Dr Lu Li
Dr Lu Li is pleased to consider applications from prospective PhD students.
Drug induced neuroadaptation, which underlines the long-lasting changes in brains and behaviour, relies not only on chemical adaptations but also on the morphological alterations of neurons and modifications of synaptic connections. The repeated administration of drugs causes dopamine to project predominantly to the striatum, where dopamine afferents and glutamate afferents from the cerebral cortex converge. Thus, it is most likely that dopamine produces various neurological effects through mediating glutamate transmission. I am interested in revealing possible roles of glutamatergic and dopaminergic integration in reward and neuroadaptation by computational modelling approaches. A quantitative multi-compartment model based on dentritic spine of the striatum is under construction, including detailed interacting signalling events which lead to spine functions.
Associated News Items
Li L, Stefan MI, Le Novère N (2012), “Calcium input frequency, duration and amplitude differentially modulate the relative activation of calcineurin and CaMKII.” PLoS One 7(9):e43810 Details
Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010), “BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models.” BMC Syst Biol 4:92 Details
Le Novère N, Hucka M, Mi H, Moodie S, Schreiber F, Sorokin A, Demir E, Wegner K, Aladjem MI, Wimalaratne SM, Bergman FT, Gauges R, Ghazal P, Kawaji H, Li L, Matsuoka Y, Villéger A, Boyd SE, Calzone L, Courtot M, Dogrusoz U, Freeman TC, Funahashi A, Ghosh S, Jouraku A, Kim S, Kolpakov F, Luna A, Sahle S, Schmidt E, Watterson S, Wu G, Goryanin I, Kell DB, Sander C, Sauro H, Snoep JL, Kohn K, Kitano H (2009), “The Systems Biology Graphical Notation.” Nat Biotechnol 27(8):735-41 Details
Le Novère N, Li L, Girault JA (2008), “DARPP-32: molecular integration of phosphorylation potential.” Cell Mol Life Sci 65(14):2125-7 Details
Le Novère N, Bornstein B, Broicher A, Courtot M, Donizelli M, Dharuri H, Li L, Sauro H, Schilstra M, Shapiro B, Snoep JL, Hucka M (2006), “BioModels Database: a free, centralized database of curated, published, quantitative kinetic models of biochemical and cellular systems.” Nucleic Acids Res 34(Database issue):D689-91 Details
Schilstra MJ, Li L, Matthews J, Finney A, Hucka M, Le Novère N (2006), “CellML2SBML: conversion of CellML into SBML.” Bioinformatics 22(8):1018-20 Details