Dr Laura Hughes
University position
Research Associate
Departments
Department of Clinical Neurosciences
Institutes
MRC Cognition and Brain Sciences Unit and Neurology Unit
Home page
http://www.mrc-cbu.cam.ac.uk/people/...
Research Theme
Interests
My current research interests are on the role of the prefrontal cortex for voluntary and goal directed actions, and prefrontal interactions with other brain systems. I use both MEG and fMRI, along with behavioural and neuropsychological data, to investigate healthy adults and patients with neurodegenerative diseases (such as Parkinson's disease and frontotemporal dementia) and patients with brain lesions (for example due to tumors or stroke). I collaborate with James Rowe and our aim is to understand the cortical networks of the intact brain and to assess changes related to disease.
Research Focus
Keywordsfrontotemporal dementia Parkinson's disease prefrontal fMRI MEG |
Clinical conditionsDementia Parkinson's disease |
Equipment
Electroencephalography (EEG)
Magnetic resonance imaging (MRI)
MEG
Collaborators
Cambridge |
Publications
2011
Hughes LE, Nestor PJ, Hodges JR, Rowe JB (2011), “Magnetoencephalography of frontotemporal dementia: spatiotemporally localized changes during semantic decisions.” Brain 134(Pt 9):2513-22 Details
Perneczky R, Ghosh BC, Hughes L, Carpenter RH, Barker RA, Rowe JB (2011), “Saccadic latency in Parkinson's disease correlates with executive function and brain atrophy, but not motor severity.” Neurobiol Dis 43(1):79-85 Details
2010
Hughes LE, Barker RA, Owen AM, Rowe JB (2010), “Parkinson's disease and healthy aging: Independent and interacting effects on action selection.” Hum Brain Mapp Details
Rossell SL, Batty RA, Hughes L (2010), “Impaired semantic memory in the formation and maintenance of delusions post-traumatic brain injury: a new cognitive model of delusions.” Eur Arch Psychiatry Clin Neurosci Details
Rowe JB, Hughes L, Nimmo-Smith I (2010), “Action selection: a race model for selected and non-selected actions distinguishes the contribution of premotor and prefrontal areas.” Neuroimage 51(2):888-96 Details
Rowe JB, Hughes LE, Barker RA, Owen AM (2010), “Dynamic causal modelling of effective connectivity from fMRI: are results reproducible and sensitive to Parkinson's disease and its treatment?” Neuroimage 52(3):1015-26 Details
2008
Hughes LE, Bates TC, Aimola Davies AM (2008), “Dissociations in rod bisection: the effect of viewing conditions on perception and action.” Cortex 44(9):1279-87 Details
Rowe J, Hughes L, Eckstein D, Owen AM (2008), “Rule-selection and action-selection have a shared neuroanatomical basis in the human prefrontal and parietal cortex.” Cereb Cortex 18(10):2275-85 Details
Rowe JB, Hughes L, Ghosh BC, Eckstein D, Williams-Gray CH, Fallon S, Barker RA, Owen AM (2008), “Parkinson's disease and dopaminergic therapy--differential effects on movement, reward and cognition.” Brain 131(Pt 8):2094-105 Details
Rowe JB, Hughes L, Williams-Gray CH, Bishop S, Fallon S, Barker RA, Owen AM (2008), “The val(158)met COMT polymorphism's effect on atrophy in healthy aging and Parkinson's disease.” Neurobiol Aging Details
2005
Hughes LE, Bates TC, Aimola Davies AM (2005), “The effects of local and global processing demands on perception and action.” Brain Cogn 59(1):71-81 Details
2004
Hughes LE, Bates TC, Aimola Davies A (2004), “Grasping at sticks: pseudoneglect for perception but not action.” Exp Brain Res 157(3):397-402 Details
2002
Hughes LE, Wilkins AJ (2002), “Reading at a distance: implications for the design of text in children's big books.” Br J Educ Psychol 72(Pt 2):213-26 Details
2000
Hughes L and Wilkins A (2000), “Typography in children’s reading schemes may be suboptimal: evidence from measures of reading rate” Journal of Research in Reading 23, 3, 314-324
Research and Collaboration
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