Professor Joe Herbert
http://www.brc.cam.ac.uk/JoeHerb... (personal home page)
I am interested in the role of the brain in adaptive responses, with particular reference to the reciprocal interaction between hormones and the brain. My experimental work is focussed on the way that neural factors, such as serotonin and glucocorticoids, regulate the formation of new neurons in the adult hippocampus, and the role these play in responses to stress. I have a large parallel clinical programme, focussed on determining the risk factors (genetic, environmental, psychosocial and endocrine) that predispose to depression in collaboration with Prof Goodyer (Psychiatry). I also work on the role of hormones in financial decision-making and risk perception.
I am director of graduate training and I was coordinator of a Marie Curie Initial training Network (10 EU Universities and 2 companies)
Tom Craig Web: http://internal.iop.kcl.ac.uk/ipublic...
Sarah Halligan Web: http:// stress disorder s.l.halliga...
Tirril Harris Web: http://www.kcl.ac.uk/depsta/...
Lynne Murray Web: http://www.reading.ac.uk/psychol...
Stephanie van Goozen Web: http://www.cf.ac.uk/psych/h...
Jay Schulkin Web: http://cbbc.georgetown.edu/profile...
Coates JM, Herbert J (2008), “Endogenous steroids and financial risk taking on a London trading floor.” Proc Natl Acad Sci U S A 105(16):6167-72 Details
Herbert J (2007), “The Minder Brain. How the brain keeps you alive, protects you from danger and ensures that you reproduce” Word Scientific Press www.theminderbrain.com
Herbert J, Goodyer IM, Grossman AB, Hastings MH, de Kloet ER, Lightman SL, Lupien SJ, Roozendaal B, Seckl JR (2006), “Do corticosteroids damage the brain?” J Neuroendocrinol 18:93-411 Details
Huang GJ, Herbert J (2006), “Stimulation of neurogenesis in the hippocampus of the adult rat by fluoxetine requires rhythmic change in corticosterone” Biol Psychiatry 59:619-24 Details
Herbert J (2013), “Cortisol and depression: three questions for psychiatry.” Psychol Med 43(3):449-69 Details
Chen X, Lepier A, Berninger B, Tolkovsky AM, Herbert J (2012), “Cultured subventricular zone progenitor cells transduced with neurogenin-2 become mature glutamatergic neurons and integrate into the dentate gyrus.” PLoS One 7(2):e31547 Details
Herbert J, Ban M, Brown GW, Harris TO, Ogilvie A, Uher R, Craig TK (2012), “Interaction between the BDNF gene Val/66/Met polymorphism and morning cortisol levels as a predictor of depression in adult women.” Br J Psychiatry 201(4):313-9 Details
St Clair MC, Goodyer IM, Dunn V, Herbert J, Jones PB, Croudace T (2012), “Depressive symptoms during adolescence: comparison between epidemiological and high risk sampling.” Soc Psychiatry Psychiatr Epidemiol 47(8):1333-41 Details
Chen X, Tolkovsky AM, Herbert J (2011), “Cell origin and culture history determine successful integration of neural precursor transplants into the dentate gyrus of the adult rat.” PLoS One 6(2):e17072 Details
Dunn VJ, Abbott RA, Croudace TJ, Wilkinson P, Jones PB, Herbert J, Goodyer IM (2011), “Profiles of family-focused adverse experiences through childhood and early adolescence: the ROOTS project a community investigation of adolescent mental health.” BMC Psychiatry 11:109 Details
Gilhooley MJ, Pinnock SB, Herbert J (2011), “Rhythmic expression of per1 in the dentate gyrus is suppressed by corticosterone: implications for neurogenesis.” Neurosci Lett 489(3):177-81 Details
Landt J, Ball SL, Holland AJ, Hon J, Owen A, Treppner P, Herbert J (2011), “Age-related changes in plasma dehydroepiandrosterone levels in adults with Down's syndrome and the risk of dementia.” J Neuroendocrinol 23(5):450-5 Details
AlAhmed S, Herbert J (2010), “Effect of agomelatine and its interaction with the daily corticosterone rhythm on progenitor cell proliferation in the dentate gyrus of the adult rat.” Neuropharmacology 59(6):375-9 Details
Murray L, Halligan SL, Goodyer I, Herbert J (2010), “Disturbances in early parenting of depressed mothers and cortisol secretion in offspring: a preliminary study.” J Affect Disord 122(3):218-23 Details
Goodyer IM, Bacon A, Ban M, Croudace T, Herbert J (2009), “Serotonin transporter genotype, morning cortisol and subsequent depression in adolescents.” Br J Psychiatry 195(1):39-45 Details
Goodyer IM, Croudace T, Dunn V, Herbert J, Jones PB (2009), “Cohort Profile: Risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.” Int J Epidemiol Details
Pinnock SB, Lazic SE, Wong HT, Wong IH, Herbert J (2009), “Synergistic effects of dehydroepiandrosterone and fluoxetine on proliferation of progenitor cells in the dentate gyrus of the adult male rat.” Neuroscience 158(4):1644-51 Details
Alahmed S, Herbert J (2008), “Strain differences in proliferation of progenitor cells in the dentate gyrus of the adult rat and the response to fluoxetine are dependent on corticosterone.” Neuroscience 157(3):677-82 Details
Fairchild G, van Goozen SH, Stollery SJ, Brown J, Gardiner J, Herbert J, Goodyer IM (2008), “Cortisol diurnal rhythm and stress reactivity in male adolescents with early-onset or adolescence-onset conduct disorder.” Biol Psychiatry 64(7):599-606 Details
Gurnell EM, Hunt PJ, Curran SE, Conway CL, Pullenayegum EM, Huppert FA, Compston JE, Herbert J, Chatterjee VK (2008), “Long-term DHEA replacement in primary adrenal insufficiency: a randomized, controlled trial.” J Clin Endocrinol Metab 93(2):400-9 Details
Herbert J (2008), “Who do we think we are? The brain and gender identity.” Brain 131(Pt 12):3115-7 Details
Herbert J (2008), “Neurogenesis and depression: breakthrough or blind alley?” J Neuroendocrinol 20(3):413-4 Details
Pinnock SB, Herbert J (2008), “Brain-derived neurotropic factor and neurogenesis in the adult rat dentate gyrus: interactions with corticosterone.” Eur J Neurosci 27(10):2493-500 Details
Halligan SL, Herbert J, Goodyer I, Murray L (2007), “Disturbances in morning cortisol secretion in association with maternal postnatal depression predict subsequent depressive symptomatology in adolescents.” Biol Psychiatry 62(1):40-6 Details
Pinnock SB, Balendra R, Chan M, Hunt LT, Turner-Stokes T, Herbert J (2007), “Interactions between nitric oxide and corticosterone in the regulation of progenitor cell proliferation in the dentate gyrus of the adult rat.” Neuropsychopharmacology 32(2):493-504 Details
Wong EY, Herbert J (2005), “Roles of mineralocorticoid and glucocorticoid receptors in the regulation of progenitor proliferation in the adult hippocampus.” Eur J Neurosci 22(4):785-92 Details
Carter RN, Pinnock SB, Herbert J (2004), “Does the amygdala modulate adaptation to repeated stress?” Neuroscience 126(1):9-19 Details
Gubba EM, Fawcett JW, Herbert J (2004), “The effects of corticosterone and dehydroepiandrosterone on neurotrophic factor mRNA expression in primary hippocampal and astrocyte cultures.” Brain Res Mol Brain Res 127(1-2):48-59 Details
Halligan SL, Herbert J, Goodyer IM, Murray L (2004), “Exposure to postnatal depression predicts elevated cortisol in adolescent offspring.” Biol Psychiatry 55(4):376-81 Details
Hatfield CF, Herbert J, van Someren EJ, Hodges JR, Hastings MH (2004), “Disrupted daily activity/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer's dementia.” Brain 127(Pt 5):1061-74 Details
Goodyer IM, Herbert J, Tamplin A (2003), “Psychoendocrine antecedents of persistent first-episode major depression in adolescents: a community-based longitudinal enquiry.” Psychol Med 33(4):601-10 Details
Karishma KK, Herbert J (2002), “Dehydroepiandrosterone (DHEA) stimulates neurogenesis in the hippocampus of the rat, promotes survival of newly formed neurons and prevents corticosterone-induced suppression.” Eur J Neurosci 16(3):445-53 Details
Gubba EM, Netherton CM, Herbert J (2000), “Endangerment of the brain by glucocorticoids: experimental and clinical evidence.” J Neurocytol 29(5-6):439-49 Details