Dr John Stockley

Interests

I am interested in using in vitro systems to model and understand complex neuron and glial interactions, particularly the interaction between oligodendrocytes, their precursors and neuronal axons for CNS repair as well as understanding memory. I am also interested in the relationship between light, cells and their environment to improve methodologies such as optogenetics, live cell imaging and flow cytometry.

Research Focus

Keywords

Stem Cells

Oligodendrocytes

Myelination

Drug Discovery

White matter plasticity

Clinical conditions

Alzheimer's disease

Birth defects

Cancers

Cerebral Palsy, leukodystrophy,

Childhood disorders

Dementia

Multiple sclerosis

Schizophrenia

Traumatic brain injury

Equipment

Automated image analysis

Bioinformatics

Cell culture

Cloning

Confocal microscopy

Fluorescence microscopy

Fluorescent in situ hybridisation

High throughput screening

Immunohistochemistry

Media Formulation

Microscopy

Optogenetics

Western Blotting

Collaborators

No collaborators listed

Associated News Items


    Publications

    2013

    Lundgaard I, Luzhynskaya A, Stockley JH, Wang Z, Evans KA, Swire M, Volbracht K, Gautier HO, Franklin RJ, Ffrench-Constant C, Attwell D, Káradóttir RT (2013), “Neuregulin and BDNF Induce a Switch to NMDA Receptor-Dependent Myelination by Oligodendrocytes.” PLoS Biol 11(12):e1001743 Details

    2012

    Káradóttir RT, Stockley JH (2012), “Deconstructing myelination: it all comes down to size.” Nat Methods 9(9):883-4 Details

    2008

    Stockley JH, O'Neill C (2008), “Understanding BACE1: essential protease for amyloid-beta production in Alzheimer's disease.” Cell Mol Life Sci 65(20):3265-89 Details

    2007

    Stockley JH, O'Neill C (2007), “The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain.” Biochem Soc Trans 35(Pt 3):574-6 Details

    2006

    Stockley JH, Ravid R, O'Neill C (2006), “Altered beta-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer's disease brain.” FEBS Lett 580(28-29):6550-60 Details