Dr Jeff Dalley

Jeff Dalley

University position

Reader

Dr Jeff Dalley is pleased to consider applications from prospective PhD students.

Departments

Department of Psychiatry and Department of Psychology

Institutes

Behavioural and Clinical Neuroscience Institute

Email

jwd20@cam.ac.uk

Home page

http://www.iccam.org.uk

Research Theme

Cognitive and Behavioural Neuroscience

Interests

Primary research interests include behavioural and cognitive neuroscience, psychopharmacology and neuromodulation of limbic cortico-striatal brain circuitry. Specific interests include behavioural and neurobiological endophenotypes in experimental animals and their translational application to complex psychiatric disorders, including schizophrenia, ADHD and OCD. Much of my present research involves understanding the genetic, neurodevelopmental and neurobiological bases of individual differences in behaviour, particularly in relation to pre-disposition to drug abuse and addiction. Experimental approaches include behavioural and cognitive testing in rodents, intravenous drug self-administration (cocaine, heroin, amphetamine, methamphetamine, MDMA), in-vivo microdialysis, intra-cerebral and systemic pharmacology, targeted neural and neurochemical brain lesions, in-vivo neurophysiology, immunohistochemistry, pre-clinical MRI and PET.

Research Focus

Keywords

drug addiction

impulsivity

brain imaging

dopamine

neuromodulation

Clinical conditions

Addiction

Attention deficit hyperactivity disorder

Cognitive impairment

Obsessive compulsive disorder

Parkinson's disease

Schizophrenia

Equipment

Behavioural analysis

Electrophysiological recording techniques

Enzyme-selective biosensors

Field potential recording

FPLC/HPLC

Immunohistochemistry

Intravenous drug self-administration

Magnetic resonance imaging (MRI)

Microscopy

Positron Emission Tomography (PET)

Collaborators

Cambridge

Franklin Aigbirhio

Ed Bullmore

Adrian Carpenter

Barry Everitt

Tim Fryer

Ole Paulsen

Trevor Robbins

Angela Roberts

Steve Sawiak

United Kingdom

Tim Aitman Web: http://www1.imperial.ac.uk/medicin...

Simon Gibbons Web: http://www.pharmacy.ac.uk/simon_g...

Glenda Gillies Web: http://www1.imperial.ac.uk/medicin...

Enrico Petretto Web: https://www1.imperial.ac.uk/medicin...

Gunter Schumann Web: http://internal.iop.kcl.ac.uk/ipublic...

Dai Stephens Web: http://www.lifesci.susx.ac.uk/home/Da...

Mark Ungless Web: http://www.csc.mrc.ac.uk/Researc...

International

Olivier Frey Web: http://www.bsse.ethz.ch/bel/peo...

Herc Neves Web: http://www.capitalbio.com/bni&ifb...

Patrick Ruther Web: http://www.imtek.de/materia...

Associated News Items


    Key publications

    Dalley JW, Fryer TD, Brichard L, Robinson ES, Theobald DE, Lääne K, Peña Y, Murphy ER, Shah Y, Probst K, Abakumova I, Aigbirhio FI, Richards HK, Hong Y, Baron JC, Everitt BJ, Robbins TW (2007), “Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement.” Science 315(5816):1267-70 Details

    Dalley JW, Lääne K, Theobald DE, Peña Y, Bruce CC, Huszar AC, Wojcieszek M, Everitt BJ, Robbins TW (2007), “Enduring deficits in sustained visual attention during withdrawal of intravenous methylenedioxymethamphetamine self-administration in rats: results from a comparative study with d-amphetamine and methamphetamine.” Neuropsychopharmacology 32(5):1195-206 Details

    Dalley JW, Lääne K, Theobald DE, Armstrong HC, Corlett PR, Chudasama Y, Robbins TW (2005), “Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens.” Proc Natl Acad Sci U S A 102(17):6189-94 Details

    Publications

    2015

    Barlow RL, Alsiö J, Jupp B, Rabinovich R, Shrestha S, Roberts AC, Robbins TW, Dalley JW (2015), “Markers of Serotonergic Function in the Orbitofrontal Cortex and Dorsal Raphé Nucleus Predict Individual Variation in Spatial-Discrimination Serial Reversal Learning.” Neuropsychopharmacology Details

    Caprioli D, Jupp B, Hong YT, Sawiak SJ, Ferrari V, Wharton L, Williamson DJ, McNabb C, Berry D, Aigbirhio FI, Robbins TW, Fryer TD, Dalley JW (2015), “Dissociable Rate-Dependent Effects of Oral Methylphenidate on Impulsivity and D2/3 Receptor Availability in the Striatum.” J Neurosci 35(9):3747-3755 Details

    Donnelly NA, Paulsen O, Robbins TW, Dalley JW (2015), “Ramping single unit activity in the medial prefrontal cortex and ventral striatum reflects the onset of waiting but not imminent impulsive actions.” Eur J Neurosci Details

    Isherwood SN, Pekcec A, Nicholson JR, Robbins TW, Dalley JW (2015), “Dissociable effects of mGluR5 allosteric modulation on distinct forms of impulsivity in rats: interaction with NMDA receptor antagonism.” Psychopharmacology (Berl) Details

    Moreira FA, Dalley JW (2015), “Dopamine receptor partial agonists and addiction.” Eur J Pharmacol Details

    Peña-Oliver Y, Giuliano C, Economidou D, Goodlett CR, Robbins TW, Dalley JW, Everitt BJ (2015), “Alcohol-Preferring Rats Show Goal Oriented Behaviour to Food Incentives but Are Neither Sign-Trackers Nor Impulsive.” PLoS One 10(6):e0131016 Details

    2014

    Barnes SA, Sawiak SJ, Caprioli D, Jupp B, Buonincontri G, Mar AC, Harte MK, Fletcher PC, Robbins TW, Neill JC, Dalley JW (2014), “Impaired Limbic Cortico-Striatal Structure and Sustained Visual Attention in a Rodent Model of Schizophrenia.” Int J Neuropsychopharmacol Details

    Dalley JW, Russell B (2014), “Molecular imaging studies in stimulant addiction: a cross-species perspective ” PET and SPECT in Psychiatry (Eds. Dierckx, Otte, de Vries, Waarde), Springer

    Donnelly NA, Holtzman T, Rich PD, Nevado-Holgado AJ, Fernando AB, Van Dijck G, Holzhammer T, Paul O, Ruther P, Paulsen O, Robbins TW, Dalley JW (2014), “Oscillatory Activity in the Medial Prefrontal Cortex and Nucleus Accumbens Correlates with Impulsivity and Reward Outcome.” PLoS One 9(10):e111300 Details

    Gallo I, Rattazzi L, Piras G, Gobbetti T, Panza E, Perretti M, Dalley JW, D'Acquisto F (2014), “Formyl Peptide Receptor as a Novel Therapeutic Target for Anxiety-Related Disorders.” PLoS One 9(12):e114626 Details

    Gillies GE, Virdee K, McArthur S, Dalley JW (2014), “Sex-dependent diversity in ventral tegmental dopaminergic neurons and developmental programing: A molecular, cellular and behavioral analysis.” Neuroscience Details

    Hayes DJ, Jupp B, Sawiak SJ, Merlo E, Caprioli D, Dalley JW (2014), “Brain γ-aminobutyric acid: a neglected role in impulsivity.” Eur J Neurosci Details

    Jupp B, Dalley JW (2014), “Convergent pharmacological mechanisms in impulsivity and addiction: insights from rodent models.” Br J Pharmacol Details

    Moreira FA, Jupp B, Belin D, Dalley JW (2014), “Endocannabinoids and striatal function: implications for addiction-related behaviours.” Behav Pharmacol Details

    Rygula R, Clarke HF, Cardinal RN, Cockcroft GJ, Xia J, Dalley JW, Robbins TW, Roberts AC (2014), “Role of Central Serotonin in Anticipation of Rewarding and Punishing Outcomes: Effects of Selective Amygdala or Orbitofrontal 5-HT Depletion.” Cereb Cortex Details

    2013

    Arunotayanun W, Dalley JW, Huang XP, Setola V, Treble R, Iversen L, Roth BL, Gibbons S (2013), “An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: Emerging 'Novel Psychoactive Drugs'” Bioorg Med Chem Lett Details

    Besson M, Pelloux Y, Dilleen R, Theobald DE, Lyon A, Belin-Rauscent A, Robbins TW, Dalley JW, Everitt BJ, Belin D (2013), “Cocaine modulation of fronto-striatal expression of zif268, D2 and 5-HT2c receptors in high and low impulsive rats.” Neuropsychopharmacology Details

    Caprioli D, Fryer TD, Sawiak SJ, Aigbirhio FI, Dalley JW (2013), “Translating positron emission tomography studies in animals to stimulant addiction: promises and pitfalls.” Curr Opin Neurobiol Details

    Caprioli D, Hong YT, Sawiak SJ, Ferrari V, Williamson DJ, Jupp B, Adrian Carpenter T, Aigbirhio FI, Everitt BJ, Robbins TW, Fryer TD, Dalley JW (2013), “Baseline-dependent effects of cocaine pre-exposure on impulsivity and D(2/3) receptor availability in the rat striatum: Possible relevance to the attention-deficit hyperactivity syndrome.” Neuropsychopharmacology Details

    Caprioli D, Sawiak SJ, Merlo E, Theobald DE, Spoelder M, Jupp B, Voon V, Carpenter TA, Everitt BJ, Robbins TW, Dalley JW (2013), “Gamma Aminobutyric Acidergic and Neuronal Structural Markers in the Nucleus Accumbens Core Underlie Trait-like Impulsive Behavior.” Biol Psychiatry Details

    Coura RS, Cressant A, Xia J, de Chaumont F, Olivo-Marin JC, Pelloux Y, Dalley JW, Granon S (2013), “Nonaggressive and adapted social cognition is controlled by the interplay between noradrenergic and nicotinic receptor mechanisms in the prefrontal cortex.” FASEB J Details

    Garcia-Reitböck P, Anichtchik O, Dalley JW, Ninkina N, Tofaris GK, Buchman V, Spillantini MG (2013), “Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra.” Exp Neurol Details

    Jupp B, Caprioli D, Dalley JW (2013), “Highly impulsive rats: modelling an endophenotype to determine the neurobiological, genetic and environmental mechanisms of addiction.” Dis Model Mech Details

    Jupp B, Caprioli D, Saigal N, Reverte I, Shrestha S, Cumming P, Everitt BJ, Robbins TW, Dalley JW (2013), “Dopaminergic and GABA-ergic markers of impulsivity in rats: evidence for anatomical localisation in ventral striatum and prefrontal cortex.” Eur J Neurosci Details

    Jupp B, Dalley JW (2013), “Behavioral endophenotypes of drug addiction: etiological insights from neuroimaging studies.” Neuropharmacology Details

    Moreno M, Economidou D, Mar AC, López-Granero C, Caprioli D, Theobald DE, Fernando A, Newman AH, Robbins TW, Dalley JW (2013), “Divergent effects of D(2/3) receptor activation in the nucleus accumbens core and shell on impulsivity and locomotor activity in high and low impulsive rats.” Psychopharmacology (Berl) Details

    Murray JE, Dilleen R, Pelloux Y, Economidou D, Dalley JW, Belin D, Everitt BJ (2013), “Increased Impulsivity Retards the Transition to Dorsolateral Striatal Dopamine Control of Cocaine Seeking.” Biol Psychiatry Details

    Riss PJ, Hong YT, Marton J, Caprioli D, Williamson DJ, Ferrari V, Saigal N, Roth BL, Henriksen G, Fryer TD, Dalley JW, Aigbirhio FI (2013), “Synthesis and evaluation of 18F-FE-PEO in rodents: an 18F-labeled full agonist for opioid receptor imaging.” J Nucl Med 54(2):299-305 Details

    Spieth S, Schumacher A, Trenkle F, Brett O, Seidl K, Herwik S, Kisban S, Ruther P, Paul O, Aarts AA, Neves HP, Rich PD, Theobald DE, Holtzman T, Dalley JW, Verhoef BE, Janssen P, Zengerle R (2013), “Approaches for drug delivery with intracortical probes.” Biomed Tech (Berl) :1-13 Details

    Van Dijck G, Van Hulle MM, Heiney SA, Blazquez PM, Meng H, Angelaki DE, Arenz A, Margrie TW, Mostofi A, Edgley S, Bengtsson F, Ekerot CF, Jörntell H, Dalley JW, Holtzman T (2013), “Probabilistic Identification of Cerebellar Cortical Neurones across Species.” PLoS One 8(3):e57669 Details

    Virdee K, McArthur S, Brischoux F, Caprioli D, Ungless MA, Robbins TW, Dalley JW, Gillies GE (2013), “Antenatal Glucocorticoid Treatment Induces Adaptations in Adult Midbrain Dopamine Neurons which Underpin Sexually Dimorphic Behavioral Resilience.” Neuropsychopharmacology Details

    Voon V, Irvine MA, Derbyshire K, Worbe Y, Lange I, Abbott S, Morein-Zamir S, Dudley R, Caprioli D, Harrison NA, Wood J, Dalley JW, Bullmore ET, Grant JE, Robbins TW (2013), “Measuring "Waiting" Impulsivity in Substance Addictions and Binge Eating Disorder in a Novel Analogue of Rodent Serial Reaction Time Task.” Biol Psychiatry Details

    2012

    Carter CS, Dalley JW (2012), “Brain Imaging in Behavioral Neuroscience” Current Topics in Behavioral Neuroscience 11: ISBN - 978-3-642-28710-7

    Dalley JW, Roiser JP (2012), “Dopamine, serotonin and impulsivity.” Neuroscience Details

    Dilleen R, Pelloux Y, Mar AC, Molander A, Robbins TW, Everitt BJ, Dalley JW, Belin D (2012), “High anxiety is a predisposing endophenotype for loss of control over cocaine, but not heroin, self-administration in rats.” Psychopharmacology (Berl) Details

    Economidou D, Theobald DE, Robbins TW, Everitt BJ, Dalley JW (2012), “Norepinephrine and Dopamine Modulate Impulsivity on the Five-Choice Serial Reaction Time Task Through Opponent Actions in the Shell and Core Sub-Regions of the Nucleus Accumbens.” Neuropsychopharmacology Details

    McNabb CB, Russell BR, Caprioli D, Nutt DJ, Gibbons S, Dalley JW (2012), “Single chemical entity legal highs: assessing the risk for long term harm.” Curr Drug Abuse Rev 5(4):304-19 Details

    Riss PJ, Hong YT, Marton J, Caprioli D, Williamson DJ, Ferrari V, Saigal N, Roth BL, Henriksen, Fryer TD, Dalley JW, Aigbirhio FI (2012), “Synthesis and evaluation of 18F-FE-PEO in rodents: an 18F-labeled full agonist for opioid receptor imaging” Journal of Nuclear Medicine

    Ruther P, Holzhammer T, Herwik S, Rich PD, Dalley JW, Paul O, Holtzman T (2012), “Compact wireless neural recording system for small animals using silicon-based probe arrays” Conf Proc IEEE Eng Med Biol Soc 2284-2287

    Schilling C, Kühn S, Paus T, Romanowski A, Banaschewski T, Barbot A, Barker GJ, Brühl R, Büchel C, Conrod PJ, Dalley JW, Flor H, Ittermann B, Ivanov N, Mann K, Martinot JL, Nees F, Rietschel M, Robbins TW, Smolka MN, Ströhle A, Kathmann N, Garavan H, Heinz A, Schumann G, Gallinat J, the IMAGEN consortium (www.imagen-europe.com) (2012), “Cortical thickness of superior frontal cortex predicts impulsiveness and perceptual reasoning in adolescence.” Mol Psychiatry Details

    Spieth S, Schumacher A, Holtzman T, Rich PD, Theobald DE, Dalley JW, Nouna R, Messner S, Zengerle R (2012), “An intra-cerebral drug delivery system for freely moving animals.” Biomed Microdevices Details

    Virdee K, Cumming P, Caprioli D, Jupp B, Rominger A, Aigbirhio FI, Fryer TD, Riss PJ, Dalley JW (2012), “Applications of positron emission tomography in animal models of neurological and neuropsychiatric disorders.” Neurosci Biobehav Rev Details

    2011

    Dalley JW, Everitt BJ, Robbins TW (2011), “Impulsivity, compulsivity, and top-down cognitive control.” Neuron 69(4):680-94 Details

    Fan D, Rich D, Holtzman T, Ruther P, Dalley JW, Lopez A, Rossi MA, Barter JW, Salas-Meza D, Herwik S, Holzhammer T, Morizio J, Yin HH (2011), “A wireless multi-channel recording system for freely behaving mice and rats.” PLoS One 6(7):e22033 Details

    Fernando AB, Economidou D, Theobald DE, Zou MF, Newman AH, Spoelder M, Caprioli D, Moreno M, Hipόlito L, Aspinall AT, Robbins TW, Dalley JW (2011), “Modulation of high impulsivity and attentional performance in rats by selective direct and indirect dopaminergic and noradrenergic receptor agonists.” Psychopharmacology (Berl) Details

    Garfield AS, Cowley M, Smith FM, Moorwood K, Stewart-Cox JE, Gilroy K, Baker S, Xia J, Dalley JW, Hurst LD, Wilkinson LS, Isles AR, Ward A (2011), “Distinct physiological and behavioural functions for parental alleles of imprinted Grb10.” Nature 469(7331):534-538 Details

    Holtzman T, Sivam V, Zhao T, Frey O, Dow van der Wal P, Dalley JW, Edgley SA (2011), “Multiple extra-synaptic spillover mechanisms regulate prolonged activity in cerebellar Golgi cell - granule cell loops.” J Physiol Details

    Kühn S, Romanowski A, Schilling C, Banaschewski T, Barbot A, Barker GJ, Brühl R, Büchel C, Conrod PJ, Czech K, Dalley JW, Flor H, Garavan H, Häke I, Ittermann B, Ivanov N, Mann K, Lathrop M, Loth E, Lüdemann K, Mallik C, Martinot JL, Palafox C, Poline JB, Reuter J, Rietschel M, Robbins TW, Smolka MN, Ness F, Walaszek B, Schumann G, Heinz A, Gallinat J, the IMAGEN consortium (2011), “Manual dexterity correlating with right lobule VI volume in right-handed 14-year-olds.” Neuroimage Details

    Lam DD, Leinninger GM, Louis GW, Garfield AS, Marston OJ, Leshan RL, Scheller EL, Christensen L, Donato J Jr, Xia J, Evans ML, Elias C, Dalley JW, Burdakov DI, Myers MG Jr, Heisler LK (2011), “Leptin does not directly affect CNS serotonin neurons to influence appetite.” Cell Metab 13(5):584-91 Details

    Molander AC, Mar A, Norbury A, Steventon S, Moreno M, Caprioli D, Theobald DE, Belin D, Everitt BJ, Robbins TW, Dalley JW (2011), “High impulsivity predicting vulnerability to cocaine addiction in rats: some relationship with novelty preference but not novelty reactivity, anxiety or stress.” Psychopharmacology (Berl) Details

    Murphy ER, Fernando AB, Urcelay GP, Robinson ES, Mar AC, Theobald DE, Dalley JW, Robbins TW (2011), “Impulsive behaviour induced by both NMDA receptor antagonism and GABA(A) receptor activation in rat ventromedial prefrontal cortex.” Psychopharmacology (Berl) Details

    Peña-Oliver Y, Buchman VL, Dalley JW, Robbins TW, Schumann G, Ripley TL, King SL, Stephens DN (2011), “Deletion of alpha-synuclein decreases impulsivity in mice.” Genes Brain Behav Details

    Riss PJ, Hong YT, Williamson D, Caprioli D, Sitnikov S, Ferrari V, Sawiak SJ, Baron JC, Dalley JW, Fryer TD, Aigbirhio FI (2011), “Validation and quantification of [(18)F]altanserin binding in the rat brain using blood input and reference tissue modeling.” J Cereb Blood Flow Metab Details

    Ruther P, Holzhammer T, Herwik S, Rich PD, Dalley JW, Paul O, Holtzman T (2011), “Compact wireless neural recording system for small animals using silicon-based probe arrays.” Conf Proc IEEE Eng Med Biol Soc 2011:2284-7 Details

    Schilling C, Kühn S, Romanowski A, Banaschewski T, Barbot A, Barker GJ, Brühl R, Büchel C, Charlet K, Conrod PJ, Czech K, Dalley JW, Flor H, Häke I, Ittermann B, Ivanov N, Mann K, Lüdemann K, Martinot JL, Palafox C, Paus T, Poline JB, Reuter J, Rietschel M, Robbins TW, Smolka MN, Ströhle A, Walaszek B, Kathmann N, Schumann G, Heinz A, Garavan H, Gallinat J, the IMAGEN consortium (2011), “Common structural correlates of trait impulsiveness and perceptual reasoning in adolescence.” Hum Brain Mapp Details

    Schneider S, Peters J, Bromberg U, Brassen S, Menz MM, Miedl SF, Loth E, Banaschewski T, Barbot A, Barker G, Conrod PJ, Dalley JW, Flor H, Gallinat J, Garavan H, Heinz A, Itterman B, Mallik C, Mann K, Artiges E, Paus T, Poline JB, Rietschel M, Reed L, Smolka MN, Spanagel R, Speiser C, Ströhle A, Struve M, Schumann G, Büchel C (2011), “Boys do it the right way: Sex-dependent amygdala lateralization during face processing in adolescents.” Neuroimage Details

    Urcelay GP, Dalley JW (2011), “Linking ADHD, Impulsivity, and Drug Abuse: A Neuropsychological Perspective.” Curr Top Behav Neurosci Details

    Voon V, Dalley JW (2011), “Parkinson disease: Impulsive choice-Parkinson disease and dopaminergic therapy.” Nat Rev Neurol Details

    2010

    Bari A, Robbins TW, Dalley JW (2010), “Impulsivity. In Animal Models of Drug Addiction. Ed. MC Olmstead” Humana Press

    Bari A, Theobald DE, Caprioli D, Mar AC, Aidoo-Micah A, Dalley JW, Robbins TW (2010), “Serotonin Modulates Sensitivity to Reward and Negative Feedback in a Probabilistic Reversal Learning Task in Rats.” Neuropsychopharmacology Details

    Cumming P, Caprioli D, Dalley JW (2010), “What have PET and 'Zippy' told us about the neuropharmacology of drug addiction?” Br J Pharmacol Details

    Economidou D, Dalley JW, Everitt BJ (2010), “Selective Norepinephrine Reuptake Inhibition by Atomoxetine Prevents Cue-Induced Heroin and Cocaine Seeking.” Biol Psychiatry Details

    Everitt BJ, Belin D, Dalley JW, Robbins TW (2010), “Dopaminergic mechanisms in drug seeking habits and the vulnerability to drug addiction” In. Dopamine Handbook (Eds. L. Iversen, S. Iversen, S. Dunnett, A. Bjorklund), Oxford University Press

    Frey O, Holtzman T, McNamara RM, Theobald DE, van der Wal PD, de Rooij NF, Dalley JW, Koudelka-Hep M (2010), “Enzyme-based choline and l-glutamate biosensor electrodes on silicon microprobe arrays.” Biosens Bioelectron Details

    Frey O, Holtzman T, McNamara RM, Theobald DEH, van der Wal PD, de Rooij NF, Dalley JW, Koudelka-Hep M (2010), “Simultaneous neurochemical stimulation and recording using an assembly of biosensor silicon microprobes and SU-8 microinjectors” Sensors and Actuators: Chemical

    Mar AC, Dalley JW (2010), “Cognition: Attention and Impulsivity. In. Koob GF, Le Moal M and Thompson RF” Encyclopedia of Behavioural Neuroscience. Oxford: Academic Press 1: 262-271

    McNamara R, Dalley JW, Robbins TW, Everitt BJ, Belin D (2010), “Trait-like impulsivity does not predict escalation of heroin self-administration in the rat.” Psychopharmacology (Berl) Details

    Schumann G, Loth E, Banaschewski T, Barbot A, Barker G, Büchel C, Conrod PJ, Dalley JW, Flor H, Gallinat J, Garavan H, Heinz A, Itterman B, Lathrop M, Mallik C, Mann K, Martinot JL, Paus T, Poline JB, Robbins TW, Rietschel M, Reed L, Smolka M, Spanagel R, Speiser C, Stephens DN, Ströhle A, Struve M (2010), “The IMAGEN study: reinforcement-related behaviour in normal brain function and psychopathology.” Mol Psychiatry 15(12):1128-39 Details

    2009

    Belin D, Bari A, Besson M, Dalley JW (2009), “Multi-disciplinary investigations of impulsivity in animal models of attention-deficit hyperactivity disorder and drug addiction vulnerability” Endophenotypes of Psychiatric and Neurodegenerative Disorders in Rodent Models

    Besson M, Belin D, McNamara R, Theobald DE, Castel A, Beckett VL, Crittenden BM, Newman AH, Everitt BJ, Robbins TW, Dalley JW (2009), “Dissociable Control of Impulsivity in Rats by Dopamine D2/3 Receptors in the Core and Shell Subregions of the Nucleus Accumbens.” Neuropsychopharmacology Details

    Dalley JW, Everitt BJ (2009), “Dopamine receptors in the learning, memory and drug reward circuitry.” Semin Cell Dev Biol 20(4):403-10 Details

    Dalley JW, Fryer TD, Aigbirhio FI, Brichard L, Richards HK, Hong YT, Baron JC, Everitt BJ, Robbins TW (2009), “Modelling human drug abuse and addiction with dedicated small animal positron emission tomography.” Neuropharmacology 56 Suppl 1:9-17 Details

    Doe CM, Relkovic D, Garfield AS, Dalley JW, Theobald DE, Humby T, Wilkinson LS, Isles AR (2009), “Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR mediated behaviour.” Hum Mol Genet Details

    Economidou D, Pelloux Y, Robbins TW, Dalley JW, Everitt BJ (2009), “High Impulsivity Predicts Relapse to Cocaine-Seeking After Punishment-Induced Abstinence.” Biol Psychiatry Details

    Man MS, Dalley JW, Roberts AC (2009), “Opposing Effects of 5,7-DHT Infusions into the Orbitofrontal Cortex and Amygdala on Flexible Responding.” Cereb Cortex Details

    O'Keeffe GC, Tyers P, Aarsland D, Dalley JW, Barker RA, Caldwell MA (2009), “Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF.” Proc Natl Acad Sci U S A Details

    2008

    Bari A, Dalley JW, Robbins TW (2008), “The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats.” Nat Protoc 3(5):759-67 Details

    Belin D, Mar AC, Dalley JW, Robbins TW, Everitt BJ (2008), “High impulsivity predicts the switch to compulsive cocaine-taking.” Science 320(5881):1352-5 Details

    Dalley JW, Mar AC, Economidou D, Robbins TW (2008), “Neurobehavioral mechanisms of impulsivity: Fronto-striatal systems and functional neurochemistry.” Pharmacol Biochem Behav 90(2):250-260 Details

    Eagle DM, Lehmann O, Theobald DE, Pena Y, Zakaria R, Ghosh R, Dalley JW, Robbins TW (2008), “Serotonin Depletion Impairs Waiting but not Stop-Signal Reaction Time in Rats: Implications for Theories of the Role of 5-HT in Behavioral Inhibition.” Neuropsychopharmacology Details

    Everitt BJ, Belin D, Economidou D, Pelloux Y, Dalley JW, Robbins TW (2008), “Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction.” Philos Trans R Soc Lond B Biol Sci Details

    Milstein J, Dalley J, Robbins T (2008), “Methylphenidate-induced impulsivity: pharmacological antagonism by {beta}-adrenoreceptor blockade.” J Psychopharmacol Details

    Murphy ER, Robinson ES, Theobald DE, Dalley JW, Robbins TW (2008), “Contrasting effects of selective lesions of nucleus accumbens core or shell on inhibitory control and amphetamine-induced impulsive behaviour.” Eur J Neurosci 28(2):353-63 Details

    O'Keeffe FE, Scott SA, Tyers P, O'Keeffe GW, Dalley JW, Zufferey R, Caldwell MA (2008), “Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parkinson's disease.” Brain 131(Pt 3):630-41 Details

    Pezze MA, Dalley JW, Robbins TW (2008), “Remediation of attentional dysfunction in rats with lesions of the medial prefrontal cortex by intra-accumbens administration of the dopamine D(2/3) receptor antagonist sulpiride.” Psychopharmacology (Berl) Details

    Robinson ES, Eagle DM, Economidou D, Theobald DE, Mar AC, Murphy ER, Robbins TW, Dalley JW (2008), “Behavioural characterisation of high impulsivity on the 5-choice serial reaction time task: Specific deficits in 'waiting' versus 'stopping'” Behav Brain Res Details

    Robinson ES, Eagle DM, Mar AC, Bari A, Banerjee G, Jiang X, Dalley JW, Robbins TW (2008), “Similar effects of the selective noradrenaline reuptake inhibitor atomoxetine on three distinct forms of impulsivity in the rat.” Neuropsychopharmacology 33(5):1028-37 Details

    2007

    Boulougouris V, Dalley JW, Robbins TW (2007), “Effects of orbitofrontal, infralimbic and prelimbic cortical lesions on serial spatial reversal learning in the rat.” Behav Brain Res 179(2):219-28 Details

    Clarke HF, Walker SC, Dalley JW, Robbins TW, Roberts AC (2007), “Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific.” Cereb Cortex 17(1):18-27 Details

    Dalley JW, Everitt BJ, Robbins TW (2007), “Trait or State?” Science 317: 1033-1035

    Everitt BJ, Hutcheson DM, Ersche KD, Pelloux Y, Dalley JW, Robbins TW (2007), “The orbital prefrontal cortex and drug addiction in laboratory animals and humans.” Ann N Y Acad Sci 1121:576-97 Details

    Milstein JA, Lehmann O, Theobald DE, Dalley JW, Robbins TW (2007), “Selective depletion of cortical noradrenaline by anti-dopamine beta-hydroxylase-saporin impairs attentional function and enhances the effects of guanfacine in the rat.” Psychopharmacology (Berl) 190(1):51-63 Details

    Pezze MA, Dalley JW, Robbins TW (2007), “Differential roles of dopamine D1 and D2 receptors in the nucleus accumbens in attentional performance on the five-choice serial reaction time task.” Neuropsychopharmacology 32(2):273-83 Details

    Robinson ES, Dalley JW, Theobald DE, Glennon JC, Pezze MA, Murphy ER, Robbins TW (2007), “Opposing Roles for 5-HT(2A) and 5-HT(2C) Receptors in the Nucleus Accumbens on Inhibitory Response Control in the 5-Choice Serial Reaction Time Task.” Neuropsychopharmacology Details

    Tait DS, Brown VJ, Farovik A, Theobald DE, Dalley JW, Robbins TW (2007), “Lesions of the dorsal noradrenergic bundle impair attentional set-shifting in the rat.” Eur J Neurosci 25(12):3719-24 Details

    2006

    Winstanley CA, Theobald DE, Dalley JW, Cardinal RN, Robbins TW (2006), “Double dissociation between serotonergic and dopaminergic modulation of medial prefrontal and orbitofrontal cortex during a test of impulsive choice.” Cereb Cortex 16(1):106-14 Details

    2005

    Clarke HF, Walker SC, Crofts HS, Dalley JW, Robbins TW, Roberts AC (2005), “Prefrontal serotonin depletion affects reversal learning but not attentional set shifting.” J Neurosci 25(2):532-8 Details

    Dalley JW, Lääne K, Pena Y, Theobald DE, Everitt BJ, Robbins TW (2005), “Attentional and motivational deficits in rats withdrawn from intravenous self-administration of cocaine or heroin.” Psychopharmacology (Berl) 182(4):579-87 Details

    Dalley JW, Theobald DE, Berry D, Milstein JA, Lääne K, Everitt BJ, Robbins TW (2005), “Cognitive sequelae of intravenous amphetamine self-administration in rats: evidence for selective effects on attentional performance.” Neuropsychopharmacology 30(3):525-37 Details

    McArthur S, McHale E, Dalley JW, Buckingham JC, Gillies GE (2005), “Altered mesencephalic dopaminergic populations in adulthood as a consequence of brief perinatal glucocorticoid exposure.” J Neuroendocrinol 17(8):475-82 Details

    Murphy ER, Dalley JW, Robbins TW (2005), “Local glutamate receptor antagonism in the rat prefrontal cortex disrupts response inhibition in a visuospatial attentional task.” Psychopharmacology (Berl) 179(1):99-107 Details

    Winstanley CA, Theobald DE, Dalley JW, Robbins TW (2005), “Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disorders.” Neuropsychopharmacology 30(4):669-82 Details

    2004

    Chudasama Y, Dalley JW, Nathwani F, Bouger P, Robbins TW (2004), “Cholinergic modulation of visual attention and working memory: dissociable effects of basal forebrain 192-IgG-saporin lesions and intraprefrontal infusions of scopolamine.” Learn Mem 11(1):78-86 Details

    Clarke HF, Dalley JW, Crofts HS, Robbins TW, Roberts AC (2004), “Cognitive inflexibility after prefrontal serotonin depletion.” Science 304(5672):878-80 Details

    Dalley JW, Cardinal RN, Robbins TW (2004), “Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates.” Neurosci Biobehav Rev 28(7):771-84 Details

    Dalley JW, Theobald DE, Bouger P, Chudasama Y, Cardinal RN, Robbins TW (2004), “Cortical cholinergic function and deficits in visual attentional performance in rats following 192 IgG-saporin-induced lesions of the medial prefrontal cortex.” Cereb Cortex 14(8):922-32 Details

    Miles FJ, Everitt BJ, Dalley JW, Dickinson A (2004), “Conditioned activity and instrumental reinforcement following long-term oral consumption of cocaine by rats.” Behav Neurosci 118(6):1331-9 Details

    Preece MA, Dalley JW, Theobald DE, Robbins TW, Reynolds GP (2004), “Region specific changes in forebrain 5-hydroxytryptamine1A and 5-hydroxytryptamine2A receptors in isolation-reared rats: an in vitro autoradiography study.” Neuroscience 123(3):725-32 Details

    Winstanley CA, Dalley JW, Theobald DE, Robbins TW (2004), “Fractionating impulsivity: contrasting effects of central 5-HT depletion on different measures of impulsive behavior.” Neuropsychopharmacology 29(7):1331-43 Details

    Winstanley CA, Theobald DE, Dalley JW, Glennon JC, Robbins TW (2004), “5-HT2A and 5-HT2C receptor antagonists have opposing effects on a measure of impulsivity: interactions with global 5-HT depletion.” Psychopharmacology (Berl) 176(3-4):376-85 Details

    2003

    Passetti F, Dalley JW, Robbins TW (2003), “Double dissociation of serotonergic and dopaminergic mechanisms on attentional performance using a rodent five-choice reaction time task.” Psychopharmacology (Berl) 165(2):136-45 Details

    Winstanley CA, Chudasama Y, Dalley JW, Theobald DE, Glennon JC, Robbins TW (2003), “Intra-prefrontal 8-OH-DPAT and M100907 improve visuospatial attention and decrease impulsivity on the five-choice serial reaction time task in rats.” Psychopharmacology (Berl) 167(3):304-14 Details

    Winstanley CA, Dalley JW, Theobald DE, Robbins TW (2003), “Global 5-HT depletion attenuates the ability of amphetamine to decrease impulsive choice on a delay-discounting task in rats.” Psychopharmacology (Berl) 170(3):320-31 Details

    2002

    Dalley JW, Chudasama Y, Theobald DE, Pettifer CL, Fletcher CM, Robbins TW (2002), “Nucleus accumbens dopamine and discriminated approach learning: interactive effects of 6-hydroxydopamine lesions and systemic apomorphine administration.” Psychopharmacology (Berl) 161(4):425-33 Details

    Dalley JW, Theobald DE, Eagle DM, Passetti F, Robbins TW (2002), “Deficits in impulse control associated with tonically-elevated serotonergic function in rat prefrontal cortex.” Neuropsychopharmacology 26(6):716-28 Details

    Dalley JW, Theobald DE, Pereira EA, Li PM, Robbins TW (2002), “Specific abnormalities in serotonin release in the prefrontal cortex of isolation-reared rats measured during behavioural performance of a task assessing visuospatial attention and impulsivity.” Psychopharmacology (Berl) 164(3):329-40 Details

    Ito R, Dalley JW, Robbins TW, Everitt BJ (2002), “Dopamine release in the dorsal striatum during cocaine-seeking behavior under the control of a drug-associated cue.” J Neurosci 22(14):6247-53 Details

    Levita L, Dalley JW, Robbins TW (2002), “Nucleus accumbens dopamine and learned fear revisited: a review and some new findings.” Behav Brain Res 137(1-2):115-27 Details

    Levita L, Dalley JW, Robbins TW (2002), “Disruption of Pavlovian contextual conditioning by excitotoxic lesions of the nucleus accumbens core.” Behav Neurosci 116(4):539-52 Details

    McGaughy J, Dalley JW, Morrison CH, Everitt BJ, Robbins TW (2002), “Selective behavioral and neurochemical effects of cholinergic lesions produced by intrabasalis infusions of 192 IgG-saporin on attentional performance in a five-choice serial reaction time task.” J Neurosci 22(5):1905-13 Details

    Parkinson JA, Dalley JW, Cardinal RN, Bamford A, Fehnert B, Lachenal G, Rudarakanchana N, Halkerston KM, Robbins TW, Everitt BJ (2002), “Nucleus accumbens dopamine depletion impairs both acquisition and performance of appetitive Pavlovian approach behaviour: implications for mesoaccumbens dopamine function.” Behav Brain Res 137(1-2):149-63 Details

    2001

    Crofts HS, Dalley JW, Collins P, Van Denderen JC, Everitt BJ, Robbins TW, Roberts AC (2001), “Differential effects of 6-OHDA lesions of the frontal cortex and caudate nucleus on the ability to acquire an attentional set.” Cereb Cortex 11(11):1015-26 Details

    Dalley JW, McGaughy J, O'Connell MT, Cardinal RN, Levita L, Robbins TW (2001), “Distinct changes in cortical acetylcholine and noradrenaline efflux during contingent and noncontingent performance of a visual attentional task.” J Neurosci 21(13):4908-14 Details

    Matthews K, Dalley JW, Matthews C, Tsai TH, Robbins TW (2001), “Periodic maternal separation of neonatal rats produces region- and gender-specific effects on biogenic amine content in postmortem adult brain.” Synapse 40(1):1-10 Details

    2000

    Granon S, Passetti F, Thomas KL, Dalley JW, Everitt BJ, Robbins TW (2000), “Enhanced and impaired attentional performance after infusion of D1 dopaminergic receptor agents into rat prefrontal cortex.” J Neurosci 20(3):1208-15 Details

    Howes SR, Dalley JW, Morrison CH, Robbins TW, Everitt BJ (2000), “Leftward shift in the acquisition of cocaine self-administration in isolation-reared rats: relationship to extracellular levels of dopamine, serotonin and glutamate in the nucleus accumbens and amygdala-striatal FOS expression.” Psychopharmacology (Berl) 151(1):55-63 Details

    Ito R, Dalley JW, Howes SR, Robbins TW, Everitt BJ (2000), “Dissociation in conditioned dopamine release in the nucleus accumbens core and shell in response to cocaine cues and during cocaine-seeking behavior in rats.” J Neurosci 20(19):7489-95 Details

    Passetti F, Dalley JW, O'Connell MT, Everitt BJ, Robbins TW (2000), “Increased acetylcholine release in the rat medial prefrontal cortex during performance of a visual attentional task.” Eur J Neurosci 12(8):3051-8 Details

    1999

    Dalley JW, Thomas KL, Howes SR, Tsai TH, Aparicio-Legarza MI, Reynolds GP, Everitt BJ, Robbins TW (1999), “Effects of excitotoxic lesions of the rat prefrontal cortex on CREB regulation and presynaptic markers of dopamine and amino acid function in the nucleus accumbens.” Eur J Neurosci 11(4):1265-74 Details

    1998

    Dalley JW, Parker CA, Wülfert E, Hudson AL, Nutt DJ (1998), “Potentiation of barbiturate-induced alterations in presynaptic noradrenergic function in rat frontal cortex by imidazol(in)e alpha2-adrenoceptor agonists.” Br J Pharmacol 125(3):441-6 Details

    1997

    Tsai TH, Matthews K, Dalley JW (1997), “Determination of glutamate in rat brain microdialysates by microbore liquid chromatography with electrochemical detection” J. Liq. Chrom. & Rel. Technol

    1996

    Dalley JW, Mason K, Stanford SC (1996), “Increased levels of extracellular noradrenaline in the frontal cortex of rats exposed to naturalistic environmental stimuli: modulation by acute systemic administration of diazepam or buspirone.” Psychopharmacology (Berl) 127(1):47-54 Details

    1995

    Dalley JW, Stanford SC (1995), “Incremental changes in extracellular noradrenaline availability in the frontal cortex induced by naturalistic environmental stimuli: a microdialysis study in the freely moving rat.” J Neurochem 65(6):2644-51 Details

    Dalley JW, Stanford SC (1995), “Contrasting effects of the imidazol(in)e alpha 2-adrenoceptor agonists, medetomidine, clonidine and UK 14,304 on extraneuronal levels of noradrenaline in the rat frontal cortex: evaluation using in vivo microdialysis and synaptosomal uptake studies.” Br J Pharmacol 114(8):1717-23 Details