Dr Rick Livesey
Dr Rick Livesey is pleased to consider applications from prospective PhD students.
http://www.gurdon.cam.ac.uk/~livese... (personal home page)
A fundamental question in neural stem cell biology is how distinct classes of neurons are generated at specific places and times in the nervous system in order for them to be incorporated correctly into neuronal circuits. We study this question in the mammal-specific region of the forebrain, the neocortex. Neurons in the cortex are organized in two ways: they belong to one of six layers of neurons, each of which is generated in a stereotyped order, and they belong to a discrete piece or area of the cortex that is dedicated to a single function such as visual processing or motor control. The majority of the research in the lab centers on the biology of neocortical stem cells and in particular how neocortical stem cells produce layer-specific neurons in order (the timing problem) and for the correct area (the patterning problem). The lab is also studying some of the clinical consequences of our research, particularly in the aetiology and pathogenesis of autistic spectrum conditions.
Neocortical explant culture
John Rubenstein Web: http://www.ucsf.edu/jlrrlab/
Michele Studer Web: http://www.tigem.it/researc...
Subkhankulova T, Livesey FJ (2006), “Comparative evaluation of linear and exponential amplification techniques for expression profiling at the single cell level” Genome Biol 7:R18 Details
Sansom SN, Hebert JM, Thammongkol U, Smith J, Nisbet G, Surani MA, McConnell SK, Livesey FJ (2005), “Genomic characterisation of a Fgf-regulated gradient-based neocortical protomap” Development 132:3947-61 Details
Livesey FJ, Young TL, Cepko CL (2004), “An analysis of the gene expression program of mammalian neural progenitor cells” Proc Natl Acad Sci U S A 101:1374-9 Details