Dr Lei Feng

University position

Visiting Researcher


Department of Psychiatry


Brain Mapping Unit



Home page

http://dietandmentalhealth.blogspot.c... (personal home page)

Research Themes

Cognitive and Behavioural Neuroscience

Developmental Neuroscience


Psychiatric-Neuroimaging Research on Autism Spectrum Disorders

Population-based cohort studies on dementia, cognitive decline and late-life depression

Systematic review and meta-analysis on the epidemiology and novel treatments of psychiatric diseases

I am particularly interested in the role of nutritional and dietary factors in promoting brain function and mental health.

My blog on diet and mental health: http://dietandmentalhealth.blogspot.co.uk

Research Focus







Clinical conditions

Alzheimer's disease


Depressive disorders


Cross-sectional and cohort studies

Magnetic resonance imaging (MRI)

Neuropsychological testing

Randomised control trials



John Suckling

United Kingdom

Michael Spencer Web: http://www.linkedin.com/in/mdsp...


Chengxuan Qiu Web: http://ki-su-arc.se/about-u...

Yi Zeng Web: http://sociology.duke.edu/people?...

Associated News Items

    Key publications

    Feng L, Wong JCM, Mahendran R, Chan ESY, Spencer MD (2014), “Intranasal oxytocin for autism spectrum disorders (ASD) (Protocol)” Cochrane Database of Systematic Review 2014, Issue 1. Art.No.: CD010928. DOI: 10.1002/14651858. CD010928

    Feng L, Isaac V, Sim S, Ng TP, Krishnan KR, Chee MW (2013), “Associations between elevated homocysteine, cognitive impairment, and reduced white matter volume in healthy old adults.” Am J Geriatr Psychiatry 21(2):164-72 Details

    Feng L, Yan Z, Sun B, Cai C, Jiang H, Kua EH, Ng TP, Qiu C (2013), “Tea consumption and depressive symptoms in older people in rural China.” J Am Geriatr Soc 61(11):1943-7 Details

    Feng L, Li J, Yap KB, Kua EH, Ng TP (2009), “Vitamin B-12, apolipoprotein E genotype, and cognitive performance in community-living older adults: evidence of a gene-micronutrient interaction.” Am J Clin Nutr 89(4):1263-8 Details

    Feng L, Ng TP, Chuah L, Niti M, Kua EH (2006), “Homocysteine, folate, and vitamin B-12 and cognitive performance in older Chinese adults: findings from the Singapore Longitudinal Ageing Study.” Am J Clin Nutr 84(6):1506-12 Details



    Feng L, Nyunt MS, Feng L, Yap KB, Ng TP (2014), “Frailty predicts new and persistent depressive symptoms among community-dwelling older adults: findings from Singapore longitudinal aging study.” J Am Med Dir Assoc 15(1):76.e7-76.e12 Details


    Chong MS, Goh LK, Lim WS, Chan M, Tay L, Chen G, Feng L, Ng TP, Tan CH, Lee TS (2013), “Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease.” J Alzheimers Dis 34(2):399-405 Details

    Feng L (2013), “Autism in children born after in vitro fertilization.” JAMA 310(19):2100-1 Details

    Feng L, Li C, Chiu H, Lee TS, Spencer MD, Wong JC (2013), “Autism spectrum disorder in Chinese populations: a brief review.” Asia Pac Psychiatry 5(2):54-60 Details

    Lee TS, Goh SJ, Quek SY, Phillips R, Guan C, Cheung YB, Feng L, Teng SS, Wang CC, Chin ZY, Zhang H, Ng TP, Lee J, Keefe R, Krishnan KR (2013), “A brain-computer interface based cognitive training system for healthy elderly: a randomized control pilot study for usability and preliminary efficacy.” PLoS One 8(11):e79419 Details

    Lu Y, Feng L, Feng L, Nyunt MS, Yap KB, Ng TP (2013), “Systemic inflammation, depression and obstructive pulmonary function: a population-based study.” Respir Res 14:53 Details

    Ruan R, Feng L, Li J, Ng TP, Zeng Y (2013), “Tea consumption and mortality in the oldest-old Chinese.” J Am Geriatr Soc 61(11):1937-42 Details

    Wen C, Wang WQ, Ding LJ, Feng L, Wong JC, Kua EH (2013), “Suicidal and help-seeking behavior in Xiamen, south China.” Asia Pac Psychiatry 5(3):168-74 Details


    Feng L (2012), “Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline.” Am J Clin Nutr 95(5):1289-90; author reply 1290 Details

    Feng L, Chong MS, Lim WS, Ng TP (2012), “The Modified Mini-Mental State Examination test: normative data for Singapore Chinese older adults and its performance in detecting early cognitive impairment.” Singapore Med J 53(7):458-62 Details

    Feng L, Li J, Kua EH, Lee TS, Yap KB, John Rush A, Ng TP (2012), “Association between tea consumption and depressive symptoms in older Chinese adults.” J Am Geriatr Soc 60(12):2358-60 Details

    Feng L, Li J, Ng TP, Lee TS, Kua EH, Zeng Y (2012), “Tea drinking and cognitive function in oldest-old Chinese.” J Nutr Health Aging 16(9):754-8 Details

    Lee CK, Collinson SL, Feng L, Ng TP (2012), “Preliminary normative neuropsychological data for an elderly chinese population.” Clin Neuropsychol 26(2):321-34 Details

    Lee TS, Goh L, Chong MS, Chua SM, Chen GB, Feng L, Lim WS, Chan M, Ng TP, Krishnan KR (2012), “Downregulation of TOMM40 expression in the blood of Alzheimer disease subjects compared with matched controls.” J Psychiatr Res 46(6):828-30 Details

    Lu Y, Nyunt MS, Gwee X, Feng L, Feng L, Kua EH, Kumar R, Ng TP (2012), “Life event stress and chronic obstructive pulmonary disease (COPD): associations with mental well-being and quality of life in a population-based study.” BMJ Open 2(6) Details

    Ng TP, Aung KC, Feng L, Scherer SC, Yap KB (2012), “Homocysteine, folate, vitamin B-12, and physical function in older adults: cross-sectional findings from the Singapore Longitudinal Ageing Study.” Am J Clin Nutr 96(6):1362-8 Details

    Song J, Xu H, Liu F, Feng L (2012), “Tea and cognitive health in late life: current evidence and future directions.” J Nutr Health Aging 16(1):31-4 Details


    Aung KC, Feng L, Yap KB, Sitoh YY, Leong IY, Ng TP (2011), “Serum albumin and hemoglobin are associated with physical function in community-living older persons in Singapore.” J Nutr Health Aging 15(10):877-82 Details

    Feng L, Ng TP, He Y, Li C, Kua EH, Zhang M (2011), “Physical Health and Cognitive Function Independently Contributed to Functional Disability among Chinese Older Adults: Data from Two Asian Metropolises.” J Aging Res 2011:960848 Details

    Gao Q, Niti M, Feng L, Yap KB, Ng TP (2011), “Omega-3 polyunsaturated fatty acid supplements and cognitive decline: Singapore Longitudinal Aging Studies.” J Nutr Health Aging 15(1):32-5 Details


    Chong MS, Lim WS, Chan SP, Feng L, Niti M, Yap P, Yeo D, Ng TP (2010), “Diagnostic performance of the Chinese Frontal Assessment Battery in early cognitive impairment in an Asian population.” Dement Geriatr Cogn Disord 30(6):525-32 Details

    Feng L (2010), “Ginkgo biloba and cognitive decline.” JAMA 303(15):1477; author reply 1477-8 Details

    Feng L, Gwee X, Kua EH, Ng TP (2010), “Cognitive function and tea consumption in community dwelling older Chinese in Singapore.” J Nutr Health Aging 14(6):433-8 Details

    Li X, Zhang Y, Feng L, Meng Q (2010), “Early event-related potentials changes during simple mental calculation in Chinese older adults with mild cognitive impairment: A case-control study.” Neurosci Lett 475(1):29-32 Details

    Lim ML, Collinson SL, Feng L, Ng TP (2010), “Cross-cultural application of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): performances of elderly Chinese Singaporeans.” Clin Neuropsychol 24(5):811-26 Details

    Lu C, Li J, Sun W, Feng L, Li L, Liu A, Li J, Mao W, Wei H, Gao L, Zhang X, Huang Z, Meng X, Wang Y (2010), “Elevated plasma S100B concentration is associated with mesial temporal lobe epilepsy in Han Chinese: a case-control study.” Neurosci Lett 484(2):139-42 Details


    Ng TP, Feng L, Niti M, Kua EH, Yap KB (2009), “Folate, vitamin B12, homocysteine, and depressive symptoms in a population sample of older Chinese adults.” J Am Geriatr Soc 57(5):871-6 Details

    Ng TP, Niti M, Feng L, Kua EH, Yap KB (2009), “Albumin, apolipoprotein E-epsilon4 and cognitive decline in community-dwelling Chinese older adults.” J Am Geriatr Soc 57(1):101-6 Details


    Ng TP, Feng L, Niti M, Kua EH, Yap KB (2008), “Tea consumption and cognitive impairment and decline in older Chinese adults.” Am J Clin Nutr 88(1):224-31 Details

    Ng TP, Feng L, Niti M, Yap KB (2008), “Albumin, haemoglobin, BMI and cognitive performance in older adults.” Age Ageing 37(4):423-9 Details