Mr Laith Alexander

Laith Alexander

University position

PhD student
Supervised by Professor Angela Roberts, Dr Hannah Clarke

Departments

Department of Physiology, Development and Neuroscience

Research Theme

Cognitive and Behavioural Neuroscience

Interests

My research focuses on the neurobiology of emotion and emotional regulation. In particular, I am interested in how connectivity between prefrontal cortical regions (area 25, 32 and 14) and subcortical structures (hippocampus and amygdala) subserves the regulation of emotional states. Using sophisticated techniques in behavioural psychology, neuropharmacology and cardiovascular monitoring I am attempting to understand how dysfunctions in this circuitry contribute to the core aspects of Major Depressive Disorder: enhanced 'negative' emotion (low mood and anxiety) and reduced 'positive' emotion (anhedonia).

Research Focus

Keywords

prefrontal cortex

amygdala

hippocampus

anxiety

anhedonia

Clinical conditions

Anxiety disorders

Depressive disorders

Equipment

Behavioural analysis

Cardiovascular monitoring

Magnetic resonance imaging (MRI)

Neuropharmacology

Neuropsychological testing

Positron Emission Tomography (PET)

Collaborators

Cambridge

Hannah Clarke

Angela Roberts

Associated News Items


    Publications

    2017

    Wallis CU, Cardinal RN, Alexander L, Roberts AC, Clarke HF (2017), “Opposing roles of primate areas 25 and 32 and their putative rodent homologs in the regulation of negative emotion” PNAS