Dr Maria Angeles Fernandez

University position

Research Associate

Departments

Department of Medical Genetics

Institutes

ARUK - Drug Discovery Institute http://cambridge-ddi.alzheimersresearchuk.org/

Email

maf62@medschl.cam.ac.uk

Home page

https://es.linkedin.com/in/mari... (personal home page)

Research Theme

Cellular and Molecular Neuroscience

Interests

My main interest is the study of signalling pathways and molecular mechanisms involved in neurodegenerative diseases like Alzheimer's and Huntington's disease, and its use as a target for the possible therapy of these diseases.

Actually, my research is focused in the study of autophagy as a therapeutic tool for the treatment of disorders associated with protein accumulation.

Research Focus

Keywords

Dementia

Autophagy

Neurodegenerative DIseases

Drug Discovery

Signalling Pathways

Clinical conditions

Alzheimer's disease

Dementia

Huntington's disease

Parkinson's disease

Equipment

Cell culture

Confocal microscopy

Fluorescence microscopy

Immunohistochemistry

Microscopy

Protein purification

Recombinant protein expression

Collaborators

Cambridge

David Rubinsztein

Associated News Items


    Key publications

    MA Mena, J Perucho, M Fernandez-Estevez and J García de Yebenes (2015), “Autophagy pathways in Huntginton´s Disease” Toxicity and autophagy in neurodenegenerative disorders. Current topics in neurotoxicity. Springer International Publishing. pp. 79-89

    M. Fernandez-Estevez, M.J. Casarejos, J.L. Sendon, J.G. Caldentey, C. Ruiz, A. Gomez, J. Perucho, J.G.de Yebenes, M.A. Mena. (2014), “Trehalose Reverses Cell Malfunction in Fibroblasts from Normal and Huntington's Disease Patients Caused by Proteosome Inhibition” Plos ONE 25;9(2)

    Perucho J., Casarejos M.J., Gómez A., Ruíz C., Fernández-Estévez M., Muñoz M.P., García de Yébenes J., Mena M.A (2013), “Striatal Infusion of Glial Conditioned Medium Diminishes Huntingtin Pathology in R6/1 Mice” Plos ONE 12;8(9)

    Publications

    2013

    Casararejos MJ, Perucho J, Gomez A, Muñoz MP, Fernandez-Estevez M, Sagredo O, Fernandez Ruiz J, Guzman M, Garcia de Yebenes J and Mena M A. (2013), “Natural Cannabinoids Improve Dopamine Neurotransmission and Tau and Amyloid Pathology in a Mouse Model of Tauopathy” J Alzheimer Dis 35(3):525-39