Dr Lu Li

Lu Li

University position

Research Associate

Dr Lu Li is pleased to consider applications from prospective PhD students.

Departments

Computer Laboratory

Institutes

Babraham Institute

Email

lu.li@babraham.ac.uk

Home page

http://www.ebi.ac.uk/compneu...

Research Themes

Systems and Computational Neuroscience

Cellular and Molecular Neuroscience

Interests

Drug induced neuroadaptation, which underlines the long-lasting changes in brains and behaviour, relies not only on chemical adaptations but also on the morphological alterations of neurons and modifications of synaptic connections. The repeated administration of drugs causes dopamine to project predominantly to the striatum, where dopamine afferents and glutamate afferents from the cerebral cortex converge. Thus, it is most likely that dopamine produces various neurological effects through mediating glutamate transmission. I am interested in revealing possible roles of glutamatergic and dopaminergic integration in reward and neuroadaptation by computational modelling approaches. A quantitative multi-compartment model based on dentritic spine of the striatum is under construction, including detailed interacting signalling events which lead to spine functions.

Computational model of DARP-32 regulation. An empty-arrow means “stimulation”;  a filled-arrow represents “yield”; an empty circle means “catalysis”; a bar-ending arrow indicates “inhibition”; a square on the edge represents a “process”.
Computational model of DARP-32 regulation in the striatum. An empty-arrow means “stimulation”; a filled-arrow represents “yield”; an empty circle means “catalysis”; a bar-ending arrow indicates “inhibition”; a square on the edge represents a “process”.
Click image to view full-size

Research Focus

Keywords

neuroadaptation

drugs of abuse

dopamine

glutamate

DARPP-32

Clinical conditions

Addiction

Alzheimer's disease

Equipment

Computational modelling

Collaborators

International

Liliana Minichiello Web: http://www-db.embl.de/jss/Emb...

Associated News Items


    Publications

    2012

    Li L, Stefan MI, Le Novère N (2012), “Calcium input frequency, duration and amplitude differentially modulate the relative activation of calcineurin and CaMKII.” PLoS One 7(9):e43810 Details

    2010

    Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010), “BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models.” BMC Syst Biol 4:92 Details

    2009

    Le Novère N, Hucka M, Mi H, Moodie S, Schreiber F, Sorokin A, Demir E, Wegner K, Aladjem MI, Wimalaratne SM, Bergman FT, Gauges R, Ghazal P, Kawaji H, Li L, Matsuoka Y, Villéger A, Boyd SE, Calzone L, Courtot M, Dogrusoz U, Freeman TC, Funahashi A, Ghosh S, Jouraku A, Kim S, Kolpakov F, Luna A, Sahle S, Schmidt E, Watterson S, Wu G, Goryanin I, Kell DB, Sander C, Sauro H, Snoep JL, Kohn K, Kitano H (2009), “The Systems Biology Graphical Notation.” Nat Biotechnol 27(8):735-41 Details

    2008

    Le Novère N, Li L, Girault JA (2008), “DARPP-32: molecular integration of phosphorylation potential.” Cell Mol Life Sci 65(14):2125-7 Details

    2006

    Le Novère N, Bornstein B, Broicher A, Courtot M, Donizelli M, Dharuri H, Li L, Sauro H, Schilstra M, Shapiro B, Snoep JL, Hucka M (2006), “BioModels Database: a free, centralized database of curated, published, quantitative kinetic models of biochemical and cellular systems.” Nucleic Acids Res 34(Database issue):D689-91 Details

    Schilstra MJ, Li L, Matthews J, Finney A, Hucka M, Le Novère N (2006), “CellML2SBML: conversion of CellML into SBML.” Bioinformatics 22(8):1018-20 Details