Dr Jonas Neher

Jonas Neher

University position

Research Associate

Departments

Department of Biochemistry

Email

jjn24@cam.ac.uk

Research Theme

Cellular and Molecular Neuroscience

The Cambridge Neuroscience Community

Interests

I am investigating the contribution of inflammation, and in particular activated microglia, to neuronal death. We have recently found that inflammatory activated microglia can actively induce neuronal death through phagocytosis in culture and I am currently investigating this phenomenon in vivo.

Research Focus

Keywords

neurodegeneration

inflammation

microglia

phagocytosis

Clinical conditions

Stroke

Equipment

Behavioural analysis

Cell culture

Confocal microscopy

Enzyme assays

Fluorescence microscopy

Immunohistochemistry

Microscopy

Collaborators

Cambridge

Jing-Wei Zhao

Publications

2011

Neher JJ, Brown GC, Kinsner-Ovaskainen A, Bal-Price A (2011), “Inflammation and Reactive Oxygen/Nitrogen Species in Glial/Neuronal Cultures” Cell Culture Techniques, Neuromethods 56:331-347

Neher JJ, Neniskyte U, Zhao JW, Bal-Price A, Tolkovsky AM, Brown GC (2011), “Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death.” J Immunol 186(8):4973-83 Details

2010

Brown GC, Neher JJ (2010), “Inflammatory neurodegeneration and mechanisms of microglial killing of neurons.” Mol Neurobiol 41(2-3):242-7 Details

2007

Jekabsone A, Neher JJ, Borutaite V, Brown GC (2007), “Nitric oxide from neuronal nitric oxide synthase sensitises neurons to hypoxia-induced death via competitive inhibition of cytochrome oxidase.” J Neurochem 103(1):346-56 Details

Neher JJ, Brown GC (2007), “Neurodegeneration in models of Gram-positive bacterial infections of the central nervous system.” Biochem Soc Trans 35(Pt 5):1166-7 Details