Dr Jonathan Gilley

University position

Senior Research Associate

Departments

Department of Clinical Neurosciences

Institutes

Cambridge Centre for Brain Repair

Email

jon.gilley@babraham.ac.uk

Home page

http://www.brc.cam.ac.uk/

Research Theme

Cellular and Molecular Neuroscience

Interests

My principle research area is investigation of the molecular mechanisms involved in axon degeneration after injury and in disease.

Research Focus

Keywords

tau

Alzheimer's disease

axonal transport

Wallerian degeneration

signalling

Clinical conditions

Alzheimer's disease

Dementia

Equipment

Behavioural analysis

Cell culture

Fluorescence microscopy

Microscopy

molecular biology

mouse genetics

Collaborators

United Kingdom

Brian Anderton Web: http://internal.iop.kcl.ac.uk/ipublic...

Diane Hanger Web: http://internal.iop.kcl.ac.uk/ipublic...

International

Jean-Pierre Brion

Associated News Items


    Key publications

    Gilley J, Orsomando G, Nascimento-Ferreira I, Coleman MP (2015), “Absence of SARM1 Rescues Development and Survival of NMNAT2-Deficient Axons” Cell Reports 10(12): 1974-1981

    Gilley J, Coleman MP (2010), “Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons.” PLoS Biol 8(1):e1000300 Details

    Gilley J, Coffer PJ, Ham J (2003), “FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons.” J Cell Biol 162(4):613-22 Details

    Publications

    2016

    Clark DE, Waszkowycz B, Wong M, Lockey PM, Adalbert R, Gilley J, Clark J, Coleman MP (2016), “Application of virtual screening to the discovery of novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with potential for the treatment of cancer and axonopathies” ioorganic & Medicinal Chemistry Letters

    Gilley J, Ando K, Seereeram A, Rodríguez-Martín T, Pooler AM, Sturdee L, Anderton BH, Brion J-P, Hanger DP, Coleman MP (2016), “Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice” Neurobiology of Aging 39: 1-18

    Rodríguez-Martín T, Pooler AM, Lau DHW, Mórotz GM, De Vos KJ, Gilley J, Coleman MP, Hanger DP (2016), “Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons” Neurobiology of disease 85: 1-10

    2015

    Di Stefano M, Nascimento-Ferreira I, Orsomando G, Mori V, Gilley J, Brown R, Janeckova L, Vargas ME, Worrell LA, Loreto A, Tickle J, Patrick J, Webster JRM, Marangoni M, Carpi FM, Pucciarelli S, Rossi F, Meng W, Sagasti A, Ribchester RR, Magni G, Coleman MP, Conforti L (2015), “A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration” Cell Death & Differentiation 22(5): 731-742

    2014

    Conforti L, Gilley J, Coleman MP (2014), “Wallerian degeneration: an emerging axon death pathway linking injury and disease.” Nat Rev Neurosci 15(6):394-409 Details

    2013

    Evans C, Cook SJ, Coleman MP, Gilley J (2013), “MEK inhibitor U0126 reverses protection of axons from Wallerian degeneration independently of MEK-ERK signaling.” PLoS One 8(10):e76505 Details

    Gilley J, Adalbert R, Yu G, Coleman MP (2013), “Rescue of peripheral and CNS axon defects in mice lacking NMNAT2.” J Neurosci 33(33):13410-24 Details

    Milde S, Gilley J, Coleman MP (2013), “Axonal trafficking of NMNAT2 and its roles in axon growth and survival in vivo.” Bioarchitecture 3(5):133-40 Details

    Milde S, Gilley J, Coleman MP (2013), “Subcellular localization determines the stability and axon protective capacity of axon survival factor Nmnat2.” PLoS Biol 11(4):e1001539 Details

    2011

    Gilley J, Adalbert R, Coleman MP (2011), “Modelling early responses to neurodegenerative mutations in mice.” Biochem Soc Trans 39(4):933-8 Details

    Gilley J, Seereeram A, Ando K, Mosely S, Andrews S, Kerschensteiner M, Misgeld T, Brion JP, Anderton B, Hanger DP, Coleman MP (2011), “Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a "P301L" tau knockin mouse.” Neurobiol Aging Details

    Hughes R, Gilley J, Kristiansen M, Ham J (2011), “The MEK-ERK pathway negatively regulates bim expression through the 3' UTR in sympathetic neurons.” BMC Neurosci 12:69 Details

    2010

    Andrews S, Gilley J, Coleman MP (2010), “Difference Tracker: ImageJ plugins for fully automated analysis of multiple axonal transport parameters.” J Neurosci Methods 193(2):281-7 Details

    Babetto E, Beirowski B, Janeckova L, Brown R, Gilley J, Thomson D, Ribchester RR, Coleman MP (2010), “Targeting NMNAT1 to axons and synapses transforms its neuroprotective potency in vivo.” J Neurosci 30(40):13291-304 Details

    2009

    Beirowski B, Babetto E, Gilley J, Mazzola F, Conforti L, Janeckova L, Magni G, Ribchester RR, Coleman MP (2009), “Non-nuclear Wld(S) determines its neuroprotective efficacy for axons and synapses in vivo.” J Neurosci 29(3):653-68 Details

    Conforti L, Wilbrey A, Morreale G, Janeckova L, Beirowski B, Adalbert R, Mazzola F, Di Stefano M, Hartley R, Babetto E, Smith T, Gilley J, Billington RA, Genazzani AA, Ribchester RR, Magni G, Coleman M (2009), “Wld S protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice.” J Cell Biol 184(4):491-500 Details

    Towers E, Gilley J, Randall R, Hughes R, Kristiansen M, Ham J (2009), “The proapoptotic dp5 gene is a direct target of the MLK-JNK-c-Jun pathway in sympathetic neurons.” Nucleic Acids Res 37(9):3044-60 Details

    2007

    Adalbert R, Gilley J, Coleman MP (2007), “Abeta, tau and ApoE4 in Alzheimer's disease: the axonal connection.” Trends Mol Med 13(4):135-42 Details

    2005

    Gilley J, Ham J (2005), “Evidence for increased complexity in the regulation of Bim expression in sympathetic neurons: involvement of novel transcriptional and translational mechanisms.” DNA Cell Biol 24(9):563-73 Details

    Ham J, Towers E, Gilley J, Terzano S, Randall R (2005), “BH3-only proteins: key regulators of neuronal apoptosis.” Cell Death Differ 12(8):1015-20 Details

    2001

    Gilley J, Fried M (2001), “One INK4 gene and no ARF at the Fugu equivalent of the human INK4A/ARF/INK4B tumour suppressor locus.” Oncogene 20(50):7447-52 Details

    1999

    Gilley J, Fried M (1999), “Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes.” Hum Mol Genet 8(7):1313-20 Details

    1998

    Gilley J, Fried M (1998), “Evolution of U24 and U36 snoRNAs encoded within introns of vertebrate rpL7a gene homologs: unique features of mammalian U36 variants.” DNA Cell Biol 17(7):591-602 Details

    1997

    Armes N, Gilley J, Fried M (1997), “The comparative genomic structure and sequence of the surfeit gene homologs in the puffer fish Fugu rubripes and their association with CpG-rich islands.” Genome Res 7(12):1138-52 Details

    Gilley J, Armes N, Fried M (1997), “Fugu genome is not a good mammalian model.” Nature 385(6614):305-6 Details