Dr Marek Czosnyka
University position
Reader
Dr Marek Czosnyka is pleased to consider applications from prospective PhD students.
Departments
Department of Clinical Neurosciences
Institutes
Home page
http://www.neurosurg.cam.ac.uk
Research Themes
Interests
Brain Physics is a very young branch of clinical neuroscience, certainly not defined in any encyclopedia. It summarizes physical interactions between volumes, flows and pressures in brain. Measurement, data processing and analysis, forecasting and modeling of various cerebral phenomena as autoregulation of CBF or pressure-volume compensation of CSF indicate first-line priorities of Brain Physics. Complete list of ongoing projects include:
1. Cerebral blood flow and its regulation
2. Cerebrospinal fluid dynamics (hydrocephalus, IIH). Multi-modal bedside monitoring in neuro-intensive care (head trauma, poor grade SAH, stroke)
3. Mathematical modeling of cerebrospinal dynamics
4. Asymmetry of cerebral blood flow, its regulation and cerebrospinal dynamics
5. Assessment of hydrodynamic properties of hydrocephalus shunts
6. Compartmental compliances of brain
NEW!: For details see 30 Lectures in Brain Physics- not only for Engineers: http://www.neurosurg.cam.ac.uk/pages/brainphys/
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Research Focus
Keywordscerebral blood flow intracranial pressure autoregulation bedside monitoring mathematical modelling |
Clinical conditionsHydrocephalus Idiopathic intracranial hypertension Stroke Subarachnoid haemorrhage Traumatic brain injury |
Equipment
Computational modelling
Computer bedside monitoring
Intracranial pressure monitoring
Transcranial doppler ultrasonography
Collaborators
CambridgePeter Kirkpatrick | United KingdomRonney Panerai Web: http://www.le.ac.uk/cv/staf... Stefan Piechnik Web: http://www.fmrib.ox.ac.uk/~stefanp/ InternationalOlivier Baledent Web: http://www.u-picardie.fr/ Ken Brady Web: http://www.hopkinsmedicine.org/anesthe... Thomas Heldt Web: http://www.rle.mit.edu/rleonli... Matthias Jaeger Web: http://www.ifado.de/en/rese... Phil Lewis Web: http://www.alfred.org.au/ Vera Novak Web: http://www.bidmc.org/Researc... Brian Owler Web: http://www.medfac.usyd.edu.au/people/... Matthias Reinhard Web: http://www.uniklinik-freiburg.de/neurolo... Bernd Schmidt Web: http://www.neurologie-chemnitz.de/Cached ... Eric Schmidt Web: http://www.chu-toulouse.fr/-neuroc... Martin Schumann Web: http://www.mh-hannover.de/index.p... Luzius Steiner Web: http://www.unibas.ch/index.c... |
Key publications
Czosnyka M, Brady K, Reinhard M, Smielewski P, Steiner LA (2009), “Monitoring of cerebrovascular autoregulation: facts, myths, and missing links.” Neurocrit Care 10(3):373-86 Details
Hu K, Lo MT, Peng CK, Novak V, Schmidt EA, Kumar A, Czosnyka M (2009), “Nonlinear Pressure-Flow Relationship Is Able to Detect Asymmetry of Brain Blood Circulation Associated with Midline Shift.” J Neurotrauma Details
Steiner LA, Pfister D, Strebel SP, Radolovich D, Smielewski P, Czosnyka M (2009), “Near-infrared spectroscopy can monitor dynamic cerebral autoregulation in adults.” Neurocrit Care 10(1):122-8 Details
Publications
2011
Carrera E, Steiner LA, Castellani G, Smielewski P, Zweifel C, Haubrich C, Pickard JD, Menon DK, Czosnyka M (2011), “Changes in cerebral compartmental compliances during mild hypocapnia in patients with traumatic brain injury.” J Neurotrauma 28(6):889-96 Details
2009
Kim DJ, Czosnyka Z, Keong N, Radolovich DK, Smielewski P, Sutcliffe MP, Pickard JD, Czosnyka M (2009), “Index of cerebrospinal compensatory reserve in hydrocephalus.” Neurosurgery 64(3):494-501; discussion 501-2 Details
López-Magaña JA, Richards HK, Radolovich DK, Kim DJ, Smielewski P, Kirkpatrick PJ, Pickard JD, Czosnyka M (2009), “Critical closing pressure: comparison of three methods.” J Cereb Blood Flow Metab 29(5):987-93 Details
Schmidt B, Klingelhöfer J, Perkes I, Czosnyka M (2009), “Cerebral autoregulatory response depends on the direction of change in perfusion pressure.” J Neurotrauma 26(5):651-6 Details
2005
Tseng MY, Czosnyka M, Richards H, Pickard JD, Kirkpatrick PJ (2005), “Effects of acute treatment with pravastatin on cerebral vasospasm, autoregulation, and delayed ischemic deficits after aneurysmal subarachnoid hemorrhage: a phase II randomized placebo-controlled trial.” Stroke 36(8):1627-32 Details
Research and Collaboration
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