Dr John Rogers

Interests

Approaches to gene therapy to promote axon regeneration. Specifically: expression of enzymes which can destroy axon-inhibitory proteoglycans, and the use of viral vectors which can express them in injured neurons.

Neurons in rat brain transduced with a herpesvirus vector expressing a gene for beta-galactosidase
Neurons in rat brain transduced with a herpes virus vector expressing a gene for beta-galactosidase (red) and induced to express c-Jun (green)
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Research Focus

Keywords

None specified

Clinical conditions

Spinal cord injury

Equipment

Cell culture

Immunohistochemistry

Recombinant protein expression

Collaborators

Cambridge

James Fawcett

Roger Keynes

Elizabeth Muir

Associated News Items


    Key publications

    Zhao RR, Muir EM, Alves JN, Rickman H, Allan AY, Kwok JC, Roet KC, Verhaagen J, Schneider BL, Bensadoun JC, Ahmed SG, Yáñez-Muñoz RJ, Keynes RJ, Fawcett JW, Rogers JH (2011), “Lentiviral vectors express chondroitinase ABC in cortical projections and promote sprouting of injured corticospinal axons.” J Neurosci Methods 201(1):228-38 Details

    Muir EM, Fyfe I, Gardiner S, Li L, Warren P, Fawcett JW, Keynes RJ, Rogers JH (2010), “Modification of N-glycosylation sites allows secretion of bacterial chondroitinase ABC from mammalian cells.” J Biotechnol 145(2):103-10 Details

    Rogers JH, Rhodes K, Roberts R, Raza M, Muir EM, Fawcett JW, Scarpini CG, Efstathiou S (2003), “A herpesvirus vector can transduce axotomized brain neurons” Exp Neurol 183:548-558

    Muir EM, Adcock KH, Morgenstern DA, Clayton R, von Stillfried N, Rhodes K, Ellis C, Fawcett JW, Rogers JH (2002), “Matrix metalloproteases and their inhibitors are produced by overlapping populations of activated astrocytes” Molecular Brain Research 100:103-117

    Publications

    2014

    Kanno H, Pressman Y, Moody A, Berg R, Muir EM, Rogers JH, Ozawa H, Itoi E, Pearse DD, Bunge MB (2014), “Combination of engineered schwann cell grafts to secrete neurotrophin and chondroitinase promotes axonal regeneration and locomotion after spinal cord injury.” J Neurosci 34(5):1838-55 Details

    2003

    Dobbertin A, Rhodes KE, Garwood J, Properzi F, Heck N, Rogers JH, Fawcett JW and Faissner A (2003), “Regulation of RPTPbeta/phosphacan expression and glycosaminoglycan epitopes in injured brain and cytokine-treated glia” Molec Cell Neurosci 24(4):951-971