Dr Martina Di Simplicio


I am psychiatrist and CBT therapist working in the Emotional Disorders and Mental Imagery group (Holmes). The focus of my research is to investigate how different cognitive styles and emotional responses can play a role in the development of emotional disorders, such as bipolar disorder. I am interested in how this can inform our better treatment, whether via medication or talking therapies.

Research Focus


Mental Imagery

Bipolar disorder

Emotion processing biases


Treatment development

Clinical conditions

Bipolar disorder

Depressive disorders


Electrophysiological recording techniques

Magnetic resonance imaging (MRI)

Neuropsychological testing


No collaborators listed

Associated News Items



    Di Simplicio M, Doallo S, Costoloni G, Rohenkohl G, Christina Nobre A, Harmer CJ (2014), “"Can you look me in the Face?" Short-Term SSRI Administration Reverts Avoidant Ocular Face Exploration in Subjects at Risk for Psychopathology.” Neuropsychopharmacology Details

    Di Simplicio M, Norbury R, Reinecke A, Harmer CJ (2014), “Paradoxical effects of short-term antidepressant treatment in fMRI emotional processing models in volunteers with high neuroticism.” Psychol Med 44(2):241-52 Details

    Freeman D, Dunn G, Murray RM, Evans N, Lister R, Antley A, Slater M, Godlewska B, Cornish R, Williams J, Di Simplicio M, Igoumenou A, Brenneisen R, Tunbridge EM, Harrison PJ, Harmer CJ, Cowen P, Morrison PD (2014), “How Cannabis Causes Paranoia: Using the Intravenous Administration of ∆9-Tetrahydrocannabinol (THC) to Identify Key Cognitive Mechanisms Leading to Paranoia.” Schizophr Bull Details

    Ivins A, Di Simplicio M, Close H, Goodwin GM, Holmes E (2014), “Mental imagery in bipolar affective disorder versus unipolar depression: Investigating cognitions at times of 'positive' mood.” J Affect Disord 166:234-42 Details


    Di Simplicio M, Costoloni G, Western D, Hanson B, Taggart P, Harmer CJ (2012), “Decreased heart rate variability during emotion regulation in subjects at risk for psychopathology.” Psychol Med 42(8):1775-83 Details

    Di Simplicio M, McInerney JE, Goodwin GM, Attenburrow MJ, Holmes EA (2012), “Revealing the mind's eye: bringing (mental) images into psychiatry.” Am J Psychiatry 169(12):1245-6 Details

    Di Simplicio M, Norbury R, Harmer CJ (2012), “Short-term antidepressant administration reduces negative self-referential processing in the medial prefrontal cortex in subjects at risk for depression.” Mol Psychiatry 17(5):503-10 Details

    Horder J, Browning M, Di Simplicio M, Cowen PJ, Harmer CJ (2012), “Effects of 7 days of treatment with the cannabinoid type 1 receptor antagonist, rimonabant, on emotional processing.” J Psychopharmacol 26(1):125-32 Details


    Serretti A, Calati R, Goracci A, Di Simplicio M, Castrogiovanni P, De Ronchi D (2010), “Antidepressants in healthy subjects: what are the psychotropic/psychological effects?” Eur Neuropsychopharmacol 20(7):433-53 Details


    Di Simplicio M, Massey-Chase R, Cowen PJ, Harmer CJ (2009), “Oxytocin enhances processing of positive versus negative emotional information in healthy male volunteers.” J Psychopharmacol 23(3):241-8 Details

    Horder J, Cowen PJ, Di Simplicio M, Browning M, Harmer CJ (2009), “Acute administration of the cannabinoid CB1 antagonist rimonabant impairs positive affective memory in healthy volunteers.” Psychopharmacology (Berl) 205(1):85-91 Details