Dr Nicolas Le Novere
University position
Group leader
Dr Nicolas Le Novere is pleased to consider applications from prospective PhD students.
Institutes
European Bioinformatics Institute
Home page
http://www.ebi.ac.uk/compneu... (personal home page)
Research Themes
Interests
My scientific interests revolve around signal transduction in neurons, ranging from the molecular structure of membrane proteins involved in neurotransmission to modelling signalling pathways. A strong focus is the molecular and cellular basis of neuroadaptation in neurons of the basal ganglia. I also develop standards and services, including ontologies, database and simulation software for computational systems biology.
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Research Focus
Keywordssynaptic plasticity systems biology modelling SBML neural circuit |
Clinical conditionsAddiction Parkinson's disease Schizophrenia |
Equipment
Computational modelling
Collaborators
United KingdomDouglas Kell Web: http://dbkgroup.org/dbk.htm InternationalJean-Antoine Girault Web: http://ifr-bi.snv.jussieu.fr/unites_... Mike Hucka Web: http://sbml.org Hiroaki Kitano Web: http://www.symbio.jst.go.jp/symbio2... |
Key publications
Fernandez E, Schiappa R, Girault JA, Le Novère N (2006), “DARPP-32 is a robust integrator of dopamine and glutamate signals” PLoS Computational Biology 2(12):e176 Details
Le Novère N, Finney A, Hucka M, Bhalla U, Campagne F, Collado-Vides J, Crampin E, Halstead M, Klipp E, Mendes P, Nielsen P, Sauro H, Shapiro B, Snoep JL, Spence HD, Wanner BL (2005), “Minimum Information Requested In the Annotation of biochemical Models (MIRIAM)” Nature Biotechnology 23:1509-1515 Details
Le Novère N, Grutter T, Changeux J-P (2002), “Models of the extracellular domain of the nicotinic receptors and of agonist and Ca++ binding sites” Proceedings of the National Academy of Sciences USA 99:3210-3215