Dr Jeffrey Huang

University position
Research Associate
Departments
Department of Veterinary Medicine
Home page
http://explore.georgetown.edu/people/...
Research Themes
Interests
Multiple sclerosis (MS) is characterised by the progressive breakdown of CNS myelin, the ensheathing membranes of CNS axons. One possible way to repair MS is to stimulate myelin regeneration by endogenous oligodendrocyte precursor cells (OPCs). My primary interest is to understand the mechanism of CNS remyelination, with the aim to identify therapeutic targets for promoting myelin repair.
I have recently moved to Georgetown University, Washington DC to set up my own lab. Please visit: http://explore.georgetown.edu/people/jh1659/?PageTemplateID=195
Research Focus
Keywordsmyelin oligodendrocytes glia regeneration stem cells |
Clinical conditionsMultiple sclerosis Traumatic brain injury |
Equipment
Cell culture
Confocal microscopy
Fluorescence microscopy
Immunohistochemistry
Microscopy
Collaborators
No collaborators listed
Publications
2012
Huang JK, Ferrari CC, Monteiro de Castro G, Lafont D, Zhao C, Zaratin P, Pouly S, Greco B, Franklin RJ (2012), “Accelerated Axonal Loss Following Acute CNS Demyelination in Mice Lacking Protein Tyrosine Phosphatase Receptor Type Z.” Am J Pathol Details
2011
Huang JK, Fancy SP, Zhao C, Rowitch DH, Ffrench-Constant C, Franklin RJ (2011), “Myelin Regeneration in Multiple Sclerosis: Targeting Endogenous Stem Cells.” Neurotherapeutics Details
Huang JK, Franklin RJ (2011), “Regenerative medicine in multiple sclerosis: Identifying pharmacological targets of adult neural stem cell differentiation.” Neurochem Int Details
Huang JK, Jarjour AA, Ffrench-Constant C, Franklin RJ (2011), “Retinoid X receptors as a potential avenue for regenerative medicine in multiple sclerosis.” Expert Rev Neurother 11(4):467-8 Details
Huang JK, Jarjour AA, Oumesmar BN, Kerninon C, Williams A, Krezel W, Kagechika H, Bauer J, Zhao C, Evercooren AB, Chambon P, Ffrench-Constant C, Franklin RJ (2011), “Retinoid X receptor gamma signaling accelerates CNS remyelination.” Nat Neurosci 14(1):45-53 Details
2010
Dhaunchak AS, Huang JK, De Faria Junior O, Roth AD, Pedraza L, Antel JP, Bar-Or A, Colman DR (2010), “A proteome map of axoglial specializations isolated and purified from human central nervous system.” Glia 58(16):1949-60 Details
Fancy SP, Kotter MR, Harrington EP, Huang JK, Zhao C, Rowitch DH, Franklin RJ (2010), “Overcoming remyelination failure in multiple sclerosis and other myelin disorders.” Exp Neurol Details
2009
Pedraza L, Huang JK, Colman D (2009), “Disposition of axonal caspr with respect to glial cell membranes: Implications for the process of myelination.” J Neurosci Res 87(15):3480-91 Details
2007
Huang JK, Dorey K, Ishibashi S, Amaya E (2007), “BDNF promotes target innervation of Xenopus mandibular trigeminal axons in vivo.” BMC Dev Biol 7:59 Details
2005
Huang JK, Phillips GR, Roth AD, Pedraza L, Shan W, Belkaid W, Mi S, Fex-Svenningsen A, Florens L, Yates JR 3rd, Colman DR (2005), “Glial membranes at the node of Ranvier prevent neurite outgrowth.” Science 310(5755):1813-7 Details
2001
Pedraza L, Huang JK, Colman DR (2001), “Organizing principles of the axoglial apparatus.” Neuron 30(2):335-44 Details
Phillips GR, Huang JK, Wang Y, Tanaka H, Shapiro L, Zhang W, Shan WS, Arndt K, Frank M, Gordon RE, Gawinowicz MA, Zhao Y, Colman DR (2001), “The presynaptic particle web: ultrastructure, composition, dissolution, and reconstitution.” Neuron 32(1):63-77 Details
2000
Tait S, Gunn-Moore F, Collinson JM, Huang J, Lubetzki C, Pedraza L, Sherman DL, Colman DR, Brophy PJ (2000), “An oligodendrocyte cell adhesion molecule at the site of assembly of the paranodal axo-glial junction.” J Cell Biol 150(3):657-66 Details
1999
Gould R, Freund C, Palmer F, Knapp PE, Huang J, Morrison H, Feinstein DL (1999), “Messenger RNAs for kinesins and dynein are located in neural processes.” Biol Bull 197(2):259-60 Details
1995
Wang ZY, Qiu QQ, Gurrieri M, Huang J, Deuel TF (1995), “WT1, the Wilms' tumor suppressor gene product, represses transcription through an interactive nuclear protein.” Oncogene 10(6):1243-7 Details
Wang ZY, Qiu QQ, Huang J, Gurrieri M, Deuel TF (1995), “Products of alternatively spliced transcripts of the Wilms' tumor suppressor gene, wt1, have altered DNA binding specificity and regulate transcription in different ways.” Oncogene 10(3):415-22 Details



