roderick HL, Bootman MD, Siklós L, Coleman MP (2012), “Intra-axonal calcium changes after axotomy in wild-type and slow Wallerian degeneration axons.” Neuroscience 225:44-54 Details

Court FA, Coleman MP (2012), “Mitochondria as a central sensor for axonal degenerative stimuli.” Trends Neurosci 35(6):364-72 Details

Gilley J, Seereeram A, Ando K, Mosely S, Andrews S, Kerschensteiner M, Misgeld T, Brion JP, Anderton B, Hanger DP, Coleman MP (2012), “Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a "P301L" tau knockin mouse.” Neurobiol Aging 33(3):621.e1-621.e15 Details

Orsomando G, Cialabrini L, Amici A, Mazzola F, Ruggieri S, Conforti L, Janeckova L, Coleman MP, Magni G (2012), “Simultaneous single-sample determination of NMNAT isozyme activities in mouse tissues.” PLoS One 7(12):e53271 Details

2011

Coleman M (2011), “Molecular signaling how do axons die?” Adv Genet 73:185-217 Details

Conforti L, Janeckova L, Wagner D, Mazzola F, Cialabrini L, Di Stefano M, Orsomando G, Magni G, Bendotti C, Smyth N, Coleman M (2011), “Reducing expression of NAD+ synthesizing enzyme NMNAT1 does not affect the rate of Wallerian degeneration.” FEBS J 278(15):2666-79 Details

Gilley J, Adalbert R, Coleman MP (2011), “Modelling early responses to neurodegenerative mutations in mice.” Biochem Soc Trans 39(4):933-8 Details

Meyer zu Horste G, Miesbach TA, Muller JI, Fledrich R, Stassart RM, Kieseier BC, Coleman MP, Sereda MW (2011), “The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration.” Neurobiol Dis 42(1):1-8 Details

2010

Andrews S, Gilley J, Coleman MP (2010), “Difference Tracker: ImageJ plugins for fully automated analysis of multiple axonal transport parameters.” J Neurosci Methods 193(2):281-7 Details

Babetto E, Beirowski B, Janeckova L, Brown R, Gilley J, Thomson D, Ribchester RR, Coleman MP (2010), “Targeting NMNAT1 to axons and synapses transforms its neuroprotective potency in vivo.” J Neurosci 30(40):13291-304 Details

Beirowski B, Morreale G, Conforti L, Mazzola F, Di Stefano M, Wilbrey A, Babetto E, Janeckova L, Magni G, Coleman MP (2010), “WldS can delay Wallerian degeneration in mice when interaction with valosin-containing protein is weakened.” Neuroscience 166(1):201-11 Details

Beirowski B, Nógrádi A, Babetto E, Garcia-Alias G, Coleman MP (2010), “Mechanisms of axonal spheroid formation in central nervous system Wallerian degeneration.” J Neuropathol Exp Neurol 69(5):455-72 Details

2009

Bridge KE, Berg N, Adalbert R, Babetto E, Dias T, Spillantini MG, Ribchester RR, Coleman MP (2009), “Late onset distal axonal swelling in YFP-H transgenic mice.” Neurobiol Aging 30(2):309-21 Details

Conforti L, Wilbrey A, Morreale G, Janeckova L, Beirowski B, Adalbert R, Mazzola F, Di Stefano M, Hartley R, Babetto E, Smith T, Gilley J, Billington RA, Genazzani AA, Ribchester RR, Magni G, Coleman M (2009), “Wld S protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice.” J Cell Biol 184(4):491-500 Details

Morreale G, Conforti L, Coadwell J, Wilbrey AL, Coleman MP (2009), “Evolutionary divergence of valosin-containing protein/cell division cycle protein 48 binding interactions among endoplasmic reticulum-associated degradation proteins.” FEBS J 276(5):1208-20 Details

Wong F, Fan L, Wells S, Hartley R, Mackenzie FE, Oyebode O, Brown R, Thomson D, Coleman MP, Blanco G, Ribchester RR (2009), “Axonal and neuromuscular synaptic phenotypes in Wld(S), SOD1(G93A) and ostes mutant mice identified by fiber-optic confocal microendoscopy.” Mol Cell Neurosci 42(4):296-307 Details

2008

Beirowski B, Babetto E, Coleman MP, Martin KR (2008), “The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model.” Eur J Neurosci 28(6):1166-79 Details

Wilbrey AL, Haley JE, Wishart TM, Conforti L, Morreale G, Beirowski B, Babetto E, Adalbert R, Gillingwater TH, Smith T, Wyllie DJ, Ribchester RR, Coleman MP (2008), “VCP binding influences intracellular distribution of the slow Wallerian degeneration protein, Wld(S).” Mol Cell Neurosci 38(3):325-40 Details

2007

Adalbert R, Gilley J, Coleman MP (2007), “Abeta, tau and ApoE4 in Alzheimer's disease: the axonal connection.” Trends Mol Med 13(4):135-42 Details

Conforti L, Adalbert R, Coleman MP (2007), “Neuronal death: where does the end begin?” Trends Neurosci 30(4):159-66 Details

Wishart TM, Macdonald SH, Chen PE, Shipston MJ, Coleman MP, Gillingwater TH, Ribchester RR (2007), “Design of a novel quantitative PCR (QPCR)-based protocol for genotyping mice carrying the neuroprotective Wallerian degeneration slow (Wlds) gene.” Mol Neurodegener 2:21 Details

2006

Adalbert R, Nógrádi A, Szabó A, Coleman MP (2006), “The slow Wallerian degeneration gene in vivo protects motor axons but not their cell bodies after avulsion and neonatal axotomy.” Eur J Neurosci 24(8):2163-8 Details

Gillingwater TH, Wishart TM, Chen PE, Haley JE, Robertson K, MacDonald SH, Middleton S, Wawrowski K, Shipston MJ, Melmed S, Wyllie DJ, Skehel PA, Coleman MP, Ribchester RR (2006), “The neuroprotective WldS gene regulates expression of PTTG1 and erythroid differentiation regulator 1-like gene in mice and human cells.” Hum Mol Genet 15(4):625-35 Details

Laser H, Conforti L, Morreale G, Mack TG, Heyer M, Haley JE, Wishart TM, Beirowski B, Walker SA, Haase G, Celik A, Adalbert R, Wagner D, Grumme D, Ribchester RR, Plomann M, Coleman MP (2006), “The slow Wallerian degeneration protein, WldS, binds directly to VCP/p97 and partially redistributes it within the nucleus.” Mol Biol Cell 17(3):1075-84 Details