Dr Andras Lakatos

Andras Lakatos

University position

Principal Investigator, MRC Clinician Scientist

Dr Andras Lakatos is pleased to consider applications from prospective PhD students.

Departments

Department of Clinical Neurosciences

Institutes

Cambridge Centre for Brain Repair

Email

AL291@cam.ac.uk

Home page

http://www.brc.cam.ac.uk/princip...

Research Themes

Cellular and Molecular Neuroscience

Clinical and Veterinary Neuroscience

Interests

Andras is interested in the adaptive changes in glia-neuron interactions following remote axonal insults, such as axonal degeneration, injury and demyelination. The particular focus is how endogenous cortical/gray matter astrocytes and stem cells responding to such cues would influence synaptic plasticity and neuronal integrity. His work involves a comparative analysis of molecules influencing synaptic maturation and neuronal survival in both animal and co-culture model systems. A more detailed understanding of these mechanisms may provide new alternative neuroprotective therapeutic targets for neurological disorders with a particular relevance to chronic demyelinating diseases, such as multiple sclerosis and also neurodegenerative conditions. He has several collaborations with Cambridge based laboratories and is also keen on progressing towards translational strategies.

Astrocyte-Neuron Interactions
Astrocyte-Neuron Interactions
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Research Focus

Keywords

Axonopathy

Demyelination

Astrocyte Response

Synaptic Plasticity

Neuroprotection

Clinical conditions

Chronic demyelinating diseases (Multiple Sclerosis)

Neurodegenerative diseases (MND/ALS)

Equipment

Calcium imaging

Cell culture

ChIP

Confocal microscopy

Fluorescence microscopy

Immunohistochemistry

In situ hybridisation

In vivo and ex vivo transgenic models

PCR

Protein biochemistry

Collaborators

Cambridge

James Fawcett

Robin Franklin

Ragnhildur Thora Karadottir

United Kingdom

Rickie Patani

Chris Sibley

Associated News Items


    Key publications

    Tyzack GE, Sitnikov S, Barson D, Adams-Carr KL, Lau NK, Kwok JC, Zhao C, Franklin RJ, Karadottir RT, Fawcett JW, Lakatos A (2014), “Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression.” Nat Commun 5:4294 Details

    Lakatos A, Smith PM, Barnett SC, Franklin RJ (2003), “Meningeal cells enhance limited CNS remyelination by transplanted olfactory ensheathing cells.” Brain 126(Pt 3):598-609 Details

    Lakatos A, Franklin RJ, Barnett SC (2000), “Olfactory ensheathing cells and Schwann cells differ in their in vitro interactions with astrocytes.” Glia 32(3):214-25 Details

    Publications

    2016

    Tyzack G, Lakatos A, Patani R (2016), “Human Stem Cell-Derived Astrocytes: Specification and Relevance for Neurological Disorders” Current Stem Cell Reports 1-12

    2014

    Köves K, Kántor O, Lakatos A, Szabó E, Kirilly E, Heinzlmann A, Szabó F (2014), “Advent and recent advances in research on the role of pituitary adenylate cyclase-activating polypeptide (PACAP)” J Mol Neurosci. 54(3):494-511

    Tyzack GE, Sitnikov S, Barson D, Adams-Carr KL, Lau NK, Kwok JC, Zhao C, Franklin RJ, Karadottir RT, Fawcett JW, Lakatos A (2014), “Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression” Nature commun 5:4294

    2006

    Jeffery ND, Smith PM, Lakatos A, Ibanez C, Ito D, Franklin RJ (2006), “Clinical canine spinal cord injury provides an opportunity to examine the issues in translating laboratory techniques into practical therapy.” Spinal Cord 44(10):584-93 Details

    2005

    Jeffery ND, Lakatos A, Franklin RJ (2005), “Autologous olfactory glial cell transplantation is reliable and safe in naturally occurring canine spinal cord injury.” J Neurotrauma 22(11):1282-93 Details

    Skinner AP, Pachnicke S, Lakatos A, Franklin RJ, Jeffery ND (2005), “Nasal and frontal sinus mucosa of the adult dog contain numerous olfactory sensory neurons and ensheathing glia.” Res Vet Sci 78(1):9-15 Details

    2004

    Dunning MD, Lakatos A, Loizou L, Kettunen M, ffrench-Constant C, Brindle KM, Franklin RJ (2004), “Superparamagnetic iron oxide-labeled Schwann cells and olfactory ensheathing cells can be traced in vivo by magnetic resonance imaging and retain functional properties after transplantation into the CNS.” J Neurosci 24(44):9799-810 Details

    2003

    Lakatos A, Barnett SC, Franklin RJ (2003), “Olfactory ensheathing cells induce less host astrocyte response and chondroitin sulphate proteoglycan expression than Schwann cells following transplantation into adult CNS white matter.” Exp Neurol 184(1):237-46 Details

    Lakatos A, Smith PM, Barnett SC, Franklin RJ (2003), “Meningeal cells enhance limited CNS remyelination by transplanted olfactory ensheathing cells.” Brain 126:598-609

    Penderis J, Woodruff RH, Lakatos A, Li WW, Dunning MD, Zhao C, Marchionni M, Franklin RJ (2003), “Increasing local levels of neuregulin (glial growth factor-2) by direct infusion into areas of demyelination does not alter remyelination in the rat CNS.” Eur J Neurosci 18(8):2253-64 Details

    2002

    Lakatos A, Franklin RJ (2002), “Transplant mediated repair of the central nervous system: an imminent solution?” Curr Opin Neurol 15(6):701-5 Details

    Sim FJ, Zhao C, Li WW, Lakatos A, Franklin RJ (2002), “Expression of the POU-domain transcription factors SCIP/Oct-6 and Brn-2 is associated with Schwann cell but not oligodendrocyte remyelination of the CNS.” Mol Cell Neurosci 20(4):669-82 Details

    Smith PM, Lakatos A, Barnett SC, Jeffery ND, Franklin RJ (2002), “Cryopreserved cells isolated from the adult canine olfactory bulb are capable of extensive remyelination following transplantation into the adult rat CNS.” Exp Neurol 176(2):402-6 Details

    2001

    Barnett SC, Thompson RJ, Lakatos A, Pitts J (2001), “Gap junctional communication and connexin expression in cultured olfactory ensheathing cells.” J Neurosci Res 65(6):520-8 Details

    2000

    Lakatos A, Franklin RJ, Barnett SC (2000), “Olfactory ensheathing cells and Schwann cells differ in their in vitro interactions with astrocytes.” Glia 32(3):214-25

    1997

    Köves K, Lakatos A, Somogyvári-Vigh A, Fogel K, Kántor O, Gööz P, Jamali UK, Grandier-Vazeille X, Arimura A (1997), “Effect of the lack of light impulses on the hypothalamic PACAP and C-fos immunoreactivities in rats.” Neurobiology (Bp) 5(3):389-402 Details

    1996

    Köves K, Molnár J, Kántor O, Görcs TJ, Lakatos A, Arimura A (1996), “New aspects of the neuroendocrine role of PACAP.” Ann N Y Acad Sci 805:648-54 Details