Professor Marek Czosnyka

Marek Czosnyka

University position

Professor

Professor Marek Czosnyka is pleased to consider applications from prospective PhD students.

Departments

Department of Clinical Neurosciences

Institutes

Neurosurgery Unit

Email

mc141@medschl.cam.ac.uk

Home page

http://www.neurosurg.cam.ac.uk

Research Themes

Clinical and Veterinary Neuroscience

Systems and Computational Neuroscience

Interests

Brain Physics summarizes physical interactions between volumes, flows and pressures in brain. Measurement, data processing and analysis, forecasting and modeling of various cerebral phenomena as autoregulation of CBF or pressure-volume compensation of CSF indicate first-line priorities of Brain Physics. Complete list of ongoing projects include:

1. Brain Autoregulation

2. Cerebrospinal fluid dynamics (hydrocephalus, IIH). Multi-modal brain monitoring (head trauma, poor grade SAH, stroke)

3. Mathematical modeling of cerebrospinal dynamics

4. Hydrodynamic properties of hydrocephalus shunts

5. Software for brain monitoring ICM+ (lead author : Dr.P.Smielewski): www.neurosurg.cam.ac.uk/icmplus

NEW!: For details see 30 Lectures in Brain Physics- not only for Engineers: http://www.neurosurg.cam.ac.uk/pages/brainphys/

NEW! Brain Physics Seminars:Tuesdays at 11:00, University Neurosurgery, Old Library, Block A, Level 4, Addenbrookes Hospital-

Find us at Facebook: Brain Physics Cambridge

Mathematical model of CBF dynamics and CSF circulation
Mathematical model of CBF dynamics and CSF circulation
Click image to view full-size

Research Focus

Keywords

cerebral blood flow

intracranial pressure

autoregulation

bedside monitoring

mathematical modelling

Clinical conditions

Cerebrovascular disorders

Hydrocephalus

Idiopathic intracranial hypertension

Stroke

Subarachnoid haemorrhage

Traumatic brain injury

Equipment

Computational modelling

Computer bedside monitoring

Intracranial pressure monitoring

Transcranial doppler ultrasonography

Collaborators

Cambridge

Topun Austin

Peter Hutchinson

Peter Kirkpatrick

David Menon

John Pickard

Peter Smielewski

United Kingdom

Ronney Panerai Web: http://www.le.ac.uk/cv/staf...

Stefan Piechnik Web: http://www.fmrib.ox.ac.uk/~stefanp/

International

Olivier Baledent Web: http://www.u-picardie.fr/

Ken Brady Web: http://www.hopkinsmedicine.org/anesthe...

Thomas Heldt Web: http://www.rle.mit.edu/rleonli...

Matthias Jaeger Web: http://www.ifado.de/en/rese...

Phil Lewis Web: http://www.alfred.org.au/

Vera Novak Web: http://www.bidmc.org/Researc...

Brian Owler Web: http://www.medfac.usyd.edu.au/people/...

Matthias Reinhard Web: http://www.uniklinik-freiburg.de/neurolo...

Bernd Schmidt Web: http://www.neurologie-chemnitz.de/Cached ...

Eric Schmidt Web: http://www.chu-toulouse.fr/-neuroc...

Martin Schumann Web: http://www.mh-hannover.de/index.p...

Luzius Steiner Web: http://www.unibas.ch/index.c...

Associated News Items


    Key publications

    Czosnyka M, Brady K, Reinhard M, Smielewski P, Steiner LA (2009), “Monitoring of cerebrovascular autoregulation: facts, myths, and missing links.” Neurocrit Care 10(3):373-86 Details

    Hu K, Lo MT, Peng CK, Novak V, Schmidt EA, Kumar A, Czosnyka M (2009), “Nonlinear Pressure-Flow Relationship Is Able to Detect Asymmetry of Brain Blood Circulation Associated with Midline Shift.” J Neurotrauma Details

    Steiner LA, Pfister D, Strebel SP, Radolovich D, Smielewski P, Czosnyka M (2009), “Near-infrared spectroscopy can monitor dynamic cerebral autoregulation in adults.” Neurocrit Care 10(1):122-8 Details

    Publications

    2014

    Capel C, Kasprowicz M, Czosnyka M, Baledent O, Smielewski P, Pickard JD, Czosnyka Z (2014), “Cerebrovascular time constant in patients suffering from hydrocephalus.” Neurol Res 36(3):255-61 Details

    Chari A, Czosnyka M, Richards HK, Pickard JD, Czosnyka ZH (2014), “Hydrocephalus shunt technology: 20 years of experience from the Cambridge Shunt Evaluation Laboratory.” J Neurosurg Details

    Damian MS, Czosnyka M (2014), “Near infrared spectroscopy monitoring-Opening a window on the first 24h after cardiac arrest?” Resuscitation Details

    Hart MG, Czosnyka M, Czosnyka ZH, Fernandes HM (2014), “Combined Intracranial Pressure Monitoring and Cerebrospinal Fluid Infusion Study to Guide Management of Slit Ventricle Syndrome.” Pediatr Neurosurg Details

    Lazaridis C, Desantis SM, Smielewski P, Menon DK, Hutchinson P, Pickard JD, Czosnyka M (2014), “Patient-specific thresholds of intracranial pressure in severe traumatic brain injury.” J Neurosurg Details

    Varsos GV, Kasprowicz M, Smielewski P, Czosnyka M (2014), “Model-based Indices Describing Cerebrovascular Dynamics.” Neurocrit Care 20(1):142-57 Details

    Varsos GV, Richards HK, Kasprowicz M, Reinhard M, Smielewski P, Brady KM, Pickard JD, Czosnyka M (2014), “Cessation of diastolic cerebral blood flow velocity: the role of critical closing pressure.” Neurocrit Care 20(1):40-8 Details

    Werndle MC, Saadoun S, Phang I, Czosnyka M, Varsos GV, Czosnyka ZH, Smielewski P, Jamous A, Bell BA, Zoumprouli A, Papadopoulos MC (2014), “Monitoring of spinal cord perfusion pressure in acute spinal cord injury: initial findings of the injured spinal cord pressure evaluation study*.” Crit Care Med 42(3):646-55 Details

    2013

    Aries MJ, Budohoski KP, Smielewski PS, Czosnyka M, Brady KM (2013), “The authors reply.” Crit Care Med 41(1):e5 Details

    Budohoski KP, Czosnyka M, Kirkpatrick PJ, Smielewski P, Steiner LA, Pickard JD (2013), “Clinical relevance of cerebral autoregulation following subarachnoid haemorrhage.” Nat Rev Neurol 9(3):152-63 Details

    Budohoski KP, Czosnyka M, Smielewski P, Varsos GV, Kasprowicz M, Brady KM, Pickard JD, Kirkpatrick PJ (2013), “Cerebral autoregulation after subarachnoid hemorrhage: comparison of three methods.” J Cereb Blood Flow Metab 33(3):449-56 Details

    Czosnyka M (2013), “Increased intracranial pressure: what to do about it and when?” Crit Care Med 41(2):688 Details

    Czosnyka Z, Pickard JD, Czosnyka M (2013), “Hydrodynamic properties of the Certas hydrocephalus shunt.” J Neurosurg Pediatr 11(2):198-204 Details

    Dias C, Maia I, Cerejo A, Varsos G, Smielewski P, Paiva JA, Czosnyka M (2013), “Pressures, Flow, and Brain Oxygenation During Plateau Waves of Intracranial Pressure.” Neurocrit Care Details

    Eisenträger A, Sobey I, Czosnyka M (2013), “Parameter estimations for the cerebrospinal fluid infusion test.” Math Med Biol 30(2):157-74 Details

    Fraser CD 3rd, Brady KM, Rhee CJ, Easley RB, Kibler K, Smielewski P, Czosnyka M, Kaczka DW, Andropoulos DB, Rusin C (2013), “The frequency response of cerebral autoregulation.” J Appl Physiol (1985) 115(1):52-6 Details

    Haubrich C, Steiner LA, Diehl RR, Kasprowicz M, Smielewski P, Pickard JD, Czosnyka M (2013), “Doppler flow velocity and intra-cranial pressure: responses to short-term mild hypocapnia help to assess the pressure-volume relationship after head injury.” Ultrasound Med Biol 39(9):1521-6 Details

    Hutchinson PJ, Kolias AG, Czosnyka M, Kirkpatrick PJ, Pickard JD, Menon DK (2013), “Intracranial pressure monitoring in severe traumatic brain injury.” BMJ 346:f1000 Details

    Lazaridis C, Smielewski P, Steiner LA, Brady KM, Hutchinson P, Pickard JD, Czosnyka M (2013), “Optimal cerebral perfusion pressure: are we ready for it?” Neurol Res 35(2):138-48 Details

    Marzban C, Illian PR, Morison D, Moore A, Kliot M, Czosnyka M, Mourad PD (2013), “A method for estimating zero-flow pressure and intracranial pressure.” J Neurosurg Anesthesiol 25(1):25-32 Details

    Oeinck M, Neunhoeffer F, Buttler KJ, Meckel S, Schmidt B, Czosnyka M, Weiller C, Reinhard M (2013), “Dynamic cerebral autoregulation in acute intracerebral hemorrhage.” Stroke 44(10):2722-8 Details

    Soehle M, Gies B, Smielewski P, Czosnyka M (2013), “Reduced complexity of intracranial pressure observed in short time series of intracranial hypertension following traumatic brain injury in adults.” J Clin Monit Comput 27(4):395-403 Details

    Varsos GV, de Riva N, Smielewski P, Pickard JD, Brady KM, Reinhard M, Avolio A, Czosnyka M (2013), “Critical closing pressure during intracranial pressure plateau waves.” Neurocrit Care 18(3):341-8 Details

    Varsos GV, Richards H, Kasprowicz M, Budohoski KP, Brady KM, Reinhard M, Avolio A, Smielewski P, Pickard JD, Czosnyka M (2013), “Critical closing pressure determined with a model of cerebrovascular impedance.” J Cereb Blood Flow Metab 33(2):235-43 Details

    Zweifel C, Czosnyka M, Smielewski P (2013), “In reply. Transcranial Doppler derived pulsatility index in the assessment of intracranial pressure: the trend is your friend.” Neurosurgery 72(2):E320 Details

    2012

    Aries MJ, Czosnyka M, Budohoski KP, Kolias AG, Radolovich DK, Lavinio A, Pickard JD, Smielewski P (2012), “Continuous monitoring of cerebrovascular reactivity using pulse waveform of intracranial pressure.” Neurocrit Care 17(1):67-76 Details

    Aries MJ, Czosnyka M, Budohoski KP, Steiner LA, Lavinio A, Kolias AG, Hutchinson PJ, Brady KM, Menon DK, Pickard JD, Smielewski P (2012), “Continuous determination of optimal cerebral perfusion pressure in traumatic brain injury.” Crit Care Med 40(8):2456-63 Details

    Bouzerar R, Czosnyka M, Czosnyka Z, Balédent O (2012), “Physical phantom of craniospinal hydrodynamics.” Acta Neurochir Suppl 113:65-9 Details

    Brady KM, Easley RB, Kibler K, Kaczka DW, Andropoulos D, Fraser CD 3rd, Smielewski P, Czosnyka M, Adams GJ, Rhee CJ, Rusin CG (2012), “Positive end-expiratory pressure oscillation facilitates brain vascular reactivity monitoring.” J Appl Physiol (1985) 113(9):1362-8 Details

    Budohoski KP, Czosnyka M, de Riva N, Smielewski P, Pickard JD, Menon DK, Kirkpatrick PJ, Lavinio A (2012), “The relationship between cerebral blood flow autoregulation and cerebrovascular pressure reactivity after traumatic brain injury.” Neurosurgery 71(3):652-60; discussion 660-1 Details

    Budohoski KP, Czosnyka M, Kirkpatrick PJ (2012), “Cerebral compromise and multimodality monitoring after SAH.” Neurosurgery 70(3):E801-2 Details

    Budohoski KP, Czosnyka M, Smielewski P, Kasprowicz M, Helmy A, Bulters D, Pickard JD, Kirkpatrick PJ (2012), “Impairment of cerebral autoregulation predicts delayed cerebral ischemia after subarachnoid hemorrhage: a prospective observational study.” Stroke 43(12):3230-7 Details

    Budohoski KP, Reinhard M, Aries MJ, Czosnyka Z, Smielewski P, Pickard JD, Kirkpatrick PJ, Czosnyka M (2012), “Monitoring cerebral autoregulation after head injury. Which component of transcranial Doppler flow velocity is optimal?” Neurocrit Care 17(2):211-8 Details

    Budohoski KP, Schmidt B, Smielewski P, Kasprowicz M, Plontke R, Pickard JD, Klingelhöfer J, Czosnyka M (2012), “Non-invasively estimated ICP pulse amplitude strongly correlates with outcome after TBI.” Acta Neurochir Suppl 114:121-5 Details

    Budohoski KP, Zweifel C, Kasprowicz M, Sorrentino E, Diedler J, Brady KM, Smielewski P, Menon DK, Pickard JD, Kirkpatrick PJ, Czosnyka M (2012), “What comes first? The dynamics of cerebral oxygenation and blood flow in response to changes in arterial pressure and intracranial pressure after head injury.” Br J Anaesth 108(1):89-99 Details

    Carpenter KL, Timofeev I, Nortje J, Czosnyka M, Pickard JD, Hutchinson PJ (2012), “A microdialysis study of oral vigabatrin administration in head injury patients: preliminary evaluation of multimodality monitoring.” Acta Neurochir Suppl 114:271-6 Details

    Czosnyka M, Citerio G (2012), “Brain compliance: the old story with a new 'et cetera'.” Intensive Care Med 38(6):925-7 Details

    Czosnyka M, Czosnyka Z, Agarwal-Harding KJ, Pickard JD (2012), “Modeling of CSF dynamics: legacy of Professor Anthony Marmarou.” Acta Neurochir Suppl 113:9-14 Details

    Czosnyka M, Czosnyka Z, Pickard JD (2012), “Programmable Shunt Assistant tested in Cambridge shunt evaluation laboratory.” Acta Neurochir Suppl 113:71-6 Details

    Czosnyka M, Richards HK, Reinhard M, Steiner LA, Budohoski K, Smielewski P, Pickard JD, Kasprowicz M (2012), “Cerebrovascular time constant: dependence on cerebral perfusion pressure and end-tidal carbon dioxide concentration.” Neurol Res 34(1):17-24 Details

    de Riva N, Budohoski KP, Smielewski P, Kasprowicz M, Zweifel C, Steiner LA, Reinhard M, Fábregas N, Pickard JD, Czosnyka M (2012), “Transcranial Doppler pulsatility index: what it is and what it isn't.” Neurocrit Care 17(1):58-66 Details

    El Sankari S, Fichten A, Gondry-Jouet C, Czosnyka M, Legars D, Deramond H, Balédent O (2012), “Correlation between tap test and CSF aqueductal stroke volume in idiopathic normal pressure hydrocephalus.” Acta Neurochir Suppl 113:43-6 Details

    Elsankari S, Czosnyka M, Lehmann P, Meyer ME, Deramond H, Balédent O (2012), “Cerebral Blood and CSF Flow Patterns in Patients Diagnosed for Cerebral Venous Thrombosis - An Observational Study.” J Clin Imaging Sci 2:41 Details

    Haubrich C, Steiner L, Kim DJ, Kasprowicz M, Smielewski P, Diehl RR, Pickard JD, Czosnyka M (2012), “How does moderate hypocapnia affect cerebral autoregulation in response to changes in perfusion pressure in TBI patients?” Acta Neurochir Suppl 114:153-6 Details

    Kashif FM, Verghese GC, Novak V, Czosnyka M, Heldt T (2012), “Model-based noninvasive estimation of intracranial pressure from cerebral blood flow velocity and arterial pressure.” Sci Transl Med 4(129):129ra44 Details

    Kasprowicz M, Bergsneider M, Czosnyka M, Hu X (2012), “Association between ICP pulse waveform morphology and ICP B waves.” Acta Neurochir Suppl 114:29-34 Details

    Kasprowicz M, Czosnyka M, Soehle M, Smielewski P, Kirkpatrick PJ, Pickard JD, Budohoski KP (2012), “Vasospasm shortens cerebral arterial time constant.” Neurocrit Care 16(2):213-8 Details

    Kasprowicz M, Diedler J, Reinhard M, Carrera E, Smielewski P, Budohoski KP, Sorrentino E, Haubrich C, Kirkpatrick PJ, Pickard JD, Czosnyka M (2012), “Time constant of the cerebral arterial bed.” Acta Neurochir Suppl 114:17-21 Details

    Kasprowicz M, Diedler J, Reinhard M, Carrera E, Steiner LA, Smielewski P, Budohoski KP, Haubrich C, Pickard JD, Czosnyka M (2012), “Time constant of the cerebral arterial bed in normal subjects.” Ultrasound Med Biol 38(7):1129-37 Details

    Kim DJ, Czosnyka Z, Kasprowicz M, Smieleweski P, Baledent O, Guerguerian AM, Pickard JD, Czosnyka M (2012), “Continuous monitoring of the Monro-Kellie doctrine: is it possible?” J Neurotrauma 29(7):1354-63 Details

    Lazaridis C, Czosnyka M (2012), “Cerebral blood flow, brain tissue oxygen, and metabolic effects of decompressive craniectomy.” Neurocrit Care 16(3):478-84 Details

    Lee JK, Yang ZJ, Wang B, Larson AC, Jamrogowicz JL, Kulikowicz E, Kibler KK, Mytar JO, Carter EL, Burman HT, Brady KM, Smielewski P, Czosnyka M, Koehler RC, Shaffner DH (2012), “Noninvasive autoregulation monitoring in a swine model of pediatric cardiac arrest.” Anesth Analg 114(4):825-36 Details

    Lewis PM, Smielewski P, Rosenfeld JV, Pickard JD, Czosnyka M (2012), “Monitoring of the association between cerebral blood flow velocity and intracranial pressure.” Acta Neurochir Suppl 114:147-51 Details

    Lewis PM, Smielewski P, Rosenfeld JV, Pickard JD, Czosnyka M (2012), “Assessment of cerebral autoregulation from respiratory oscillations in ventilated patients after traumatic brain injury.” Acta Neurochir Suppl 114:141-6 Details

    Lu CW, Czosnyka M, Shieh JS, Smielewska A, Pickard JD, Smielewski P (2012), “Complexity of intracranial pressure correlates with outcome after traumatic brain injury.” Brain 135(Pt 8):2399-408 Details

    Mytar J, Kibler KK, Easley RB, Smielewski P, Czosnyka M, Andropoulos DB, Brady KM (2012), “Static autoregulation is intact early after severe unilateral brain injury in a neonatal Swine model.” Neurosurgery 71(1):138-45 Details

    Reinhard M, Rutsch S, Lambeck J, Wihler C, Czosnyka M, Weiller C, Hetzel A (2012), “Dynamic cerebral autoregulation associates with infarct size and outcome after ischemic stroke.” Acta Neurol Scand 125(3):156-62 Details

    Rhee CJ, Kibler KK, Easley RB, Andropoulos DB, Czosnyka M, Smielewski P, Brady KM (2012), “Renovascular reactivity measured by near-infrared spectroscopy.” J Appl Physiol (1985) 113(2):307-14 Details

    Sánchez-Porras R, Santos E, Czosnyka M, Zheng Z, Unterberg AW, Sakowitz OW (2012), “'Long' pressure reactivity index (L-PRx) as a measure of autoregulation correlates with outcome in traumatic brain injury patients.” Acta Neurochir (Wien) 154(9):1575-81 Details

    Smielewski P, Czosnyka Z, Kasprowicz M, Pickard JD, Czosnyka M (2012), “ICM+: a versatile software for assessment of CSF dynamics.” Acta Neurochir Suppl 114:75-9 Details

    Sorrentino E, Diedler J, Kasprowicz M, Budohoski KP, Haubrich C, Smielewski P, Outtrim JG, Manktelow A, Hutchinson PJ, Pickard JD, Menon DK, Czosnyka M (2012), “Critical thresholds for cerebrovascular reactivity after traumatic brain injury.” Neurocrit Care 16(2):258-66 Details

    Weerakkody RA, Czosnyka M, Zweifel C, Castellani G, Smielewski P, Brady K, Pickard JD, Czosnyka Z (2012), “Near infrared spectroscopy as possible non-invasive monitor of slow vasogenic ICP waves.” Acta Neurochir Suppl 114:181-5 Details

    Zweifel C, Czosnyka M, Carrera E, de Riva N, Pickard JD, Smielewski P (2012), “Reliability of the blood flow velocity pulsatility index for assessment of intracranial and cerebral perfusion pressures in head-injured patients.” Neurosurgery 71(4):853-61 Details

    2011

    Burkhart CS, Rossi A, Dell-Kuster S, Gamberini M, Möckli A, Siegemund M, Czosnyka M, Strebel SP, Steiner LA (2011), “Effect of age on intraoperative cerebrovascular autoregulation and near-infrared spectroscopy-derived cerebral oxygenation.” Br J Anaesth 107(5):742-8 Details

    Carrera E, Kim DJ, Castellani G, Zweifel C, Smielewski P, Pickard JD, Czosnyka M (2011), “Effect of hyper- and hypocapnia on cerebral arterial compliance in normal subjects.” J Neuroimaging 21(2):121-5 Details

    Carrera E, Kim DJ, Castellani G, Zweifel C, Smielewski P, Pickard JD, Kirkpatrick PJ, Czosnyka M (2011), “Cerebral arterial compliance in patients with internal carotid artery disease.” Eur J Neurol 18(5):711-8 Details

    Carrera E, Steiner LA, Castellani G, Smielewski P, Zweifel C, Haubrich C, Pickard JD, Menon DK, Czosnyka M (2011), “Changes in cerebral compartmental compliances during mild hypocapnia in patients with traumatic brain injury.” J Neurotrauma 28(6):889-96 Details

    Czosnyka Z, Owler B, Keong N, Santarius T, Baledent O, Pickard JD, Czosnyka M (2011), “Impact of duration of symptoms on CSF dynamics in idiopathic normal pressure hydrocephalus.” Acta Neurol Scand 123(6):414-8 Details

    Diedler J, Zweifel C, Budohoski KP, Kasprowicz M, Sorrentino E, Haubrich C, Brady KM, Czosnyka M, Pickard JD, Smielewski P (2011), “The limitations of near-infrared spectroscopy to assess cerebrovascular reactivity: the role of slow frequency oscillations.” Anesth Analg 113(4):849-57 Details

    Gilmore MM, Stone BS, Shepard JA, Czosnyka M, Easley RB, Brady KM (2011), “Relationship between cerebrovascular dysautoregulation and arterial blood pressure in the premature infant.” J Perinatol 31(11):722-9 Details

    Haubrich C, Steiner L, Kasprowicz M, Diedler J, Carrera E, Diehl RR, Smielewski P, Czosnyka M (2011), “Short-term moderate hypocapnia augments detection of optimal cerebral perfusion pressure.” J Neurotrauma 28(7):1133-7 Details

    Hutchinson PJ, Timofeev I, Kolias AG, Corteen EA, Czosnyka M, Menon DK, Pickard JD, Kirkpatrick PJ (2011), “Decompressive craniectomy for traumatic brain injury: the jury is still out.” Br J Neurosurg 25(3):441-2 Details

    Lee JK, Brady KM, Mytar JO, Kibler KK, Carter EL, Hirsch KG, Hogue CW, Easley RB, Jordan LC, Smielewski P, Czosnyka M, Shaffner DH, Koehler RC (2011), “Cerebral blood flow and cerebrovascular autoregulation in a swine model of pediatric cardiac arrest and hypothermia.” Crit Care Med 39(10):2337-45 Details

    Nasr N, Czosnyka M, Arevalo F, Hanaire H, Guidolin B, Larrue V (2011), “Autonomic neuropathy is associated with impairment of dynamic cerebral autoregulation in type 1 diabetes.” Auton Neurosci 160(1-2):59-63 Details

    Radolovich DK, Aries MJ, Castellani G, Corona A, Lavinio A, Smielewski P, Pickard JD, Czosnyka M (2011), “Pulsatile intracranial pressure and cerebral autoregulation after traumatic brain injury.” Neurocrit Care 15(3):379-86 Details

    Reinhard M, Roth M, Guschlbauer B, Czosnyka M, Timmer J, Weiller C, Hetzel A (2011), “The course of dynamic cerebral autoregulation during cervical internal carotid artery occlusion.” Neurol Res 33(9):921-6 Details

    Santos E, Diedler J, Sykora M, Orakcioglu B, Kentar M, Czosnyka M, Unterberg A, Sakowitz OW (2011), “Low-frequency sampling for PRx calculation does not reduce prognostication and produces similar CPPopt in intracerebral haemorrhage patients.” Acta Neurochir (Wien) 153(11):2189-95 Details

    Sorrentino E, Budohoski KP, Kasprowicz M, Smielewski P, Matta B, Pickard JD, Czosnyka M (2011), “Critical thresholds for transcranial Doppler indices of cerebral autoregulation in traumatic brain injury.” Neurocrit Care 14(2):188-93 Details

    Timofeev I, Carpenter KL, Nortje J, Al-Rawi PG, O'Connell MT, Czosnyka M, Smielewski P, Pickard JD, Menon DK, Kirkpatrick PJ, Gupta AK, Hutchinson PJ (2011), “Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients.” Brain 134(Pt 2):484-94 Details

    Timofeev I, Czosnyka M, Carpenter KL, Nortje J, Kirkpatrick PJ, Al-Rawi PG, Menon DK, Pickard JD, Gupta AK, Hutchinson PJ (2011), “Interaction between brain chemistry and physiology after traumatic brain injury: impact of autoregulation and microdialysis catheter location.” J Neurotrauma 28(6):849-60 Details

    Weerakkody RA, Czosnyka M, Schuhmann MU, Schmidt E, Keong N, Santarius T, Pickard JD, Czosnyka Z (2011), “Clinical assessment of cerebrospinal fluid dynamics in hydrocephalus. Guide to interpretation based on observational study.” Acta Neurol Scand 124(2):85-98 Details

    2010

    Bijlenga P, Czosnyka M, Budohoski KP, Soehle M, Pickard JD, Kirkpatrick PJ, Smielewski P (2010), “"Optimal cerebral perfusion pressure" in poor grade patients after subarachnoid hemorrhage.” Neurocrit Care 13(1):17-23 Details

    Brady K, Joshi B, Zweifel C, Smielewski P, Czosnyka M, Easley RB, Hogue CW Jr (2010), “Real-time continuous monitoring of cerebral blood flow autoregulation using near-infrared spectroscopy in patients undergoing cardiopulmonary bypass.” Stroke 41(9):1951-6 Details

    Brady KM, Mytar JO, Kibler KK, Hogue CW Jr, Lee JK, Czosnyka M, Smielewski P, Easley RB (2010), “Noninvasive autoregulation monitoring with and without intracranial pressure in the naive piglet brain.” Anesth Analg 111(1):191-5 Details

    Carrera E, Kim DJ, Castellani G, Zweifel C, Czosnyka Z, Kasparowicz M, Smielewski P, Pickard JD, Czosnyka M (2010), “What shapes pulse amplitude of intracranial pressure?” J Neurotrauma 27(2):317-24 Details

    Diedler J, Czosnyka M (2010), “Merits and pitfalls of multimodality brain monitoring.” Neurocrit Care 12(3):313-6 Details

    Joshi B, Brady K, Lee J, Easley B, Panigrahi R, Smielewski P, Czosnyka M, Hogue CW Jr (2010), “Impaired autoregulation of cerebral blood flow during rewarming from hypothermic cardiopulmonary bypass and its potential association with stroke.” Anesth Analg 110(2):321-8 Details

    Kasprowicz M, Asgari S, Bergsneider M, Czosnyka M, Hamilton R, Hu X (2010), “Pattern recognition of overnight intracranial pressure slow waves using morphological features of intracranial pressure pulse.” J Neurosci Methods 190(2):310-8 Details

    Kasprowicz M, Schmidt E, Kim DJ, Haubrich C, Czosnyka Z, Smielewski P, Czosnyka M (2010), “Evaluation of the cerebrovascular pressure reactivity index using non-invasive finapres arterial blood pressure.” Physiol Meas 31(9):1217-28 Details

    Kim DJ, Carrera E, Czosnyka M, Keong N, Smielewski P, Balédent O, Sutcliffe MP, Pickard JD, Czosnyka Z (2010), “Cerebrospinal compensation of pulsating cerebral blood volume in hydrocephalus.” Neurol Res 32(6):587-92 Details

    Li LM, Timofeev I, Czosnyka M, Hutchinson PJ (2010), “Review article: the surgical approach to the management of increased intracranial pressure after traumatic brain injury.” Anesth Analg 111(3):736-48 Details

    Radolovich DK, Czosnyka M, Timofeev I, Lavinio A, Kim DJ, Jaeger M, Hutchinson P, Gupta A, Pickard JD, Smielewski P (2010), “Transient changes in brain tissue oxygen in response to modifications of cerebral perfusion pressure: an observational study.” Anesth Analg 110(1):165-73 Details

    Reinhard M, Neunhoeffer F, Gerds TA, Niesen WD, Buttler KJ, Timmer J, Schmidt B, Czosnyka M, Weiller C, Hetzel A (2010), “Secondary decline of cerebral autoregulation is associated with worse outcome after intracerebral hemorrhage.” Intensive Care Med 36(2):264-71 Details

    Weerakkody RA, Czosnyka M, Zweifel C, Castellani G, Smielewski P, Keong N, Haubrich C, Pickard J, Czosnyka Z (2010), “Slow vasogenic fluctuations of intracranial pressure and cerebral near infrared spectroscopy--an observational study.” Acta Neurochir (Wien) 152(10):1763-9 Details

    Zweifel C, Castellani G, Czosnyka M, Carrera E, Brady KM, Kirkpatrick PJ, Pickard JD, Smielewski P (2010), “Continuous assessment of cerebral autoregulation with near-infrared spectroscopy in adults after subarachnoid hemorrhage.” Stroke 41(9):1963-8 Details

    Zweifel C, Castellani G, Czosnyka M, Helmy A, Manktelow A, Carrera E, Brady KM, Hutchinson PJ, Menon DK, Pickard JD, Smielewski P (2010), “Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients.” J Neurotrauma 27(11):1951-8 Details

    Zweifel C, Czosnyka M, Lavinio A, Castellani G, Kim DJ, Carrera E, Pickard JD, Kirkpatrick PJ, Smielewski P (2010), “A comparison study of cerebral autoregulation assessed with transcranial Doppler and cortical laser Doppler flowmetry.” Neurol Res 32(4):425-8 Details

    2009

    Brady KM, Lee JK, Kibler KK, Easley RB, Koehler RC, Czosnyka M, Smielewski P, Shaffner DH (2009), “The lower limit of cerebral blood flow autoregulation is increased with elevated intracranial pressure.” Anesth Analg 108(4):1278-83 Details

    Brady KM, Shaffner DH, Lee JK, Easley RB, Smielewski P, Czosnyka M, Jallo GI, Guerguerian AM (2009), “Continuous monitoring of cerebrovascular pressure reactivity after traumatic brain injury in children.” Pediatrics 124(6):e1205-12 Details

    Castellani G, Zweifel C, Kim DJ, Carrera E, Radolovich DK, Smielewski P, Hutchinson PJ, Pickard JD, Czosnyka M (2009), “Plateau waves in head injured patients requiring neurocritical care.” Neurocrit Care 11(2):143-50 Details

    Kim DJ, Czosnyka Z, Keong N, Radolovich DK, Smielewski P, Sutcliffe MP, Pickard JD, Czosnyka M (2009), “Index of cerebrospinal compensatory reserve in hydrocephalus.” Neurosurgery 64(3):494-501; discussion 501-2 Details

    Kim DJ, Kasprowicz M, Carrera E, Castellani G, Zweifel C, Lavinio A, Smielewski P, Sutcliffe MP, Pickard JD, Czosnyka M (2009), “The monitoring of relative changes in compartmental compliances of brain.” Physiol Meas 30(7):647-59 Details

    Lee JK, Kibler KK, Benni PB, Easley RB, Czosnyka M, Smielewski P, Koehler RC, Shaffner DH, Brady KM (2009), “Cerebrovascular reactivity measured by near-infrared spectroscopy.” Stroke 40(5):1820-6 Details

    López-Magaña JA, Richards HK, Radolovich DK, Kim DJ, Smielewski P, Kirkpatrick PJ, Pickard JD, Czosnyka M (2009), “Critical closing pressure: comparison of three methods.” J Cereb Blood Flow Metab 29(5):987-93 Details

    Petrella G, Czosnyka M, Smielewski P, Allin D, Guazzo EP, Pickard JD, Czosnyka ZH (2009), “In vivo assessment of hydrocephalus shunt.” Acta Neurol Scand 120(5):317-23 Details

    Radolovich DK, Czosnyka M, Timofeev I, Lavinio A, Hutchinson P, Gupta A, Pickard JD, Smielewski P (2009), “Reactivity of brain tissue oxygen to change in cerebral perfusion pressure in head injured patients.” Neurocrit Care 10(3):274-9 Details

    Schmidt B, Klingelhöfer J, Perkes I, Czosnyka M (2009), “Cerebral autoregulatory response depends on the direction of change in perfusion pressure.” J Neurotrauma 26(5):651-6 Details

    Stoquart-Elsankari S, Lehmann P, Villette A, Czosnyka M, Meyer ME, Deramond H, Balédent O (2009), “A phase-contrast MRI study of physiologic cerebral venous flow.” J Cereb Blood Flow Metab 29(6):1208-15 Details

    Tseng MY, Hutchinson PJ, Richards HK, Czosnyka M, Pickard JD, Erber WN, Brown S, Kirkpatrick PJ (2009), “Acute systemic erythropoietin therapy to reduce delayed ischemic deficits following aneurysmal subarachnoid hemorrhage: a Phase II randomized, double-blind, placebo-controlled trial. Clinical article.” J Neurosurg 111(1):171-80 Details

    2008

    Allin DM, Czosnyka M, Richards HK, Pickard JD, Czosnyka ZH (2008), “Investigation of the hydrodynamic properties of a new MRI-resistant programmable hydrocephalus shunt.” Cerebrospinal Fluid Res 5:8 Details

    Czosnyka M, Radolovich D, Balestreri M, Lavinio A, Hutchinson P, Timofeev I, Smielewski P, Pickard JD (2008), “Gender-related differences in intracranial hypertension and outcome after traumatic brain injury.” Acta Neurochir Suppl 102:25-8 Details

    Czosnyka M, Smielewski P, Lavinio A, Pickard JD, Panerai R (2008), “An assessment of dynamic autoregulation from spontaneous fluctuations of cerebral blood flow velocity: a comparison of two models, index of autoregulation and mean flow index.” Anesth Analg 106(1):234-9, table of contents Details

    Czosnyka Z, Czosnyka M, Lavinio A, Keong N, Pickard JD (2008), “Clinical testing of CSF circulation.” Eur J Anaesthesiol Suppl 42:142-5 Details

    Czosnyka Z, Keong N, Kim DJ, Radolovich D, Smielewski P, Lavinio A, Schmidt EA, Momjian S, Owler B, Pickard JD, Czosnyka M (2008), “Pulse amplitude of intracranial pressure waveform in hydrocephalus.” Acta Neurochir Suppl 102:137-40 Details

    Hu K, Peng CK, Czosnyka M, Zhao P, Novak V (2008), “Nonlinear assessment of cerebral autoregulation from spontaneous blood pressure and cerebral blood flow fluctuations.” Cardiovasc Eng 8(1):60-71 Details

    Lavinio A, Czosnyka Z, Czosnyka M (2008), “Cerebrospinal fluid dynamics: disturbances and diagnostics.” Eur J Anaesthesiol Suppl 42:137-41 Details

    Lavinio A, Ene-Iordache B, Nodari I, Girardini A, Cagnazzi E, Rasulo F, Smielewski P, Czosnyka M, Latronico N (2008), “Cerebrovascular reactivity and autonomic drive following traumatic brain injury.” Acta Neurochir Suppl 102:3-7 Details

    Narayanan N, Leffler CW, Czosnyka M, Daley ML (2008), “Assessment of cerebrovascular resistance with model of cerebrovascular pressure transmission.” Acta Neurochir Suppl 102:37-41 Details

    Pickard JD, Czosnyka Z, Czosnyka M, Owler B, Higgins JN (2008), “Coupling of sagittal sinus pressure and cerebrospinal fluid pressure in idiopathic intracranial hypertension--a preliminary report.” Acta Neurochir Suppl 102:283-5 Details

    Schmidt B, Weinhold M, Czosnyka M, May SA, Steinmeier R, Klingelhöfer J (2008), “Accuracy of non-invasive ICP assessment can be increased by an initial individual calibration.” Acta Neurochir Suppl 102:49-52 Details

    Schuhmann MU, Sood S, McAllister JP, Jaeger M, Ham SD, Czosnyka Z, Czosnyka M (2008), “Value of overnight monitoring of intracranial pressure in hydrocephalic children.” Pediatr Neurosurg 44(4):269-79 Details

    Smielewski P, Lavinio A, Timofeev I, Radolovich D, Perkes I, Pickard JD, Czosnyka M (2008), “ICM+, a flexible platform for investigations of cerebrospinal dynamics in clinical practice.” Acta Neurochir Suppl 102:145-51 Details

    Soehle M, Czosnyka M, Chatfield DA, Hoeft A, Peña A (2008), “Variability and fractal analysis of middle cerebral artery blood flow velocity and arterial blood pressure in subarachnoid hemorrhage.” J Cereb Blood Flow Metab 28(1):64-73 Details

    Timofeev I, Czosnyka M, Nortje J, Smielewski P, Kirkpatrick P, Gupta A, Hutchinson P (2008), “Effect of decompressive craniectomy on intracranial pressure and cerebrospinal compensation following traumatic brain injury.” J Neurosurg 108(1):66-73 Details

    Timofeev I, Dahyot-Fizelier C, Keong N, Nortje J, Al-Rawi PG, Czosnyka M, Menon DK, Kirkpatrick PJ, Gupta AK, Hutchinson PJ (2008), “Ventriculostomy for control of raised ICP in acute traumatic brain injury.” Acta Neurochir Suppl 102:99-104 Details

    Turalska M, Latka M, Czosnyka M, Pierzchala K, West BJ (2008), “Generation of very low frequency cerebral blood flow fluctuations in humans.” Acta Neurochir Suppl 102:43-7 Details

    2007

    Brady KM, Lee JK, Kibler KK, Smielewski P, Czosnyka M, Easley RB, Koehler RC, Shaffner DH (2007), “Continuous time-domain analysis of cerebrovascular autoregulation using near-infrared spectroscopy.” Stroke 38(10):2818-25 Details

    Bromby A, Czosnyka Z, Allin D, Richards HK, Pickard JD, Czosnyka M (2007), “Laboratory study on "intracranial hypotension" created by pumping the chamber of a hydrocephalus shunt.” Cerebrospinal Fluid Res 4:2 Details

    Czosnyka M, Czosnyka Z, Keong N, Lavinio A, Smielewski P, Momjian S, Schmidt EA, Petrella G, Owler B, Pickard JD (2007), “Pulse pressure waveform in hydrocephalus: what it is and what it isn't.” Neurosurg Focus 22(4):E2 Details

    Czosnyka M, Smielewski P, Lavinio A, Czosnyka Z, Pickard JD (2007), “A synopsis of brain pressures: which? when? are they all useful?” Neurol Res 29(7):672-9 Details

    Czosnyka M, Smielewski P, Timofeev I, Lavinio A, Guazzo E, Hutchinson P, Pickard JD (2007), “Intracranial pressure: more than a number.” Neurosurg Focus 22(5):E10 Details

    Eide PK, Czosnyka M, Sorteberg W, Pickard JD, Smielewski P (2007), “Association between intracranial, arterial pulse pressure amplitudes and cerebral autoregulation in head injury patients.” Neurol Res 29(6):578-82 Details

    Eklund A, Smielewski P, Chambers I, Alperin N, Malm J, Czosnyka M, Marmarou A (2007), “Assessment of cerebrospinal fluid outflow resistance.” Med Biol Eng Comput 45(8):719-35 Details

    Haubrich C, Czosnyka Z, Lavinio A, Smielewski P, Diehl RR, Pickard JD, Czosnyka M (2007), “Is there a direct link between cerebrovascular activity and cerebrospinal fluid pressure-volume compensation?” Stroke 38(10):2677-80 Details

    Lavinio A, Schmidt EA, Haubrich C, Smielewski P, Pickard JD, Czosnyka M (2007), “Noninvasive evaluation of dynamic cerebrovascular autoregulation using Finapres plethysmograph and transcranial Doppler.” Stroke 38(2):402-4 Details

    Lavinio A, Timofeev I, Nortje J, Outtrim J, Smielewski P, Gupta A, Hutchinson PJ, Matta BF, Pickard JD, Menon D, Czosnyka M (2007), “Cerebrovascular reactivity during hypothermia and rewarming.” Br J Anaesth 99(2):237-44 Details

    Lewis PM, Smielewski P, Pickard JD, Czosnyka M (2007), “Slow oscillations in middle cerebral artery cerebral blood flow velocity and aging.” Neurol Res 29(3):260-3 Details

    Lewis PM, Smielewski P, Pickard JD, Czosnyka M (2007), “Dynamic cerebral autoregulation: should intracranial pressure be taken into account?” Acta Neurochir (Wien) 149(6):549-55; discussion 555 Details

    Soehle M, Chatfield DA, Czosnyka M, Kirkpatrick PJ (2007), “Predictive value of initial clinical status, intracranial pressure and transcranial Doppler pulsatility after subarachnoid haemorrhage.” Acta Neurochir (Wien) 149(6):575-83 Details

    Tseng MY, Al-Rawi PG, Czosnyka M, Hutchinson PJ, Richards H, Pickard JD, Kirkpatrick PJ (2007), “Enhancement of cerebral blood flow using systemic hypertonic saline therapy improves outcome in patients with poor-grade spontaneous subarachnoid hemorrhage.” J Neurosurg 107(2):274-82 Details

    Tseng MY, Hutchinson PJ, Czosnyka M, Richards H, Pickard JD, Kirkpatrick PJ (2007), “Effects of acute pravastatin treatment on intensity of rescue therapy, length of inpatient stay, and 6-month outcome in patients after aneurysmal subarachnoid hemorrhage.” Stroke 38(5):1545-50 Details

    Tseng MY, Hutchinson PJ, Turner CL, Czosnyka M, Richards H, Pickard JD, Kirkpatrick PJ (2007), “Biological effects of acute pravastatin treatment in patients after aneurysmal subarachnoid hemorrhage: a double-blind, placebo-controlled trial.” J Neurosurg 107(6):1092-100 Details

    2006

    Allin DM, Czosnyka ZH, Czosnyka M, Richards HK, Pickard JD (2006), “In vitro hydrodynamic properties of the Miethke ProGAV hydrocephalus shunt.” Cerebrospinal Fluid Res 3:9 Details

    Balestreri M, Czosnyka M, Hutchinson P, Steiner LA, Hiler M, Smielewski P, Pickard JD (2006), “Impact of intracranial pressure and cerebral perfusion pressure on severe disability and mortality after head injury.” Neurocrit Care 4(1):8-13 Details

    Czosnyka M, Hutchinson PJ, Balestreri M, Hiler M, Smielewski P, Pickard JD (2006), “Monitoring and interpretation of intracranial pressure after head injury.” Acta Neurochir Suppl 96:114-8 Details

    Daley ML, Leffler CW, Czosnyka M, Pickard JD (2006), “Intracranial pressure monitoring: modeling cerebrovascular pressure transmission.” Acta Neurochir Suppl 96:103-7 Details

    Guendling K, Smielewski P, Czosnyka M, Lewis P, Nortje J, Timofeev I, Hutchinson PJ, Pickard JD (2006), “Use of ICM+ software for on-line analysis of intracranial and arterial pressures in head-injured patients.” Acta Neurochir Suppl 96:108-13 Details

    Hiler M, Czosnyka M, Hutchinson P, Balestreri M, Smielewski P, Matta B, Pickard JD (2006), “Predictive value of initial computerized tomography scan, intracranial pressure, and state of autoregulation in patients with traumatic brain injury.” J Neurosurg 104(5):731-7 Details

    Hu X, Nenov V, Glenn TC, Steiner LA, Czosnyka M, Bergsneider M, Martin N (2006), “Nonlinear analysis of cerebral hemodynamic and intracranial pressure signals for characterization of autoregulation.” IEEE Trans Biomed Eng 53(2):195-209 Details

    Hutchinson PJ, Corteen E, Czosnyka M, Mendelow AD, Menon DK, Mitchell P, Murray G, Pickard JD, Rickels E, Sahuquillo J, Servadei F, Teasdale GM, Timofeev I, Unterberg A, Kirkpatrick PJ (2006), “Decompressive craniectomy in traumatic brain injury: the randomized multicenter RESCUEicp study (www.RESCUEicp.com).” Acta Neurochir Suppl 96:17-20 Details

    Hutchinson PJ, Gimson A, Al-Rawi PG, O'Connell MT, Czosnyka M, Menon DK (2006), “Microdialysis in the management of hepatic encephalopathy.” Neurocrit Care 5(3):202-5 Details

    Pickard JD, Spiegelhalter D, Czosnyka M (2006), “Health economics and the search for shunt-responsive symptomatic hydrocephalus in the elderly.” J Neurosurg 105(6):811-3; discussion 813-4 Details

    Timofeev I, Kirkpatrick PJ, Corteen E, Hiler M, Czosnyka M, Menon DK, Pickard JD, Hutchinson PJ (2006), “Decompressive craniectomy in traumatic brain injury: outcome following protocol-driven therapy.” Acta Neurochir Suppl 96:11-6 Details

    Tseng MY, Czosnyka M, Richards H, Pickard JD, Kirkpatrick PJ (2006), “Effects of acute treatment with statins on cerebral autoregulation in patients after aneurysmal subarachnoid hemorrhage.” Neurosurg Focus 21(3):E10 Details

    2005

    Balestreri M, Czosnyka M, Steiner LA, Hiler M, Schmidt EA, Matta B, Menon D, Hutchinson P, Pickard JD (2005), “Association between outcome, cerebral pressure reactivity and slow ICP waves following head injury.” Acta Neurochir Suppl 95:25-8 Details

    Bech-Azeddine R, Gjerris F, Waldemar G, Czosnyka M, Juhler M (2005), “Intraventricular or lumbar infusion test in adult communicating hydrocephalus? Practical consequences and clinical outcome of shunt operation.” Acta Neurochir (Wien) 147(10):1027-35; discussion 1035-6 Details

    Czosnyka M, Balestreri M, Steiner L, Smielewski P, Hutchinson PJ, Matta B, Pickard JD (2005), “Age, intracranial pressure, autoregulation, and outcome after brain trauma.” J Neurosurg 102(3):450-4 Details

    Czosnyka M, Steiner L, Balestreri M, Schmidt E, Smielewski P, Hutchinson PJ, Pickard JD (2005), “Concept of "true ICP" in monitoring and prognostication in head trauma.” Acta Neurochir Suppl 95:341-4 Details

    Czosnyka Z, Czosnyka M, Owler B, Momjian S, Kasprowicz M, Schmidt EA, Smielewski P, Pickard JD (2005), “Clinical testing of CSF circulation in hydrocephalus.” Acta Neurochir Suppl 95:247-51 Details

    Czosnyka Z, Czosnyka M, Pickard JD (2005), “CSF pulse pressure and B waves.” J Neurosurg 103(4):767-8; author reply 768 Details

    Czosnyka Z, van den Boogaard F, Czosnyka M, Momjian S, Gelling L, Pickard JD (2005), “The relationship between CSF circulation and cerebrovascular pressure-reactivity in normal pressure hydrocephalus.” Acta Neurochir Suppl 95:207-11 Details

    Czosnyka ZH, Cieslicki K, Czosnyka M, Pickard JD (2005), “Hydrocephalus shunts and waves of intracranial pressure.” Med Biol Eng Comput 43(1):71-7 Details

    Czosnyka ZH, Czosnyka M, Richards HK, Pickard JD (2005), “Evaluation of three new models of hydrocephalus shunts.” Acta Neurochir Suppl 95:223-7 Details

    Daley ML, Leffler CW, Czosnyka M, Pickard JD (2005), “Plateau waves: changes of cerebrovascular pressure transmission.” Acta Neurochir Suppl 95:327-32 Details

    Juniewicz H, Kasprowicz M, Czosnyka M, Czosnyka Z, Gizewski S, Dzik M, Pickard JD (2005), “Analysis of intracranial pressure during and after the infusion test in patients with communicating hydrocephalus.” Physiol Meas 26(6):1039-48 Details

    Kumar A, Schmidt EA, Hiler M, Smielewski P, Pickard JD, Czosnyka M (2005), “Asymmetry of critical closing pressure following head injury.” J Neurol Neurosurg Psychiatry 76(11):1570-3 Details

    Pickard JD, Coleman MR, Czosnyka M (2005), “Hydrocephalus, ventriculomegaly and the vegetative state: a review.” Neuropsychol Rehabil 15(3-4):224-36 Details

    Pickard JD, Hutchinson PJ, Coles JP, Steiner LA, Johnston AJ, Fryer TD, Coleman MR, Smielewski P, Chatfield DA, Aigbirhio F, Williams GB, Rice K, Clark JC, Salmond CH, Sahakian BJ, Bradley PG, Carpenter TA, Salvador R, Pena A, Gillard JH, Cunningham AS, Piechnik S, Czosnyka M, Menon DK (2005), “Imaging of cerebral blood flow and metabolism in brain injury in the ICU.” Acta Neurochir Suppl 95:459-64 Details

    Reinhard M, Roth M, Guschlbauer B, Harloff A, Timmer J, Czosnyka M, Hetzel A (2005), “Dynamic cerebral autoregulation in acute ischemic stroke assessed from spontaneous blood pressure fluctuations.” Stroke 36(8):1684-9 Details

    Schmidt B, Bocklisch SF, Pässler M, Czosnyka M, Schwarze JJ, Klingelhöfer J (2005), “Fuzzy pattern classification of hemodynamic data can be used to determine noninvasive intracranial pressure.” Acta Neurochir Suppl 95:345-9 Details

    Schmidt EA, Czosnyka Z, Momjian S, Czosnyka M, Bech RA, Pickard JD (2005), “Intracranial baroreflex yielding an early cushing response in human.” Acta Neurochir Suppl 95:253-6 Details

    Smielewski P, Czosnyka M, Steiner L, Belestri M, Piechnik S, Pickard JD (2005), “ICM+: software for on-line analysis of bedside monitoring data after severe head trauma.” Acta Neurochir Suppl 95:43-9 Details

    Steiner LA, Balestreri M, Johnston AJ, Coles JP, Chatfield DA, Pickard JD, Menon DK, Czosnyka M (2005), “Effects of moderate hyperventilation on cerebrovascular pressure-reactivity after head injury.” Acta Neurochir Suppl 95:17-20 Details

    Steiner LA, Balestreri M, Johnston AJ, Coles JP, Smielewski P, Pickard JD, Menon DK, Czosnyka M (2005), “Predicting the response of intracranial pressure to moderate hyperventilation.” Acta Neurochir (Wien) 147(5):477-83; discussion 483 Details

    Tseng MY, Czosnyka M, Richards H, Pickard JD, Kirkpatrick PJ (2005), “Effects of acute treatment with pravastatin on cerebral vasospasm, autoregulation, and delayed ischemic deficits after aneurysmal subarachnoid hemorrhage: a phase II randomized placebo-controlled trial.” Stroke 36(8):1627-32 Details

    2004

    Balestreri M, Czosnyka M, Chatfield DA, Steiner LA, Schmidt EA, Smielewski P, Matta B, Pickard JD (2004), “Predictive value of Glasgow Coma Scale after brain trauma: change in trend over the past ten years.” J Neurol Neurosurg Psychiatry 75(1):161-2 Details

    Balestreri M, Czosnyka M, Steiner LA, Schmidt E, Smielewski P, Matta B, Pickard JD (2004), “Intracranial hypertension: what additional information can be derived from ICP waveform after head injury?” Acta Neurochir (Wien) 146(2):131-41 Details

    Czosnyka M, Czosnyka Z, Momjian S, Pickard JD (2004), “Cerebrospinal fluid dynamics.” Physiol Meas 25(5):R51-76 Details

    Czosnyka M, Pickard JD (2004), “Monitoring and interpretation of intracranial pressure.” J Neurol Neurosurg Psychiatry 75(6):813-21 Details

    Czosnyka M, Richards HK, Czosnyka Z, Pickard JD (2004), “Normal-pressure hydrocephalus.” J Neurosurg 101(6):1083-4; author reply 1084 Details

    Kasprowicz M, Czosnyka Z, Czosnyka M, Momjian S, Juniewicz H, Pickard JD (2004), “Slight elevation of baseline intracranial pressure after fluid infusion into CSF space in patients with hydrocephalus.” Neurol Res 26(6):628-31 Details

    Kasprowicz M, Koszewski W, Juniewicz H, Czosnyka M (2004), “[Modeling of cerebrospinal fluid circulation with consideration of a pressure-volume curve in infusion tests of patients with suspected hydrocephalus. Preliminary report].” Neurol Neurochir Pol 38(2):109-14; discussion 115 Details

    Minhas PS, Smielewski P, Kirkpatrick PJ, Pickard JD, Czosnyka M (2004), “Pressure autoregulation and positron emission tomography-derived cerebral blood flow acetazolamide reactivity in patients with carotid artery stenosis.” Neurosurgery 55(1):63-7; discussion 67-8 Details

    Momjian S, Czosnyka Z, Czosnyka M, Pickard JD (2004), “Link between vasogenic waves of intracranial pressure and cerebrospinal fluid outflow resistance in normal pressure hydrocephalus.” Br J Neurosurg 18(1):56-61 Details

    Momjian S, Owler BK, Czosnyka Z, Czosnyka M, Pena A, Pickard JD (2004), “Pattern of white matter regional cerebral blood flow and autoregulation in normal pressure hydrocephalus.” Brain 127(Pt 5):965-72 Details

    Owler BK, Momjian S, Czosnyka Z, Czosnyka M, Péna A, Harris NG, Smielewski P, Fryer T, Donovan T, Coles J, Carpenter A, Pickard JD (2004), “Normal pressure hydrocephalus and cerebral blood flow: a PET study of baseline values.” J Cereb Blood Flow Metab 24(1):17-23 Details

    Owler BK, Pena A, Momjian S, Czosnyka Z, Czosnyka M, Harris NG, Smielewski P, Fryer T, Donvan T, Carpenter A, Pickard JD (2004), “Changes in cerebral blood flow during cerebrospinal fluid pressure manipulation in patients with normal pressure hydrocephalus: a methodological study.” J Cereb Blood Flow Metab 24(5):579-87 Details

    Reinhard M, Roth M, Müller T, Guschlbauer B, Timmer J, Czosnyka M, Hetzel A (2004), “Effect of carotid endarterectomy or stenting on impairment of dynamic cerebral autoregulation.” Stroke 35(6):1381-7 Details

    Soehle M, Czosnyka M, Pickard JD, Kirkpatrick PJ (2004), “Critical closing pressure in subarachnoid hemorrhage: effect of cerebral vasospasm and limitations of a transcranial Doppler-derived estimation.” Stroke 35(6):1393-8 Details

    Soehle M, Czosnyka M, Pickard JD, Kirkpatrick PJ (2004), “Continuous assessment of cerebral autoregulation in subarachnoid hemorrhage.” Anesth Analg 98(4):1133-9, table of contents Details

    Steiner LA, Balestreri M, Johnston AJ, Czosnyka M, Coles JP, Chatfield DA, Smielewski P, Pickard JD, Menon DK (2004), “Sustained moderate reductions in arterial CO2 after brain trauma time-course of cerebral blood flow velocity and intracranial pressure.” Intensive Care Med 30(12):2180-7 Details

    Steiner LA, Johnston AJ, Czosnyka M, Chatfield DA, Salvador R, Coles JP, Gupta AK, Pickard JD, Menon DK (2004), “Direct comparison of cerebrovascular effects of norepinephrine and dopamine in head-injured patients.” Crit Care Med 32(4):1049-54 Details

    2003

    Balestreri M, Steiner LA, Czosnyka M (2003), “Sex-related differences and traumatic brain injury.” J Neurosurg 99(3):616; author reply 616-7 Details

    Czosnyka M, Czosnyka Z, Momjian S, Schmidt E (2003), “Calculation of the resistance to CSF outflow.” J Neurol Neurosurg Psychiatry 74(9):1354; author reply 1354-5 Details

    Czosnyka M, Czosnyka Z, Schmidt EA, Momjian S (2003), “Cerebrospinal fluid production.” J Neurosurg 99(1):206-7; author reply 207 Details

    Czosnyka M, Czosnyka ZH, Richards HK, Pickard JD (2003), “Hydrodynamic properties of extraventricular drainage systems.” Neurosurgery 52(3):619-23; discussion 623 Details

    Czosnyka M, Smielewski P, Czosnyka Z, Piechnik S, Steiner LA, Schmidt E, Gooskens I, Soehle M, Lang EW, Matta BF, Pickard JD (2003), “Continuous assessment of cerebral autoregulation: clinical and laboratory experience.” Acta Neurochir Suppl 86:581-5 Details

    Gooskens I, Schmidt EA, Czosnyka M, Piechnik SK, Smielewski P, Kirkpatrick PJ, Pickard JD (2003), “Pressure-autoregulation, CO2 reactivity and asymmetry of haemodynamic parameters in patients with carotid artery stenotic disease. A clinical appraisal.” Acta Neurochir (Wien) 145(7):527-32; discussion 532 Details

    Johnston AJ, Czosnyka M (2003), “Measuring cerebral autoregulation in stroke patients.” Stroke 34(6):e39-40; author reply e39-40 Details

    Kasprowicz M, Czosnyka M, Czosnyka Z, Momjian S, Smielewski P, Juniewicz H, Pickard JD (2003), “Hysteresis of the cerebrospinal pressure-volume curve in hydrocephalus.” Acta Neurochir Suppl 86:529-32 Details

    Lang EW, Czosnyka M, Mehdorn HM (2003), “Tissue oxygen reactivity and cerebral autoregulation after severe traumatic brain injury.” Crit Care Med 31(1):267-71 Details

    Minhas PS, Menon DK, Smielewski P, Czosnyka M, Kirkpatrick PJ, Clark JC, Pickard JD (2003), “Positron emission tomographic cerebral perfusion disturbances and transcranial Doppler findings among patients with neurological deterioration after subarachnoid hemorrhage.” Neurosurgery 52(5):1017-22; discussion 1022-4 Details

    Reinhard M, Roth M, Müller T, Czosnyka M, Timmer J, Hetzel A (2003), “Cerebral autoregulation in carotid artery occlusive disease assessed from spontaneous blood pressure fluctuations by the correlation coefficient index.” Stroke 34(9):2138-44 Details

    Schmidt B, Czosnyka M, Raabe A, Yahya H, Schwarze JJ, Sackerer D, Sander D, Klingelhöfer J (2003), “Adaptive noninvasive assessment of intracranial pressure and cerebral autoregulation.” Stroke 34(1):84-9 Details

    Schmidt EA, Czosnyka M, Steiner LA, Balestreri M, Smielewski P, Piechnik SK, Matta BF, Pickard JD (2003), “Asymmetry of pressure autoregulation after traumatic brain injury.” J Neurosurg 99(6):991-8 Details

    Schmidt EA, Piechnik SK, Smielewski P, Raabe A, Matta BF, Czosnyka M (2003), “Symmetry of cerebral hemodynamic indices derived from bilateral transcranial Doppler.” J Neuroimaging 13(3):248-54 Details

    Steiner LA, Coles JP, Czosnyka M, Minhas PS, Fryer TD, Aigbirhio FI, Clark JC, Smielewski P, Chatfield DA, Donovan T, Pickard JD, Menon DK (2003), “Cerebrovascular pressure reactivity is related to global cerebral oxygen metabolism after head injury.” J Neurol Neurosurg Psychiatry 74(6):765-70 Details

    Steiner LA, Coles JP, Johnston AJ, Chatfield DA, Smielewski P, Fryer TD, Aigbirhio FI, Clark JC, Pickard JD, Menon DK, Czosnyka M (2003), “Assessment of cerebrovascular autoregulation in head-injured patients: a validation study.” Stroke 34(10):2404-9 Details

    Steiner LA, Coles JP, Johnston AJ, Czosnyka M, Fryer TD, Smielewski P, Chatfield DA, Salvador R, Aigbirhio FI, Clark JC, Menon DK, Pickard JD (2003), “Responses of posttraumatic pericontusional cerebral blood flow and blood volume to an increase in cerebral perfusion pressure.” J Cereb Blood Flow Metab 23(11):1371-7 Details

    Steiner LA, Czosnyka M (2003), “Estimation of critical closing pressure and cerebral perfusion pressure using transcranial Doppler.” Br J Anaesth 90(3):396-7; author reply 396-7 Details

    Steiner LA, Johnston AJ, Chatfield DA, Czosnyka M, Coleman MR, Coles JP, Gupta AK, Pickard JD, Menon DK (2003), “The effects of large-dose propofol on cerebrovascular pressure autoregulation in head-injured patients.” Anesth Analg 97(2):572-6, table of contents Details

    Steiner LA, Johnston AJ, Salvador R, Czosnyka M, Menon DK (2003), “Validation of a tonometric noninvasive arterial blood pressure monitor in the intensive care setting.” Anaesthesia 58(5):448-54 Details

    2002

    Czosnyka M, Smielewski P, Piechnik S, Pickard JD (2002), “Clinical significance of cerebral autoregulation.” Acta Neurochir Suppl 81:117-9 Details

    Czosnyka Z, Czosnyka M, Richards HK, Pickard JD (2002), “Laboratory testing of hydrocephalus shunts -- conclusion of the U.K. Shunt evaluation programme.” Acta Neurochir (Wien) 144(6):525-38; discussion 538 Details

    Czosnyka ZH, Czosnyka M, Pickard JD (2002), “Shunt testing in-vivo: a method based on the data from the UK shunt evaluation laboratory.” Acta Neurochir Suppl 81:27-30 Details

    Czosnyka ZH, Czosnyka M, Whitfield PC, Donovan T, Pickard JD (2002), “Cerebral autoregulation among patients with symptoms of hydrocephalus.” Neurosurgery 50(3):526-32; discussion 532-3 Details

    Kett-White R, Hutchinson PJ, Al-Rawi PG, Czosnyka M, Gupta AK, Pickard JD, Kirkpatrick PJ (2002), “Cerebral oxygen and microdialysis monitoring during aneurysm surgery: effects of blood pressure, cerebrospinal fluid drainage, and temporary clipping on infarction.” J Neurosurg 96(6):1013-9 Details

    Kett-White R, Hutchinson PJ, Czosnyka M, al-Rawi P, Gupta A, Pickard JD, Kirkpatrick PJ (2002), “Effects of variation in cerebral haemodynamics during aneurysm surgery on brain tissue oxygen and metabolism.” Acta Neurochir Suppl 81:327-9 Details

    Kett-White R, Hutchinson PJ, Czosnyka M, Boniface S, Pickard JD, Kirkpatrick PJ (2002), “Multi-modal monitoring of acute brain injury.” Adv Tech Stand Neurosurg 27:87-134 Details

    Lang EW, Mehdorn HM, Dorsch NW, Czosnyka M (2002), “Continuous monitoring of cerebrovascular autoregulation: a validation study.” J Neurol Neurosurg Psychiatry 72(5):583-6 Details

    Peña A, Harris NG, Bolton MD, Czosnyka M, Pickard JD (2002), “Communicating hydrocephalus: the biomechanics of progressive ventricular enlargement revisited.” Acta Neurochir Suppl 81:59-63 Details

    Peña A, Owler BK, Fryer TD, Minhas P, Czosnyka M, Crawford PJ, Pickard JD (2002), “A case study of hemispatial neglect using finite element analysis and positron emission tomography.” J Neuroimaging 12(4):360-7 Details

    Piechnik SK, Czosnyka M, Cieślicki K, Cieśla D (2002), “Problems in application of purely linear models in cerebral circulation.” J Biomech 35(4):553-4 Details

    Schmidt B, Czosnyka M, Klingelhöfer J (2002), “Clinical applications of a non-invasive ICP monitoring method.” Eur J Ultrasound 16(1-2):37-45 Details

    Schmidt EA, Czosnyka M, Smielewski P, Piechnik SK, Pickard JD (2002), “Asymmetry of cerebral autoregulation following head injury.” Acta Neurochir Suppl 81:133-4 Details

    Steiner LA, Czosnyka M (2002), “Should we measure cerebral blood flow in head-injured patients?” Br J Neurosurg 16(5):429-39 Details

    Steiner LA, Czosnyka M (2002), “Assessing drug effects on cerebral autoregulation using the static rate of autoregulation.” Anesth Analg 95(5):1463; author reply 1463-4 Details

    Steiner LA, Czosnyka M, Piechnik SK, Smielewski P, Chatfield D, Menon DK, Pickard JD (2002), “Continuous monitoring of cerebrovascular pressure reactivity allows determination of optimal cerebral perfusion pressure in patients with traumatic brain injury.” Crit Care Med 30(4):733-8 Details

    Taylor R, Czosnyka Z, Czosnyka M, Pickard JD (2002), “Factors determining mean ICP in hydrocephalic patients with Hakim-programmable valve: implications of the parallel arrangement of the CSF outflow resistance and shunt.” Acta Neurochir Suppl 81:23-6 Details

    Taylor R, Czosnyka Z, Czosnyka M, Pickard JD (2002), “A laboratory model of testing shunt performance after implantation.” Br J Neurosurg 16(1):30-5 Details

    Tisell M, Edsbagge M, Stephensen H, Czosnyka M, Wikkelsø C (2002), “Elastance correlates with outcome after endoscopic third ventriculostomy in adults with hydrocephalus caused by primary aqueductal stenosis.” Neurosurgery 50(1):70-7 Details

    2001

    Czosnyka M (2001), “Pulsatility index.” J Neurosurg 94(4):685-6 Details

    Czosnyka M, Czosnyka ZH, Whitfield PC, Donovan T, Pickard JD (2001), “Age dependence of cerebrospinal pressure-volume compensation in patients with hydrocephalus.” J Neurosurg 94(3):482-6 Details

    Czosnyka M, Richards HK (2001), “Transcranial Doppler identification of changing autoregulatory thresholds after autoregulatory impairment.” Neurosurgery 49(6):1484-5 Details

    Czosnyka M, Smielewski P, Piechnik S, Steiner LA, Pickard JD (2001), “Cerebral autoregulation following head injury.” J Neurosurg 95(5):756-63 Details

    Czosnyka ZH, Czosnyka M, Richards HK, Pickard JD (2001), “Laboratory evaluation of the phoenix CRx diamond valve.” Neurosurgery 48(3):689-93; discussion 693-4 Details

    Piechnik SK, Czosnyka M, Harris NG, Minhas PS, Pickard JD (2001), “A model of the cerebral and cerebrospinal fluid circulations to examine asymmetry in cerebrovascular reactivity.” J Cereb Blood Flow Metab 21(2):182-92 Details

    Piechnik SK, Czosnyka M, Richards HK, Whitfield PC, Pickard JD (2001), “Cerebral venous blood outflow: a theoretical model based on laboratory simulation.” Neurosurgery 49(5):1214-22; discussion 1222-3 Details

    Schmidt EA, Czosnyka M, Gooskens I, Piechnik SK, Matta BF, Whitfield PC, Pickard JD (2001), “Preliminary experience of the estimation of cerebral perfusion pressure using transcranial Doppler ultrasonography.” J Neurol Neurosurg Psychiatry 70(2):198-204 Details

    Whitfield PC, Kirkpatrick PJ, Czosnyka M, Pickard JD (2001), “Management of severe traumatic brain injury by decompressive craniectomy.” Neurosurgery 49(1):225-6 Details

    Whitfield PC, Patel H, Hutchinson PJ, Czosnyka M, Parry D, Menon D, Pickard JD, Kirkpatrick PJ (2001), “Bifrontal decompressive craniectomy in the management of posttraumatic intracranial hypertension.” Br J Neurosurg 15(6):500-7 Details

    2000

    Czosnyka M (2000), “Association between arterial and intracranial pressures.” Br J Neurosurg 14(2):127-8 Details

    Czosnyka M, Copeman J, Czosnyka Z, McConnell R, Dickinson C, Pickard JD (2000), “Post-traumatic hydrocephalus: influence of craniectomy on the CSF circulation.” J Neurol Neurosurg Psychiatry 68(2):246-8 Details

    Czosnyka M, Smielewski P, Piechnik S, Schmidt EA, Seeley H, al-Rawi P, Matta BF, Kirkpatrick PJ, Pickard JD (2000), “Continuous assessment of cerebral autoregulation--clinical verification of the method in head injured patients.” Acta Neurochir Suppl 76:483-4 Details

    Czosnyka Z, Czosnyka M, Copeman J, Pickard JD (2000), “A randomized, controlled study of a programmable shunt valve versus a conventional valve for patients with hydrocephalus.” Neurosurgery 47(5):1250-1 Details

    Laing RJ, Smielewski P, Czosnyka M, Quaranta N, Moffat DA (2000), “A study of perioperative lumbar cerebrospinal fluid pressure in patients undergoing acoustic neuroma surgery.” Skull Base Surg 10(4):179-85 Details

    Lam JM, Smielewski P, Czosnyka M, Pickard JD, Kirkpatrick PJ (2000), “Predicting delayed ischemic deficits after aneurysmal subarachnoid hemorrhage using a transient hyperemic response test of cerebral autoregulation.” Neurosurgery 47(4):819-25; discussions 825-6 Details

    Schmidt B, Czosnyka M, Schwarze JJ, Sander D, Gerstner W, Lumenta CB, Klingelhöfer J (2000), “Evaluation of a method for noninvasive intracranial pressure assessment during infusion studies in patients with hydrocephalus.” J Neurosurg 92(5):793-800 Details

    Schmidt EA, Czosnyka M, Matta BF, Gooskens I, Piechnik S, Pickard JD (2000), “Non-invasive cerebral perfusion pressure (nCPP): evaluation of the monitoring methodology in head injured patients.” Acta Neurochir Suppl 76:451-2 Details

    1999

    Czosnyka M, Richards HK, Czosnyka Z, Piechnik S, Pickard JD, Chir M (1999), “Vascular components of cerebrospinal fluid compensation.” J Neurosurg 90(4):752-9 Details

    Czosnyka M, Smielewski P, Piechnik S, Al-Rawi PG, Kirkpatrick PJ, Matta BF, Pickard JD (1999), “Critical closing pressure in cerebrovascular circulation.” J Neurol Neurosurg Psychiatry 66(5):606-11 Details

    Czosnyka M, Smielewski P, Piechnik S, Schmidt EA, Al-Rawi PG, Kirkpatrick PJ, Pickard JD (1999), “Hemodynamic characterization of intracranial pressure plateau waves in head-injury patients.” J Neurosurg 91(1):11-9 Details

    Czosnyka Z, Czosnyka M, Pickard JD (1999), “Hydrodynamic performance of a new siphon preventing device: the SiphonGuard.” J Neurol Neurosurg Psychiatry 66(3):408-9 Details

    Iddon JL, Pickard JD, Cross JJ, Griffiths PD, Czosnyka M, Sahakian BJ (1999), “Specific patterns of cognitive impairment in patients with idiopathic normal pressure hydrocephalus and Alzheimer's disease: a pilot study.” J Neurol Neurosurg Psychiatry 67(6):723-32 Details

    Piechnik SK, Yang X, Czosnyka M, Smielewski P, Fletcher SH, Jones AL, Pickard JD (1999), “The continuous assessment of cerebrovascular reactivity: a validation of the method in healthy volunteers.” Anesth Analg 89(4):944-9 Details

    Raabe A, Czosnyka M, Piper I, Seifert V (1999), “Monitoring of intracranial compliance: correction for a change in body position.” Acta Neurochir (Wien) 141(1):31-6; discussion 35-6 Details

    Richards HK, Czosnyka M, Pickard JD (1999), “Assessment of critical closing pressure in the cerebral circulation as a measure of cerebrovascular tone.” Acta Neurochir (Wien) 141(11):1221-7 discussion 1226-7 Details

    Schmidt B, Czosnyka M, Schwarze JJ, Sander D, Gerstner W, Lumenta CB, Pickard JD, Klingelhöfer J (1999), “Cerebral vasodilatation causing acute intracranial hypertension: a method for noninvasive assessment.” J Cereb Blood Flow Metab 19(9):990-6 Details

    Williams EJ, Bunch CS, Carpenter TA, Downey SP, Kendall IV, Czosnyka M, Pickard JD, Martin J, Menon DK (1999), “Magnetic resonance imaging compatibility testing of intracranial pressure probes. Technical note.” J Neurosurg 91(4):706-9 Details

    1998

    Czosnyka M, Matta BF, Smielewski P, Kirkpatrick PJ, Pickard JD (1998), “Cerebral perfusion pressure in head-injured patients: a noninvasive assessment using transcranial Doppler ultrasonography.” J Neurosurg 88(5):802-8 Details

    Czosnyka M, Smielewski P, Kirkpatrick P, Piechnik S, Laing R, Pickard JD (1998), “Continuous monitoring of cerebrovascular pressure-reactivity in head injury.” Acta Neurochir Suppl 71:74-7 Details

    Czosnyka Z, Czosnyka M, Richards H, Pickard JD (1998), “Hydrodynamic properties of hydrocephalus shunts.” Acta Neurochir Suppl 71:334-9 Details

    Czosnyka Z, Czosnyka M, Richards H, Pickard JD (1998), “Chhabra hydrocephalus shunt: lessons for gravitational valves.” J Neurol Neurosurg Psychiatry 65(3):406-7 Details

    Czosnyka Z, Czosnyka M, Richards HK, Pickard JD (1998), “Posture-related overdrainage: comparison of the performance of 10 hydrocephalus shunts in vitro.” Neurosurgery 42(2):327-33; discussion 333-4 Details

    Kirkpatrick PJ, Lam J, Al-Rawi P, Smielewski P, Czosnyka M (1998), “Defining thresholds for critical ischemia by using near-infrared spectroscopy in the adult brain.” J Neurosurg 89(3):389-94 Details

    Kirkpatrick PJ, Smielewski P, Al-Rawi P, Czosnyka M (1998), “Resolving extra- and intracranial signal changes during adult near infrared spectroscopy.” Neurol Res 20 Suppl 1:S19-22 Details

    Minhas PS, Smielewski P, Czosnyka M, Kirkpatrick PJ (1998), “Preoperative carbon dioxide reactivity studies do not predict the hemodynamic changes seen during carotid endarterectomy after internal carotid artery clamping.” J Stroke Cerebrovasc Dis 7(1):44-51 Details

    Piechnik S, Czosnyka M, Smielewski P, Pickard JD (1998), “Indices for decreased cerebral blood flow control--a modelling study.” Acta Neurochir Suppl 71:269-71 Details

    Price DJ, Saxena A, Czosnyka M (1998), “The relationship of vasogenic waves to ICP and cerebral perfusion pressure in head injured patients.” Acta Neurochir Suppl 71:297-9 Details

    Raabe A, Menon DK, Gupta S, Czosnyka M, Pickard JD (1998), “Jugular venous and arterial concentrations of serum S-100B protein in patients with severe head injury: a pilot study.” J Neurol Neurosurg Psychiatry 65(6):930-2 Details

    Richards HK, Czosnyka M, Whitehouse H, Pickard JD (1998), “Increase in transcranial Doppler pulsatility index does not indicate the lower limit of cerebral autoregulation.” Acta Neurochir Suppl 71:229-32 Details

    Schmidt B, Schwarze JJ, Czosnyka M, Sander D, Wittich I, Klingelhöfer J (1998), “A method for a simulation of continuous intracranial pressure curves.” Comput Biomed Res 31(4):231-43 Details

    Smielewski P, Czosnyka M, Pickard JD, Kirkpatrick P (1998), “Assessment of cerebrovascular reactivity in patients with carotid artery disease using near-infrared spectroscopy.” Acta Neurochir Suppl 71:263-5 Details

    1997

    Czosnyka M, Czosnyka Z, Pickard JD (1997), “Laboratory testing of the Spiegelberg brain pressure monitor: a technical report.” J Neurol Neurosurg Psychiatry 63(6):732-5 Details

    Czosnyka M, Czosnyka Z, Whitehouse H, Pickard JD (1997), “Hydrodynamic properties of hydrocephalus shunts: United Kingdom Shunt Evaluation Laboratory.” J Neurol Neurosurg Psychiatry 62(1):43-50 Details

    Czosnyka M, Piechnik S, Richards HK, Kirkpatrick P, Smielewski P, Pickard JD (1997), “Contribution of mathematical modelling to the interpretation of bedside tests of cerebrovascular autoregulation.” J Neurol Neurosurg Psychiatry 63(6):721-31 Details

    Czosnyka M, Smielewski P, Kirkpatrick P, Laing RJ, Menon D, Pickard JD (1997), “Continuous assessment of the cerebral vasomotor reactivity in head injury.” Neurosurgery 41(1):11-7; discussion 17-9 Details

    Gupta AK, Menon DK, Czosnyka M, Smielewski P, Jones JG (1997), “Thresholds for hypoxic cerebral vasodilation in volunteers.” Anesth Analg 85(4):817-20 Details

    Gupta AK, Menon DK, Czosnyka M, Smielewski P, Kirkpatrick PJ, Jones JG (1997), “Non-invasive measurement of cerebral blood volume in volunteers.” Br J Anaesth 78(1):39-43 Details

    Richards HK, Kozniewska E, Czosnyka M, Pickard JD (1997), “Changes in transcranial Doppler flow velocity waveform following inhibition of nitric oxide synthesis. Experimental study in anaesthetised rabbits.” Acta Neurochir (Wien) 139(1):63-9; discussion 69-70 Details

    Smielewski P, Czosnyka M, Kirkpatrick P, Pickard JD (1997), “Evaluation of the transient hyperemic response test in head-injured patients.” J Neurosurg 86(5):773-8 Details

    Smielewski P, Czosnyka M, Pickard JD, Kirkpatrick P (1997), “Clinical evaluation of near-infrared spectroscopy for testing cerebrovascular reactivity in patients with carotid artery disease.” Stroke 28(2):331-8 Details

    Smielewski P, Czosnyka M, Zabolotny W, Kirkpatrick P, Richards H, Pickard JD (1997), “A computing system for the clinical and experimental investigation of cerebrovascular reactivity.” Int J Clin Monit Comput 14(3):185-98 Details

    1996

    Czosnyka M, Czosnyka Z, Pickard JD (1996), “Laboratory testing of three intracranial pressure microtransducers: technical report.” Neurosurgery 38(1):219-24 Details

    Czosnyka M, Guazzo E, Whitehouse M, Smielewski P, Czosnyka Z, Kirkpatrick P, Piechnik S, Pickard JD (1996), “Significance of intracranial pressure waveform analysis after head injury.” Acta Neurochir (Wien) 138(5):531-41; discussion 541-2 Details

    Czosnyka M, Harland S, Piechnik S, Kirkpatrick P, Czosnyka Z, Menon D (1996), “Systematic overestimation of intracranial pressure measured using a Camino pressure monitor.” J Neurol Neurosurg Psychiatry 61(4):427-8 Details

    Czosnyka M, Kirkpatrick PJ, Pickard JD (1996), “Multimodal monitoring and assessment of cerebral haemodynamic reserve after severe head injury.” Cerebrovasc Brain Metab Rev 8(4):273-95 Details

    Czosnyka M, Richards HK, Whitehouse HE, Pickard JD (1996), “Relationship between transcranial Doppler-determined pulsatility index and cerebrovascular resistance: an experimental study.” J Neurosurg 84(1):79-84 Details

    Czosnyka M, Smielewski P, Kirkpatrick P, Menon DK, Pickard JD (1996), “Monitoring of cerebral autoregulation in head-injured patients.” Stroke 27(10):1829-34 Details

    Czosnyka M, Whitehouse H, Smielewski P, Simac S, Pickard JD (1996), “Testing of cerebrospinal compensatory reserve in shunted and non-shunted patients: a guide to interpretation based on an observational study.” J Neurol Neurosurg Psychiatry 60(5):549-58 Details

    Kirkpatrick PJ, Czosnyka M, Pickard JD (1996), “Multimodal monitoring in neurointensive care.” J Neurol Neurosurg Psychiatry 60(2):131-9 Details

    Kirkpatrick PJ, Smielewski P, Piechnik S, Pickard JD, Czosnyka M (1996), “Early effects of mannitol in patients with head injuries assessed using bedside multimodality monitoring.” Neurosurgery 39(4):714-20; discussion 720-1 Details

    Smielewski P, Czosnyka M, Kirkpatrick P, McEroy H, Rutkowska H, Pickard JD (1996), “Assessment of cerebral autoregulation using carotid artery compression.” Stroke 27(12):2197-203 Details

    Smielewski P, Kirkpatrick PJ, Richards H, Pickard JD, Czosnyka M (1996), “A feedback-controlled pump produces stable hypotension in anaesthetised rabbits.” J Cereb Blood Flow Metab 16(3):532-6 Details

    1995

    Kirkpatrick PJ, Smielewski P, Czosnyka M, Menon DK, Pickard JD (1995), “Near-infrared spectroscopy use in patients with head injury.” J Neurosurg 83(6):963-70 Details

    Kirkpatrick PJ, Smielewski P, Whitfield PC, Czosnyka M, Menon D, Pickard JD (1995), “An observational study of near-infrared spectroscopy during carotid endarterectomy.” J Neurosurg 82(5):756-63 Details

    Richards HK, Czosnyka M, Kirkpatrick PJ, Pickard JD (1995), “Estimation of laser-Doppler flux biological zero using basilar artery flow velocity in the rabbit.” Am J Physiol 268(1 Pt 2):H213-7 Details

    Smielewski P, Czosnyka M, Iyer V, Piechnik S, Whitehouse H, Pickard J (1995), “Computerised transient hyperaemic response test--a method for the assessment of cerebral autoregulation.” Ultrasound Med Biol 21(5):599-611 Details

    Smielewski P, Czosnyka M, Roszkowski M, Walencik A (1995), “Identification of the cerebrospinal compensatory mechanisms via computer-controlled drainage of the cerebrospinal fluid.” Childs Nerv Syst 11(5):297-300 Details

    Smielewski P, Kirkpatrick P, Minhas P, Pickard JD, Czosnyka M (1995), “Can cerebrovascular reactivity be measured with near-infrared spectroscopy?” Stroke 26(12):2285-92 Details

    Zabolotny W, Czosnyka M, Walencik A (1995), “Cerebrospinal fluid pulse pressure waveform analysis in hydrocephalic children.” Childs Nerv Syst 11(7):397-9 Details

    1994

    Berdyga J, Czernicki Z, Czosnyka M (1994), “[Evaluation of intracranial volume compensation analyzing changes of harmonic components of intracranial pressure pulse wave].” Neurol Neurochir Pol 28(2):195-9 Details

    Czosnyka M, Guazzo E, Iyer V, Kirkpatrick P, Smielewski P, Whitehouse H, Pickard JD (1994), “Testing of cerebral autoregulation in head injury by waveform analysis of blood flow velocity and cerebral perfusion pressure.” Acta Neurochir Suppl (Wien) 60:468-71 Details

    Czosnyka M, Price DJ, Williamson M (1994), “Monitoring of cerebrospinal dynamics using continuous analysis of intracranial pressure and cerebral perfusion pressure in head injury.” Acta Neurochir (Wien) 126(2-4):113-9 Details

    Czosnyka M, Richards H, Kirkpatrick P, Pickard J (1994), “Assessment of cerebral autoregulation with ultrasound and laser Doppler wave forms--an experimental study in anesthetized rabbits.” Neurosurgery 35(2):287-92; discussion 292-3 Details

    Czosnyka M, Richards H, Pickard JD, Harris N, Iyer V (1994), “Frequency-dependent properties of cerebral blood transport--an experimental study in anaesthetized rabbits.” Ultrasound Med Biol 20(4):391-9 Details

    Czosnyka M, Whitehouse H, Smielewski P, Kirkpatrick P, Guazzo EP, Pickard JD (1994), “Computer supported multimodal bed-side monitoring for neuro intensive care.” Int J Clin Monit Comput 11(4):223-32 Details

    Kirkpatrick PJ, Smielewski P, Czosnyka M, Pickard JD (1994), “Continuous monitoring of cortical perfusion by laser Doppler flowmetry in ventilated patients with head injury.” J Neurol Neurosurg Psychiatry 57(11):1382-8 Details

    Whitehouse HE, Czosnyka M, Pickard JD (1994), “Shunt audit: a computerized method for testing the performance characteristics of CSF shunts in vitro.” Childs Nerv Syst 10(3):158-61 Details

    1993

    Czosnyka M, Batorski L, Roszkowski M, Tomaszewski J, Wocjan J, Walencik A, Zabolotny W (1993), “Cerebrospinal compensation in hydrocephalic children.” Childs Nerv Syst 9(1):17-22 Details

    Czosnyka M, Harris NG, Pickard JD, Piechnik S (1993), “CO2 cerebrovascular reactivity as a function of perfusion pressure--a modelling study.” Acta Neurochir (Wien) 121(3-4):159-65 Details

    Pickard JD, Czosnyka M (1993), “Management of raised intracranial pressure.” J Neurol Neurosurg Psychiatry 56(8):845-58 Details

    1992

    Børgesen SE, Albeck MJ, Gjerris F, Czosnyka M, Laniewski P (1992), “Computerized infusion test compared to steady pressure constant infusion test in measurement of resistance to CSF outflow.” Acta Neurochir (Wien) 119(1-4):12-6 Details

    Czosnyka M, Pickard J, Whitehouse H, Piechnik S (1992), “The hyperaemic response to a transient reduction in cerebral perfusion pressure. A modelling study.” Acta Neurochir (Wien) 115(3-4):90-7 Details

    Nelson RJ, Czosnyka M, Pickard JD, Maksymowicz W, Perry S, Martin JL, Lovick AH (1992), “Experimental aspects of cerebrospinal hemodynamics: the relationship between blood flow velocity waveform and cerebral autoregulation.” Neurosurgery 31(4):705-9; discussion 709-10 Details

    1990

    Czosnyka M, Batorski L, Laniewski P, Maksymowicz W, Koszewski W, Zaworski W (1990), “A computer system for the identification of the cerebrospinal compensatory model.” Acta Neurochir (Wien) 105(3-4):112-6 Details

    Czosnyka M, Maksymowicz W, Batorski L, Koszewski W, Czosnyka Z (1990), “Comparison between classic-differential and automatic shunt functioning on the basis of infusion tests.” Acta Neurochir (Wien) 106(1-2):1-8 Details

    Tychmanowicz K, Czernicki Z, Czosnyka M, Pawłowski G, Uchman G (1990), “Early pathomorphological changes and intracranial volume-pressure: relations following the experimental sagittal sinus occlusion.” Acta Neurochir Suppl (Wien) 51:233-5 Details

    Wocjan J, Batorski L, Roszkowski M, Tomaszewski J, Czosnyka M, Pawłowski G, Wołłk-Laniewski P (1990), “[Characteristics of intracranial volume-pressure relationship in hydrocephalic children with reference to age].” Neurol Neurochir Pol 24(5-6):303-8 Details

    1989

    Maksymowicz W, Czosnyka M, Koszewski W, Szymanska A, Traczewski W (1989), “The role of cerebrospinal compensatory parameters in the estimation of functioning of implanted shunt system in patients with communicating hydrocephalus (preliminary report).” Acta Neurochir (Wien) 101(3-4):112-6 Details

    1988

    Czosnyka M, Wollk-Laniewski P, Batorski L, Zaworski W (1988), “Analysis of intracranial pressure waveform during infusion test.” Acta Neurochir (Wien) 93(3-4):140-5 Details