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  • Psychiatry
  • Institute
  • Brain Mapping Unit
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    Dr Meng-Chuan Lai

    University Position
    Affiliated Member

    Interests

    As a clinician scientist, my vision is to bridge and integrate multi-level biological-cognitive-psychological-social research and clinical services. My clinical interests are in the risk and resilience processes across the lifespan in individuals with atypical social, cognitive and affective development (e.g., the autism spectrum, ADHD, anxiety and mood disorders) and children and youths with medical illness, as well as how sex/gender modulates these processes. My current research investigates cognitive and neuro/biological bases of autism and associated neurodevelopmental conditions, and their emerging comorbidities across the lifespan. A particular focus is on females with autism and the complex relationships between autism and sexual differentiation, gender socialization, and sex/gender differences. I am also interested in mind-brain-body interactions, psychiatric nosology (especially in clarifying the vast heterogeneity in psychiatric conditions) and cross-discipline integration.

    Key Publications

    Publications

    On the brain structure heterogeneity of autism: Parsing out acquisition site effects with significance-weighted principal component analysis.

    DOI: http://doi.org/10.1002/hbm.23449
    Journal: Hum Brain Mapp
    E-pub date: 1 Mar 2017
    Authors: FJ Martinez-Murcia, M-C Lai, JM Górriz, J Ramírez, AMH Young, SCL Deoni, C Ecker, MV Lombardo, MRC AIMS Consortium,, S Baron-Cohen, DGM Murphy, ET Bullmore, J Suckling

    Identifying the lost generation of adults with autism spectrum conditions.

    DOI: http://doi.org/10.1016/S2215-0366(15)00277-1
    Journal: Lancet Psychiatry
    E-pub date: 1 Nov 2015
    Authors: M-C Lai, S Baron-Cohen

    Sex/gender differences and autism: setting the scene for future research.

    DOI: http://doi.org/10.1016/j.jaac.2014.10.003
    Journal: J Am Acad Child Adolesc Psychiatry
    E-pub date: 1 Jan 2015
    Authors: M-C Lai, MV Lombardo, B Auyeung, B Chakrabarti, S Baron-Cohen

    ‘Reading the Mind in the Eyes’: an fMRI study of adolescents with autism and their siblings.

    DOI: http://doi.org/10.1017/S0033291714000233
    Journal: Psychological Medicine
    E-pub date: 12 Nov 2014
    Authors: RJ Holt, LR Chura, M-C Lai, J Suckling, E von dem Hagen, AJ Calder, ET Bullmore, S Baron-Cohen, MD Spencer

    The neuropsychology of male adults with high-functioning autism or asperger syndrome.

    DOI: http://doi.org/10.1002/aur.1394
    Journal: Autism Res
    E-pub date: 1 Oct 2014
    Authors: CE Wilson, F Happé, SJ Wheelwright, C Ecker, MV Lombardo, P Johnston, E Daly, CM Murphy, D Spain, M-C Lai, B Chakrabarti, DA Sauter, MRC AIMS Consortium, S Baron-Cohen, DGM Murphy

    Attenuation of typical sex differences in 800 adults with autism vs. 3,900 controls.

    DOI: http://doi.org/10.1371/journal.pone.0102251
    Journal: PLoS One
    E-pub date: 1 Aug 2014
    Authors: S Baron-Cohen, S Cassidy, B Auyeung, C Allison, M Achoukhi, S Robertson, A Pohl, M-C Lai

    A meta-analysis of sex differences in human brain structure.

    DOI: http://doi.org/10.1016/j.neubiorev.2013.12.004
    Journal: Neuroscience and Biobehavioral Reviews
    E-pub date: 1 Feb 2014
    Authors: ANV Ruigrok, G Salimi-Khorshidi, M-C Lai, S Baron-Cohen, MV Lombardo, RJ Tait, J Suckling

    Are power calculations useful? A multicentre neuroimaging study.

    DOI: http://doi.org/10.1002/hbm.22465
    Journal: Human Brain Mapping
    E-pub date: 1 Jan 2014
    Authors: J Suckling, J Henty, C Ecker, SC Deoni, MV Lombardo, S Baron-Cohen, P Jezzard, A Barnes, B Chakrabarti, C Ooi, M-C Lai, SC Williams, DGM Murphy, E Bullmore, MRC AIMS Consortium

    Autism

    DOI: http://doi.org/10.1016/S0140-6736(13)61539-1
    Journal:
    E-pub date: 1 Jan 2014
    Authors: MC Lai, MV Lombardo, S Baron-Cohen

    Biological sex affects the neurobiology of autism.

    DOI: http://doi.org/10.1093/brain/awt216
    Journal: Brain
    E-pub date: 1 Sep 2013
    Authors: M-C Lai, MV Lombardo, J Suckling, ANV Ruigrok, B Chakrabarti, C Ecker, SCL Deoni, MC Craig, DGM Murphy, ET Bullmore, MRC AIMS Consortium, S Baron-Cohen

    Subgrouping the autism “spectrum”: reflections on DSM-5.

    DOI: http://doi.org/10.1371/journal.pbio.1001544
    Journal: PLoS Biol
    E-pub date: 1 Aug 2013
    Authors: M-C Lai, MV Lombardo, B Chakrabarti, S Baron-Cohen

    Brain surface anatomy in adults with autism: the relationship between surface area, cortical thickness, and autistic symptoms.

    DOI: http://doi.org/10.1001/jamapsychiatry.2013.265
    Journal: JAMA Psychiatry
    E-pub date: 1 Jan 2013
    Authors: C Ecker, C Ginestet, Y Feng, P Johnston, MV Lombardo, M-C Lai, J Suckling, L Palaniyappan, E Daly, CM Murphy, SC Williams, ET Bullmore, S Baron-Cohen, M Brammer, DGM Murphy, MRC AIMS Consortium

    Self-referential and social cognition in a case of autism and agenesis of the corpus callosum.

    DOI: http://doi.org/10.1186/2040-2392-3-14
    Journal: Mol Autism
    E-pub date: 21 Nov 2012
    Authors: MV Lombardo, B Chakrabarti, M-C Lai, MRC AIMS Consortium, S Baron-Cohen

    Fetal programming effects of testosterone on the reward system and behavioral approach tendencies in humans.

    DOI: http://doi.org/10.1016/j.biopsych.2012.05.027
    Journal: Biological Psychiatry
    E-pub date: 15 Nov 2012
    Authors: MV Lombardo, E Ashwin, B Auyeung, B Chakrabarti, M-C Lai, K Taylor, G Hackett, ET Bullmore, S Baron-Cohen

    Cognition in males and females with autism: similarities and differences.

    DOI: http://doi.org/10.1371/journal.pone.0047198
    Journal: PLoS One
    E-pub date: 1 Aug 2012
    Authors: M-C Lai, MV Lombardo, ANV Ruigrok, B Chakrabarti, SJ Wheelwright, B Auyeung, C Allison, MRC AIMS Consortium, S Baron-Cohen

    Sex differences and autism: brain function during verbal fluency and mental rotation.

    DOI: http://doi.org/10.1371/journal.pone.0038355
    Journal: PLoS One
    E-pub date: 1 Aug 2012
    Authors: FDCC Beacher, E Radulescu, L Minati, S Baron-Cohen, MV Lombardo, M-C Lai, A Walker, D Howard, MA Gray, NA Harrison, HD Critchley

    Individual differences in brain structure underpin empathizing-systemizing cognitive styles in male adults.

    DOI: http://doi.org/10.1016/j.neuroimage.2012.03.018
    Journal: Neuroimage
    E-pub date: 16 Jul 2012
    Authors: M-C Lai, MV Lombardo, B Chakrabarti, C Ecker, SA Sadek, SJ Wheelwright, DGM Murphy, J Suckling, ET Bullmore, MRC AIMS Consortium, S Baron-Cohen

    White matter microstructural abnormalities in the frontal lobe of adults with antisocial personality disorder.

    DOI: http://doi.org/10.1016/j.cortex.2011.06.005
    Journal: Cortex
    E-pub date: 1 Feb 2012
    Authors: F Sundram, Q Deeley, S Sarkar, E Daly, R Latham, M Craig, M Raczek, T Fahy, M Picchioni, UK AIMS Network, GJ Barker, DGM Murphy

    Autism attenuates sex differences in brain structure: a combined voxel-based morphometry and diffusion tensor imaging study.

    DOI: http://doi.org/10.3174/ajnr.A2880
    Journal: AJNR Am J Neuroradiol
    E-pub date: 1 Jan 2012
    Authors: FD Beacher, L Minati, S Baron-Cohen, MV Lombardo, M-C Lai, MA Gray, NA Harrison, HD Critchley

    A behavioral comparison of male and female adults with high functioning autism spectrum conditions.

    DOI: http://doi.org/10.1371/journal.pone.0020835
    Journal: PLoS One
    E-pub date: 1 Aug 2011
    Authors: M-C Lai, MV Lombardo, G Pasco, ANV Ruigrok, SJ Wheelwright, SA Sadek, B Chakrabarti, MRC AIMS Consortium, S Baron-Cohen

    A shift to randomness of brain oscillations in people with autism.

    DOI: http://doi.org/10.1016/j.biopsych.2010.06.027
    Journal: Biol Psychiatry
    E-pub date: 15 Dec 2010
    Authors: M-C Lai, MV Lombardo, B Chakrabarti, SA Sadek, G Pasco, SJ Wheelwright, ET Bullmore, S Baron-Cohen, MRC AIMS Consortium, J Suckling