Dr Menghon Cheah

Interests

My research focuses on investigating the extracellular and intracellular mechanisms for axon regeneration in the central nervous system after injury. In addition to a plethora of inhibitory factors present in the injured microenviroment, the absence of growth promoting factors and the neurons themselves lacking the regenerative potential are all possible contributing factors. By understanding how neurons respond to injury and the corresponding cellular mechanisms, one can hopefully develop a treatment for spinal cord injury.

DRG sensory neurons
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Research Focus

Keywords

spinal cord injury

axon regeneration

intracellular

extracellular

gene therapy

Clinical conditions

Movement disorders

Spinal cord injury

Equipment

Behavioural analysis

Cell culture

Electrophysiological recording techniques

Fluorescence microscopy

Immunohistochemistry

Microscopy

Recombinant protein expression

Collaborators

No collaborators listed

Associated News Items


    Key publications

    Cheah M, Andrews MR, Chew DJ, Moloney EB, Verhaagen J, Fässler R, Fawcett JW (2016), “Expression of an Activated Integrin Promotes Long-Distance Sensory Axon Regeneration in the Spinal Cord” J Neurosci 36(27):7283-97

    Publications

    2016

    Andrews MR, Soleman S, Cheah M, Tumbarello DA, Mason MR, Moloney E, Verhaagen J, Bensadoun JC, Schneider B, Aebischer P, Fawcett JW (2016), “Axonal Localization of Integrins in the CNS Is Neuronal Type and Age Dependent” eNeuro 3(4)

    Cheah M, Fawcett JW, Haenzi B (2016), “Differential regenerative ability of sensory and motor neurons” Neurosci Lett

    2014

    Kappagantula S, Andrews MR, Cheah M, Abad-Rodriguez J, Dotti CG, Fawcett JW (2014), “Neu3 sialidase-mediated ganglioside conversion is necessary for axon regeneration and is blocked in CNS axons.” J Neurosci 34(7):2477-92 Details