Professor John T O'Brien

John T O'Brien

University position

Professor

Professor John T O'Brien is pleased to consider applications from prospective PhD students.

Departments

Department of Psychiatry

Email

john.obrien@medschl.cam.ac.uk

Home page

http://www.psychiatry.cam.ac.uk/

Research Themes

Cognitive and Behavioural Neuroscience

Clinical and Veterinary Neuroscience

Interests

My research interests in dementia include the role of biomarkers, especially MRI, SPECT and PET imaging, in the differential and early diagnosis of dementia, including identifying those ‘at risk’ of future cognitive decline and developing markers of disease progression. These imaging biomarkers are being applied to cohorts of patients with Alzheimer’s disease, Lewy Body dementia and Vascular Cognitive impairment.

My other main research interest is in late-life depression, especially the role of vascular and inflammatory factors in precipitating and perpetuating depression in late-life and the ability of vascular interventions to improve or prevent depressive and cognitive symptoms.

I am also Associate Director and National Dementia Lead for the Dementias and Neurodegenerative Disease Research Network (DeNDRoN) and we undertake a number of clinical studies in dementia, including trials of pharmacological and non-pharmacological management.

Research Focus

Keywords

Neuro-imaging

Dementia

Depression

Lewy Body Dementia

Clinical conditions

Alzheimer's disease

Dementia

Lewy-Body Dementia

Parkinson's disease

Equipment

Clinical assessment

Magnetic resonance imaging (MRI)

Neuropsychological testing

Positron Emission Tomography (PET)

Collaborators

Cambridge

Franklin Aigbirhio

Roger Barker

Ed Bullmore

James Rowe

Barbara Sahakian

Peter St George Hyslop

Associated News Items


Publications

2014

Gore RL, Vardy ER, O'Brien JT (2014), “Delirium and dementia with Lewy bodies: distinct diagnoses or part of the same spectrum?” J Neurol Neurosurg Psychiatry Details

Grosset DG, Tatsch K, Oertel WH, Tolosa E, Bajaj N, Kupsch A, O'Brien JT, Seibyl J, Walker Z, Sherwin P, Chen C, Grachev ID (2014), “Safety Analysis of 10 Clinical Trials and for 13 Years After First Approval of Ioflupane 123I Injection (DaTscan).” J Nucl Med Details

Hackett ML, Köhler S, O'Brien JT, Mead GE (2014), “Neuropsychiatric outcomes of stroke.” Lancet Neurol 13(5):525-34 Details

Lowther ER, O'Brien JT, Firbank MJ, Blamire AM (2014), “Lewy body compared with Alzheimer dementia is associated with decreased functional connectivity in resting state networks.” Psychiatry Res Details

Mak E, Su L, Williams GB, O'Brien JT (2014), “Neuroimaging characteristics of dementia with Lewy bodies.” Alzheimers Res Ther 6(2):18 Details

Mukaetova-Ladinska EB, Abdel-All Z, Andrade J, Alves da Silva J, O'Brien JT, Kalaria RN (2014), “Plasma and platelet clusterin ratio is altered in Alzheimer's disease patients with distinct neuropsychiatric symptoms: findings from a pilot study.” Int J Geriatr Psychiatry Details

O'Brien JT (2014), “Clinical significance of white matter changes.” Am J Geriatr Psychiatry 22(2):133-7 Details

O'Brien JT (2014), “The importance of longitudinal cohort studies in understanding risk and protective factors for dementia.” Int Psychogeriatr 26(4):541-2 Details

O'Brien JT, Oertel WH, McKeith IG, Grosset DG, Walker Z, Tatsch K, Tolosa E, Sherwin PF, Grachev ID (2014), “Is ioflupane I123 injection diagnostically effective in patients with movement disorders and dementia? Pooled analysis of four clinical trials.” BMJ Open 4(7):e005122 Details

Seibyl JP, Kupsch A, Booij J, Grosset DG, Costa DC, Hauser RA, Darcourt J, Bajaj N, Walker Z, Marek K, McKeith I, O'Brien JT, Tatsch K, Tolosa E, Dierckx RA, Grachev ID (2014), “Individual-Reader Diagnostic Performance and Between-Reader Agreement in Assessment of Subjects with Parkinsonian Syndrome or Dementia Using 123I-Ioflupane Injection (DaTscan) Imaging.” J Nucl Med Details

Vann Jones SA, O'Brien JT (2014), “The prevalence and incidence of dementia with Lewy bodies: a systematic review of population and clinical studies.” Psychol Med 44(4):673-83 Details

Whitfield DR, Vallortigara J, Alghamdi A, Hortobágyi T, Ballard C, Thomas AJ, O'Brien JT, Aarsland D, Francis PT (2014), “Depression and Synaptic Zinc Regulation in Alzheimer Disease, Dementia with Lewy Bodies, and Parkinson Disease Dementia.” Am J Geriatr Psychiatry Details

Yarnall AJ, Breen DP, Duncan GW, Khoo TK, Coleman SY, Firbank MJ, Nombela C, Winder-Rhodes S, Evans JR, Rowe JB, Mollenhauer B, Kruse N, Hudson G, Chinnery PF, O'Brien JT, Robbins TW, Wesnes K, Brooks DJ, Barker RA, Burn DJ, ICICLE-PD Study Group (2014), “Characterizing mild cognitive impairment in incident Parkinson disease: The ICICLE-PD Study.” Neurology 82(4):308-16 Details

2013

Allan LM, Rowan EN, Thomas AJ, Polvikoski TM, O'Brien JT, Kalaria RN (2013), “Long-term incidence of depression and predictors of depressive symptoms in older stroke survivors.” Br J Psychiatry 203(6):453-60 Details

Banerjee S, Hellier J, Romeo R, Dewey M, Knapp M, Ballard C, Baldwin R, Bentham P, Fox C, Holmes C, Katona C, Lawton C, Lindesay J, Livingston G, McCrae N, Moniz-Cook E, Murray J, Nurock S, Orrell M, O'Brien J, Poppe M, Thomas A, Walwyn R, Wilson K, Burns A (2013), “Study of the use of antidepressants for depression in dementia: the HTA-SADD trial--a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine.” Health Technol Assess 17(7):1-166 Details

Barnett NA, O'Brien JT (2013), “Patient involvement in research: an audit of study feedback to participants.” Int Psychogeriatr 25(8):1387-8 Details

Colloby SJ, Taylor JP, Davison CM, Lloyd JJ, Firbank MJ, McKeith IG, O'Brien JT (2013), “Multivariate spatial covariance analysis of 99mTc-exametazime SPECT images in dementia with Lewy bodies and Alzheimer's disease: utility in differential diagnosis.” J Cereb Blood Flow Metab 33(4):612-8 Details

Davison CM, O'Brien JT (2013), “A comparison of FDG-PET and blood flow SPECT in the diagnosis of neurodegenerative dementias: a systematic review.” Int J Geriatr Psychiatry Details

Donaghy P, Thomas AJ, O'Brien JT (2013), “Amyloid PET Imaging in Lewy Body Disorders.” Am J Geriatr Psychiatry Details

Duncan GW, Firbank MJ, O'Brien JT, Burn DJ (2013), “Magnetic resonance imaging: a biomarker for cognitive impairment in Parkinson's disease?” Mov Disord 28(4):425-38 Details

Duncan GW, Khoo TK, Coleman SY, Brayne C, Yarnall AJ, O'Brien JT, Barker RA, Burn DJ (2013), “The incidence of Parkinson's disease in the North-East of England.” Age Ageing Details

Duncan GW, Khoo TK, Yarnall AJ, O'Brien JT, Coleman SY, Brooks DJ, Barker RA, Burn DJ (2013), “Health-related quality of life in early Parkinson's disease: The impact of nonmotor symptoms.” Mov Disord Details

Ford AH, Duncan GW, Firbank MJ, Yarnall AJ, Khoo TK, Burn DJ, O'Brien JT (2013), “Rapid eye movement sleep behavior disorder in Parkinson's disease: magnetic resonance imaging study.” Mov Disord 28(6):832-6 Details

Jefferis JM, Clarke MP, Mosimann UP, O'Brien JT, Taylor JP (2013), “The influence of two common dementia types on visual symptoms.” Acta Ophthalmol 91(2):e159-60 Details

Kenny ER, O'Brien JT, Firbank MJ, Blamire AM (2013), “Subcortical connectivity in dementia with Lewy bodies and Alzheimer's disease.” Br J Psychiatry 203:209-14 Details

Khoo TK, Yarnall AJ, Duncan GW, Coleman S, O'Brien JT, Brooks DJ, Barker RA, Burn DJ (2013), “The spectrum of nonmotor symptoms in early Parkinson disease.” Neurology 80(3):276-81 Details

Kreisel SH, Blahak C, Bäzner H, Inzitari D, Pantoni L, Poggesi A, Chabriat H, Erkinjuntti T, Fazekas F, Ferro JM, Langhorne P, O'Brien J, Scheltens P, Visser MC, Wahlund LO, Waldemar G, Wallin A, Hennerici MG (2013), “Deterioration of gait and balance over time: the effects of age-related white matter change--the LADIS study.” Cerebrovasc Dis 35(6):544-53 Details

McAleese KE, Firbank M, Hunter D, Sun L, Hall R, Neal JW, Mann DM, Esiri M, Jellinger KA, O'Brien JT, Attems J (2013), “Magnetic resonance imaging of fixed post mortem brains reliably reflects subcortical vascular pathology of frontal, parietal and occipital white matter.” Neuropathol Appl Neurobiol 39(5):485-97 Details

Moleiro C, Madureira S, Verdelho A, Ferro JM, Poggesi A, Chabriat H, Erkinjuntti T, Fazekas F, Hennerici M, O'Brien J, Pantoni L, Salvadori E, Scheltens P, Visser MC, Wahlund LO, Waldemar G, Wallin A, Inzitari D, LADIS Study (2013), “Confirmatory factor analysis of the Neuropsychological Assessment Battery of the LADIS study: a longitudinal analysis.” J Clin Exp Neuropsychol 35(3):269-78 Details

Mukaetova-Ladinska EB, Abdell-All Z, Andrade J, da Silva JA, Boksha I, Burbaeva G, Kalaria RJ, O'Brien JT (2013), “Platelet Tau Protein as a Potential Peripheral Biomarker in Alzheimer's disease: An Explorative Study.” Curr Alzheimer Res Details

O'Brien JT (2013), “Commentary.” Int Psychogeriatr 25(2):181-4 Details

O'Brien JT (2013), “Introduction.” Int Psychogeriatr 25(2):174-5 Details

O'Donovan J, Watson R, Colloby SJ, Blamire AM, O'Brien JT (2013), “Assessment of regional MR diffusion changes in dementia with Lewy bodies and Alzheimer's disease.” Int Psychogeriatr :1-9 Details

O'Donovan J, Watson R, Colloby SJ, Firbank MJ, Burton EJ, Barber R, Blamire AM, O'Brien JT (2013), “Does posterior cortical atrophy on MRI discriminate between Alzheimer's disease, dementia with Lewy bodies, and normal aging?” Int Psychogeriatr 25(1):111-9 Details

Poggesi A, Gouw A, van der Flier W, Pracucci G, Chabriat H, Erkinjuntti T, Fazekas F, Ferro JM, Hennerici M, Langhorne P, O'Brien JT, Visser MC, Wahlund LO, Waldemar G, Wallin A, Scheltens P, Inzitari D, Pantoni L (2013), “Cerebral white matter changes are associated with abnormalities on neurological examination in non-disabled elderly: the LADIS study.” J Neurol 260(4):1014-21 Details

Romeo R, Knapp M, Hellier J, Dewey M, Ballard C, Baldwin R, Bentham P, Burns A, Fox C, Holmes C, Katona C, Lawton C, Lindesay J, Livingston G, McCrae N, Moniz-Cook E, Murray J, Nurock S, O'Brien J, Poppe M, Thomas A, Walwyn R, Wilson K, Banerjee S (2013), “Cost-effectiveness analyses for mirtazapine and sertraline in dementia: randomised controlled trial.” Br J Psychiatry 202:121-8 Details

Taylor JP, Colloby SJ, McKeith IG, O'Brien JT (2013), “Covariant perfusion patterns provide clues to the origin of cognitive fluctuations and attentional dysfunction in dementia with Lewy bodies.” Int Psychogeriatr 25(12):1917-28 Details

Tryambake D, He J, Firbank MJ, O'Brien JT, Blamire AM, Ford GA (2013), “Intensive blood pressure lowering increases cerebral blood flow in older subjects with hypertension.” Hypertension 61(6):1309-15 Details

Vardy ER, Ford AH, Gallagher P, Watson R, McKeith IG, Blamire A, O'Brien JT (2013), “Distinct cognitive phenotypes in Alzheimer's disease in older people.” Int Psychogeriatr 25(10):1659-66 Details

Verdelho A, Madureira S, Moleiro C, Ferro JM, O'Brien JT, Poggesi A, Pantoni L, Fazekas F, Scheltens P, Waldemar G, Wallin A, Erkinjuntti T, Inzitari D, LADIS Study (2013), “Depressive symptoms predict cognitive decline and dementia in older people independently of cerebral white matter changes: the LADIS study.” J Neurol Neurosurg Psychiatry 84(11):1250-4 Details

Wardlaw JM, Smith EE, Biessels GJ, Cordonnier C, Fazekas F, Frayne R, Lindley RI, O'Brien JT, Barkhof F, Benavente OR, Black SE, Brayne C, Breteler M, Chabriat H, Decarli C, de Leeuw FE, Doubal F, Duering M, Fox NC, Greenberg S, Hachinski V, Kilimann I, Mok V, Oostenbrugge Rv, Pantoni L, Speck O, Stephan BC, Teipel S, Viswanathan A, Werring D, Chen C, Smith C, van Buchem M, Norrving B, Gorelick PB, Dichgans M, STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1) (2013), “Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration.” Lancet Neurol 12(8):822-38 Details

Wood JS, Firbank MJ, Mosimann UP, Watson R, Barber R, Blamire AM, O'Brien JT (2013), “Testing visual perception in dementia with Lewy bodies and Alzheimer disease.” Am J Geriatr Psychiatry 21(6):501-8 Details

Wood JS, Watson R, Firbank MJ, Mosimann UP, Barber R, Blamire AM, O'Brien JT (2013), “Longitudinal testing of visual perception in dementia with Lewy bodies and Alzheimer's disease.” Int J Geriatr Psychiatry 28(6):567-72 Details

2012

Bohr IJ, Kenny E, Blamire A, O'Brien JT, Thomas AJ, Richardson J, Kaiser M (2012), “Resting-state functional connectivity in late-life depression: higher global connectivity and more long distance connections.” Front Psychiatry 3:116 Details

Burton EJ, Mukaetova-Ladinska EB, Perry RH, Jaros E, Barber R, O'Brien JT (2012), “Neuropathological correlates of volumetric MRI in autopsy-confirmed Lewy body dementia.” Neurobiol Aging 33(7):1228-36 Details

Burton EJ, Mukaetova-Ladinska EB, Perry RH, Jaros E, Barber R, O'Brien JT (2012), “Quantitative neurodegenerative pathology does not explain the degree of hippocampal atrophy on MRI in degenerative dementia.” Int J Geriatr Psychiatry 27(12):1267-74 Details

Colloby SJ, Firbank MJ, He J, Thomas AJ, Vasudev A, Parry SW, O'Brien JT (2012), “Regional cerebral blood flow in late-life depression: arterial spin labelling magnetic resonance study.” Br J Psychiatry 200(2):150-5 Details

Colloby SJ, McParland S, O'Brien JT, Attems J (2012), “Neuropathological correlates of dopaminergic imaging in Alzheimer's disease and Lewy body dementias.” Brain 135(Pt 9):2798-808 Details

Damangir S, Manzouri A, Oppedal K, Carlsson S, Firbank MJ, Sonnesyn H, Tysnes OB, O'Brien JT, Beyer MK, Westman E, Aarsland D, Wahlund LO, Spulber G (2012), “Multispectral MRI segmentation of age related white matter changes using a cascade of support vector machines.” J Neurol Sci 322(1-2):211-6 Details

Firbank MJ, Allan LM, Burton EJ, Barber R, O'Brien JT, Kalaria RN (2012), “Neuroimaging predictors of death and dementia in a cohort of older stroke survivors.” J Neurol Neurosurg Psychiatry 83(3):263-7 Details

Firbank MJ, Teodorczuk A, van der Flier WM, Gouw AA, Wallin A, Erkinjuntti T, Inzitari D, Wahlund LO, Pantoni L, Poggesi A, Pracucci G, Langhorne P, O'Brien JT, LADIS group (2012), “Relationship between progression of brain white matter changes and late-life depression: 3-year results from the LADIS study.” Br J Psychiatry 201(1):40-5 Details

Gemmell E, Bosomworth H, Allan L, Hall R, Khundakar A, Oakley AE, Deramecourt V, Polvikoski TM, O'Brien JT, Kalaria RN (2012), “Hippocampal neuronal atrophy and cognitive function in delayed poststroke and aging-related dementias.” Stroke 43(3):808-14 Details

Howard R, McShane R, Lindesay J, Ritchie C, Baldwin A, Barber R, Burns A, Dening T, Findlay D, Holmes C, Hughes A, Jacoby R, Jones R, Jones R, McKeith I, Macharouthu A, O'Brien J, Passmore P, Sheehan B, Juszczak E, Katona C, Hills R, Knapp M, Ballard C, Brown R, Banerjee S, Onions C, Griffin M, Adams J, Gray R, Johnson T, Bentham P, Phillips P (2012), “Donepezil and memantine for moderate-to-severe Alzheimer's disease.” N Engl J Med 366(10):893-903 Details

Jordan A, Regnard C, O'Brien JT, Hughes JC (2012), “Pain and distress in advanced dementia: choosing the right tools for the job.” Palliat Med 26(7):873-8 Details

Kenny ER, Blamire AM, Firbank MJ, O'Brien JT (2012), “Functional connectivity in cortical regions in dementia with Lewy bodies and Alzheimer's disease.” Brain 135(Pt 2):569-81 Details

Lopes MA, Firbank MJ, Widdrington M, Blamire AM, Kalaria RN, O'Brien JT (2012), “Post-stroke dementia: the contribution of thalamus and basal ganglia changes.” Int Psychogeriatr 24(4):568-76 Details

Mukaetova-Ladinska EB, Abdel-All Z, Andrade J, McNally RJ, James PW, Kalaria RN, O'Brien JT (2012), “Increase in platelet immunoglobulin in Alzheimer's disease is normalised following cholinesterase inhibitor treatment: preliminary results.” J Alzheimers Dis 32(2):431-6 Details

Mukaetova-Ladinska EB, Abdel-All Z, Dodds S, Andrade J, Alves da Silva J, Kalaria RN, O'Brien JT (2012), “Platelet immunoglobulin and amyloid precursor protein as potential peripheral biomarkers for Alzheimer's disease: findings from a pilot study.” Age Ageing 41(3):408-12 Details

Oppedal K, Aarsland D, Firbank MJ, Sonnesyn H, Tysnes OB, O'Brien JT, Beyer MK (2012), “White matter hyperintensities in mild lewy body dementia.” Dement Geriatr Cogn Dis Extra 2(1):481-95 Details

Sinha N, Firbank M, O'Brien JT (2012), “Biomarkers in dementia with Lewy bodies: a review.” Int J Geriatr Psychiatry 27(5):443-53 Details

Taylor JP, Firbank MJ, He J, Barnett N, Pearce S, Livingstone A, Vuong Q, McKeith IG, O'Brien JT (2012), “Visual cortex in dementia with Lewy bodies: magnetic resonance imaging study.” Br J Psychiatry 200(6):491-8 Details

Taylor JP, O'Brien J (2012), “Neuroimaging of dementia with Lewy bodies.” Neuroimaging Clin N Am 22(1):67-81, viii Details

Vasudev A, Saxby BK, OʼBrien JT, Colloby SJ, Firbank MJ, Brooker H, Wesnes K, Thomas AJ (2012), “Relationship between cognition, magnetic resonance white matter hyperintensities, and cardiovascular autonomic changes in late-life depression.” Am J Geriatr Psychiatry 20(8):691-9 Details

Watson R, Blamire AM, Colloby SJ, Wood JS, Barber R, He J, O'Brien JT (2012), “Characterizing dementia with Lewy bodies by means of diffusion tensor imaging.” Neurology 79(9):906-14 Details

Watson R, O'Brien JT, Barber R, Blamire AM (2012), “Patterns of gray matter atrophy in dementia with Lewy bodies: a voxel-based morphometry study.” Int Psychogeriatr 24(4):532-40 Details

2011

Allan LM, Rowan EN, Firbank MJ, Thomas AJ, Parry SW, Polvikoski TM, O'Brien JT, Kalaria RN (2011), “Long term incidence of dementia, predictors of mortality and pathological diagnosis in older stroke survivors.” Brain 134(Pt 12):3716-27 Details

Banerjee S, Hellier J, Dewey M, Romeo R, Ballard C, Baldwin R, Bentham P, Fox C, Holmes C, Katona C, Knapp M, Lawton C, Lindesay J, Livingston G, McCrae N, Moniz-Cook E, Murray J, Nurock S, Orrell M, O'Brien J, Poppe M, Thomas A, Walwyn R, Wilson K, Burns A (2011), “Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial.” Lancet 378(9789):403-11 Details

Colloby SJ, Firbank MJ, Pakrasi S, Perry EK, Pimlott SL, Wyper DJ, McKeith IG, Williams ED, O'Brien JT (2011), “Alterations in nicotinic α4β2 receptor binding in vascular dementia using ¹²³I-5IA-85380 SPECT: comparison with regional cerebral blood flow.” Neurobiol Aging 32(2):293-301 Details

Colloby SJ, Firbank MJ, Thomas AJ, Vasudev A, Parry SW, O'Brien JT (2011), “White matter changes in late-life depression: a diffusion tensor imaging study.” J Affect Disord 135(1-3):216-20 Details

Colloby SJ, Firbank MJ, Vasudev A, Parry SW, Thomas AJ, O'Brien JT (2011), “Cortical thickness and VBM-DARTEL in late-life depression.” J Affect Disord 133(1-2):158-64 Details

Colloby SJ, Vasudev A, O'Brien JT, Firbank MJ, Parry SW, Thomas AJ (2011), “Relationship of orthostatic blood pressure to white matter hyperintensities and subcortical volumes in late-life depression.” Br J Psychiatry 199(5):404-10 Details

Firbank MJ, Blamire AM, Teodorczuk A, Teper E, Mitra D, O'Brien JT (2011), “Diffusion tensor imaging in Alzheimer's disease and dementia with Lewy bodies.” Psychiatry Res 194(2):176-83 Details

Firbank MJ, He J, Blamire AM, Singh B, Danson P, Kalaria RN, O'Brien JT (2011), “Cerebral blood flow by arterial spin labeling in poststroke dementia.” Neurology 76(17):1478-84 Details

Frederiksen KS, Garde E, Skimminge A, Barkhof F, Scheltens P, van Straaten EC, Fazekas F, Baezner H, Verdelho A, Ferro JM, Erkinjuntti T, Jokinen H, Wahlund LO, O'Brien JT, Basile AM, Pantoni L, Inzitari D, Waldemar G (2011), “Corpus callosum tissue loss and development of motor and global cognitive impairment: the LADIS study.” Dement Geriatr Cogn Disord 32(4):279-86 Details

Frisoni GB, Hampel H, O'Brien JT, Ritchie K, Winblad B (2011), “Revised criteria for Alzheimer's disease: what are the lessons for clinicians?” Lancet Neurol 10(7):598-601 Details

Frisoni GB, Winblad B, O'Brien JT (2011), “Revised NIA-AA criteria for the diagnosis of Alzheimer's disease: a step forward but not yet ready for widespread clinical use.” Int Psychogeriatr 23(8):1191-6 Details

Howard R, Phillips P, Johnson T, O'Brien J, Sheehan B, Lindesay J, Bentham P, Burns A, Ballard C, Holmes C, McKeith I, Barber R, Dening T, Ritchie C, Jones R, Baldwin A, Passmore P, Findlay D, Hughes A, Macharouthu A, Banerjee S, Jones R, Knapp M, Brown RG, Jacoby R, Adams J, Griffin M, Gray R (2011), “Determining the minimum clinically important differences for outcomes in the DOMINO trial.” Int J Geriatr Psychiatry 26(8):812-7 Details

Jones EL, Kalaria RN, Sharp SI, O'Brien JT, Francis PT, Ballard CG (2011), “Genetic associations of autopsy-confirmed vascular dementia subtypes.” Dement Geriatr Cogn Disord 31(4):247-53 Details

Jordan A, Hughes J, Pakresi M, Hepburn S, O'Brien JT (2011), “The utility of PAINAD in assessing pain in a UK population with severe dementia.” Int J Geriatr Psychiatry 26(2):118-26 Details

Köhler S, Ashton CH, Marsh R, Thomas AJ, Barnett NA, O'Brien JT (2011), “Electrophysiological changes in late life depression and their relation to structural brain changes.” Int Psychogeriatr 23(1):141-8 Details

Morris CM, Ballard CG, Allan L, Rowan E, Stephens S, Firbank M, Ford GA, Kenny RA, O'Brien JT, Kalaria RN (2011), “NOS3 gene rs1799983 polymorphism and incident dementia in elderly stroke survivors.” Neurobiol Aging 32(3):554.e1-6 Details

Narayan SK, Firbank MJ, Saxby BK, Stansby G, Hansrani M, O'Brien JT, Ford GA (2011), “Elevated plasma homocysteine is associated with increased brain atrophy rates in older subjects with mild hypertension.” Dement Geriatr Cogn Disord 31(5):341-8 Details

Narayan SK, Saxby BK, Firbank MJ, O'Brien JT, Harrington F, McKeith IG, Hansrani M, Stansby G, Ford GA (2011), “Plasma homocysteine and cognitive decline in older hypertensive subjects.” Int Psychogeriatr 23(10):1607-15 Details

O'Brien JT, Burns A, BAP Dementia Consensus Group (2011), “Clinical practice with anti-dementia drugs: a revised (second) consensus statement from the British Association for Psychopharmacology.” J Psychopharmacol 25(8):997-1019 Details

Quigley H, Colloby SJ, O'Brien JT (2011), “PET imaging of brain amyloid in dementia: a review.” Int J Geriatr Psychiatry 26(10):991-9 Details

Smart SD, Firbank MJ, O'Brien JT (2011), “Validation of automated white matter hyperintensity segmentation.” J Aging Res 2011:391783 Details

Taylor JP, Firbank M, Barnett N, Pearce S, Livingstone A, Mosimann U, Eyre J, McKeith IG, O'Brien JT (2011), “Visual hallucinations in dementia with Lewy bodies: transcranial magnetic stimulation study.” Br J Psychiatry 199(6):492-500 Details

Vasudev A, O'Brien JT, Tan MP, Parry SW, Thomas AJ (2011), “A study of orthostatic hypotension, heart rate variability and baroreflex sensitivity in late-life depression.” J Affect Disord 131(1-3):374-8 Details

Wood JS, Firbank MJ, Mosimann UP, Taylor JP, O'Brien JT (2011), “Development of a novel FMRI compatible visual perception prototype battery to test older people with and without dementia.” J Geriatr Psychiatry Neurol 24(2):73-83 Details

2010

Colloby SJ, Perry EK, Pakrasi S, Pimlott SL, Wyper DJ, McKeith IG, Williams ED, O'Brien JT (2010), “Nicotinic 123I-5IA-85380 single photon emission computed tomography as a predictor of cognitive progression in Alzheimer's disease and dementia with Lewy bodies.” Am J Geriatr Psychiatry 18(1):86-90 Details

Colloby SJ, Taylor JP, Firbank MJ, McKeith IG, Williams ED, O'Brien JT (2010), “Covariance 99mTc-exametazime SPECT patterns in Alzheimer's disease and dementia with Lewy bodies: utility in differential diagnosis.” J Geriatr Psychiatry Neurol 23(1):54-62 Details

Dubois B, Feldman HH, Jacova C, Cummings JL, Dekosky ST, Barberger-Gateau P, Delacourte A, Frisoni G, Fox NC, Galasko D, Gauthier S, Hampel H, Jicha GA, Meguro K, O'Brien J, Pasquier F, Robert P, Rossor M, Salloway S, Sarazin M, de Souza LC, Stern Y, Visser PJ, Scheltens P (2010), “Revising the definition of Alzheimer's disease: a new lexicon.” Lancet Neurol 9(11):1118-27 Details

Firbank MJ, Blamire AM, Teodorczuk A, Teper E, Burton EJ, Mitra D, O'Brien JT (2010), “High resolution imaging of the medial temporal lobe in Alzheimer's disease and dementia with Lewy bodies.” J Alzheimers Dis 21(4):1129-40 Details

Firbank MJ, Narayan SK, Saxby BK, Ford GA, O'Brien JT (2010), “Homocysteine is associated with hippocampal and white matter atrophy in older subjects with mild hypertension.” Int Psychogeriatr 22(5):804-11 Details

Hort J, O'Brien JT, Gainotti G, Pirttila T, Popescu BO, Rektorova I, Sorbi S, Scheltens P, EFNS Scientist Panel on Dementia (2010), “EFNS guidelines for the diagnosis and management of Alzheimer's disease.” Eur J Neurol 17(10):1236-48 Details

Ihara M, Polvikoski TM, Hall R, Slade JY, Perry RH, Oakley AE, Englund E, O'Brien JT, Ince PG, Kalaria RN (2010), “Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer's disease, and dementia with Lewy bodies.” Acta Neuropathol 119(5):579-89 Details

Kenny ER, O'Brien JT, Cousins DA, Richardson J, Thomas AJ, Firbank MJ, Blamire AM (2010), “Functional connectivity in late-life depression using resting-state functional magnetic resonance imaging.” Am J Geriatr Psychiatry 18(7):643-51 Details

Köhler S, Thomas AJ, Barnett NA, O'Brien JT (2010), “The pattern and course of cognitive impairment in late-life depression.” Psychol Med 40(4):591-602 Details

Köhler S, Thomas AJ, Lloyd A, Barber R, Almeida OP, O'Brien JT (2010), “White matter hyperintensities, cortisol levels, brain atrophy and continuing cognitive deficits in late-life depression.” Br J Psychiatry 196(2):143-9 Details

Köhler S, van Boxtel MP, van Os J, Thomas AJ, O'Brien JT, Jolles J, Verhey FR, Allardyce J (2010), “Depressive symptoms and cognitive decline in community-dwelling older adults.” J Am Geriatr Soc 58(5):873-9 Details

Teodorczuk A, Firbank MJ, Pantoni L, Poggesi A, Erkinjuntti T, Wallin A, Wahlund LO, Scheltens P, Waldemar G, Schrotter G, Ferro JM, Chabriat H, Bazner H, Visser M, Inzitari D, O'Brien JT, LADIS Group (2010), “Relationship between baseline white-matter changes and development of late-life depressive symptoms: 3-year results from the LADIS study.” Psychol Med 40(4):603-10 Details

2009

Ballard C, Margallo-Lana M, O'Brien JT, James I, Howard R, Fossey J (2009), “Top cited papers in International Psychogeriatrics: 6a. Quality of life for people with dementia living in residential and nursing home care: the impact of performance on activities of daily living, behavioral and psychological symptoms, language skills, and psychotropic drugs.” Int Psychogeriatr 21(6):1026-30 Details

Bousser MG, Amarenco P, Chamorro A, Fisher M, Ford I, Fox K, Hennerici MG, Mattle HP, Rothwell PM, PERFORM Study Investigators (2009), “Rationale and design of a randomized, double-blind, parallel-group study of terutroban 30 mg/day versus aspirin 100 mg/day in stroke patients: the prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) study.” Cerebrovasc Dis 27(5):509-18 Details

Burton EJ, Barber R, Mukaetova-Ladinska EB, Robson J, Perry RH, Jaros E, Kalaria RN, O'Brien JT (2009), “Medial temporal lobe atrophy on MRI differentiates Alzheimer's disease from dementia with Lewy bodies and vascular cognitive impairment: a prospective study with pathological verification of diagnosis.” Brain 132(Pt 1):195-203 Details

Inzitari D, Pracucci G, Poggesi A, Carlucci G, Barkhof F, Chabriat H, Erkinjuntti T, Fazekas F, Ferro JM, Hennerici M, Langhorne P, O'Brien J, Scheltens P, Visser MC, Wahlund LO, Waldemar G, Wallin A, Pantoni L, LADIS Study Group (2009), “Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort.” BMJ 339:b2477 Details

Molloy S, Minett T, O'Brien JT, McKeith IG, Burn DJ (2009), “Levodopa use and sleep in patients with dementia with Lewy bodies.” Mov Disord 24(4):609-12 Details

O'Brien JT, McKeith IG, Walker Z, Tatsch K, Booij J, Darcourt J, Marquardt M, Reininger C, DLB Study Group (2009), “Diagnostic accuracy of 123I-FP-CIT SPECT in possible dementia with Lewy bodies.” Br J Psychiatry 194(1):34-9 Details

Richardson J, Kerr SR, Shaw F, Kenny RA, O'Brien JT, Thomas AJ (2009), “A study of orthostatic hypotension in late-life depression.” Am J Geriatr Psychiatry 17(11):996-9 Details

Simpson JE, Hosny O, Wharton SB, Heath PR, Holden H, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C, Shaw PJ, Lewis CE, Ince PG, Medical Research Council Cognitive Function and Ageing Study Neuropathology Group (2009), “Microarray RNA expression analysis of cerebral white matter lesions reveals changes in multiple functional pathways.” Stroke 40(2):369-75 Details

Singh B, O'Brien JT (2009), “When should drug treatment be started for people with dementia?” Maturitas 62(3):230-4 Details

Thomas AJ, Gallagher P, Robinson LJ, Porter RJ, Young AH, Ferrier IN, O'Brien JT (2009), “A comparison of neurocognitive impairment in younger and older adults with major depression.” Psychol Med 39(5):725-33 Details

Watson R, Blamire AM, O'Brien JT (2009), “Magnetic resonance imaging in lewy body dementias.” Dement Geriatr Cogn Disord 28(6):493-506 Details

2008

Colloby SJ, Firbank MJ, Pakrasi S, Lloyd JJ, Driver I, McKeith IG, Williams ED, O'Brien JT (2008), “A comparison of 99mTc-exametazime and 123I-FP-CIT SPECT imaging in the differential diagnosis of Alzheimer's disease and dementia with Lewy bodies.” Int Psychogeriatr 20(6):1124-40 Details

Firbank MJ, Barber R, Burton EJ, O'Brien JT (2008), “Validation of a fully automated hippocampal segmentation method on patients with dementia.” Hum Brain Mapp 29(12):1442-9 Details

Kenny ER, Burton EJ, O'Brien JT (2008), “A volumetric magnetic resonance imaging study of entorhinal cortex volume in dementia with lewy bodies. A comparison with Alzheimer's disease and Parkinson's disease with and without dementia.” Dement Geriatr Cogn Disord 26(3):218-25 Details

O'Brien J (2008), “Antipsychotics for people with dementia.” BMJ 337:a602 Details

O'Brien JT (2008), “A promising new treatment for Alzheimer's disease?” Lancet Neurol 7(9):768-9 Details

O'Brien JT, Colloby SJ, Pakrasi S, Perry EK, Pimlott SL, Wyper DJ, McKeith IG, Williams ED (2008), “Nicotinic alpha4beta2 receptor binding in dementia with Lewy bodies using 123I-5IA-85380 SPECT demonstrates a link between occipital changes and visual hallucinations.” Neuroimage 40(3):1056-63 Details

O'Brien JT, Williams ER (2008), “Hydration of gaseous copper dications probed by IR action spectroscopy.” J Phys Chem A 112(26):5893-901 Details

Prell JS, O'Brien JT, Holm AI, Leib RD, Donald WA, Williams ER (2008), “Electron capture by a hydrated gaseous peptide: effects of water on fragmentation and molecular survival.” J Am Chem Soc 130(38):12680-9 Details

Taylor JP, Rowan EN, Lett D, O'Brien JT, McKeith IG, Burn DJ (2008), “Poor attentional function predicts cognitive decline in patients with non-demented Parkinson's disease independent of motor phenotype.” J Neurol Neurosurg Psychiatry 79(12):1318-23 Details

Teper E, O'Brien JT (2008), “Vascular factors and depression.” Int J Geriatr Psychiatry 23(10):993-1000 Details

Thomas AJ, O'Brien JT (2008), “Depression and cognition in older adults.” Curr Opin Psychiatry 21(1):8-13 Details

2007

Ballard CG, Chalmers KA, Todd C, McKeith IG, O'Brien JT, Wilcock G, Love S, Perry EK (2007), “Cholinesterase inhibitors reduce cortical Abeta in dementia with Lewy bodies.” Neurology 68(20):1726-9 Details

Boddy F, Rowan EN, Lett D, O'Brien JT, McKeith IG, Burn DJ (2007), “Subjectively reported sleep quality and excessive daytime somnolence in Parkinson's disease with and without dementia, dementia with Lewy bodies and Alzheimer's disease.” Int J Geriatr Psychiatry 22(6):529-35 Details

Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J, Delacourte A, Galasko D, Gauthier S, Jicha G, Meguro K, O'brien J, Pasquier F, Robert P, Rossor M, Salloway S, Stern Y, Visser PJ, Scheltens P (2007), “Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria.” Lancet Neurol 6(8):734-46 Details

Firbank MJ, Blamire AM, Krishnan MS, Teodorczuk A, English P, Gholkar A, Harrison R, O'Brien JT (2007), “Atrophy is associated with posterior cingulate white matter disruption in dementia with Lewy bodies and Alzheimer's disease.” Neuroimage 36(1):1-7 Details

Firbank MJ, Blamire AM, Krishnan MS, Teodorczuk A, English P, Gholkar A, Harrison RM, O'Brien JT (2007), “Diffusion tensor imaging in dementia with Lewy bodies and Alzheimer's disease.” Psychiatry Res 155(2):135-45 Details

Firbank MJ, Burton EJ, Barber R, Stephens S, Kenny RA, Ballard C, Kalaria RN, O'Brien JT (2007), “Medial temporal atrophy rather than white matter hyperintensities predict cognitive decline in stroke survivors.” Neurobiol Aging 28(11):1664-9 Details

Firbank MJ, Wiseman RM, Burton EJ, Saxby BK, O'Brien JT, Ford GA (2007), “Brain atrophy and white matter hyperintensity change in older adults and relationship to blood pressure. Brain atrophy, WMH change and blood pressure.” J Neurol 254(6):713-21 Details

Howard RJ, Juszczak E, Ballard CG, Bentham P, Brown RG, Bullock R, Burns AS, Holmes C, Jacoby R, Johnson T, Knapp M, Lindesay J, O'Brien JT, Wilcock G, Katona C, Jones RW, DeCesare J, Rodger M, CALM-AD Trial Group (2007), “Donepezil for the treatment of agitation in Alzheimer's disease.” N Engl J Med 357(14):1382-92 Details

McKeith I, O'Brien J, Walker Z, Tatsch K, Booij J, Darcourt J, Padovani A, Giubbini R, Bonuccelli U, Volterrani D, Holmes C, Kemp P, Tabet N, Meyer I, Reininger C, DLB Study Group (2007), “Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study.” Lancet Neurol 6(4):305-13 Details

O'Brien JT (2007), “Role of imaging techniques in the diagnosis of dementia.” Br J Radiol 80 Spec No 2:S71-7 Details

O'Brien JT (2007), “Introduction: for debate: should neuroimaging be a routine investigation in all cases of suspected dementia?” Int Psychogeriatr 19(3):525-6 Details

O'Brien JT, Colloby SJ, Pakrasi S, Perry EK, Pimlott SL, Wyper DJ, McKeith IG, Williams ED (2007), “Alpha4beta2 nicotinic receptor status in Alzheimer's disease using 123I-5IA-85380 single-photon-emission computed tomography.” J Neurol Neurosurg Psychiatry 78(4):356-62 Details

Pakrasi S, Colloby SJ, Firbank MJ, Perry EK, Wyper DJ, Owens J, McKeith IG, Williams ED, O'Brien JT (2007), “Muscarinic acetylcholine receptor status in Alzheimer's disease assessed using (R, R) 123I-QNB SPECT.” J Neurol 254(7):907-13 Details

Porter RJ, Gallagher P, O'Brien JT (2007), “Effects of rapid tryptophan depletion on salivary cortisol in older people recovered from depression, and the healthy elderly.” J Psychopharmacol 21(1):71-5 Details

Rowan E, McKeith IG, Saxby BK, O'Brien JT, Burn D, Mosimann U, Newby J, Daniel S, Sanders J, Wesnes K (2007), “Effects of donepezil on central processing speed and attentional measures in Parkinson's disease with dementia and dementia with Lewy bodies.” Dement Geriatr Cogn Disord 23(3):161-7 Details

Simpson JE, Fernando MS, Clark L, Ince PG, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C, Shaw PJ, Lewis CE, Wharton SB, MRC Cognitive Function and Ageing Neuropathology Study Group (2007), “White matter lesions in an unselected cohort of the elderly: astrocytic, microglial and oligodendrocyte precursor cell responses.” Neuropathol Appl Neurobiol 33(4):410-9 Details

Simpson JE, Ince PG, Higham CE, Gelsthorpe CH, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C, Shaw PJ, Stoeber K, Williams GH, Lewis CE, Wharton SB, MRC Cognitive Function and Ageing Neuropathology Study Group (2007), “Microglial activation in white matter lesions and nonlesional white matter of ageing brains.” Neuropathol Appl Neurobiol 33(6):670-83 Details

Taylor JP, Colloby SJ, McKeith IG, Burn DJ, Williams D, Patterson J, O'Brien JT (2007), “Cholinesterase inhibitor use does not significantly influence the ability of 123I-FP-CIT imaging to distinguish Alzheimer's disease from dementia with Lewy bodies.” J Neurol Neurosurg Psychiatry 78(10):1069-71 Details

Teodorczuk A, O'Brien JT, Firbank MJ, Pantoni L, Poggesi A, Erkinjuntti T, Wallin A, Wahlund LO, Gouw A, Waldemar G, Schmidt R, Ferro JM, Chabriat H, Bäzner H, Inzitari D, LADIS Group (2007), “White matter changes and late-life depressive symptoms: longitudinal study.” Br J Psychiatry 191:212-7 Details

Thomas AJ, Morris C, Davis S, Jackson E, Harrison R, O'Brien JT (2007), “Soluble cell adhesion molecules in late-life depression.” Int Psychogeriatr 19(5):914-20 Details

2006

Burn DJ, Rowan EN, Allan LM, Molloy S, O'Brien JT, McKeith IG (2006), “Motor subtype and cognitive decline in Parkinson's disease, Parkinson's disease with dementia, and dementia with Lewy bodies.” J Neurol Neurosurg Psychiatry 77(5):585-9 Details

Burton EJ, McKeith IG, Burn DJ, Firbank MJ, O'Brien JT (2006), “Progression of white matter hyperintensities in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia: a comparison with normal aging.” Am J Geriatr Psychiatry 14(10):842-9 Details

Colloby SJ, Pakrasi S, Firbank MJ, Perry EK, Piggott MA, Owens J, Wyper DJ, McKeith IG, Burn DJ, Williams ED, O'Brien JT (2006), “In vivo SPECT imaging of muscarinic acetylcholine receptors using (R,R) 123I-QNB in dementia with Lewy bodies and Parkinson's disease dementia.” Neuroimage 33(2):423-9 Details

Fernando MS, Simpson JE, Matthews F, Brayne C, Lewis CE, Barber R, Kalaria RN, Forster G, Esteves F, Wharton SB, Shaw PJ, O'Brien JT, Ince PG, MRC Cognitive Function and Ageing Neuropathology Study Group (2006), “White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury.” Stroke 37(6):1391-8 Details

Krishnan MS, O'Brien JT, Firbank MJ, Pantoni L, Carlucci G, Erkinjuntti T, Wallin A, Wahlund LO, Scheltens P, van Straaten EC, Inzitari D, LADIS Group (2006), “Relationship between periventricular and deep white matter lesions and depressive symptoms in older people. The LADIS Study.” Int J Geriatr Psychiatry 21(10):983-9 Details

McKeith IG, Rowan E, Askew K, Naidu A, Allan L, Barnett N, Lett D, Mosimann UP, Burn D, O'Brien JT (2006), “More severe functional impairment in dementia with lewy bodies than Alzheimer disease is related to extrapyramidal motor dysfunction.” Am J Geriatr Psychiatry 14(7):582-8 Details

Molloy SA, Rowan EN, O'Brien JT, McKeith IG, Wesnes K, Burn DJ (2006), “Effect of levodopa on cognitive function in Parkinson's disease with and without dementia and dementia with Lewy bodies.” J Neurol Neurosurg Psychiatry 77(12):1323-8 Details

Mosimann UP, Rowan EN, Partington CE, Collerton D, Littlewood E, O'Brien JT, Burn DJ, McKeith IG (2006), “Characteristics of visual hallucinations in Parkinson disease dementia and dementia with lewy bodies.” Am J Geriatr Psychiatry 14(2):153-60 Details

O'Brien JT (2006), “NICE and anti-dementia drugs: a triumph of health economics over clinical wisdom?” Lancet Neurol 5(12):994-6 Details

O'Brien JT (2006), “Vascular cognitive impairment.” Am J Geriatr Psychiatry 14(9):724-33 Details

O'Brien JT (2006), “Depression and comorbidity.” Am J Geriatr Psychiatry 14(3):187-90 Details

O'Brien JT, Firbank MJ, Krishnan MS, van Straaten EC, van der Flier WM, Petrovic K, Pantoni L, Simoni M, Erkinjuntti T, Wallin A, Wahlund LO, Inzitari D, LADIS Group (2006), “White matter hyperintensities rather than lacunar infarcts are associated with depressive symptoms in older people: the LADIS study.” Am J Geriatr Psychiatry 14(10):834-41 Details

Pakrasi S, Thomas A, Mosimann UP, Cousins DA, Lett D, Burn DJ, O'Brien JT, McKeith IG (2006), “Cholinesterase inhibitors in advanced Dementia with Lewy bodies: increase or stop?” Int J Geriatr Psychiatry 21(8):719-21 Details

Thomas AJ, Hendriksen M, Piggott M, Ferrier IN, Perry E, Ince P, O'Brien JT (2006), “A study of the serotonin transporter in the prefrontal cortex in late-life depression and Alzheimer's disease with and without depression.” Neuropathol Appl Neurobiol 32(3):296-303 Details

2005

Aarsland D, Perry R, Larsen JP, McKeith IG, O'Brien JT, Perry EK, Burn D, Ballard CG (2005), “Neuroleptic sensitivity in Parkinson's disease and parkinsonian dementias.” J Clin Psychiatry 66(5):633-7 Details

Burton EJ, McKeith IG, Burn DJ, O'Brien JT (2005), “Brain atrophy rates in Parkinson's disease with and without dementia using serial magnetic resonance imaging.” Mov Disord 20(12):1571-6 Details

Colloby SJ, Williams ED, Burn DJ, Lloyd JJ, McKeith IG, O'Brien JT (2005), “Progression of dopaminergic degeneration in dementia with Lewy bodies and Parkinson's disease with and without dementia assessed using 123I-FP-CIT SPECT.” Eur J Nucl Med Mol Imaging 32(10):1176-85 Details

Firbank MJ, Burn DJ, McKeith IG, O'Brien JT (2005), “Longitudinal study of cerebral blood flow SPECT in Parkinson's disease with dementia, and dementia with Lewy bodies.” Int J Geriatr Psychiatry 20(8):776-82 Details

Firbank MJ, Molloy S, McKeith IG, Burn DJ, O'Brien JT (2005), “Longitudinal change in 99mTcHMPAO cerebral perfusion SPECT in Parkinson's disease over one year.” J Neurol Neurosurg Psychiatry 76(10):1448-51 Details

Firbank MJ, O'Brien JT, Pakrasi S, Pantoni L, Simoni M, Erkinjuntti T, Wallin A, Wahlund LO, van Straaten I, Inzitari D (2005), “White matter hyperintensities and depression--preliminary results from the LADIS study.” Int J Geriatr Psychiatry 20(7):674-9 Details

McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VM, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M, Consortium on DLB (2005), “Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium.” Neurology 65(12):1863-72 Details

Minett TS, Dean JL, Firbank M, English P, O'Brien JT (2005), “Subjective memory complaints, white-matter lesions, depressive symptoms, and cognition in elderly patients.” Am J Geriatr Psychiatry 13(8):665-71 Details

Molloy S, McKeith IG, O'Brien JT, Burn DJ (2005), “The role of levodopa in the management of dementia with Lewy bodies.” J Neurol Neurosurg Psychiatry 76(9):1200-3 Details

Mosimann UP, Müri RM, Burn DJ, Felblinger J, O'Brien JT, McKeith IG (2005), “Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies.” Brain 128(Pt 6):1267-76 Details

O'Brien JT, Firbank MJ, Mosimann UP, Burn DJ, McKeith IG (2005), “Change in perfusion, hallucinations and fluctuations in consciousness in dementia with Lewy bodies.” Psychiatry Res 139(2):79-88 Details

Pakrasi S, O'Brien JT (2005), “Emission tomography in dementia.” Nucl Med Commun 26(3):189-96 Details

Porter RJ, Phipps AJ, Gallagher P, Scott A, Stevenson PS, O'Brien JT (2005), “Effects of acute tryptophan depletion on mood and cognitive functioning in older recovered depressed subjects.” Am J Geriatr Psychiatry 13(7):607-15 Details

Rasmussen LS, O'Brien JT, Silverstein JH, Johnson TW, Siersma VD, Canet J, Jolles J, Hanning CD, Kuipers HM, Abildstrom H, Papaioannou A, Raeder J, Yli-Hankala A, Sneyd JR, Munoz L, Moller JT, ISPOCD2 Investigators (2005), “Is peri-operative cortisol secretion related to post-operative cognitive dysfunction?” Acta Anaesthesiol Scand 49(9):1225-31 Details

Tam CW, Burton EJ, McKeith IG, Burn DJ, O'Brien JT (2005), “Temporal lobe atrophy on MRI in Parkinson disease with dementia: a comparison with Alzheimer disease and dementia with Lewy bodies.” Neurology 64(5):861-5 Details

Thomas AJ, Davis S, Morris C, Jackson E, Harrison R, O'Brien JT (2005), “Increase in interleukin-1beta in late-life depression.” Am J Psychiatry 162(1):175-7 Details

2004

Ballard CG, Burton EJ, Barber R, Stephens S, Kenny RA, Kalaria RN, O'Brien JT (2004), “NINDS AIREN neuroimaging criteria do not distinguish stroke patients with and without dementia.” Neurology 63(6):983-8 Details

Ballard CG, Jacoby R, Del Ser T, Khan MN, Munoz DG, Holmes C, Nagy Z, Perry EK, Joachim C, Jaros E, O'Brien JT, Perry RH, McKeith IG (2004), “Neuropathological substrates of psychiatric symptoms in prospectively studied patients with autopsy-confirmed dementia with lewy bodies.” Am J Psychiatry 161(5):843-9 Details

Ballard CG, Thomas A, Fossey J, Lee L, Jacoby R, Lana MM, Bannister C, McShane R, Swann A, Juszczak E, O'Brien JT (2004), “A 3-month, randomized, placebo-controlled, neuroleptic discontinuation study in 100 people with dementia: the neuropsychiatric inventory median cutoff is a predictor of clinical outcome.” J Clin Psychiatry 65(1):114-9 Details

Ballmaier M, O'Brien JT, Burton EJ, Thompson PM, Rex DE, Narr KL, McKeith IG, DeLuca H, Toga AW (2004), “Comparing gray matter loss profiles between dementia with Lewy bodies and Alzheimer's disease using cortical pattern matching: diagnosis and gender effects.” Neuroimage 23(1):325-35 Details

Burton EJ, McKeith IG, Burn DJ, Williams ED, O'Brien JT (2004), “Cerebral atrophy in Parkinson's disease with and without dementia: a comparison with Alzheimer's disease, dementia with Lewy bodies and controls.” Brain 127(Pt 4):791-800 Details

Colloby SJ, O'Brien JT, Fenwick JD, Firbank MJ, Burn DJ, McKeith IG, Williams ED (2004), “The application of statistical parametric mapping to 123I-FP-CIT SPECT in dementia with Lewy bodies, Alzheimer's disease and Parkinson's disease.” Neuroimage 23(3):956-66 Details

Fernando MS, O'Brien JT, Perry RH, English P, Forster G, McMeekin W, Slade JY, Golkhar A, Matthews FE, Barber R, Kalaria RN, Ince PG, Neuropathology Group of MRC CFAS (2004), “Comparison of the pathology of cerebral white matter with post-mortem magnetic resonance imaging (MRI) in the elderly brain.” Neuropathol Appl Neurobiol 30(4):385-95 Details

Firbank MJ, Lloyd AJ, Ferrier N, O'Brien JT (2004), “A volumetric study of MRI signal hyperintensities in late-life depression.” Am J Geriatr Psychiatry 12(6):606-12 Details

Hendricksen M, Thomas AJ, Ferrier IN, Ince P, O'Brien JT (2004), “Neuropathological study of the dorsal raphe nuclei in late-life depression and Alzheimer's disease with and without depression.” Am J Psychiatry 161(6):1096-102 Details

Kenny RA, Shaw FE, O'Brien JT, Scheltens PH, Kalaria R, Ballard C (2004), “Carotid sinus syndrome is common in dementia with Lewy bodies and correlates with deep white matter lesions.” J Neurol Neurosurg Psychiatry 75(7):966-71 Details

Lloyd AJ, Ferrier IN, Barber R, Gholkar A, Young AH, O'Brien JT (2004), “Hippocampal volume change in depression: late- and early-onset illness compared.” Br J Psychiatry 184:488-95 Details

Mosimann UP, Mather G, Wesnes KA, O'Brien JT, Burn DJ, McKeith IG (2004), “Visual perception in Parkinson disease dementia and dementia with Lewy bodies.” Neurology 63(11):2091-6 Details

O'Brien JT, Colloby S, Fenwick J, Williams ED, Firbank M, Burn D, Aarsland D, McKeith IG (2004), “Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodies.” Arch Neurol 61(6):919-25 Details

O'Brien JT, Lloyd A, McKeith I, Gholkar A, Ferrier N (2004), “A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects.” Am J Psychiatry 161(11):2081-90 Details

Paling SM, Williams ED, Barber R, Burton EJ, Crum WR, Fox NC, O'Brien JT (2004), “The application of serial MRI analysis techniques to the study of cerebral atrophy in late-onset dementia.” Med Image Anal 8(1):69-79 Details

Thomas AJ, Davis S, Ferrier IN, Kalaria RN, O'Brien JT (2004), “Elevation of cell adhesion molecule immunoreactivity in the anterior cingulate cortex in bipolar disorder.” Biol Psychiatry 55(6):652-5 Details

Thomas AJ, Kalaria RN, O'Brien JT (2004), “Depression and vascular disease: what is the relationship?” J Affect Disord 79(1-3):81-95 Details

Wiseman RM, Saxby BK, Burton EJ, Barber R, Ford GA, O'Brien JT (2004), “Hippocampal atrophy, whole brain volume, and white matter lesions in older hypertensive subjects.” Neurology 63(10):1892-7 Details

2003

Almeida OP, Burton EJ, Ferrier N, McKeith IG, O'Brien JT (2003), “Depression with late onset is associated with right frontal lobe atrophy.” Psychol Med 33(4):675-81 Details

Almeida OP, Burton EJ, McKeith I, Gholkar A, Burn D, O'Brien JT (2003), “MRI study of caudate nucleus volume in Parkinson's disease with and without dementia with Lewy bodies and Alzheimer's disease.” Dement Geriatr Cogn Disord 16(2):57-63 Details

Burn DJ, O'Brien JT (2003), “Use of functional imaging in Parkinsonism and dementia.” Mov Disord 18 Suppl 6:S88-95 Details

Burn DJ, Rowan EN, Minett T, Sanders J, Myint P, Richardson J, Thomas A, Newby J, Reid J, O'Brien JT, McKeith IG (2003), “Extrapyramidal features in Parkinson's disease with and without dementia and dementia with Lewy bodies: A cross-sectional comparative study.” Mov Disord 18(8):884-9 Details

Cousins DA, Burton EJ, Burn D, Gholkar A, McKeith IG, O'Brien JT (2003), “Atrophy of the putamen in dementia with Lewy bodies but not Alzheimer's disease: an MRI study.” Neurology 61(9):1191-5 Details

Firbank MJ, Colloby SJ, Burn DJ, McKeith IG, O'Brien JT (2003), “Regional cerebral blood flow in Parkinson's disease with and without dementia.” Neuroimage 20(2):1309-19 Details

Firbank MJ, Minett T, O'Brien JT (2003), “Changes in DWI and MRS associated with white matter hyperintensities in elderly subjects.” Neurology 61(7):950-4 Details

Grace J, O'Brien JT (2003), “Association of life events and psychosocial factors with early but not late onset depression in the elderly: implications for possible differences in aetiology.” Int J Geriatr Psychiatry 18(6):473-8 Details

Karas GB, Burton EJ, Rombouts SA, van Schijndel RA, O'Brien JT, Scheltens Ph, McKeith IG, Williams D, Ballard C, Barkhof F (2003), “A comprehensive study of gray matter loss in patients with Alzheimer's disease using optimized voxel-based morphometry.” Neuroimage 18(4):895-907 Details

McKeith IG, Burn DJ, Ballard CG, Collerton D, Jaros E, Morris CM, McLaren A, Perry EK, Perry R, Piggott MA, O'Brien JT (2003), “Dementia with Lewy bodies.” Semin Clin Neuropsychiatry 8(1):46-57 Details

O'Brien JT, Erkinjuntti T, Reisberg B, Roman G, Sawada T, Pantoni L, Bowler JV, Ballard C, DeCarli C, Gorelick PB, Rockwood K, Burns A, Gauthier S, DeKosky ST (2003), “Vascular cognitive impairment.” Lancet Neurol 2(2):89-98 Details

O'Brien JT, Thomas A, English P, Perry R, Jaros E (2003), “A prospectively studied clinicopathological case of 'vascular depression'.” Int J Geriatr Psychiatry 18(7):656-7 Details

O'Brien KK, Saxby BK, Ballard CG, Grace J, Harrington F, Ford GA, O'Brien JT, Swan AG, Fairbairn AF, Wesnes K, del Ser T, Edwardson JA, Morris CM, McKeith IG (2003), “Regulation of attention and response to therapy in dementia by butyrylcholinesterase.” Pharmacogenetics 13(4):231-9 Details

Pakrasi S, Mukaetova-Ladinska EB, McKeith IG, O'Brien JT (2003), “Clinical predictors of response to Acetyl Cholinesterase Inhibitors: experience from routine clinical use in Newcastle.” Int J Geriatr Psychiatry 18(10):879-86 Details

Porter RJ, Lunn BS, O'Brien JT (2003), “Effects of acute tryptophan depletion on cognitive function in Alzheimer's disease and in the healthy elderly.” Psychol Med 33(1):41-9 Details

Thomas AJ, O'Brien JT, Barber R, McMeekin W, Perry R (2003), “A neuropathological study of periventricular white matter hyperintensities in major depression.” J Affect Disord 76(1-3):49-54 Details

Thomas AJ, Perry R, Kalaria RN, Oakley A, McMeekin W, O'Brien JT (2003), “Neuropathological evidence for ischemia in the white matter of the dorsolateral prefrontal cortex in late-life depression.” Int J Geriatr Psychiatry 18(1):7-13 Details

2002

Ballard CG, O'Brien JT, Reichelt K, Perry EK (2002), “Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa.” J Clin Psychiatry 63(7):553-8 Details

Burton EJ, Karas G, Paling SM, Barber R, Williams ED, Ballard CG, McKeith IG, Scheltens P, Barkhof F, O'Brien JT (2002), “Patterns of cerebral atrophy in dementia with Lewy bodies using voxel-based morphometry.” Neuroimage 17(2):618-30 Details

Colloby SJ, Fenwick JD, Williams ED, Paling SM, Lobotesis K, Ballard C, McKeith I, O'Brien JT (2002), “A comparison of (99m)Tc-HMPAO SPET changes in dementia with Lewy bodies and Alzheimer's disease using statistical parametric mapping.” Eur J Nucl Med Mol Imaging 29(5):615-22 Details

Davis S, Thomas A, Perry R, Oakley A, Kalaria RN, O'Brien JT (2002), “Glial fibrillary acidic protein in late life major depressive disorder: an immunocytochemical study.” J Neurol Neurosurg Psychiatry 73(5):556-60 Details

Firbank MJ, Harrison RM, O'Brien JT (2002), “A comprehensive review of proton magnetic resonance spectroscopy studies in dementia and Parkinson's disease.” Dement Geriatr Cogn Disord 14(2):64-76 Details

O'Brien JT, Wiseman R, Burton EJ, Barber B, Wesnes K, Saxby B, Ford GA (2002), “Cognitive associations of subcortical white matter lesions in older people.” Ann N Y Acad Sci 977:436-44 Details

Phipps AJ, O'Brien JT (2002), “Memory clinics and clinical governance--a UK perspective.” Int J Geriatr Psychiatry 17(12):1128-32 Details

Porter RJ, Barnett NA, Idey A, McGuckin EA, O'Brien JT (2002), “Effects of hydrocortisone administration on cognitive function in the elderly.” J Psychopharmacol 16(1):65-71 Details

Porter RJ, Marshall EF, O'Brien JT (2002), “Effects of rapid tryptophan depletion on salivary and plasma cortisol in Alzheimer's disease and the healthy elderly.” J Psychopharmacol 16(1):73-8 Details

Thomas AJ, Ferrier IN, Kalaria RN, Davis S, O'Brien JT (2002), “Cell adhesion molecule expression in the dorsolateral prefrontal cortex and anterior cingulate cortex in major depression in the elderly.” Br J Psychiatry 181:129-34 Details

Thomas AJ, O'Brien JT, Davis S, Ballard C, Barber R, Kalaria RN, Perry RH (2002), “Ischemic basis for deep white matter hyperintensities in major depression: a neuropathological study.” Arch Gen Psychiatry 59(9):785-92 Details

Thomas AJ, Perry R, Barber R, Kalaria RN, O'Brien JT (2002), “Pathologies and pathological mechanisms for white matter hyperintensities in depression.” Ann N Y Acad Sci 977:333-9 Details

2001

Ballard CG, O'Brien JT, Swann AG, Thompson P, Neill D, McKeith IG (2001), “The natural history of psychosis and depression in dementia with Lewy bodies and Alzheimer's disease: persistence and new cases over 1 year of follow-up.” J Clin Psychiatry 62(1):46-9 Details

Barber R, McKeith IG, Ballard C, Gholkar A, O'Brien JT (2001), “A comparison of medial and lateral temporal lobe atrophy in dementia with Lewy bodies and Alzheimer's disease: magnetic resonance imaging volumetric study.” Dement Geriatr Cogn Disord 12(3):198-205 Details

Court JA, Ballard CG, Piggott MA, Johnson M, O'Brien JT, Holmes C, Cairns N, Lantos P, Perry RH, Jaros E, Perry EK (2001), “Visual hallucinations are associated with lower alpha bungarotoxin binding in dementia with Lewy bodies.” Pharmacol Biochem Behav 70(4):571-9 Details

Jackson EJ, Rajah S, Morris C, Ballard C, Thomas AJ, O'Brien JT (2001), “Is apolipoprotein e4 associated with cognitive decline in depression?” Int J Geriatr Psychiatry 16(4):436-7 Details

Kalaria RN, Ballard CG, Ince PG, Kenny RA, McKeith IG, Morris CM, O'Brien JT, Perry EK, Perry RH, Edwardson JA (2001), “Multiple substrates of late-onset dementia: implications for brain protection.” Novartis Found Symp 235:49-60; discussion 60-5 Details

Lloyd AJ, Grace JB, Jaros E, Perry RH, Fairbairn AF, Swann AG, O'Brien JT, McKeith IG (2001), “Depression in late life, cognitive decline and white matter pathology in two clinico-pathologically investigated cases.” Int J Geriatr Psychiatry 16(3):281-7 Details

Lobotesis K, Fenwick JD, Phipps A, Ryman A, Swann A, Ballard C, McKeith IG, O'Brien JT (2001), “Occipital hypoperfusion on SPECT in dementia with Lewy bodies but not AD.” Neurology 56(5):643-9 Details

Middelkoop HA, van der Flier WM, Burton EJ, Lloyd AJ, Paling S, Barber R, Ballard C, McKeith IG, O'Brien JT (2001), “Dementia with Lewy bodies and AD are not associated with occipital lobe atrophy on MRI.” Neurology 57(11):2117-20 Details

O'Brien JT, Ames D, Desmond P, Lichtenstein M, Binns D, Schweitzer I, Davis S, Tress B (2001), “Combined magnetic resonance imaging and single-photon emission tomography scanning in the discrimination of Alzheimer's disease from age-matched controls.” Int Psychogeriatr 13(2):149-61 Details

O'Brien JT, Ballard CG (2001), “Drugs for Alzheimer's disease.” BMJ 323(7305):123-4 Details

O'Brien JT, Paling S, Barber R, Williams ED, Ballard C, McKeith IG, Gholkar A, Crum WR, Rossor MN, Fox NC (2001), “Progressive brain atrophy on serial MRI in dementia with Lewy bodies, AD, and vascular dementia.” Neurology 56(10):1386-8 Details

Thomas AJ, Ferrier IN, Kalaria RN, Perry RH, Brown A, O'Brien JT (2001), “A neuropathological study of vascular factors in late-life depression.” J Neurol Neurosurg Psychiatry 70(1):83-7 Details

2000

Barber R, Ballard C, McKeith IG, Gholkar A, O'Brien JT (2000), “MRI volumetric study of dementia with Lewy bodies: a comparison with AD and vascular dementia.” Neurology 54(6):1304-9 Details

Barber R, Gholkar A, Scheltens P, Ballard C, McKeith IG, O'Brien JT (2000), “MRI volumetric correlates of white matter lesions in dementia with Lewy bodies and Alzheimer's disease.” Int J Geriatr Psychiatry 15(10):911-6 Details

McKeith IG, Ballard CG, Perry RH, Ince PG, O'Brien JT, Neill D, Lowery K, Jaros E, Barber R, Thompson P, Swann A, Fairbairn AF, Perry EK (2000), “Prospective validation of consensus criteria for the diagnosis of dementia with Lewy bodies.” Neurology 54(5):1050-8 Details

O'Brien JT, Metcalfe S, Swann A, Hobson J, Jobst K, Ballard C, McKeith I, Gholkar A (2000), “Medial temporal lobe width on CT scanning in Alzheimer's disease: comparison with vascular dementia, depression and dementia with Lewy bodies.” Dement Geriatr Cogn Disord 11(2):114-8 Details

Porter RJ, Lunn BS, Walker LL, Gray JM, Ballard CG, O'Brien JT (2000), “Cognitive deficit induced by acute tryptophan depletion in patients with Alzheimer's disease.” Am J Psychiatry 157(4):638-40 Details

Thomas AJ, Ferrier IN, Kalaria RN, Woodward SA, Ballard C, Oakley A, Perry RH, O'Brien JT (2000), “Elevation in late-life depression of intercellular adhesion molecule-1 expression in the dorsolateral prefrontal cortex.” Am J Psychiatry 157(10):1682-4 Details

Walker MP, Ayre GA, Cummings JL, Wesnes K, McKeith IG, O'Brien JT, Ballard CG (2000), “The Clinician Assessment of Fluctuation and the One Day Fluctuation Assessment Scale. Two methods to assess fluctuating confusion in dementia.” Br J Psychiatry 177:252-6 Details

Walker MP, Ayre GA, Cummings JL, Wesnes K, McKeith IG, O'Brien JT, Ballard CG (2000), “Quantifying fluctuation in dementia with Lewy bodies, Alzheimer's disease, and vascular dementia.” Neurology 54(8):1616-25 Details

1999

Barber R, Gholkar A, Scheltens P, Ballard C, McKeith IG, Morris CM, O'Brien JT (1999), “Apolipoprotein E epsilon4 allele, temporal lobe atrophy, and white matter lesions in late-life dementias.” Arch Neurol 56(8):961-5 Details

Barber R, Gholkar A, Scheltens P, Ballard C, McKeith IG, O'Brien JT (1999), “Medial temporal lobe atrophy on MRI in dementia with Lewy bodies.” Neurology 52(6):1153-8 Details

Erkinjuntti T, Bowler JV, DeCarli CS, Fazekas F, Inzitari D, O'Brien JT, Pantoni L, Rockwood K, Scheltens P, Wahlund LO, Desmond DW (1999), “Imaging of static brain lesions in vascular dementia: implications for clinical trials.” Alzheimer Dis Assoc Disord 13 Suppl 3:S81-90 Details

Harvey GT, Hughes J, McKeith IG, Briel R, Ballard C, Gholkar A, Scheltens P, Perry RH, Ince P, O'Brien JT (1999), “Magnetic resonance imaging differences between dementia with Lewy bodies and Alzheimer's disease: a pilot study.” Psychol Med 29(1):181-7 Details

McKeith IG, O'Brien JT, Ballard C (1999), “Diagnosing dementia with Lewy bodies.” Lancet 354(9186):1227-8 Details

1998

Porter RJ, O'Brien JT (1998), “SSRIs may well be best treatment for elderly depressed subjects.” BMJ 316(7131):631 Details

1997

Ballard CG, O'Brien JT, Coope B, Wilcock G (1997), “Psychotic symptoms in dementia and the rate of cognitive decline.” J Am Geriatr Soc 45(8):1031-2 Details

O'Brien JT, Ames D, Schweitzer I, Desmond P, Coleman P, Tress B (1997), “Clinical, magnetic resonance imaging and endocrinological differences between delusional and non-delusional depression in the elderly.” Int J Geriatr Psychiatry 12(2):211-8 Details

O'Brien JT, Desmond P, Ames D, Schweitzer I, Chiu E, Tress B (1997), “Temporal lobe magnetic resonance imaging can differentiate Alzheimer's disease from normal ageing, depression, vascular dementia and other causes of cognitive impairment.” Psychol Med 27(6):1267-75 Details

O'Brien JT, Desmond P, Ames D, Schweitzer I, Tress B (1997), “Magnetic resonance imaging correlates of memory impairment in the healthy elderly: association with medial temporal lobe atrophy but not white matter lesions.” Int J Geriatr Psychiatry 12(3):369-74 Details

Williams JH, O'Brien JT, Cullum S (1997), “Time course of response to electroconvulsive therapy in elderly depressed subjects.” Int J Geriatr Psychiatry 12(5):563-6 Details

1996

Berman AT, O'Brien JT, Israelite C (1996), “Use of the rotating hinge for salvage of the infected total knee arthroplasty.” Orthopedics 19(1):73-6 Details

O'Brien JT, Ames D (1996), “White matter lesions in depression and Alzheimer's disease.” Br J Psychiatry 169(5):671 Details

O'Brien JT, Ames D, Schweitzer I, Colman P, Desmond P, Tress B (1996), “Clinical and magnetic resonance imaging correlates of hypothalamic-pituitary-adrenal axis function in depression and Alzheimer's disease.” Br J Psychiatry 168(6):679-87 Details

O'Brien JT, Ames D, Schweitzer I, Mastwyk M, Colman P (1996), “Enhanced adrenal sensitivity to adrenocorticotrophic hormone (ACTH) is evidence of HPA axis hyperactivity in Alzheimer's disease.” Psychol Med 26(1):7-14 Details

O'Brien JT, Sale C, Palmer A, Lin R, Kitson M (1996), “Schizophrenia with poor prognosis associated with hemi-atrophy of the left temporal lobe.” J Nerv Ment Dis 184(11):710-1 Details

Page MP, Howard RJ, O'Brien JT, Buxton-Thomas MS, Pickering AD (1996), “Use of neural networks in brain SPECT to diagnose Alzheimer's disease.” J Nucl Med 37(2):195-200 Details

1994

Desmond PM, O'Brien JT, Tress BM, Ames DJ, Clement JG, Clement P, Schweitzer I, Tuckwell V, Robinson GS (1994), “Volumetric and visual assessment of the mesial temporal structures in Alzheimer's disease.” Aust N Z J Med 24(5):547-53 Details

O'Brien JT (1994), “Cost-effectiveness of antidepressants.” Br J Psychiatry 165(3):411-2 Details

O'Brien JT, Desmond P, Ames D, Schweitzer I, Tuckwell V, Tress B (1994), “The differentiation of depression from dementia by temporal lobe magnetic resonance imaging.” Psychol Med 24(3):633-40 Details

O'Brien JT, Schweitzer I, Ames D, Mastwyk M, Colman P (1994), “The function of the hypothalamic-pituitary-adrenal axis in Alzheimer's disease. Response to insulin hypoglycaemia.” Br J Psychiatry 165(5):650-7 Details

O'Brien JT, Schweitzer I, Ames D, Tuckwell V, Mastwyk M (1994), “Cortisol suppression by dexamethasone in the healthy elderly: effects of age, dexamethasone levels, and cognitive function.” Biol Psychiatry 36(6):389-94 Details

1993

O'Brien JT, Sahakian BJ, Checkley SA (1993), “Cognitive impairments in patients with seasonal affective disorder.” Br J Psychiatry 163:338-43 Details

1992

O'Brien JT, Eagger S, Syed GM, Sahakian BJ, Levy R (1992), “A study of regional cerebral blood flow and cognitive performance in Alzheimer's disease.” J Neurol Neurosurg Psychiatry 55(12):1182-7 Details

O'Brien JT, Levy R (1992), “Age associated memory impairment.” BMJ 304(6818):5-6 Details

O'Brien JT, Tarbuck AF (1992), “Suicide and vehicle exhaust emissions.” BMJ 304(6838):1376 Details

1991

O'Brien JT, Eagger S, Levy R (1991), “Effects of tetrahydroaminoacridine on liver function in patients with Alzheimer's disease.” Age Ageing 20(2):129-31 Details