Dr Leonidas Chouliaras

University position

Clinical Lecturer

Dr Leonidas Chouliaras is pleased to consider applications from prospective PhD students.

Departments

Department of Psychiatry

Email

lc716@medschl.cam.ac.uk

Home page

https://scholar.google.com/citatio... (personal home page)

Research Themes

Cellular and Molecular Neuroscience

Clinical and Veterinary Neuroscience

Interests

My research interests include the role of epigenetic mechanisms in neurodegeneration, and particularly in Lewy Body Dementia, Alzheimer’s disease and mild cognitive impairment.

My projects focus on genome-wide profiling of DNA methylation and hydroxymethylation in post-mortem brain tissues and also in peripheral blood. Exploring disease driven changes in the epigenetic landscape has the potential to improve our understanding of the pathophysiology of neurodegenerative disorders and aid in the identification of novel pathways as therapeutic targets. Work on peripheral epigenetic profiling in combination with multimodal neuroimaging techniques can aid in the development of early risk markers of disease before the onset of any symptoms. 

Research Focus

Keywords

Epigenetics

DNA methylation

DNA hydroxymethylation

cell sorting

Clinical conditions

Alzheimer's disease

Cognitive impairment

Dementia

Lewy Body Dementia

Mild Cognitive Impairment

Equipment

Epigenomics

Genome-wide profiling

Immunohistochemistry

Collaborators

Cambridge

Nikitas Arnaoutoglou

Elijah Mak

John T O'Brien

Li Su

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