Dr Jeffrey Huang

Jeffrey Huang

University position

Research Associate

Departments

Department of Veterinary Medicine

Home page

http://explore.georgetown.edu/people/...

Research Themes

Cellular and Molecular Neuroscience

Clinical and Veterinary Neuroscience

Interests

Multiple sclerosis (MS) is characterised by the progressive breakdown of CNS myelin, the ensheathing membranes of CNS axons. One possible way to repair MS is to stimulate myelin regeneration by endogenous oligodendrocyte precursor cells (OPCs). My primary interest is to understand the mechanism of CNS remyelination, with the aim to identify therapeutic targets for promoting myelin repair.

I have recently moved to Georgetown University, Washington DC to set up my own lab. Please visit: http://explore.georgetown.edu/people/jh1659/?PageTemplateID=195

Volcano plot
Volcano plot
Click image to view full-size

Research Focus

Keywords

myelin

oligodendrocytes

glia

regeneration

stem cells

Clinical conditions

Multiple sclerosis

Traumatic brain injury

Equipment

Cell culture

Confocal microscopy

Fluorescence microscopy

Immunohistochemistry

Microscopy

Collaborators

No collaborators listed

Publications

2012

Huang JK, Ferrari CC, Monteiro de Castro G, Lafont D, Zhao C, Zaratin P, Pouly S, Greco B, Franklin RJ (2012), “Accelerated Axonal Loss Following Acute CNS Demyelination in Mice Lacking Protein Tyrosine Phosphatase Receptor Type Z.” Am J Pathol Details

2011

Huang JK, Fancy SP, Zhao C, Rowitch DH, Ffrench-Constant C, Franklin RJ (2011), “Myelin Regeneration in Multiple Sclerosis: Targeting Endogenous Stem Cells.” Neurotherapeutics Details

Huang JK, Franklin RJ (2011), “Regenerative medicine in multiple sclerosis: Identifying pharmacological targets of adult neural stem cell differentiation.” Neurochem Int Details

Huang JK, Jarjour AA, Ffrench-Constant C, Franklin RJ (2011), “Retinoid X receptors as a potential avenue for regenerative medicine in multiple sclerosis.” Expert Rev Neurother 11(4):467-8 Details

Huang JK, Jarjour AA, Oumesmar BN, Kerninon C, Williams A, Krezel W, Kagechika H, Bauer J, Zhao C, Evercooren AB, Chambon P, Ffrench-Constant C, Franklin RJ (2011), “Retinoid X receptor gamma signaling accelerates CNS remyelination.” Nat Neurosci 14(1):45-53 Details

2010

Dhaunchak AS, Huang JK, De Faria Junior O, Roth AD, Pedraza L, Antel JP, Bar-Or A, Colman DR (2010), “A proteome map of axoglial specializations isolated and purified from human central nervous system.” Glia 58(16):1949-60 Details

Fancy SP, Kotter MR, Harrington EP, Huang JK, Zhao C, Rowitch DH, Franklin RJ (2010), “Overcoming remyelination failure in multiple sclerosis and other myelin disorders.” Exp Neurol Details

2009

Pedraza L, Huang JK, Colman D (2009), “Disposition of axonal caspr with respect to glial cell membranes: Implications for the process of myelination.” J Neurosci Res 87(15):3480-91 Details

2007

Huang JK, Dorey K, Ishibashi S, Amaya E (2007), “BDNF promotes target innervation of Xenopus mandibular trigeminal axons in vivo.” BMC Dev Biol 7:59 Details

2005

Huang JK, Phillips GR, Roth AD, Pedraza L, Shan W, Belkaid W, Mi S, Fex-Svenningsen A, Florens L, Yates JR 3rd, Colman DR (2005), “Glial membranes at the node of Ranvier prevent neurite outgrowth.” Science 310(5755):1813-7 Details

2001

Pedraza L, Huang JK, Colman DR (2001), “Organizing principles of the axoglial apparatus.” Neuron 30(2):335-44 Details

Phillips GR, Huang JK, Wang Y, Tanaka H, Shapiro L, Zhang W, Shan WS, Arndt K, Frank M, Gordon RE, Gawinowicz MA, Zhao Y, Colman DR (2001), “The presynaptic particle web: ultrastructure, composition, dissolution, and reconstitution.” Neuron 32(1):63-77 Details

2000

Tait S, Gunn-Moore F, Collinson JM, Huang J, Lubetzki C, Pedraza L, Sherman DL, Colman DR, Brophy PJ (2000), “An oligodendrocyte cell adhesion molecule at the site of assembly of the paranodal axo-glial junction.” J Cell Biol 150(3):657-66 Details

1999

Gould R, Freund C, Palmer F, Knapp PE, Huang J, Morrison H, Feinstein DL (1999), “Messenger RNAs for kinesins and dynein are located in neural processes.” Biol Bull 197(2):259-60 Details

1995

Wang ZY, Qiu QQ, Gurrieri M, Huang J, Deuel TF (1995), “WT1, the Wilms' tumor suppressor gene product, represses transcription through an interactive nuclear protein.” Oncogene 10(6):1243-7 Details

Wang ZY, Qiu QQ, Huang J, Gurrieri M, Deuel TF (1995), “Products of alternatively spliced transcripts of the Wilms' tumor suppressor gene, wt1, have altered DNA binding specificity and regulate transcription in different ways.” Oncogene 10(3):415-22 Details