Dr Jonas Neher
I am investigating the contribution of inflammation, and in particular activated microglia, to neuronal death. We have recently found that inflammatory activated microglia can actively induce neuronal death through phagocytosis in culture and I am currently investigating this phenomenon in vivo.
Neher JJ, Brown GC, Kinsner-Ovaskainen A, Bal-Price A (2011), “Inflammation and Reactive Oxygen/Nitrogen Species in Glial/Neuronal Cultures” Cell Culture Techniques, Neuromethods 56:331-347
Neher JJ, Neniskyte U, Zhao JW, Bal-Price A, Tolkovsky AM, Brown GC (2011), “Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death.” J Immunol 186(8):4973-83 Details
Brown GC, Neher JJ (2010), “Inflammatory neurodegeneration and mechanisms of microglial killing of neurons.” Mol Neurobiol 41(2-3):242-7 Details
Jekabsone A, Neher JJ, Borutaite V, Brown GC (2007), “Nitric oxide from neuronal nitric oxide synthase sensitises neurons to hypoxia-induced death via competitive inhibition of cytochrome oxidase.” J Neurochem 103(1):346-56 Details
Neher JJ, Brown GC (2007), “Neurodegeneration in models of Gram-positive bacterial infections of the central nervous system.” Biochem Soc Trans 35(Pt 5):1166-7 Details