Professor Joe Herbert
University position
Professor
Departments
Department of Clinical Neurosciences
Home page
http://www.brc.cam.ac.uk/JoeHerb... (personal home page)
Research Themes
Interests
I am interested in the role of the brain in adaptive responses, with particular reference to the reciprocal interaction between hormones and the brain. My experimental work is focussed on the way that neural factors, such as serotonin and glucocorticoids, regulate the formation of new neurons in the adult hippocampus, and the role these play in responses to stress. I have a large parallel clinical programme, focussed on determining the risk factors (genetic, environmental, psychosocial and endocrine) that predispose to depression. I also work on the role of hormones in financial decision-making and risk perception.
I am coordinator of a Marie Curie Initial training Network (10 EU Universities and 2 companies)
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Research Focus
Keywordsneurogenesis hippocampus stress depression hormones |
Clinical conditionsDepressive disorders |
Equipment
No equipment indicated
Collaborators
CambridgeValerie Dunn | United KingdomTom Craig Web: http://internal.iop.kcl.ac.uk/ipublic... Sarah Halligan Web: http:// stress disorder s.l.halliga... Tirril Harris Web: http://www.kcl.ac.uk/depsta/... Lynne Murray Web: http://www.reading.ac.uk/psychol... Stephanie van Goozen Web: http://www.cf.ac.uk/psych/h... InternationalJay Schulkin Web: http://cbbc.georgetown.edu/profile... |
Key publications
Coates JM, Herbert J (2008), “Endogenous steroids and financial risk taking on a London trading floor.” Proc Natl Acad Sci U S A 105(16):6167-72 Details
Herbert J (2007), “The Minder Brain. How the brain keeps you alive, protects you from danger and ensures that you reproduce” Word Scientific Press www.theminderbrain.com
Herbert J, Goodyer IM, Grossman AB, Hastings MH, de Kloet ER, Lightman SL, Lupien SJ, Roozendaal B, Seckl JR (2006), “Do corticosteroids damage the brain?” J Neuroendocrinol 18:93-411 Details
Huang GJ, Herbert J (2006), “Stimulation of neurogenesis in the hippocampus of the adult rat by fluoxetine requires rhythmic change in corticosterone” Biol Psychiatry 59:619-24 Details
Publications
2009
Goodyer IM, Bacon A, Ban M, Croudace T, Herbert J (2009), “Serotonin transporter genotype, morning cortisol and subsequent depression in adolescents.” Br J Psychiatry 195(1):39-45 Details
Goodyer IM, Croudace T, Dunn V, Herbert J, Jones PB (2009), “Cohort Profile: Risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.” Int J Epidemiol Details
Murray L, Halligan SL, Goodyer I, Herbert J (2009), “Disturbances in early parenting of depressed mothers and cortisol secretion in offspring: A preliminary study.” J Affect Disord Details
2008
Alahmed S, Herbert J (2008), “Strain differences in proliferation of progenitor cells in the dentate gyrus of the adult rat and the response to fluoxetine are dependent on corticosterone.” Neuroscience 157(3):677-82 Details
Fairchild G, van Goozen SH, Stollery SJ, Brown J, Gardiner J, Herbert J, Goodyer IM (2008), “Cortisol diurnal rhythm and stress reactivity in male adolescents with early-onset or adolescence-onset conduct disorder.” Biol Psychiatry 64(7):599-606 Details
Gurnell EM, Hunt PJ, Curran SE, Conway CL, Pullenayegum EM, Huppert FA, Compston JE, Herbert J, Chatterjee VK (2008), “Long-term DHEA replacement in primary adrenal insufficiency: a randomized, controlled trial.” J Clin Endocrinol Metab 93(2):400-9 Details
Herbert J (2008), “Who do we think we are? The brain and gender identity.” Brain 131(Pt 12):3115-7 Details
Herbert J (2008), “Neurogenesis and depression: breakthrough or blind alley?” J Neuroendocrinol 20(3):413-4 Details
Pinnock SB, Herbert J (2008), “Brain-derived neurotropic factor and neurogenesis in the adult rat dentate gyrus: interactions with corticosterone.” Eur J Neurosci 27(10):2493-500 Details
Pinnock SB, Lazic SE, Wong HT, Wong IH, Herbert J (2008), “Synergistic effects of dehydroepiandrosterone and fluoxetine on proliferation of progenitor cells in the dentate gyrus of the adult male rat.” Neuroscience Details
2007
Halligan SL, Herbert J, Goodyer I, Murray L (2007), “Disturbances in morning cortisol secretion in association with maternal postnatal depression predict subsequent depressive symptomatology in adolescents.” Biol Psychiatry 62(1):40-6 Details
Pinnock SB, Balendra R, Chan M, Hunt LT, Turner-Stokes T, Herbert J (2007), “Interactions between nitric oxide and corticosterone in the regulation of progenitor cell proliferation in the dentate gyrus of the adult rat.” Neuropsychopharmacology 32(2):493-504 Details
2005
Wong EY, Herbert J (2005), “Roles of mineralocorticoid and glucocorticoid receptors in the regulation of progenitor proliferation in the adult hippocampus.” Eur J Neurosci 22(4):785-92 Details
2004
Carter RN, Pinnock SB, Herbert J (2004), “Does the amygdala modulate adaptation to repeated stress?” Neuroscience 126(1):9-19 Details
Gubba EM, Fawcett JW, Herbert J (2004), “The effects of corticosterone and dehydroepiandrosterone on neurotrophic factor mRNA expression in primary hippocampal and astrocyte cultures.” Brain Res Mol Brain Res 127(1-2):48-59 Details
Halligan SL, Herbert J, Goodyer IM, Murray L (2004), “Exposure to postnatal depression predicts elevated cortisol in adolescent offspring.” Biol Psychiatry 55(4):376-81 Details
Hatfield CF, Herbert J, van Someren EJ, Hodges JR, Hastings MH (2004), “Disrupted daily activity/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer's dementia.” Brain 127(Pt 5):1061-74 Details
2003
Goodyer IM, Herbert J, Tamplin A (2003), “Psychoendocrine antecedents of persistent first-episode major depression in adolescents: a community-based longitudinal enquiry.” Psychol Med 33(4):601-10 Details
2002
Karishma KK, Herbert J (2002), “Dehydroepiandrosterone (DHEA) stimulates neurogenesis in the hippocampus of the rat, promotes survival of newly formed neurons and prevents corticosterone-induced suppression.” Eur J Neurosci 16(3):445-53 Details
2000
Gubba EM, Netherton CM, Herbert J (2000), “Endangerment of the brain by glucocorticoids: experimental and clinical evidence.” J Neurocytol 29(5-6):439-49 Details